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Immunoglobulin heavy chain variable region analysis in dairy goats.

Abstract：

:Based on the goat genome database, we have annotated the genomic organization of the goat immunoglobulin heavy chain variable region. The goat IgH locus is present on seven genome scaffolds, and contains ten VH, three DH and six JH segments. After the exclusion of three shorter segments, the VH genes were divided into two gene families based on sequence similarity. By analyzing the IgH cDNA sequences, we further identified that VH2 (54.2%), DH1 (61.7%) and JH1 (60.5%) segments were most frequently utilized in the expression of the immunoglobulin variable region, and that point mutations introduced by somatic hypermutation were the major mutation present in these expressed variable region. Compared with human and horses, DH-DH fusion occurred at a higher frequency in goat V(D)J recombination. These results provided variable insights into goat immunoglobulin heavy chain variable region genome loci and repertoire diversity.

journal_name

Immunobiology

journal_title

Immunobiology

authors

Du L,Wang S,Zhu Y,Zhao H,Basit A,Yu X,Li Q,Sun X

doi

10.1016/j.imbio.2018.07.005

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

599-607

issue

11

eissn

0171-2985

issn

1878-3279

pii

S0171-2985(18)30042-1

journal_volume

223

pub_type

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