The role of ficolins in innate immunity.

abstract：:Mast cells serve important roles as sentinels against bacterial infection by secreting mediators stored in granules. Much of their effectiveness depends upon recruiting and/or modulating other immune cells. The location of mast cells implies that they recognize pathogens invading tissues or mucosal tissues. Acinetobac...

journal_title：Immunobiology

authors： Kikuchi-Ueda T,Kamoshida G,Ubagai T,Nakano R,Nakano A,Akuta T,Hikosaka K,Tansho-Nagakawa S,Kikuchi H,Ono Y

更新日期：2017-11-01 00:00:00

abstract：:Pemphigus Vulgaris (PV), a relatively common autoimmune blistering disease in India, primarily mediated by anti-Desmoglein 3 (anti-Dsg3) autoantibodies. T-helper 17 (Th17) and T-regulatory (Treg) cells play significant role in regulating immune homeostasis in autoimmune disorders. To understand immunopathogenesis of P...

journal_title：Immunobiology

authors： Asothai R,Anand V,Das D,Antil PS,Khandpur S,Sharma VK,Sharma A

更新日期：2015-10-01 00:00:00

abstract：:Autoimmune lymphoproliferative syndrome (ALPS) is a primary immunodeficiency caused by impaired Fas/FasL-mediated apoptosis of lymphocytes and is characterized by chronic nonmalignant or benign lymphoproliferation, autoimmune manifestations and expansion of double negative (DN) T-cells (TCRαβ+CD4-CD8-). Most cases of ...

journal_title：Immunobiology

authors： Martínez-Feito A,Melero J,Mora-Díaz S,Rodríguez-Vigil C,Elduayen R,González-Granado LI,Pérez-Méndez D,Sánchez-Zapardiel E,Ruiz-García R,Menchén M,Díaz-Madroñero J,Paz-Artal E,Del Orbe-Barreto R,Riñón M,Allende LM

更新日期：2016-01-01 00:00:00

abstract：:Mycoplasma arthritidis produces a so-far only partially characterized soluble material (MAS) that has a potent mitogenic effect on T lymphocytes of several species. Similar to staphylococcal enterotoxins and a number of related toxins secreted by other species of bacteria, nanogram quantities of these so-called supera...

journal_title：Immunobiology

authors： Brand JM,Kirchner H,Neustock P,Kruse A

更新日期：1992-11-01 00:00:00

abstract：:Hematopoietic cells express multiple receptors which bind the Fc domain of IgG. We utilized transfection of COS-1 cells, a cell line which lacks endogenous Fc receptors, to study the expression and function of Fc gamma RI, the high affinity Fc gamma receptor in the absence of other Fc gamma receptors. Fc gamma RI was ...

journal_title：Immunobiology

authors： Indik Z,Chien P,Levinson AI,Schreiber AD

更新日期：1992-08-01 00:00:00

abstract：:A review of 250 patients with the catastrophic antiphospholipid (Asherson's) syndrome (CAPS) taken from the web site organized by the Europhospholipid Group (http://www.med.ub.es/MIMMUN/FORUM/CAPS.HTM) is presented in this paper. A short historical overview of the antiphospholipid syndrome (APS) is followed by a descr...

journal_title：Immunobiology

authors： Asherson RA

更新日期：2005-01-01 00:00:00

abstract：:T cells play a pivotal role in controlling the immune response and have been the focus of extensive research. We studied the process of in vitro generation of antigen-specific T effector cells (Teffs) to assess the dynamics of antigen presentation and determine the best conditions for cell therapy. We used a peptidic ...

journal_title：Immunobiology

authors： de Lastic AL,Rodi M,Mouzaki A

更新日期：2016-08-01 00:00:00

abstract：:We utilized antisera specific for murine IL 1 alpha and IL 1 beta proteins to characterize cell-associated IL 1 according to two distinct criteria, immunochemical detection of radiolabeled IL 1 polypeptides and inhibition of IL 1 activity in cell lysates. Evidence is presented that IL 1 alpha and IL 1 beta are each sy...

journal_title：Immunobiology

authors： Günther C,Röllinghoff M,Beuscher HU

更新日期：1989-02-01 00:00:00

abstract：:CD45RA monoclonal antibodies recognize the higher molecular weight isoforms (220 and 205 kDa) of leukocyte common antigen family (CD45), which are typically expressed on B cells and unstimulated T cells. We have found that there are at least three distinct CD45RA monoclonal antibodies which react with platelet 42 kDa ...

journal_title：Immunobiology

authors： Holada K,Dyr JE,Koubek K,Suttnar J,Simák J

更新日期：1995-02-01 00:00:00

abstract：:The distribution of MEL-14+ lymphocytes was investigated by both fluorocytometric analysis and complement-dependent-cellular-cytotoxicity (CDCC) tests in which rabbit anti-rat Ig was added with complement at a secondary step. When CDCC was employed to detect MEL-14+ cells, almost half of the thymocytes were found to b...

