Abstract:
:L-alanine was shown earlier to play a significant role for the proliferation of lymphocytes in vitro. In the present work the effect of L-alanine and some other amino acids on thymocyte proliferation was studied in vivo by local administration into one thymus lobe of guinea pigs. Proliferating cells were pulse labelled with bromodeoxyuridine (BrdUrd). The labelling index of the treated lobe significantly exceeded that of the contralateral, control lobe at 48 h after treatment with 10 or 100 micrograms L-alanine, indicating stimulated proliferation. The higher dose, which was also tested after other time intervals, stimulated also at 24 h. The difference in proliferative activity between the lobes was verified by mitotic studies. The effect of L-alanine was mainly on the large, low density, highly proliferating precursor cells. No other amino acids tested (D-alanine, cysteine, hydroxyproline, serine, tryptophan), or pyruvate produced significant differences between the treated and control lobes.
journal_name
Immunobiologyjournal_title
Immunobiologyauthors
Hägglund B,Sandberg Gdoi
10.1016/S0171-2985(11)80487-0subject
Has Abstractpub_date
1993-06-01 00:00:00pages
62-9issue
1-2eissn
0171-2985issn
1878-3279pii
S0171-2985(11)80487-0journal_volume
188pub_type
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