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B16 melanoma cells increase B-1 cell survival, IL-10 production and radioresistance in vitro.

Abstract：

:B-1 cells can be differentiated from B-2 cells because they are predominantly located in the peritoneal and pleural cavities and have distinct phenotypic patterns and activation properties. The role of both cell populations in cancer progression is still controversial. Previous studies have indicated that direct contact between B-1 cells and B16 melanoma tumor cells (B16) increases the metastatic potential of the tumor cells. However, cellular changes that are induced in B-1 cells during the interaction between these two cell types have not been evaluated. In the present study, it is hypothesized that B-1 cells are modified after their interaction with tumor cells, leading to both increased cell viability and rate of proliferation. Additionally, soluble factors that were secreted by B16 cells were sufficient to augment B-1 cell viability and to modify the production of IL-10 by B-1 cells. Impressively, after direct or indirect contact with the B16 cells, B-1 cells became resistant to radiation-induced cell death. Thus, future studies that assess the importance of concomitant immunity and other conventional therapies in cancer treatment are needed.

journal_name

Immunobiology

journal_title

Immunobiology

authors

Laurindo MF,Thies FG,Perez EC,Novaes e Brito RR,Mariano M,Popi AF

doi

10.1016/j.imbio.2012.07.032

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

609-19

issue

4

eissn

0171-2985

issn

1878-3279

pii

S0171-2985(12)00196-9

journal_volume

218

pub_type

杂志文章

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