journal_title：Immunobiology

authors： Iwabuchi K,Ohgama J,Ogasawara K,Iwabuchi C,Negishi I,Good RA,Onoé K

更新日期：1991-03-01 00:00:00

abstract：:Regulatory properties of macrophages associated with alternative activation serve to limit the exaggerated inflammatory response during pneumonia caused by Pseudomonas aeruginosa infection. Arginase-1 is an important effector of these macrophages believed to play an essential role in decreasing injury and promoting re...

journal_title：Immunobiology

authors： Haydar D,Gonzalez R,Garvy BA,Garneau-Tsodikova S,Thamban Chandrika N,Bocklage TJ,Feola DJ

更新日期：2020-11-24 00:00:00

abstract：:We investigated the effects of ML I and its isolated chains, A and B, in regard to selected functions of phagocytes (human granulocytes, paraffin-oil stimulated M phi from guinea pigs). On these cells, ML I has no cytotoxic effect between 10(-14) and 10(-8) (trypan blue exclusion and ethidium bromide exclusion). Over ...

journal_title：Immunobiology

authors： Metzner G,Franz H,Kindt A,Fahlbusch B,Süss J

更新日期：1985-07-01 00:00:00

abstract：:Periodontitis is a chronic oral pathology caused by impaired immune response against oral bacteria resulting in tissue inflammation and damage. Among the members of innate immune response, the first line of defence against pathogens, inflammasomes are macro-molecular protein complexes that can be activated by differen...

journal_title：Immunobiology

authors： Zupin L,Navarra CO,Robino A,Bevilacqua L,Di Lenarda R,Gasparini P,Crovella S

更新日期：2017-05-01 00:00:00

abstract：:Macrophages orchestrate the initiation and resolution of inflammation by producing pro- and anti-inflammatory products. An imbalance in these mediators may originate from a deficient or excessive immune response. Therefore, macrophages are valid therapeutic targets to restore homeostasis under inflammatory conditions....

journal_title：Immunobiology

authors： Bernal L,Alvarado-Vázquez A,Ferreira DW,Paige CA,Ulecia-Morón C,Hill B,Caesar M,Romero-Sandoval EA

更新日期：2017-02-01 00:00:00

abstract：:Exposure of resident peritoneal macrophages or thioglycollate-induced macrophages (TG-Mø) to influenza or Sendai virus-infected spleen cell culture supernatants (MAS) resulted in macrophage activation. When normal resident macrophages were used as effector cells, both infected P815 and L929 cells were lysed in the pre...

journal_title：Immunobiology

authors： Mak NK,Ada GL

更新日期：1984-05-01 00:00:00

abstract：:Recent evidences suggest a significant role of Plasmacytoid dendritic cells (PDC) role in the pathogenesis of lupus erythematosus (LE) via production of type I IFN. Taking advantage on the availability of multiple reagents (CD123, BDCA2, and CD2ap) specifically recognizing PDC on fixed tissues, we investigated the occ...

journal_title：Immunobiology

authors： Vermi W,Lonardi S,Morassi M,Rossini C,Tardanico R,Venturini M,Sala R,Tincani A,Poliani PL,Calzavara-Pinton PG,Cerroni L,Santoro A,Facchetti F

更新日期：2009-01-01 00:00:00

abstract：:Previous work has shown that purified rat macrophages lack both accessory activity for T lymphocyte responses to mitogens and stimulatory activity in a mixed leukocyte reaction, in marked contrast to the potent activity of dendritic cells. This study was designed to re-evaluate macrophages as accessory cells by treati...

journal_title：Immunobiology

authors： Bowers WE,Ruhoff MS,Goodell EM,Stoltenborg JK

更新日期：1988-02-01 00:00:00

abstract：:Visceral leishmaniasis (VL) caused by Leishmania donovani persists as a major public health issue in tropical and subtropical areas of the world. Current treatment of this disease relies on use of drugs. It is doubtful that chemotherapy can alone eradicate the disease, so there is a need for an effective vaccine. Kill...

journal_title：Immunobiology

authors： Thakur A,Kaur H,Kaur S

更新日期：2015-09-01 00:00:00

abstract：AIM:To study the antiinflammatory effect of lidocaine in intestinal epithelial cells. METHODS:HT-29 and T-84 cells were grown in culture with and without TNF-alpha, lidocaine, aconitine and veratridine. The secretion of IL-8 and IP-10 was measured by ELISA. A cDNA microarray was used to assess gene expression. Real-ti...

journal_title：Immunobiology

authors： Lang A,Ben Horin S,Picard O,Fudim E,Amariglio N,Chowers Y

更新日期：2010-04-01 00:00:00

abstract：:Carboxypeptidase N (CPN) is a member of the carboxypeptidase family of enzymes that cleave carboxy-terminal lysine and arginine residues from a large number of biologically active peptides and proteins. These enzymes are best known for their roles in modulating the activity of kinins, complement anaphylatoxins and coa...

