Tissue and serum mRNA profile of MMPs-2/9 as a potential novel biomarker for the most individual approach in infantile hemangiomas and cancer disease.

abstract：:Myeloid-derived suppressor cells (MDSCs) are heterogeneous cells capable of abrogating T and B cells responses and have been identified in numerous cancers. As with other regulatory cell populations, they aim to maintain balance between host-defence-associated inflammation and ensuing tissue pathology. MDSC accumulati...

journal_title：Immunobiology

authors： Tamadaho RSE,Hoerauf A,Layland LE

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Following any acute irritation lung function declines rapidly. Reasons for pulmonary deterioration in humans had been attributed to the action of either interleukin-6 or interleukin-8 in the lungs. OBJECTIVES:The present study investigates the association between immune response and decline in lung function...

journal_title：Immunobiology

authors： Wölbeling F,Munder A,Kerber-Momot T,Neumann D,Hennig C,Hansen G,Tümmler B,Baumann U

更新日期：2011-08-01 00:00:00

abstract：:Interleukin-1beta (IL-1beta) is a potent proinflammatory cytokine that initiates and amplifies a wide variety of effects associated with innate immunity and host responses to microbial invasion and tissue injury. Production and release of IL-1beta are stimulated by either pathogen-associated molecular pattern molecule...

journal_title：Immunobiology

authors： Eder C

更新日期：2009-01-01 00:00:00

abstract：:A C1q receptor that upregulates the phagocytic capacity of professional phagocytes, C1qRp, has been identified, and its primary structure determined by cDNA cloning and sequencing. Monoclonal antibodies that immunoprecipitate this 126,000 Mr polypeptide inhibit the enhancement of phagocytosis triggered not only by C1q...

journal_title：Immunobiology

authors： Tenner AJ

更新日期：1998-08-01 00:00:00

abstract：:Signal transduction by the Toll-like receptors (TLRs) is a key component of innate immunity against many pathogens and also underlies a large burden of human diseases. Therefore, the mechanisms and regulation of signaling from the TLRs are of considerable interest. Here we seek to determine the molecular mechanism by ...

journal_title：Immunobiology

authors： Zsengellér ZK,Gerard NP

更新日期：2020-03-01 00:00:00

abstract：:Complement assays have for many years utilised buffers based on barbitone (veronal) despite the well-recognised toxicity of this agent and the tight regulations on its use in most countries. The use of barbitone in complement assay buffers is steeped in history, from a time when no other suitable buffers were availabl...

journal_title：Immunobiology

authors： Zelek WM,Harris CL,Morgan BP

更新日期：2018-12-01 00:00:00

abstract：:The putative expression of distinct terminally fucosylated glycoconjugates among murine lymphocyte subpopulations was sought using a Biomphalaria alexandrina-derived lectin (BaSI), of proven specificity to a fucosyllactose determinant, and the fucose-binding lectin from Lotus tetragonolobus seeds. Direct labeling of i...

journal_title：Immunobiology

authors： Mansour MH,Abdul-Salam F,Al-Shemary T

更新日期：2005-01-01 00:00:00

abstract：:The specificity of cytotoxic T lymphocyte (CTL) responses generated in the presence of lymphokines was studied. Thymic responder cells were activated in the presence of stimulator cells that differed in their metabolic activity. After 5 days of culture, the cytotoxic response was estimated in a 4-h 51Cr-release test. ...

journal_title：Immunobiology

authors： Männel DN,Dröge W,Falk W

更新日期：1985-09-01 00:00:00

abstract：:Surfactant protein D has multiple functions in innate immunity in the lung. The generation of SP-D knock-out mice has revealed a central role for this protein in the control of lung inflammation. Accumulating evidence in mouse models of infection and inflammation indicates that truncated recombinant forms of surfactan...

journal_title：Immunobiology

authors： Clark H,Reid KB

更新日期：2002-09-01 00:00:00

abstract：:BCG infection of mice provides a convenient model to study natural and cellular immunity to mycobacteria and the mechanisms of granuloma formation and repair. We have used a range of macrophage (M phi) membrane molecules and secretory products to investigate resident M phi-pathogen interactions and T lymphocyte-depend...

journal_title：Immunobiology

authors： Gordon S,Keshav S,Stein M

更新日期：1994-10-01 00:00:00

abstract：:In the thymus of non-obese diabetic (NOD) mice, the expression of the autoimmune regulator (Aire) gene varies with age, and its down-regulation in young mice precedes the later emergence of type 1 diabetes mellitus (T1D). In addition, the insulin (Ins2) peripheral tissue antigen (PTA) gene, which is Aire-dependent, is...

