Effect of fetal calf serum on cytokine release by bone marrow-derived macrophages during infection with intracellular bacteria.

abstract：:Peritoneal exudate T lymphocytes (PETLs) that mediate delayed-type hypersensitivity (DTH) to sheep red blood cells in mice were modified by in vitro treatment methods which modify surface carbohydrate constituents. Neuraminidase treatment resulted in the release of both N-acetylneuraminic acid and N-glycolyl-neuramini...

journal_title：Immunobiology

authors： Kaufmann SH,Schauer R,Hahn H

更新日期：1981-01-01 00:00:00

abstract：:Most malignant tumors contain so-called tumor-associated macrophages (TAM) as a major component of their leukocytic infiltrate. To investigate the impact of the tumor microenvironment on activation and differentiation of macrophages, we established a 3-dimensional model system by culturing human monocytes within multi...

journal_title：Immunobiology

authors： Gottfried E,Faust S,Fritsche J,Kunz-Schughart LA,Andreesen R,Miyake K,Kreutz M

更新日期：2003-01-01 00:00:00

abstract：:Blood dendritic cell precursors (DCps) are identified as mononuclear leukocytes expressing HLA-DR but lacking the characteristic antigens associated with T cells (CD3), NK cells (CD16 and CD56) and B cells (CD 19). Dendritic cell precursors are distinguished from monocytes by their lack of expression of CD64 rather th...

journal_title：Immunobiology

authors： Macey MG,Jawad N,McCarthy DA,Newland AC,Brown KA

更新日期：2000-05-01 00:00:00

abstract：:The CD83 molecule (CD83) is a well-known surface marker present on mature dendritic cells (mDC). In this study, we show that CD83 is also expressed on a subset of T cells which mediate regulatory T cell (Treg)-like suppressor functions in vitro and in vivo. Treg-associated molecules including CD25, cytotoxic T lymphoc...

journal_title：Immunobiology

authors： Kreiser S,Eckhardt J,Kuhnt C,Stein M,Krzyzak L,Seitz C,Tucher C,Knippertz I,Becker C,Günther C,Steinkasserer A,Lechmann M

更新日期：2015-02-01 00:00:00

abstract：:Recent studies have suggested that odontoblasts are involved in the dental pulp immune response to oral pathogens that invade human dentin during the caries process. How odontoblasts regulate the early inflammatory and immune pulp response to Gram-positive bacteria, which predominate in shallow and moderate dentin car...

journal_title：Immunobiology

authors： Farges JC,Carrouel F,Keller JF,Baudouin C,Msika P,Bleicher F,Staquet MJ

更新日期：2011-04-01 00:00:00

abstract：:Cytophotometric measurements of DNA, dry mass (total proteins) and surface localized IgM and Ia were performed on individual cells of a Burkitt lymphoma derived cell line after X-irradiation and after polyploidization. Blockage of cell division was achieved with 250 r, and an arrest in G2 was found 48 hr after irradia...

journal_title：Immunobiology

authors： Killander D,Klein E,Shapiro I,Lundin L

更新日期：1980-07-01 00:00:00

abstract：:Macrophages orchestrate the initiation and resolution of inflammation by producing pro- and anti-inflammatory products. An imbalance in these mediators may originate from a deficient or excessive immune response. Therefore, macrophages are valid therapeutic targets to restore homeostasis under inflammatory conditions....

journal_title：Immunobiology

authors： Bernal L,Alvarado-Vázquez A,Ferreira DW,Paige CA,Ulecia-Morón C,Hill B,Caesar M,Romero-Sandoval EA

更新日期：2017-02-01 00:00:00

abstract：:Cryptococcus neoformans is a pathogenic fungus causing life threatening infections in humans. The present in vitro study aimed to investigate the opsonizing properties of a well characterized serum ficolin (rat ficolin-A), a member of carbohydrate-recognition molecules of the innate immune system, in the defence again...

journal_title：Immunobiology

authors： Schelenz S,Kirchhof N,Bidula S,Wallis R,Sexton DW

更新日期：2013-04-01 00:00:00

abstract：:Guinea pig (gp) platelets react to nanomolar doses of the complement-derived anaphylatoxin C5a with a shape change, aggregation and release of biogenic amines and nucleotides from their granules. We have investigated the specific receptor for C5a on gp platelets which mediates these biological effects. Competitive bin...

journal_title：Immunobiology

authors： Kretzschmar T,Kahl K,Rech K,Bautsch W,Köhl J,Bitter-Suermann D

更新日期：1991-11-01 00:00:00

abstract：:In a subgroup of CVID T cell abnormalities have been reported. Peripheral blood T lymphocytes from patients with common variable immunodeficiency (CVID) and blood donors were examined for expression of CD8alpha, CD8beta and CD28. In CVID, three CD8+ T cells could be defined: CD8beta(high)CD28+ (expressing CD8beta at a...