journal_title：Immunobiology

authors： Hu X,Wetsel RA,Ramos TN,Mueller-Ortiz SL,Schoeb TR,Barnum SR

更新日期：2014-02-01 00:00:00

abstract：:Paracoccidioides brasiliensis is a dimorphic fungus from the Paracoccidioides genus, which is the causative agent of paracoccidioidomycosis, a chronic, subacute or acute mycosis, with visceral and cutaneous involvement. This disease that is acquired through inhalation primarily attacks the lungs but, can spread to oth...

journal_title：Immunobiology

authors： Bachiega TF,Dias-Melicio LA,Fernandes RK,de Almeida Balderramas H,Rodrigues DR,Ximenes VF,de Campos Soares ÂM

更新日期：2016-02-01 00:00:00

abstract：:The immunoglobulin production capacities of peripheral blood lymphocytes obtained from patients with various chronic inflammatory liver diseases and from normal individuals were compared. Using a reverse hemolytic plaque assay, immunoglobulin-secreting cells (ISC) were counted immediately after isolation (immediate IS...

journal_title：Immunobiology

authors： Sieber G,Teichmann JV,Möller B,Hopf U

更新日期：1988-12-01 00:00:00

abstract：:The goal of our work was to titer the IgG, IgM and IgA in Pentaglobin® (a preparation enriched in IgM), targeting specific surface antigens of Gram-positive and Gram-negative bacteria as well as a C. albicans strain. Lipopolysaccharides from Gram-negative bacteria, peptidoglycan and lipoteichoic acid from the other mi...

journal_title：Immunobiology

authors： Stracquadanio S,Lo Verde F,Cialfi A,Zega A,Stefani S,Cafiso V

更新日期：2020-03-01 00:00:00

abstract：:It is commonly accepted that dendritic cells (DCs) play a pivotal role in the induction of adaptive T cell-mediated immune responses. The clonal expansion of antigen-specific T cells within secondary lymphoid organs reflects the efficiency of antigen processing and presentation by DCs. Consequently, the quantification...

journal_title：Immunobiology

authors： Florian C,Barth T,Wege AK,Männel DN,Ritter U

更新日期：2010-09-01 00:00:00

abstract：:Purified CD8+ T cells from influenza A/WSN-immune BALB/c (H-2d) mice respond with the generation of secondary A/WSN-specific Tc cells in vitro when stimulated with a synthetic peptide (NPP) with a sequence derived from influenza A virus nucleoprotein with high affinity for Kd class I MHC molecules. The process of the ...

journal_title：Immunobiology

authors： Kos FJ,Müllbacher A

更新日期：1992-11-01 00:00:00

abstract：:Telomere erosion and residual replicative capacity can be used as markers of the replicative history of somatic cells. We have investigated telomere length, in vitro replicative capacity and rate of telomere erosion in T and B lymphocyte populations from patients with primary antibody deficiency requiring immunoglobul...

journal_title：Immunobiology

authors： Tucker VC,Rye AD,Harrison J,King L,Duddridge M,Browning MJ

更新日期：2004-01-01 00:00:00

abstract：:CD163 and CD91 are scavenging receptors with highly increased expression during the differentiation of monocytes into the anti-inflammatory macrophage phenotype. In addition, CD91 is expressed in monocyte-derived dendritic cells (MoDCs), where the receptor is suggested to be important for internalization of CD91-targe...

journal_title：Immunobiology

authors： Maniecki MB,Møller HJ,Moestrup SK,Møller BK

更新日期：2006-01-01 00:00:00

abstract：:Cytokines are important mediators of the effects observed after the administration of endotoxin. One of them, tumor necrosis factor, is particularly important since it plays a cardinal role in two major endotoxin activities: its antitumor effect and its capacity to induce a systemic inflammatory response syndrome. TNF...

journal_title：Immunobiology

authors： Brouckaert P,Libert C,Everaerdt B,Takahashi N,Cauwels A,Fiers W

更新日期：1993-04-01 00:00:00

abstract：:The humoral immune response against alpha(1-->3) dextran (Dex) in BALB/c mice is characterized by the formation of predominantly IgM antibodies bearing the J558 idiotype. IgG antibodies do not appear in euthymic mice. In athymic animals, however, the response proceeds to a vigorous IgG production. In euthymic mice for...

journal_title：Immunobiology

authors： Specht C,Junker R,Krüger A,Rademaekers A,Redlich H,Kölsch E

更新日期：1999-09-01 00:00:00

abstract：:"Brucelline INRA" is an aqueous extract of a rough strain of Brucella melitensis that is used to test cutaneous delayed hypersensitivity in man and animals. The cellular response of mice (either normal, or sensitized by a previous brucella infection) was investigated with local implanted "cell-traps" and by immunologi...

journal_title：Immunobiology

authors： Bureau JP,Caravano R,Garelli L,Lemaire J

更新日期：1989-03-01 00:00:00