BCG-induced granuloma formation in murine tissues.

abstract：:Soluble MHC antigens are detected in body fluids but their role and origin are still unclear. This study examined whether serum IA antigens, isolated from BALB/c mice (sIA(d)), could modulate the immune response. Specific purification procedures isolated intact IA molecules, which were thereafter applied to functional...

journal_title：Immunobiology

authors： Marios-Frankiskos S,Panagiota M,Katerina B,Athanassakis I

更新日期：2010-03-01 00:00:00

abstract：:Guinea pig (gp) platelets react to nanomolar doses of the complement-derived anaphylatoxin C5a with a shape change, aggregation and release of biogenic amines and nucleotides from their granules. We have investigated the specific receptor for C5a on gp platelets which mediates these biological effects. Competitive bin...

journal_title：Immunobiology

authors： Kretzschmar T,Kahl K,Rech K,Bautsch W,Köhl J,Bitter-Suermann D

更新日期：1991-11-01 00:00:00

abstract：:The role of the thymic microenvironment in the development of murine thymic B cells has yet to be fully clarified. We therefore investigate the microenvironment that supports the development of mature thymic B cells (sIg+/B220+/CD43-B cells) from thymic B cell progenitors with immunophenotypes of sIg-/B220med/CD43+ ce...

journal_title：Immunobiology

authors： Sugihara A,Inaba M,Mori SI,Taketani S,Adachi Y,Hisha H,Inaba K,Toki J,Horio T,Gershwin ME,Ikehara S

更新日期：2000-04-01 00:00:00

abstract：:Alternative macrophage activation is largely defined by IL-4Rα stimulation but the contribution of Toll-like receptor (TLR) signaling to this phenotype is not currently known. We have investigated macrophage activation status under Th2 conditions in the absence of the core TLR adaptor molecule, MyD88. No impairment wa...

journal_title：Immunobiology

authors： Mylonas KJ,Hoeve MA,MacDonald AS,Allen JE

更新日期：2013-04-01 00:00:00

abstract：:It is established that (1) subclinical Bordetella pertussis colonization of the nasopharynx persists in highly vaccinated populations, and (2) B. pertussis toxin is a potent adjuvant that, when co-administered with neural antigens, induces neuropathology in experimental autoimmune encephalomyelitis, the principle anim...

journal_title：Immunobiology

authors： Rubin K,Glazer S

更新日期：2016-04-01 00:00:00

abstract：:Based on our findings that HIV-1 gp41 independently of CD4 can bind to the human helper T lymphoid cell line H9, B cell line Raji and monocyte cell line U937, we characterized putative binding of HIV-1 gp41 to human peripheral blood lymphocytes (PBLs) and monocytes. Using flow cytometry (FACS), we demonstrated that th...

journal_title：Immunobiology

authors： Chen YH,Böck G,Vornhagen R,Steindl F,Katinger H,Dierich MP

更新日期：1993-08-01 00:00:00

abstract：:Dogs with lymphoma are established as good model for human non-Hodgkin lymphoma studies. Canine cell lines derived from lymphomas may be valuable tools for testing new therapeutic drugs. In this context, we established a canine T-cell line, PER-VAS, from a primary aggressive T-cell lymphoma with large granular morphol...

journal_title：Immunobiology

authors： Bonnefont-Rebeix C,Fournel-Fleury C,Ponce F,Belluco S,Watrelot D,Bouteille SE,Rapiteau S,Razanajaona-Doll D,Pin JJ,Leroux C,Marchal T

更新日期：2016-01-01 00:00:00

abstract：:Airway epithelial cells induce a tolerogenic microenvironment by modulating immune cells in the lung. We recently showed that the supernatant of airway epithelial cells induces two marker genes of alternative activation, Ym1 and Ms4a8a, in respiratory myeloid cells. This induction was partially mediated by glucocortic...

journal_title：Immunobiology

authors： Ng Kuet Leong N,Brombacher F,Dalpke AH,Weitnauer M

更新日期：2017-05-01 00:00:00

abstract：:The distribution of MEL-14+ lymphocytes was investigated by both fluorocytometric analysis and complement-dependent-cellular-cytotoxicity (CDCC) tests in which rabbit anti-rat Ig was added with complement at a secondary step. When CDCC was employed to detect MEL-14+ cells, almost half of the thymocytes were found to b...

journal_title：Immunobiology

authors： Iwabuchi K,Ohgama J,Ogasawara K,Iwabuchi C,Negishi I,Good RA,Onoé K

更新日期：1991-03-01 00:00:00

abstract：:Macrophage pre-treatment with bacterial lipopolysaccharide (LPS) boosts subsequent activation of the NLRP3 inflammasome, which controls caspase-1-dependent pro-inflammatory cytokine maturation. Previous work has attributed this phenomenon (known as LPS 'priming') to LPS-dependent induction of NLRP3 expression. Whilst ...

