Abstract:
:We were able to characterize about 25 antigenic proteins of cultured synovial fibroblasts with apparent molecular weights of 15-230 kd by SDS-electrophoresis and immunoblotting using guinea pig antiserum. Some of these proteins were bovine-serum-derived, adsorbed onto fibroblasts from culture medium. Both rheumatoid and normal sera contained natural antibodies reacting with synovial fibroblast as well as bovine serum antigens when studied with immunoblotting. The amounts of antibodies were quantitated with enzyme immunoassay, measuring IgG and IgA class antibodies against plasma membrane preparations of rheumatoid and normal synovial fibroblasts. No rheumatoid arthritis-related changes were detected in synovial fibroblast protein antigens or antibodies against them in rheumatoid patient specimens.
journal_name
Immunobiologyjournal_title
Immunobiologyauthors
Heino J,Kouri T,Jalkanen M,Lehtonen OPdoi
10.1016/S0171-2985(84)80014-5subject
Has Abstractpub_date
1984-05-01 00:00:00pages
360-7issue
4-5eissn
0171-2985issn
1878-3279pii
S0171-2985(84)80014-5journal_volume
166pub_type
杂志文章相关文献
IMMUNOBIOLOGY文献大全abstract::The tubercle bacillus is a facultative intracellular parasite that grows well in non-activated macrophages. When large numbers of these bacilli have grown intracellularly within such macrophages, a cytotoxic immune response, herein called tissue-damaging (or necrotizing) delayed-type hypersensitivity (DTH), kills the ...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1016/S0171-2985(11)80452-3
更新日期:1994-10-01 00:00:00
abstract::The Early Growth Response Genes (EGR-1 to AT133/EGR-4) encode a family of proteins that are composed of three homologous consecutive zinc fingers of the Cys2-His2 type and different flanking sequence. Upon growth stimulation of resting cells the four EGR-genes are simultaneously transcribed. We have analyzed the expre...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(97)80039-3
更新日期:1997-12-01 00:00:00
abstract::Pythiosis is a life-threatening disease caused by the fungus-like microorganism Pythium insidiosum that can lead to death if not treated. Since P. insidiosum has particular cell wall characteristics, pythiosis is difficult to treat, as it does not respond well to traditional antifungal drugs. In our study, we investig...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2017.10.033
更新日期:2018-03-01 00:00:00
abstract::Cytotoxicity and production of cytokines are two important functions of NK cells. These two different NK functions were studied in a syngeneic rat model in relation to MHC class I expression. We focussed on the mechanism by which NK cells modulate MHC class I expression on target cells and how this interferes with NK ...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/s0171-2985(00)80037-6
更新日期:2000-11-01 00:00:00
abstract::Although there have been numerous attempts to develop a successful vaccine against leishmaniasis, based on the clinical trial in this field, no vaccine against Leishmania in routine way can be found for globally effective vaccination in human. Amongst, first generation vaccines consisting of parasite fractions or whol...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2017.12.003
更新日期:2018-01-01 00:00:00
abstract::Alternative macrophage activation is largely defined by IL-4Rα stimulation but the contribution of Toll-like receptor (TLR) signaling to this phenotype is not currently known. We have investigated macrophage activation status under Th2 conditions in the absence of the core TLR adaptor molecule, MyD88. No impairment wa...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2012.07.006
更新日期:2013-04-01 00:00:00
abstract::We utilized antisera specific for murine IL 1 alpha and IL 1 beta proteins to characterize cell-associated IL 1 according to two distinct criteria, immunochemical detection of radiolabeled IL 1 polypeptides and inhibition of IL 1 activity in cell lysates. Evidence is presented that IL 1 alpha and IL 1 beta are each sy...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/s0171-2985(89)80064-6
更新日期:1989-02-01 00:00:00
abstract::Sialoadhesin (Sn) is a surface receptor expressed on resident macrophages with the ability to bind with sialic acids. During inflammation, an upregulation of Sn is observed. Upon binding of monoclonal antibodies to Sn, the receptor becomes internalized and this has been observed in multiple species. The latter charact...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2016.11.013
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Analysis of peripheral blood lymphocyte subsets has become an essential tool in the evaluation of outcome of diagnostic and research related questions in immunological and pathological conditions. Periodic evaluation and establishment of normal lymphocyte reference ranges are required in clinical and researc...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2014.02.010
更新日期:2014-07-01 00:00:00
