Alternative activation of macrophages by filarial nematodes is MyD88-independent.

abstract：:Monoclonal mouse anti-Thy-1.2 antibody of IgG3 isotype (MTA) inhibits in a significant and long-term manner the regional graft-versus-host reaction (GVHR) when administered to donors as well as to recipients. The process of sensitization in the reaction of delayed type hypersensitivity to SRBC (DTH) is, on the other h...

journal_title：Immunobiology

authors： Sůla K,Sobotková E,Svobodová M,Nouza K

更新日期：1988-07-01 00:00:00

abstract：:Suppressor monocytes, Concanavalin A(ConA)-induced suppressor T cells, and short-lived suppressor lymphocytes have been describe in humans. The present study was performed to evaluate spontaneous suppression in a test system similar to that employed for the demonstration of ConA-induced suppressor cells: Lymphocytes w...

journal_title：Immunobiology

authors： Gattringer C,Huber H,Michlmayr G,Braunsteiner H

更新日期：1981-01-01 00:00:00

abstract：:Hematopoietic cells express multiple receptors which bind the Fc domain of IgG. We utilized transfection of COS-1 cells, a cell line which lacks endogenous Fc receptors, to study the expression and function of Fc gamma RI, the high affinity Fc gamma receptor in the absence of other Fc gamma receptors. Fc gamma RI was ...

journal_title：Immunobiology

authors： Indik Z,Chien P,Levinson AI,Schreiber AD

更新日期：1992-08-01 00:00:00

abstract：:Chemokine CCL21 can effectively attract CCR7(+) dendritic cells (DCs), however its role in this event is poorly understood. In this report, we investigated the effect of exogenous CCL21 expressed in breast cancer MCF-7 on human monocyte-derived DCs. CCL21-transfected MCF-7 stimulation prompted DC functions: migration,...

journal_title：Immunobiology

authors： Wu S,Xing W,Peng J,Yuan X,Zhao X,Lei P,Li W,Wang M,Zhu H,Huang B,Huang L,Shen G

更新日期：2008-01-01 00:00:00

abstract：:The CD300 glycoproteins are a family of related leucocyte surface molecules that modulate a diverse array of cell processes via their paired triggering and inhibitory receptor functions. All family members have a single Ig-V like domain and they share a common evolutionary pathway. At least one member of the family ha...

journal_title：Immunobiology

authors： Clark GJ,Ju X,Azlan M,Tate C,Ding Y,Hart DN

更新日期：2009-01-01 00:00:00

abstract：:Erythrocytes from paroxysmal nocturnal hemoglobinuria patients (PNH-E) are much more susceptible to lysis by acid-activated human serum than normal human erythrocytes. Acidification of normal human serum to pH 6.4 in the absence of erythrocytes generates this lytic activity independently of the alternative pathway of ...

journal_title：Immunobiology

authors： Hänsch G,Hammer C,Jiji R,Rother U,Shin M

更新日期：1983-03-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a lung inflammatory disease characterized by progressive airflow limitation, chronic respiratory symptoms and frequent exacerbations. There is an unmet need to identify novel therapeutic alternatives beside bronchodilators that prevent disease progression. Levels of both...

journal_title：Immunobiology

authors： Douaoui S,Djidjik R,Boubakeur M,Ghernaout M,Touil-Boukoffa C,Oumouna M,Derrar F,Amrani Y

更新日期：2020-05-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) is an environmental sensor and ligand-activated transcription factor that is critically involved in the regulation of inflammatory responses and the induction of tolerance by modulating immune cells. As dendritic cells (DCs) express high AhR levels, they are efficient to induce immu...

journal_title：Immunobiology

authors： Michalski J,Deinzer A,Stich L,Zinser E,Steinkasserer A,Knippertz I

更新日期：2020-07-01 00:00:00

abstract：:Recent studies have suggested that odontoblasts are involved in the dental pulp immune response to oral pathogens that invade human dentin during the caries process. How odontoblasts regulate the early inflammatory and immune pulp response to Gram-positive bacteria, which predominate in shallow and moderate dentin car...

journal_title：Immunobiology

authors： Farges JC,Carrouel F,Keller JF,Baudouin C,Msika P,Bleicher F,Staquet MJ

更新日期：2011-04-01 00:00:00

abstract：:Glypican-3 (GPC3) is an attractive target for chimeric antigen receptor (CAR)-T cell therapy, as it is overexpressed in most hepatocellular carcinoma (HCC) tissues but shows restricted expression in healthy adult tissues. Herein, we generated GPC3-specific CAR-T cells for HCC therapy by electroporation with plasmid DN...

