当前位置： SCI文献检索 > IMMUNOBIOLOGY期刊下所有文献 > Complement receptor 1 (CR1) and Alzheimer's disease.

Complement receptor 1 (CR1) and Alzheimer's disease.

Abstract：

:Alzheimer's disease (AD) is the most common neurodegenerative disease and it poses an ever-increasing burden to an aging population. Several loci responsible for the rare, autosomal dominant form of AD have been identified (APP, PS1 and PS2), and these have facilitated the development of the amyloid cascade hypothesis of AD aetiology. The late onset form of the disease (LOAD) is poorly defined genetically, and up until recently the only known risk factor was the ε4 allele of APOE. Recent genome-wide association studies (GWAS) have identified common genetic variants that increase risk of LOAD. Two of the genes highlighted in these studies, CLU and CR1, suggest a role for the complement system in the aetiology of AD. In this review we analyse the evidence for an involvement of complement in AD. In particular we focus on one gene, CR1, and its role in the complement cascade. CR1 is a receptor for the complement fragments C3b and C4b and is expressed on many different cell types, particularly in the circulatory system. We look at the evidence for genetic polymorphisms in the gene and the possible physiological effects of these well-documented changes. Finally, we discuss the possible impact of CR1 genetic polymorphisms in relation to the amyloid cascade hypothesis of AD and the way in which CR1 may lead to AD pathogenesis.

journal_name

Immunobiology

journal_title

Immunobiology

authors

Crehan H,Holton P,Wray S,Pocock J,Guerreiro R,Hardy J

doi

10.1016/j.imbio.2011.07.017

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

244-50

issue

2

eissn

0171-2985

issn

1878-3279

pii

S0171-2985(11)00148-3

journal_volume

217

pub_type

杂志文章,评审

相关文献

IMMUNOBIOLOGY文献大全
  • Hydroxytyrosol modulates Par j 1-induced IL-10 production by PBMCs in healthy subjects.

    abstract：:Several papers have demonstrated the importance of substances from natural sources which can exert powerful anti-inflammatory effects. In this respect, hydroxytyrosol, one of the major elements of the phenolic components of olive oil, has been extensively studied for its anti-inflammatory activities and safety profile...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2016.07.009

    authors： Bonura A,Vlah S,Longo A,Bulati M,Melis MR,Cibella F,Colombo P

    更新日期：2016-12-01 00:00:00

  • Antigenicity of proteins from cultured synovial fibroblasts.

    abstract：:We were able to characterize about 25 antigenic proteins of cultured synovial fibroblasts with apparent molecular weights of 15-230 kd by SDS-electrophoresis and immunoblotting using guinea pig antiserum. Some of these proteins were bovine-serum-derived, adsorbed onto fibroblasts from culture medium. Both rheumatoid a...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(84)80014-5

    authors： Heino J,Kouri T,Jalkanen M,Lehtonen OP

    更新日期：1984-05-01 00:00:00

  • Experimental approaches to understanding virulence in toxoplasmosis.

    abstract：:Toxoplasma gondii is a widespread protozoan parasite that causes severe disease only in immunocompromised individuals. Equipped with excellent animal models and relatively advanced systems for genetics, T. gondii provides an excellent system for understanding pathogenesis. Resistance to toxoplasmosis is governed by ra...

    journal_title：Immunobiology

    pub_type： 杂志文章,评审

    doi：10.1016/S0171-2985(99)80061-8

    authors： Sibley LD,Mordue D,Howe DK

    更新日期：1999-12-01 00:00:00

  • Identification of genes expressed in tumor-associated macrophages.

    abstract：:Most malignant tumors contain so-called tumor-associated macrophages (TAM) as a major component of their leukocytic infiltrate. To investigate the impact of the tumor microenvironment on activation and differentiation of macrophages, we established a 3-dimensional model system by culturing human monocytes within multi...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1078/0171-2985-00246

    authors： Gottfried E,Faust S,Fritsche J,Kunz-Schughart LA,Andreesen R,Miyake K,Kreutz M