journal_title：Immunobiology

authors： Oliveira EH,Macedo C,Donate PB,Almeida RS,Pezzi N,Nguyen C,Rossi MA,Sakamoto-Hojo ET,Donadi EA,Passos GA

更新日期：2013-01-01 00:00:00

abstract：:Tuberculosis due to Mycobacterium tuberculosis infection is a leading cause of death worldwide. Recognition of this pathogen is crucial for the activation of innate and adaptive immune responses. Nucleotide-binding oligomerization domain (Nod)1 and Nod2 are cytoplasmic receptors that can detect unique muropeptides of ...

journal_title：Immunobiology

authors： Lee JY,Hwang EH,Kim DJ,Oh SM,Lee KB,Shin SJ,Park JH

更新日期：2016-01-01 00:00:00

abstract：:Pythiosis is a life-threatening disease caused by the fungus-like microorganism Pythium insidiosum that can lead to death if not treated. Since P. insidiosum has particular cell wall characteristics, pythiosis is difficult to treat, as it does not respond well to traditional antifungal drugs. In our study, we investig...

journal_title：Immunobiology

authors： Ledur PC,Tondolo JSM,Jesus FPK,Verdi CM,Loreto ÉS,Alves SH,Santurio JM

更新日期：2018-03-01 00:00:00

abstract：:The immunoglobulin production capacities of peripheral blood lymphocytes obtained from patients with various chronic inflammatory liver diseases and from normal individuals were compared. Using a reverse hemolytic plaque assay, immunoglobulin-secreting cells (ISC) were counted immediately after isolation (immediate IS...

journal_title：Immunobiology

authors： Sieber G,Teichmann JV,Möller B,Hopf U

更新日期：1988-12-01 00:00:00

abstract：:BALB/c mice injected with 0.2 mg TNP-ovalbumin (OA) within 24 hours after birth showed reduced levels of functionally active TNP-specific B cells and, accordingly, of plaque-forming cells (PFC) after challenge with carrier-bound TNP until the age of 8 weeks. Yet, when B cells of tolerized mice were cultured in the abs...

journal_title：Immunobiology

authors： Zöller M,Andrighetto G

更新日期：1987-12-01 00:00:00

abstract：:Erythrocytes from paroxysmal nocturnal hemoglobinuria patients (PNH-E) are much more susceptible to lysis by acid-activated human serum than normal human erythrocytes. Acidification of normal human serum to pH 6.4 in the absence of erythrocytes generates this lytic activity independently of the alternative pathway of ...

journal_title：Immunobiology

authors： Hänsch G,Hammer C,Jiji R,Rother U,Shin M

更新日期：1983-03-01 00:00:00

abstract：:When sheep red blood cells (SRBC) were injected intraperitoneally (i.p.), intravenously (i.v.), or into the Peyer's patches, definite plaque-forming cell (PFC) and rosette-forming cell (RFC) responses were induced in the spleen but not in the mesenteric lymph nodes (MLN). When SRBC were injected directly into the sple...

journal_title：Immunobiology

authors： Kojima T,Kamei H,Kondo T,Nakashima I,Kato N

更新日期：1982-05-01 00:00:00

abstract：:Acute lung injury (ALI) is an acute inflammatory disorder. Toll-like receptor-4 (TLR-4) and Stanniocalcin -1 (STC-1) had roles in lung endothelial protection. This study aims to assess TLR-4 and SCT-1 genes expressions in peripheral blood of ALI patients. Total RNA was extracted from peripheral blood of 48 subjects (2...

journal_title：Immunobiology

authors： Esawy MM,Shabana MA,Baioumy SA,Ismail NA

更新日期：2019-11-01 00:00:00

abstract：:Peritoneal as well as peripheral blood, but not spleen macrophages inhibit natural killer (NK) cell activity directed against adherent growing target cells. Inhibition was observed with macrophages (Mø): spleen cell ratios as low as 0.01:1. It was independent from the activation status of Mø and was not MHC restricted...

journal_title：Immunobiology

authors： Zöller M,Matzku S

更新日期：1982-12-01 00:00:00

abstract：:High Mphi:T cell ratios suppress the immune response to the retroviral superantigen Mls by IFNgamma-triggered production of the arg- and trp-consuming enzymes iNOS and IDO. Attempts to reverse suppression by treatment with pro-inflammatory cytokines revealed that IL-6 improved the T cell response to Mls and the pro-he...

journal_title：Immunobiology

authors： Silberman D,Bucknum A,Kozlowski M,Matlack R,Riggs J

更新日期：2010-01-01 00:00:00

abstract：:The distribution of membrane-associated nucleotide pyrophosphatase activity has been investigated on mouse leucocytes of different origin. It is shown that enzyme-specific activity is higher on bone-marrow cells than on cells derived from peripheral organs. Since thymus lymphocytes show the lowest activity, it is obvi...