abstract::Gammaherpesviruses (gammaHV) establish a life-long latency in the host and are associated with a number of malignant human diseases. It is generally believed that T cells play a major role in controlling the initial acute infection and subsequently maintaining the virus in a quiescent state. However, the nature of the...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1078/0171-2985-00104
更新日期:2001-12-01 00:00:00
abstract::IgE-mediated food allergies are an important cause of life-threatening hypersensitivity reactions. Orally administered peanut antigens mixed with the mucosal adjuvant cholera toxin (CT) induce a strong peanut extract (PE)-specific serum IgE response that is correlated with T-helper type 1 (Th1) and type 2 (Th2)-like T...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2010.02.004
更新日期:2010-12-01 00:00:00
abstract::Chitin and β-glucan are conserved throughout evolution in the fungal cell wall and are the most common polysaccharides in fungal species. Together, these two polysaccharides form a structural scaffold that is essential for the survival of the fungus. In the present study, we demonstrated that Aspergillus fumigatus alk...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2013.10.003
更新日期:2014-03-01 00:00:00
abstract::Chemokines are important mediators of leukocyte recruitment and activation that play critical roles in the pathology of inflammatory diseases such as atherosclerosis, rheumatoid arthritis and asthma. The vaccinia virus (strain Lister) expresses a 35 kDa soluble protein ('35K') that binds and inactivates a wide range o...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1078/0171-2985-00228
更新日期:2003-01-01 00:00:00
abstract::Mast cells serve important roles as sentinels against bacterial infection by secreting mediators stored in granules. Much of their effectiveness depends upon recruiting and/or modulating other immune cells. The location of mast cells implies that they recognize pathogens invading tissues or mucosal tissues. Acinetobac...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2017.05.015
更新日期:2017-11-01 00:00:00
abstract::In the present report, we describe that synthetic inhibitors of and polyclonal and monoclonal antibodies against the membrane ectoenzyme dipeptidyl peptidase IV (DP IV, CD26) inhibit the production of IL-2 and IL-6 and, concomitantly, DNA synthesis of pokeweed mitogen-stimulated peripheral blood mononuclear cells (PBM...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(11)80223-8
更新日期:1993-08-01 00:00:00
abstract::In an immunohistochemical study using monoclonal antibodies, which exclusively recognize cells of the monocyte-macrophage lineage, and monoclonal antibodies against the Ia-antigen, we describe the occurrence of macrophages in the developing and adult central nervous system (CNS). In normal adult brain, no macrophages ...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(87)80083-9
更新日期:1987-01-01 00:00:00
abstract::The octamer motif is a crucial regulatory element for immunoglobulin promoter and enhancer function. We have investigated the molecular mechanisms that underlie octamer-mediated gene activation in B cells. This B cell-specific transcriptional regulation is subject to a novel type of regulatory mechanism. We could demo...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1016/S0171-2985(11)80540-1
更新日期:1995-07-01 00:00:00
abstract::BCG infection of mice provides a convenient model to study natural and cellular immunity to mycobacteria and the mechanisms of granuloma formation and repair. We have used a range of macrophage (M phi) membrane molecules and secretory products to investigate resident M phi-pathogen interactions and T lymphocyte-depend...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1016/S0171-2985(11)80442-0
更新日期:1994-10-01 00:00:00
abstract::A mouse ear reaction for testing cell mediated immunity of human lymphocytes using the local graft-versus-host reaction assay is described. Five million human mononuclears were locally injected into the ears of immune suppressed NZW mice. The reaction mounted was quantitated by determining the 125I-Iodo-Deoxyuridine (...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(85)80050-4
更新日期:1985-02-01 00:00:00
abstract::OK-432, a streptococcal preparation, has been shown as an effective activator to induce human monocyte-derived dendritic cells maturation. During this process, the activation of Toll-like receptor 4 plays an important role. However, the signaling pathway involved in has not been fully understood. In the present study,...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2008.10.008
更新日期:2009-01-01 00:00:00
abstract::All-trans retinoic acid (ATRA) is a potent retinoid, which has been used successfully in different clinical settings as a potential drug to treat COPD and emphysema. In the present study, we analyzed genes modulated by ATRA by performing mRNA expression array analysis on alveolar macrophages after treatment with ATRA....