    更新日期：2003-01-01 00:00:00

  • The effects of increased heme oxygenase-1 on the lymphoproliferative response in dogs with visceral leishmaniasis.

    abstract：:Canine visceral leishmaniasis (CVL) is known to affect the cellular immunity of infected dogs, through impairing lymphoproliferation and microbicidal mechanisms. This study examined heme oxygenase-1 (HO-1) and its metabolites, oxidative stress and IL-10 levels in CVL and investigated correlations between these paramet...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2016.12.006

    authors： Almeida BF,Silva KL,Chiku VM,Leal AA,Venturin GL,Narciso LG,Fink MF,Eugênio FR,Santos PS,Ciarlini PC,Lima VM

    更新日期：2017-05-01 00:00:00

  • Molecular identification and functional characterization of a tumor necrosis factor (TNF) gene in Crassostrea hongkongensis.

    abstract：:Tumor necrosis factor superfamily (TNFSF) represents a group of multifunctional inflammatory cytokines that have been shown to participate in a variety of pathological and immunological process. However, the functions of these proteins in oyster are still poorly understood. In the present study, an oyster TNF homolog ...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2017.02.002

    authors： Qu F,Xiang Z,Zhang Y,Li J,Xiao S,Zhang Y,Qin Y,Zhou Y,Yu Z

    更新日期：2017-05-01 00:00:00

  • Interferon regulatory factor 3 plays a role in macrophage responses to interferon-γ.

    abstract：:IFN-γ produced during viral infections activates the IFN-γ receptor (IFNGR) complex for STAT1 transcriptional activity leading to expression of Interferon Regulatory Factors (IRF). Simultaneous activation of TBK/IKKε via TLR3 during viral infections activates the transcription factor IRF3. Together these transcription...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2019.04.004

    authors： Guinn ZP,Petro TM

    更新日期：2019-07-01 00:00:00

  • Enriched natural killing and antibody-dependent cellular cytotoxicity in lymphocyte populations adherent to tumor cell monolayers.

    abstract：:We have previously shown that human peripheral blood lymphocytes that do not adhere to natural killer (NK)-sensitive target cell monolayers are at least partially depleted of NK activity. To demonstrate directly that NK effector cells adhere to the monolayers, we have now recovered the adherent populations by treatmen...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(82)80052-1

    authors： Jensen PJ,Koren HS

    更新日期：1982-05-01 00:00:00

  • Tissue and serum mRNA profile of MMPs-2/9 as a potential novel biomarker for the most individual approach in infantile hemangiomas and cancer disease.

    abstract：:Propranolol is a widely-known beta-blocker approved for treating infantile hemangiomas (IH). The mechanisms behind the spectacular IH involution after propranolol treatment remain unclear. Recently, there is strong evidence of overexpression of numerous angiogenic factors in IH tissues, and it is reported that propran...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2017.05.014

    authors： Taran K,Wnęk A,Kobos J,Andrzejewska E,Przewratil P

    更新日期：2017-11-01 00:00:00

  • Collagen induced arthritis (CIA) in mice features regulatory transcriptional network connecting major histocompatibility complex (MHC H2) with autoantigen genes in the thymus.

    abstract：:Considering that imbalance of central tolerance in the thymus contributes to aggressive autoimmunity, we compared the expression of peripheral tissue autoantigens (PTA) genes, which are involved in self-representation in the thymic stroma, of two mouse strains; DBA-1/J (MHC-H2(q)) susceptible and DBA-2/J (MHC-H2(d)) r...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2010.09.007

    authors： Donate PB,Fornari TA,Junta CM,Magalhães DA,Macedo C,Cunha TM,Nguyen C,Cunha FQ,Passos GA

    更新日期：2011-05-01 00:00:00

  • Flow cytometric analysis of different adhesion molecules expression on circulating CD14- and CD64- human dendritic cell precursors.

