Rat macrophages inhibit natural killer (NK) cell activity against adherent growing target cells.

abstract：BACKGROUND:Analysis of peripheral blood lymphocyte subsets has become an essential tool in the evaluation of outcome of diagnostic and research related questions in immunological and pathological conditions. Periodic evaluation and establishment of normal lymphocyte reference ranges are required in clinical and researc...

journal_title：Immunobiology

authors： Valiathan R,Deeb K,Diamante M,Ashman M,Sachdeva N,Asthana D

更新日期：2014-07-01 00:00:00

abstract：:Cell walls from Streptococcus pyogenes strain Sv (Group A, M type 3) were lysed with M1 endo-N-acetylmuramidase, and the group A-specific carbohydrate antigen was purified by Sephadex G-100 gel filtration. The initial eluting antigen (M1gA) peak was assessed for mitogenic and polyclonal lymphocyte-activating propertie...

journal_title：Immunobiology

authors： Morisaki I,Kimura S,Torii M,Michalek SM,McGhee JR,Okahashi N,Hamada S

更新日期：1985-11-01 00:00:00

abstract：:Human cell lines of myelo/monocytic origin express the cellular receptor for urokinase-type plasminogen activator (uPA-R). The receptor localizes urokinase-type plasminogen activator (uPA) to the surface of the cell, where it can convert plasminogen to the active serine proteinase plasmin. Plasmin may subsequently acc...

journal_title：Immunobiology

authors： Herijgers N,Vettel U,Schaefer B,Spring H,Todd RF 3rd,Kramer MD

更新日期：1995-11-01 00:00:00

abstract：:Ficolins are a group of proteins containing both a collagen-like domain and a fibrinogen-like domain and are found in varying tissues. Ficolins present in sera have a lectin activity toward N-acetylglucosamine through their fibrinogen-like domains. The domain organizations between ficolins and mannose-binding lectin (...

journal_title：Immunobiology

authors： Matsushita M,Fujita T

更新日期：2002-09-01 00:00:00

abstract：:In the thymus of non-obese diabetic (NOD) mice, the expression of the autoimmune regulator (Aire) gene varies with age, and its down-regulation in young mice precedes the later emergence of type 1 diabetes mellitus (T1D). In addition, the insulin (Ins2) peripheral tissue antigen (PTA) gene, which is Aire-dependent, is...

journal_title：Immunobiology

authors： Oliveira EH,Macedo C,Donate PB,Almeida RS,Pezzi N,Nguyen C,Rossi MA,Sakamoto-Hojo ET,Donadi EA,Passos GA

更新日期：2013-01-01 00:00:00

abstract：:Human T-lymphocyte clones showing proliferative and cytotoxic responses specific for HLA antigens were isolated. To obtain enriched numbers of functionally active colonies, the cells were first sensitized in vitro in a tertiary mixed lymphocyte culture (MLC), using 10 stimulating cells for each responding cell. To ass...

journal_title：Immunobiology

authors： Schendel DJ,Wank R

更新日期：1981-01-01 00:00:00

abstract：:Cytophotometric measurements of DNA, dry mass (total proteins) and surface localized IgM and Ia were performed on individual cells of a Burkitt lymphoma derived cell line after X-irradiation and after polyploidization. Blockage of cell division was achieved with 250 r, and an arrest in G2 was found 48 hr after irradia...

journal_title：Immunobiology

authors： Killander D,Klein E,Shapiro I,Lundin L

更新日期：1980-07-01 00:00:00

abstract：:People deficient in C1-INH present recurrent angioedema localized to subcutaneous or mucous tissues. The defect can be caused by impaired synthesis, due to a genetic defect (hereditary angioedema), or by increased catabolism (acquired angioedema). In our experience the majority of patients with acquired angioedema (16...

journal_title：Immunobiology

authors： Cicardi M,Bergamaschini L,Cugno M,Beretta A,Zingale LC,Colombo M,Agostoni A

更新日期：1998-08-01 00:00:00

abstract：:In order to evaluate the role of CD8+ T cells in cutaneous leishmaniasis, major histocompatibility complex (MHC) class II-deficient mice of C57BL/6 background lacking functional CD4+ T cells were infected with Leishmania major. In contrast to C57BL/6 wild-type mice which are resistant to infection with L. major, these...

journal_title：Immunobiology

authors： Erb K,Blank C,Ritter U,Bluethmann H,Moll H

更新日期：1996-07-01 00:00:00

abstract：:T-lymphocytes, including Th17-cells and T-cells expressing acetylcholine (ACh), are key components of systemic inflammation in chronic obstructive pulmonary disease (COPD). We investigated whether ACh promotes Th17 cells in COPD. ACh, IL-17A, IL-22, RORγt, FOXP3 expression and AChIL-17A, AChIL-22, AChRORγt coexpressio...