journal_title：Immunobiology

authors： Brockhaus A,Bösing-Schneider R,Sund H

更新日期：1982-01-01 00:00:00

abstract：:Mono Mac 6 is a human monocytic cell line with several features of mature blood monocytes such as CD 14 antigen expression, phagocytotic ability, and the functional ability to produce cytokines. This line is often used as an in vitro model to demonstrate the actions of monocytes. In our study, the production of cytoki...

journal_title：Immunobiology

authors： Neustock P,Brand JM,Kruse A,Kirchner H

更新日期：1993-07-01 00:00:00

abstract：:Blood dendritic cell precursors (DCps) are identified as mononuclear leukocytes expressing HLA-DR but lacking the characteristic antigens associated with T cells (CD3), NK cells (CD16 and CD56) and B cells (CD 19). Dendritic cell precursors are distinguished from monocytes by their lack of expression of CD64 rather th...

journal_title：Immunobiology

authors： Macey MG,Jawad N,McCarthy DA,Newland AC,Brown KA

更新日期：2000-05-01 00:00:00

abstract：:Regulatory properties of macrophages associated with alternative activation serve to limit the exaggerated inflammatory response during pneumonia caused by Pseudomonas aeruginosa infection. Arginase-1 is an important effector of these macrophages believed to play an essential role in decreasing injury and promoting re...

journal_title：Immunobiology

authors： Haydar D,Gonzalez R,Garvy BA,Garneau-Tsodikova S,Thamban Chandrika N,Bocklage TJ,Feola DJ

更新日期：2020-11-24 00:00:00

abstract：:Cryptococcus neoformans is a pathogenic fungus causing life threatening infections in humans. The present in vitro study aimed to investigate the opsonizing properties of a well characterized serum ficolin (rat ficolin-A), a member of carbohydrate-recognition molecules of the innate immune system, in the defence again...

journal_title：Immunobiology

authors： Schelenz S,Kirchhof N,Bidula S,Wallis R,Sexton DW

更新日期：2013-04-01 00:00:00

abstract：:C1q binds to many non-self and altered-self-materials. These include microorganisms, immune complexes, apoptotic and necrotic cells and their breakdown products, and amyloids. C1q binding to amyloid fibrils found as extracellular deposits in tissues, and subsequent complement activation are involved in the pathology o...

journal_title：Immunobiology

authors： Sim RB,Kishore U,Villiers CL,Marche PN,Mitchell DA

更新日期：2007-01-01 00:00:00

abstract：:Asthma is characterized by inflammation, pulmonary remodeling and bronchial hyperresponsiveness. We have previously shown that treatment with angiotensin-(1-7) [Ang-(1-7)] promotes resolution of eosinophilic inflammation and prevents chronic allergic lung inflammation. Here, we evaluated the effect of treatment with t...

journal_title：Immunobiology

authors： Magalhães GS,Gregório JF,Ramos KE,Cançado-Ribeiro ATP,Baroni IF,Barcelos LS,Pinho V,Teixeira MM,Santos RAS,Rodrigues-Machado MG,Campagnole-Santos MJ

更新日期：2020-05-01 00:00:00

abstract：:Reggie-1/flotillin-2 is a plasma membrane-associated cytoplasmic protein, which defines non-caveolar raft microdomains. Reggie-1/flotillin-2 is enriched in detergent insoluble (TX100) membrane fractions (DIG), co-localizes with activated GPI-linked proteins and the fyn-kinase in neurons and T cells, and thus apparentl...

journal_title：Immunobiology

authors： Solomon S,Masilamani M,Rajendran L,Bastmeyer M,Stuermer CA,Illges H

更新日期：2002-03-01 00:00:00

abstract：:In the last decade new glucocorticoid (GC)-signalling mechanisms have emerged. The evolving field of non-genomic GC actions was precipitated from two major directions: (i) some rapid/acute clinical GC applications could not be explained based on the relatively slowly appearing genomic GC action and (ii) accumulating e...

journal_title：Immunobiology

authors： Boldizsar F,Talaber G,Szabo M,Bartis D,Palinkas L,Nemeth P,Berki T

更新日期：2010-07-01 00:00:00

abstract：:The inability of spontaneous and some laboratory-induced tumors to stimulate the immune system has continuously raised the question of the validity of using immunological maneuvers in order to control tumor growth. In this project we suggest that a tumor which is nonimmunogenic still has an immunogenic potential that ...

journal_title：Immunobiology

authors： Klein BY,Sharon R,Tarcic N,Naor D

更新日期：1982-10-01 00:00:00