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2011.10.022
更新日期:2012-06-01 00:00:00
abstract::This study investigated the actin scavenger function of the vitamin D binding protein (DBP) in vivo using DBP null (-/-) mice. Intravenous injection of G-actin into wild-type (DBP+/+) and DBP-/- mice showed that contrary to expectations, DBP+/+ mice developed more severe acute lung inflammation. Inflammation was restr...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2013.10.001
更新日期:2014-03-01 00:00:00
abstract::Interleukin (IL)-27, a member of the IL-6/IL-12 heterodimeric cytokine family, induces pro-inflammatory responses including early T helper (Th)1 differentiation and generation of cytotoxic T lymphocytes, and also anti-inflammatory responses including the differentiation to IL-10-producing regulatory T cells, inhibitio...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2012.07.028
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:Male reproductive tract infection and inflammation are important aetiological factors of infertility. Experimental Autoimmune Orchitis (EAO) is a model of chronic inflammation useful to study mechanisms of inflammatory reactions leading to testicular impairment. EAO is characterised by interstitial cell infi...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2012.04.007
更新日期:2012-08-01 00:00:00
abstract::In mice, monoclonal antibody (mAb) to the alpha1 integrin abrogate gastro-intestinal damage during graft-versus-host-disease (GVHD), suggesting anti alpha1 mAb as candidates for treatment in humans as well. Our current data show that one such reagent, mAb 1B3.1, when immobilized to plastic wells via rabbit- anti murin...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/s0171-2985(00)80031-5
更新日期:2000-09-01 00:00:00
abstract::Details of the "Trojan Horse" mechanism by which Zika virus (ZIKV) crosses the blood-brain barrier (BBB) remain unclear. However, the migration of ZIKV-infected monocytes to the brain is thought to be dependent on both pattern-recognition and chemokine receptors. In this study, we investigated whether the migration of...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2019.08.007
更新日期:2019-11-01 00:00:00
abstract::The process of thymopoiesis is tightly regulated by a series of selection events which ensure that only functional T-lymphocytes directed against foreign antigens are exported into the periphery. The adaptive immune response largely depends on the regulation of thymocyte development, and thymocytes which fail selectio...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2007.05.003
更新日期:2007-01-01 00:00:00
abstract::Visceral leishmaniasis (VL) caused by Leishmania donovani persists as a major public health issue in tropical and subtropical areas of the world. Current treatment of this disease relies on use of drugs. It is doubtful that chemotherapy can alone eradicate the disease, so there is a need for an effective vaccine. Kill...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2015.05.014
更新日期:2015-09-01 00:00:00
abstract::Successful reconstitution of T lymphocytes after allogeneic haematopoietic stem cell transplantation (HSCT) is needed to establish the graft-versus-leukaemia effect and an effective anti-microbial defense, but the ratio between functionally different T-cell subsets needs to be balanced to avoid graft-versus-host disea...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2017.10.023
更新日期:2018-02-01 00:00:00
abstract::Pregnancy is known to induce a transient depression of maternal cell-mediated immunity, to prevent rejection of the fetus, while at the same time it keeps adequate maternal host defense mechanisms to fight infection. Presently, the aim of this paper was to investigate a possible endocrine and immunologic alteration ob...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2014.09.005
更新日期:2015-01-01 00:00:00