journal_title：Immunobiology

authors： Profita M,Albano GD,Riccobono L,Di Sano C,Montalbano AM,Gagliardo R,Anzalone G,Bonanno A,Pieper MP,Gjomarkaj M

更新日期：2014-05-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common neurodegenerative disease and it poses an ever-increasing burden to an aging population. Several loci responsible for the rare, autosomal dominant form of AD have been identified (APP, PS1 and PS2), and these have facilitated the development of the amyloid cascade hypothesis...

journal_title：Immunobiology

authors： Crehan H,Holton P,Wray S,Pocock J,Guerreiro R,Hardy J

更新日期：2012-02-01 00:00:00

abstract：:In contrast to murine spleen M phi, resident peritoneal M phi from health mice express very little Forssman glycolipid antigen (Fo). The following experiments suggest that Fo expression by peritoneal M phi may be associated with inflammation. Balb/c and CBA/J mice were given inflammatory stimuli by i.p. injection of l...

journal_title：Immunobiology

authors： von Kleist R,Schmitt E,Westermann J,Mühlradt PF

更新日期：1990-06-01 00:00:00

abstract：:Mycoplasma arthritidis produces a so-far only partially characterized soluble material (MAS) that has a potent mitogenic effect on T lymphocytes of several species. Similar to staphylococcal enterotoxins and a number of related toxins secreted by other species of bacteria, nanogram quantities of these so-called supera...

journal_title：Immunobiology

authors： Brand JM,Kirchner H,Neustock P,Kruse A

更新日期：1992-11-01 00:00:00

abstract：:Lymphocytes from spleen, thymus and lymph nodes from individual young adult (3--4 months) and aged (26--30 months) NMRI mice were stimulated with the mitogens Con A, PHA and LPS. 24 hours later, the number of cell with increased RNA-content (G1 cells) was determined by cytofluorometry. In parallel the 3H-thymidine inc...

journal_title：Immunobiology

authors： Joncourt F,Bettens F,Kristensen F,de Weck AL

更新日期：1981-06-01 00:00:00

abstract：:Propranolol is a widely-known beta-blocker approved for treating infantile hemangiomas (IH). The mechanisms behind the spectacular IH involution after propranolol treatment remain unclear. Recently, there is strong evidence of overexpression of numerous angiogenic factors in IH tissues, and it is reported that propran...

journal_title：Immunobiology

authors： Taran K,Wnęk A,Kobos J,Andrzejewska E,Przewratil P

更新日期：2017-11-01 00:00:00

abstract：:It is established that (1) subclinical Bordetella pertussis colonization of the nasopharynx persists in highly vaccinated populations, and (2) B. pertussis toxin is a potent adjuvant that, when co-administered with neural antigens, induces neuropathology in experimental autoimmune encephalomyelitis, the principle anim...

journal_title：Immunobiology

authors： Rubin K,Glazer S

更新日期：2016-04-01 00:00:00

abstract：:The immunoglobulin production capacities of peripheral blood lymphocytes obtained from patients with various chronic inflammatory liver diseases and from normal individuals were compared. Using a reverse hemolytic plaque assay, immunoglobulin-secreting cells (ISC) were counted immediately after isolation (immediate IS...

journal_title：Immunobiology

authors： Sieber G,Teichmann JV,Möller B,Hopf U

更新日期：1988-12-01 00:00:00

abstract：:Non-antigen-specific activation of human B lymphocytes for IgE production in vitro requires the presence of interleukin 4 and non-cognate physical interaction with T cells. The latter can be replaced by antibodies directed against the B cells' CD40 structure. Antigen-specific induction of immunoglobulin responses, inc...

journal_title：Immunobiology

authors： Armerding D,van Reijsen FC,Hren A,Mudde GC

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:Following any acute irritation lung function declines rapidly. Reasons for pulmonary deterioration in humans had been attributed to the action of either interleukin-6 or interleukin-8 in the lungs. OBJECTIVES:The present study investigates the association between immune response and decline in lung function...

journal_title：Immunobiology

authors： Wölbeling F,Munder A,Kerber-Momot T,Neumann D,Hennig C,Hansen G,Tümmler B,Baumann U

更新日期：2011-08-01 00:00:00

abstract：:Recently, it could be shown that Cyclosporin A (CsA) inhibited the activation of T and B lymphocytes by interfering with an early step of the activation, namely the stimulation of the plasma membrane-bound lysophosphatide acyltransferase. In this report, we compared three CsA-derivatives, Dihydro-Cyclosporin C (Dihydr...