journal_title：Immunobiology

authors： Schroder K,Sagulenko V,Zamoshnikova A,Richards AA,Cridland JA,Irvine KM,Stacey KJ,Sweet MJ

更新日期：2012-12-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common neurodegenerative disease and it poses an ever-increasing burden to an aging population. Several loci responsible for the rare, autosomal dominant form of AD have been identified (APP, PS1 and PS2), and these have facilitated the development of the amyloid cascade hypothesis...

journal_title：Immunobiology

authors： Crehan H,Holton P,Wray S,Pocock J,Guerreiro R,Hardy J

更新日期：2012-02-01 00:00:00

abstract：:During bacterial peritonitis of patients on continuous ambulatory peritoneal dialysis (CAPD) leukocytes, particularly polymorphonuclear neutrophilic granulocytes (PMNs), migrate into the peritoneal cavity. However, at the site of inflammation PMNs are not sufficiently able to protect the host against micro-organisms. ...

journal_title：Immunobiology

authors： Elsner J,Sach M,Knopf HP,Norgauer J,Kapp A,Schollmeyer P,Dobos GJ

更新日期：1995-08-01 00:00:00

abstract：:Vaccines capable of inducing mucosal immunity in early postnatal life until adulthood, protecting early sexual initiation, should be considered as strategies to vaccination against HIV. The HIV-1 GAG protein as a chimera with the lysosome-associated membrane protein (LAMP/gag), encoded by a DNA vaccine, is targeted to...

journal_title：Immunobiology

authors： Goldoni AL,Maciel M Jr,Rigato PO,Piubelli O,de Brito CA,Melo A,Marques ET,August JT,Duarte AJ,Sato MN

更新日期：2011-04-01 00:00:00

abstract：:Sialoadhesin (Sn) is a surface receptor expressed on resident macrophages with the ability to bind with sialic acids. During inflammation, an upregulation of Sn is observed. Upon binding of monoclonal antibodies to Sn, the receptor becomes internalized and this has been observed in multiple species. The latter charact...

journal_title：Immunobiology

authors： De Schryver M,Leemans A,Pintelon I,Cappoen D,Maes L,Caljon G,Cos P,Delputte PL

更新日期：2017-06-01 00:00:00

abstract：:Intravenous (i.v.) immunization of mice with irradiated (2000 rads) allogeneic lymphoid cells induces the generation of suppressor T cells. Such suppressor T cells can suppress the anti-host delayed type hypersensitivity (DTH) by other T cells during acute Graft-versus-Host reactions in irradiated recipient mice. Supp...

journal_title：Immunobiology

authors： Bril H,Molendijk-Lok BD,Hussaarts-Odijk LM,Benner R

更新日期：1985-04-01 00:00:00

abstract：:Ficolins are a group of proteins containing both a collagen-like domain and a fibrinogen-like domain and are found in varying tissues. Ficolins present in sera have a lectin activity toward N-acetylglucosamine through their fibrinogen-like domains. The domain organizations between ficolins and mannose-binding lectin (...

journal_title：Immunobiology

authors： Matsushita M,Fujita T

更新日期：2002-09-01 00:00:00

abstract：:Details of the "Trojan Horse" mechanism by which Zika virus (ZIKV) crosses the blood-brain barrier (BBB) remain unclear. However, the migration of ZIKV-infected monocytes to the brain is thought to be dependent on both pattern-recognition and chemokine receptors. In this study, we investigated whether the migration of...

journal_title：Immunobiology

authors： de Carvalho GC,Borget MY,Bernier S,Garneau D,da Silva Duarte AJ,Dumais N

更新日期：2019-11-01 00:00:00

abstract：:Th2 cells play a central role in type I allergies. However, the source of interleukin-4 which may lead to a Th1/Th2 imbalance is unknown. Valpha24+CD161+ Natural killer T (NKT) cells secrete high amounts of interleukin-4 and/or interferon-gamma and are assumed to participate in the initiation of Th1/Th2 immune respons...

journal_title：Immunobiology

authors： Prell C,Konstantopoulos N,Heinzelmann B,Frankenberger B,Reinhardt D,Schendel DJ,Krauss-Etschmann S

更新日期：2003-01-01 00:00:00

abstract：:Tuberculosis due to Mycobacterium tuberculosis infection is a leading cause of death worldwide. Recognition of this pathogen is crucial for the activation of innate and adaptive immune responses. Nucleotide-binding oligomerization domain (Nod)1 and Nod2 are cytoplasmic receptors that can detect unique muropeptides of ...

journal_title：Immunobiology

authors： Lee JY,Hwang EH,Kim DJ,Oh SM,Lee KB,Shin SJ,Park JH

更新日期：2016-01-01 00:00:00

abstract：:Macrophages are key players not only during initiation of inflammation but also during its resolution. This is achieved by their high functional plasticity and the demand to recognize an enormous repertoire of danger signals and cytokines/chemokines derived from adaptive immune cells. Studies predominantly conducted o...