journal_title：Immunobiology

authors： Wang P,Qin W,Liu T,Jiang D,Cui L,Liu X,Fang Y,Tang X,Jin H,Qian Q

更新日期：2020-01-01 00:00:00

abstract：:BALB/c mice injected with 0.2 mg TNP-ovalbumin (OA) within 24 hours after birth showed reduced levels of functionally active TNP-specific B cells and, accordingly, of plaque-forming cells (PFC) after challenge with carrier-bound TNP until the age of 8 weeks. Yet, when B cells of tolerized mice were cultured in the abs...

journal_title：Immunobiology

authors： Zöller M,Andrighetto G

更新日期：1987-12-01 00:00:00

abstract：:OK-432, a streptococcal preparation, has been shown as an effective activator to induce human monocyte-derived dendritic cells maturation. During this process, the activation of Toll-like receptor 4 plays an important role. However, the signaling pathway involved in has not been fully understood. In the present study,...

journal_title：Immunobiology

authors： Pan K,Wang H,Liu WL,Zhang HK,Zhou J,Li JJ,Weng DS,Huang W,Sun JC,Liang XT,Xia JC

更新日期：2009-01-01 00:00:00

abstract：:MHC class II molecules presenting MHC class II restricted antigens play an important role in the activation of CD4+ T cells, which are the central orchestrating cells of an immune response. This review focuses on the particular role of MHC class II molecules in tumour immunology. The MHC class II antigen presentation ...

journal_title：Immunobiology

authors： Chamuleau ME,Ossenkoppele GJ,van de Loosdrecht AA

更新日期：2006-01-01 00:00:00

abstract：:Understanding the mechanisms governing the type of induced immune response after microbial invasion, could be of crucial importance for the rational design of a bacteria-based vaccine. Targeting a vaccine directly to dendritic cells (DCs), which are considered the most powerful antigen presenting cells, could be extre...

journal_title：Immunobiology

authors： Rescigno M,Rotta G,Valzasina B,Ricciardi-Castagnoli P

更新日期：2001-12-01 00:00:00

abstract：:By quantitative and functional methods, changes were assessed in NK(ASGM-1+) cell numbers and NK cell-mediated lytic function of the spleen and bone marrow of mice bearing a tumor of hemopoietic origin (FLV-induced erythroleukemia) for 9 days +/- simultaneous administration of indomethacin (10 micrograms/ml drinking w...

journal_title：Immunobiology

authors： Christopher FL,Dussault I,Miller SC

更新日期：1991-12-01 00:00:00

abstract：:Individuals infected with Strongyloides stercoralis have been reported to produce different immunoglobulins isotypes, yet few studies have evaluated their use in strongyloidiasis diagnosis. The aim of this work was to evaluate the immunoreactivity of different classes and subclasses of anti-S. stercoralis circulating ...

journal_title：Immunobiology

authors： De Souza JN,Cruz ADV,Araújo WAC,Sampaio LM,Allegretti SM,Teixeira MCA,Handali S,Galvão-Castro B,Soares NM

更新日期：2020-03-01 00:00:00

abstract：:The part played by MHC antigens on lymphocyte homing has been investigated by inducing modifications of their expression on lymphoid cells. A significant, though moderate, enhancement of H-2 antigen expression has been observed following in vitro treatment of lymphocytes with alpha-IFN. A decrease has been obtained af...

journal_title：Immunobiology

authors： Navarro J,El Ansary M,Royo C,de Maeyer E,Touraine JL

更新日期：1984-12-01 00:00:00

abstract：:A long-lasting skin tolerance to non-H-2 alloantigens has been reported to be readily induced, when the recipient mice were primed intravenously (i.v.) with 5 x 10(7) spleen cells (SC) plus 1.5 x 10(7) bone marrow cells (BMC) from the H-2 identical strains of mice, and treated intraperitoneally (i.p.) with 200 mg/kg C...

journal_title：Immunobiology

authors： Tomita Y,Nomoto K

更新日期：1990-11-01 00:00:00

abstract：:Human urinary colony-stimulating factor (CSF-HU) has been partially purified using five purification procedures (preparation II) for clinical use. In phase I study, six healthy volunteers were injected with preparation II of CSF-HU by a single intravenous droplet infusion. Two volunteers received 4 X 10(6) units (U), ...

journal_title：Immunobiology

authors： Motoyoshi K,Ishizaka Y,Miura Y,Takaku F

更新日期：1986-09-01 00:00:00

abstract：:Recent evidences suggest a significant role of Plasmacytoid dendritic cells (PDC) role in the pathogenesis of lupus erythematosus (LE) via production of type I IFN. Taking advantage on the availability of multiple reagents (CD123, BDCA2, and CD2ap) specifically recognizing PDC on fixed tissues, we investigated the occ...

journal_title：Immunobiology

authors： Vermi W,Lonardi S,Morassi M,Rossini C,Tardanico R,Venturini M,Sala R,Tincani A,Poliani PL,Calzavara-Pinton PG,Cerroni L,Santoro A,Facchetti F