    abstract：:Blood dendritic cell precursors (DCps) are identified as mononuclear leukocytes expressing HLA-DR but lacking the characteristic antigens associated with T cells (CD3), NK cells (CD16 and CD56) and B cells (CD 19). Dendritic cell precursors are distinguished from monocytes by their lack of expression of CD64 rather th...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(00)80053-4

    authors： Macey MG,Jawad N,McCarthy DA,Newland AC,Brown KA

    更新日期：2000-05-01 00:00:00

  • Activation of the first component of complement, C1: comparison of the effect of sixteen different enzymes on serum C1.

    abstract：:In this study, the effect of sixteen different enzymes on serum C1 and its subcomponents was investigated. The sixteen enzymes could be divided into three groups. First, enzymes which activate native C1: trypsin (optimal concentration 2.4 x 10(-4) mM); alpha-chymotrypsin (2.3 x 10(3) mM); thrombin (1.0 x 10(-5) mM); p...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(83)80058-8

    authors： Heinz HP,Loos M

    更新日期：1983-08-01 00:00:00

  • Cytokine production of the human monocytic cell line Mono Mac 6 in comparison to mature monocytes in peripheral blood mononuclear cells.

    abstract：:Mono Mac 6 is a human monocytic cell line with several features of mature blood monocytes such as CD 14 antigen expression, phagocytotic ability, and the functional ability to produce cytokines. This line is often used as an in vitro model to demonstrate the actions of monocytes. In our study, the production of cytoki...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(11)80237-8

    authors： Neustock P,Brand JM,Kruse A,Kirchner H

    更新日期：1993-07-01 00:00:00

  • Induction of tolerance to non-H-2 alloantigens is not restricted by the MHC molecules expressed on the donor cells in cyclophosphamide-induced tolerance.

    abstract：:A long-lasting skin tolerance to non-H-2 alloantigens has been reported to be readily induced, when the recipient mice were primed intravenously (i.v.) with 5 x 10(7) spleen cells (SC) plus 1.5 x 10(7) bone marrow cells (BMC) from the H-2 identical strains of mice, and treated intraperitoneally (i.p.) with 200 mg/kg C...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(11)80511-5

    authors： Tomita Y,Nomoto K

    更新日期：1990-11-01 00:00:00

  • Activation of human macrophage sodium channels regulates RNA processing to increase expression of the DNA repair protein PPP1R10.

    abstract：:Prior work demonstrated that a splice variant of SCN5A, a voltage-gated sodium channel gene, acts as a cytoplasmic sensor for viral dsRNA in human macrophages. Expression of this channel also polarizes macrophages to an anti-inflammatory phenotype in vitro and in vivo. Here we utilized global expression analysis of sp...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2018.10.005

    authors： White CR,Dungan M,Carrithers MD

    更新日期：2019-01-01 00:00:00

  • DAP10 contributes to CD8(+) T cell-mediated cytotoxic effector mechanisms during Mycobacterium tuberculosis infection.

    abstract：:The activating C-type lectin-like receptor NKG2D, which is expressed by mouse NK cells and activated CD8 T cells, was previously demonstrated to be involved in tumor rejection and as a defense mechanism against viral and bacterial infections. Because CD8 T cells are important for protective immune responses during chr...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2010.09.010

    authors： Hessmann M,Rausch A,Rückerl D,Adams PS,Simon M,Gilfillan S,Colonna M,Ehlers S,Hölscher C

    更新日期：2011-05-01 00:00:00

  • Population dynamics of natural killer cells in the spleen and bone marrow of normal and leukemic mice during in vivo exposure to interleukin-2.

    abstract：:By quantitative and functional methods, changes were assessed in NK(ASGM-1+) cell numbers and NK cell-mediated lytic function of the spleen and bone marrow of mice bearing a tumor of hemopoietic origin (FLV-induced erythroleukemia) for 9 days +/- simultaneous administration of indomethacin (10 micrograms/ml drinking w...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(11)80570-X

    authors： Christopher FL,Dussault I,Miller SC

    更新日期：1991-12-01 00:00:00

  • Interaction of lipoteichoic acid and CpG-DNA during activation of innate immune cells.