journal_title：Immunobiology

authors： Ley S,Weigert A,Brüne B

更新日期：2010-09-01 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) are heterogeneous cells capable of abrogating T and B cells responses and have been identified in numerous cancers. As with other regulatory cell populations, they aim to maintain balance between host-defence-associated inflammation and ensuing tissue pathology. MDSC accumulati...

journal_title：Immunobiology

authors： Tamadaho RSE,Hoerauf A,Layland LE

更新日期：2018-01-01 00:00:00

abstract：:Asthma is an airway inflammatory disorder. Vitamin (Vit) D is a potent immuno-modulator. It suppresses Interleukin (IL)-17 and induces IL-10. This study aims to investigate the role of IL-17A and IL-10 in predicting asthma control in case of Vit D supplementation. Seventy-nine patients enrolled in this study (42 patie...

journal_title：Immunobiology

authors： Shabana MA,Esawy MM,Ismail NA,Said AM

更新日期：2019-11-01 00:00:00

abstract：:Splenic B cells of BALB/c mice were stimulated in vitro either with lipopolysaccharide (LPS), dextran sulphate (DxS), or with both LPS and DxS. The absolute frequency of B cells that differentiate into clones of immunoglobulin (Ig)-secreting cells upon activation with these mitogens was determined by means of limiting...

journal_title：Immunobiology

authors： Bos NA,Meeuwsen CG,de Visser H,Benner R

更新日期：1988-02-01 00:00:00

abstract：:IgE-mediated food allergies are an important cause of life-threatening hypersensitivity reactions. Orally administered peanut antigens mixed with the mucosal adjuvant cholera toxin (CT) induce a strong peanut extract (PE)-specific serum IgE response that is correlated with T-helper type 1 (Th1) and type 2 (Th2)-like T...

journal_title：Immunobiology

authors： Fecek RJ,Marcondes Rezende M,Busch R,Hassing I,Pieters R,Cuff CF

更新日期：2010-12-01 00:00:00

abstract：:The activation of cytotoxic T lymphocytes (CTL) in vivo was found to be augmented by glutathione if injected i.p. in the late phase but not in the early phase of the response. The effect of glutathione possibly resembles the augmenting effect of 2-mercaptoethanol in lymphocyte cultures. ...

journal_title：Immunobiology

authors： Dröge W,Pottmeyer-Gerber C,Schmidt H,Nick S

更新日期：1986-08-01 00:00:00

abstract：:We studied immunohistological and biochemical aspects of the CD44 molecule with a mAb produced in our lab: GRHL-1. The characteristic expression of this antigen in cells of B lineage was analyzed. This mAb showed identical immunohistological patterns of reactivity to other mAbs included in CD44 cluster, on a variety l...

journal_title：Immunobiology

authors： Collado A,de Andres A,Cañadas E,Ruiz-Cabello F,Gomez O,Pedrinaci S,Garrido F

更新日期：1991-09-01 00:00:00

abstract：:Erythrocytes from paroxysmal nocturnal hemoglobinuria patients (PNH-E) are much more susceptible to lysis by acid-activated human serum than normal human erythrocytes. Acidification of normal human serum to pH 6.4 in the absence of erythrocytes generates this lytic activity independently of the alternative pathway of ...

journal_title：Immunobiology

authors： Hänsch G,Hammer C,Jiji R,Rother U,Shin M

更新日期：1983-03-01 00:00:00

abstract：:B-1 cells can be differentiated from B-2 cells because they are predominantly located in the peritoneal and pleural cavities and have distinct phenotypic patterns and activation properties. The role of both cell populations in cancer progression is still controversial. Previous studies have indicated that direct conta...

journal_title：Immunobiology

authors： Laurindo MF,Thies FG,Perez EC,Novaes e Brito RR,Mariano M,Popi AF

更新日期：2013-04-01 00:00:00

abstract：:Tumor necrosis factor superfamily (TNFSF) represents a group of multifunctional inflammatory cytokines that have been shown to participate in a variety of pathological and immunological process. However, the functions of these proteins in oyster are still poorly understood. In the present study, an oyster TNF homolog ...

journal_title：Immunobiology

authors： Qu F,Xiang Z,Zhang Y,Li J,Xiao S,Zhang Y,Qin Y,Zhou Y,Yu Z

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Ficolins serve as soluble recognition molecules in the lectin pathway of complement. They are known to participate in the systemic host-response to infection but their role in local pulmonary defence is still incompletely understood. The purpose of this study was to clarify whether acute lung and systemic in...

journal_title：Immunobiology

authors： Plovsing RR,Berg RM,Munthe-Fog L,Konge L,Iversen M,Møller K,Garred P

更新日期：2016-05-01 00:00:00