更新日期：2009-01-01 00:00:00

abstract：AIM:To study the antiinflammatory effect of lidocaine in intestinal epithelial cells. METHODS:HT-29 and T-84 cells were grown in culture with and without TNF-alpha, lidocaine, aconitine and veratridine. The secretion of IL-8 and IP-10 was measured by ELISA. A cDNA microarray was used to assess gene expression. Real-ti...

journal_title：Immunobiology

authors： Lang A,Ben Horin S,Picard O,Fudim E,Amariglio N,Chowers Y

更新日期：2010-04-01 00:00:00

abstract：:Non-antigen-specific activation of human B lymphocytes for IgE production in vitro requires the presence of interleukin 4 and non-cognate physical interaction with T cells. The latter can be replaced by antibodies directed against the B cells' CD40 structure. Antigen-specific induction of immunoglobulin responses, inc...

journal_title：Immunobiology

authors： Armerding D,van Reijsen FC,Hren A,Mudde GC

更新日期：1993-07-01 00:00:00

abstract：:Based on our findings that HIV-1 gp41 independently of CD4 can bind to the human helper T lymphoid cell line H9, B cell line Raji and monocyte cell line U937, we characterized putative binding of HIV-1 gp41 to human peripheral blood lymphocytes (PBLs) and monocytes. Using flow cytometry (FACS), we demonstrated that th...

journal_title：Immunobiology

authors： Chen YH,Böck G,Vornhagen R,Steindl F,Katinger H,Dierich MP

更新日期：1993-08-01 00:00:00

abstract：:In the thymus of non-obese diabetic (NOD) mice, the expression of the autoimmune regulator (Aire) gene varies with age, and its down-regulation in young mice precedes the later emergence of type 1 diabetes mellitus (T1D). In addition, the insulin (Ins2) peripheral tissue antigen (PTA) gene, which is Aire-dependent, is...

journal_title：Immunobiology

authors： Oliveira EH,Macedo C,Donate PB,Almeida RS,Pezzi N,Nguyen C,Rossi MA,Sakamoto-Hojo ET,Donadi EA,Passos GA

更新日期：2013-01-01 00:00:00

abstract：:The humoral immune response against alpha(1-->3) dextran (Dex) in BALB/c mice is characterized by the formation of predominantly IgM antibodies bearing the J558 idiotype. IgG antibodies do not appear in euthymic mice. In athymic animals, however, the response proceeds to a vigorous IgG production. In euthymic mice for...

journal_title：Immunobiology

authors： Specht C,Junker R,Krüger A,Rademaekers A,Redlich H,Kölsch E

更新日期：1999-09-01 00:00:00

abstract：:Both the complement system and collectins play important roles in our innate immune system. The collectins, which are characterized by their inclusion of a collagen-like region and a calcium-dependent carbohydrate recognition domain, are pattern recognition molecules and include the well characterized proteins mannan-...

journal_title：Immunobiology

authors： Hansen SW,Ohtani K,Roy N,Wakamiya N

更新日期：2016-10-01 00:00:00

abstract：:Heat shock proteins (Hsps) or stress proteins are highly conserved molecules and expressed in all cell types under stressful conditions like heat, cold, hypoxia and infections. The objective of the present study was to determine the effect of dengue virus infection on relative expression of stress proteins and their r...

journal_title：Immunobiology

authors： Padwad YS,Mishra KP,Jain M,Chanda S,Karan D,Ganju L

更新日期：2009-01-01 00:00:00

abstract：:Dendritic cells (DCs) play a key role in the orchestration of the immune system by virtue of their capacity to control both immunity and tolerance induction. The functions of DCs depend on the subset as well as their location and activation state. A number of in vitro protocols, developed to recapitulate DC generation...

journal_title：Immunobiology

authors： Conti L,Gessani S

更新日期：2008-01-01 00:00:00

abstract：:B-1 cells can be differentiated from B-2 cells because they are predominantly located in the peritoneal and pleural cavities and have distinct phenotypic patterns and activation properties. The role of both cell populations in cancer progression is still controversial. Previous studies have indicated that direct conta...

journal_title：Immunobiology

authors： Laurindo MF,Thies FG,Perez EC,Novaes e Brito RR,Mariano M,Popi AF

更新日期：2013-04-01 00:00:00

abstract：:Beside the lung, thoracic lymph nodes are most affected during silicosis. The mechanisms leading to enlargement of the lymph nodes and partial activation of lymph node cells are still unclear. The present study demonstrates an increase in iNOS mRNA expression in the lung draining lymph nodes of rats at 1, 2, and 8 mon...

journal_title：Immunobiology

authors： Friedetzky A,Grau V,Wieckenberg M,Lewen A,Gemsa D,Garn H

更新日期：2002-07-01 00:00:00