    abstract：:The innate immune system recognizes pathogen-associated molecular patterns (PAMP) to cope with evolving infections. Toll-like receptors (TLRs) play a pivotal role in recognition of PAMPs. In the course of infection not a single but rather a full panel of different microbial components interacts with distinct TLRs simu...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1078/0171-2985-00189

    authors： Dalpke AH,Frey M,Morath S,Hartung T,Heeg K

    更新日期：2002-10-01 00:00:00

  • Evaluation of the expression and function of the P2X7 receptor and ART1 in human regulatory T-cell subsets.

    abstract：:Regulatory T cells that express CD39 (CD39+ Treg) exhibit specific immunomodulatory properties. Ectonucleotidase CD39 hydrolyses ATP and ADP. ATP is a ligand of the P2X7 receptor and induces the shedding of CD62L and apoptosis. However, the role of ATP in CD39+ Treg cells has not been defined. Furthermore, NAD can act...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2015.07.018

    authors： Cortés-Garcia JD,López-López C,Cortez-Espinosa N,García-Hernández MH,Guzmán-Flores JM,Layseca-Espinosa E,Portales-Cervantes L,Portales-Pérez DP

    更新日期：2016-01-01 00:00:00

  • No evidence for humoral autoimmunity against cardiomyocytes, adrenergic or muscarinic receptors in patients with Tako-Tsubo cardiomyopathy.

    abstract：BACKGROUND:An association between Tako-Tsubo cardiomyopathy (TTC) and underlying malignancies has been observed, suggesting that TTC might be the consequence of paraneoplastic phenomena. This study investigates the presence of autoantibodies against cardiomyocytes as well as adrenergic (β1, β2) and muscarinic (M2) rece...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2018.11.005

    authors： Juenemann M,Nef H,Möllmann H,Singh P,Troidl C,Schramm P,Kaps M,Gerriets T,Blaes F,Tschernatsch M

    更新日期：2019-03-01 00:00:00

  • RAGE and CCR7 mediate the transmigration of Zika-infected monocytes through the blood-brain barrier.

    abstract：:Details of the "Trojan Horse" mechanism by which Zika virus (ZIKV) crosses the blood-brain barrier (BBB) remain unclear. However, the migration of ZIKV-infected monocytes to the brain is thought to be dependent on both pattern-recognition and chemokine receptors. In this study, we investigated whether the migration of...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2019.08.007

    authors： de Carvalho GC,Borget MY,Bernier S,Garneau D,da Silva Duarte AJ,Dumais N

    更新日期：2019-11-01 00:00:00

  • The in vitro activity of lectin I from mistletoe (ML I) and its isolated A and B chains on functions of macrophages and polymorphonuclear cells.

    abstract：:We investigated the effects of ML I and its isolated chains, A and B, in regard to selected functions of phagocytes (human granulocytes, paraffin-oil stimulated M phi from guinea pigs). On these cells, ML I has no cytotoxic effect between 10(-14) and 10(-8) (trypan blue exclusion and ethidium bromide exclusion). Over ...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(85)80002-4

    authors： Metzner G,Franz H,Kindt A,Fahlbusch B,Süss J

    更新日期：1985-07-01 00:00:00

  • Antibody responsiveness during immunization and challenge of genetically modified antibody responder mice with murine hepatitis virus 3.

    abstract：:The aim of this study was to evaluate some immunological patterns involved in natural and acquired resistance against MHV3 using the original model of genetically modified lines of mice selected for high (HIII) and low (LIII) antibody responsiveness. As previously shown, a lower pre-existing anti-MHV antibody level wa...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1078/0171-2985-00239

    authors： Vassão RC,Consales CA,Sant'Anna OA,Pereira CA

    更新日期：2003-01-01 00:00:00

  • Regulation of Streptococcus pneumoniae distribution by Toll-like receptor 2 in vivo.