journal_title：Immunobiology

authors： Kroggel R,Goppelt-Strübe M,Martin M,Resch K

更新日期：1987-09-01 00:00:00

abstract：:We were able to characterize about 25 antigenic proteins of cultured synovial fibroblasts with apparent molecular weights of 15-230 kd by SDS-electrophoresis and immunoblotting using guinea pig antiserum. Some of these proteins were bovine-serum-derived, adsorbed onto fibroblasts from culture medium. Both rheumatoid a...

journal_title：Immunobiology

authors： Heino J,Kouri T,Jalkanen M,Lehtonen OP

更新日期：1984-05-01 00:00:00

abstract：:CD4(+)CD25(+)Foxp3(+) T regulatory cells (Tregs) and CD1d-restricted invariant natural killer T (iNKT) cells are two cell types that are known to regulate immune reactions. Depletion or inactivation of Tregs using specific anti-CD25 antibodies in combination with immunostimulation is an attractive modality especially ...

journal_title：Immunobiology

authors： Rosalia RA,Štěpánek I,Polláková V,Šímová J,Bieblová J,Indrová M,Moravcová S,Přibylová H,Bontkes HJ,Bubeník J,Sparwasser T,Reiniš M

更新日期：2013-06-01 00:00:00

abstract：:L-alanine was shown earlier to play a significant role for the proliferation of lymphocytes in vitro. In the present work the effect of L-alanine and some other amino acids on thymocyte proliferation was studied in vivo by local administration into one thymus lobe of guinea pigs. Proliferating cells were pulse labelle...

journal_title：Immunobiology

authors： Hägglund B,Sandberg G

更新日期：1993-06-01 00:00:00

abstract：:This study assessed variation in plasma levels of the complement regulatorC1 inhibitor (C1inh) in patients with age related macular degeneration (AMD) and controls. Plasma from391 AMD cases and 370 controls was assayed by rate nephelometry to determine C1inh protein levels. Protein levels were analysed for relationshi...

journal_title：Immunobiology

authors： Gibson J,Hakobyan S,Cree AJ,Collins A,Harris CL,Ennis S,Morgan BP,Lotery AJ

更新日期：2012-02-01 00:00:00

abstract：CONTEXT:The PDS gene (SLC26A4) is responsible for Pendred syndrome (PS). Genetic analysis of PDS using Tunisian samples showed evidence for linkage and association with autoimmune thyroid diseases (AITD) emergence. In addition, the PDS gene product, pendrin, was recently identified as a novel autoantigen in Graves' dis...

journal_title：Immunobiology

authors： Belguith-Maalej S,Rebuffat SA,Charfeddine I,Mnif M,Nadir RF,Abid M,Ghorbel A,Peraldi-Roux S,Ayadi H,Hadj-Kacem H

更新日期：2011-05-01 00:00:00

abstract：:We examined the expression of seven V alpha or V beta T cell receptor (TCR) segments on human CD4+ and CD8+ T cells. Confirming previously published results, we found a preferential expression of four V segment gene products on CD4+ T cells. One of these markers (V beta 6.7) was constantly expressed on more CD4+ T cel...

journal_title：Immunobiology

authors： Dannecker G,Mecheri S,Heuser M,Ihle J,Hoffmann MK,Niethammer D

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:The soluble form of the haptoglobin-hemoglobin (Hp-Hb) scavenger receptor (sCD163) is a specific plasma/serum marker for macrophage activity. Here, we have characterized molecular forms in serum and investigated a role of sCD163 as a binder of Hp-Hb complexes. METHODS:The sCD163 species in serum (from 50 he...

journal_title：Immunobiology

authors： Møller HJ,Nielsen MJ,Maniecki MB,Madsen M,Moestrup SK

更新日期：2010-05-01 00:00:00

abstract：:Respiratory viral infections have been implicated in the origin of, protection from and exacerbation of allergy-related symptoms in a variety of ways. Viral infections are closely linked to infantile wheezing. Severe bronchiolitis in early infancy may predispose to chronic childhood asthma as well as allergic sensitiz...

journal_title：Immunobiology

authors： Xepapadaki P,Papadopoulos NG

更新日期：2007-01-01 00:00:00

abstract：:Five mouse hybridoma cell lines producing monoclonal antibody against bovine luteinizing hormone (LH) have been established and the respective antibodies characterized by radioimmunoassay, immunofluorescence and immunoelectrophoresis. All antibodies belong to the IgG class and bind to staphylococcus protein A. Intrasp...

journal_title：Immunobiology

authors： Kofler R,Kalchschmid E,Berger P,Wick G

更新日期：1981-01-01 00:00:00

abstract：:The recent purification and cloning of T cell-derived growth factors, should lead to rapid progress in delineating their role in the generation of accessory cells and the regulation of their function. The techniques that have allowed detailed in vitro studies of the T-dependent mast cells, should be generally applicab...

journal_title：Immunobiology

authors： Schrader JW,Clark-Lewis I,Wong GH

更新日期：1984-12-01 00:00:00