    abstract：:The phagocyte pattern recognition receptor Toll-like receptor 2 (TLR2) and the multi-receptor adaptor MyD88 contribute to the reduction of bacterial load in infections with intra- and extra-cellular Gram-positive bacteria. Their mechanism of antibacterial action is mostly unresolved but evident in vivo by an increased...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2005.05.017

    authors： Echchannaoui H,Bachmann P,Letiembre M,Espinosa M,Landmann R

    更新日期：2005-01-01 00:00:00

  • Caffeine: Well-known as psychotropic substance, but little as immunomodulator.

    abstract：:To date, numerable reviews are found in the literature prominent to the effect of caffeine on the immune system, with the latest review published in 2006. Database screening reveals around three thousand articles that have been published during the last decade. Interestingly, less than hundred articles involved humans...

    journal_title：Immunobiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.imbio.2018.08.011

    authors： Al Reef T,Ghanem E

    更新日期：2018-12-01 00:00:00

  • Reactive oxygen species (ROS), but not nitric oxide (NO), contribute to strain differences in the susceptibility to experimental arthritis in rats.

    abstract：:There is extensive evidence for the critical role of reactive oxygen species (ROS) and nitric oxide (NO) produced by phagocytes in development of inflammatory processes and pathogenesis of numerous diseases, including rheumatoid arthritis (RA). Apart from their function as mediators of inflammation and tissue damage, ...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2006.11.012

    authors： Miletić T,Kovacević-Jovanović V,Vujić V,Stanojević S,Mitić K,Lazarević-Macanović M,Dimitrijević M

    更新日期：2007-01-01 00:00:00

  • IL-10 production from dendritic cells is associated with DC SIGN in human leprosy.

    abstract：:The defective antigen presenting ability of antigen presenting cells (APCs) modulates host cytokines and co-stimulatory signals that may lead to severity of leprosy. In the present study, we sought to evaluate the phenotypic features of APCs along with whether DC SIGN (DC-specific intercellular adhesion molecule-grabb...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2013.05.004

    authors： Kumar S,Naqvi RA,Bhat AA,Rani R,Ali R,Agnihotri A,Khanna N,Rao DN

    更新日期：2013-12-01 00:00:00

  • Identifying patients with neutrophil elastase (ELANE) mutations from patients with a presumptive diagnosis of autoimmune neutropenia.

    abstract：:To differentiate severe congenital neutropenia (SCN) from autoimmune neutropenia (AIN) in patients with persistent neutropenia ≤1000/mm(3) over three months, we evaluated anti-neutrophil auto-antibodies, candidate genes of ELANA, HAX1 and GCSFR, and neutrophil elastase (NE) activity in 38 patients (21 females; average...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2012.09.001

    authors： Lee WI,Chen SH,Huang JL,Jaing TH,Chung HT,Yeh KW,Chen LC,Yao TC,Hsieh MY,Lin SJ,Kuo ML

    更新日期：2013-05-01 00:00:00

  • Increased levels of Th17 cells are associated with non-neuronal acetylcholine in COPD patients.

    abstract：:T-lymphocytes, including Th17-cells and T-cells expressing acetylcholine (ACh), are key components of systemic inflammation in chronic obstructive pulmonary disease (COPD). We investigated whether ACh promotes Th17 cells in COPD. ACh, IL-17A, IL-22, RORγt, FOXP3 expression and AChIL-17A, AChIL-22, AChRORγt coexpressio...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2014.01.004

    authors： Profita M,Albano GD,Riccobono L,Di Sano C,Montalbano AM,Gagliardo R,Anzalone G,Bonanno A,Pieper MP,Gjomarkaj M

    更新日期：2014-05-01 00:00:00

  • Antibody-mediated binding of fluorescent HIV Gag and influenza nucleoprotein tetramers to blood cells.

    abstract：:Antibody-mediated elimination of foreign antigens contributes to immune protection from viral infection. We have generated phycoerythrin-conjugated HIV-1 Gag/p24 and influenza virus nucleoprotein tetramers for flow cytometric analysis of blood cell populations involved in antibody-mediated immunity. We show that in th...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2009.02.004

    authors： Reiche S,Bussmann BM,Dwai Y,Jassoy C

    更新日期：2010-03-01 00:00:00