journal_title：Immunobiology

authors： Werwitzke S,Drescher B,Schmidt RE,Witte T

更新日期：2000-08-01 00:00:00

abstract：:A heterogeneous set of cells that are commonly grouped as "myeloid cells", interacts in a complex landscape of physiological and pathological situations. In this review we attempt to trace a profile of the "myeloid connection" through different normal and pathological states, by analyzing common metabolic pathways of ...

journal_title：Immunobiology

authors： Peranzoni E,Marigo I,Dolcetti L,Ugel S,Sonda N,Taschin E,Mantelli B,Bronte V,Zanovello P

更新日期：2007-01-01 00:00:00

abstract：:Vaccines capable of inducing mucosal immunity in early postnatal life until adulthood, protecting early sexual initiation, should be considered as strategies to vaccination against HIV. The HIV-1 GAG protein as a chimera with the lysosome-associated membrane protein (LAMP/gag), encoded by a DNA vaccine, is targeted to...

journal_title：Immunobiology

authors： Goldoni AL,Maciel M Jr,Rigato PO,Piubelli O,de Brito CA,Melo A,Marques ET,August JT,Duarte AJ,Sato MN

更新日期：2011-04-01 00:00:00

abstract：:Cytokines are important mediators of the effects observed after the administration of endotoxin. One of them, tumor necrosis factor, is particularly important since it plays a cardinal role in two major endotoxin activities: its antitumor effect and its capacity to induce a systemic inflammatory response syndrome. TNF...

journal_title：Immunobiology

authors： Brouckaert P,Libert C,Everaerdt B,Takahashi N,Cauwels A,Fiers W

更新日期：1993-04-01 00:00:00

abstract：:BASILEA rabbits lack the expression of chi-polypeptide chains and compensate for this lack with expression of lambda polypeptide light chains. These rabbits were immunized with streptococcal group A-variant vaccines. The heterogeneity of the lambda polypeptide chains of specific antibodies was analyzed and compared wi...

journal_title：Immunobiology

authors： Weiss S,Hild K,Braun DG

更新日期：1979-08-01 00:00:00

abstract：:BCG infection of mice provides a convenient model to study natural and cellular immunity to mycobacteria and the mechanisms of granuloma formation and repair. We have used a range of macrophage (M phi) membrane molecules and secretory products to investigate resident M phi-pathogen interactions and T lymphocyte-depend...

journal_title：Immunobiology

authors： Gordon S,Keshav S,Stein M

更新日期：1994-10-01 00:00:00

abstract：:We have previously shown that human peripheral blood lymphocytes that do not adhere to natural killer (NK)-sensitive target cell monolayers are at least partially depleted of NK activity. To demonstrate directly that NK effector cells adhere to the monolayers, we have now recovered the adherent populations by treatmen...

journal_title：Immunobiology

authors： Jensen PJ,Koren HS

更新日期：1982-05-01 00:00:00

abstract：:Based on the similar effects that HIV-1 gp41 like human type I interferons (IFN-alpha and -beta) upregulated MHC expression and inhibited lymphocyte proliferation, we compared amino acid sequences of gp41 and human type I interferons (IFN-alpha and -beta), and found sequence-similarity existing between the immunosuppr...

journal_title：Immunobiology

authors： Chen YH,Dierich MP

更新日期：1998-02-01 00:00:00

abstract：:Activated macrophages have various characteristics in common with exudate and resident macrophages, but the ability to inhibit intracellular proliferation of the protozoa Toxoplasma gondii, the expression of Ia antigen and the capacity to produce H2O2 varies among these cells. Assessment of these features of macrophag...

journal_title：Immunobiology

authors： Nibbering PH,Langermans JA,van de Gevel JS,van der Hulst MB,van Furth R

更新日期：1991-12-01 00:00:00

abstract：:Trypanosoma cruzi is a real challenge to the host's immune system, because it requires strong humoral and cellular immune response to remove circulating trypomastigote forms, and to prevent the replication of amastigote forms in tissues, involving many regulator and effector components. This protozoan is responsible f...

journal_title：Immunobiology

authors： Basso B,Marini V

更新日期：2015-03-01 00:00:00

abstract：:Paracoccidioides brasiliensis is a dimorphic fungus from the Paracoccidioides genus, which is the causative agent of paracoccidioidomycosis, a chronic, subacute or acute mycosis, with visceral and cutaneous involvement. This disease that is acquired through inhalation primarily attacks the lungs but, can spread to oth...

journal_title：Immunobiology

authors： Bachiega TF,Dias-Melicio LA,Fernandes RK,de Almeida Balderramas H,Rodrigues DR,Ximenes VF,de Campos Soares ÂM

更新日期：2016-02-01 00:00:00

abstract：:Pemphigus Vulgaris (PV), a relatively common autoimmune blistering disease in India, primarily mediated by anti-Desmoglein 3 (anti-Dsg3) autoantibodies. T-helper 17 (Th17) and T-regulatory (Treg) cells play significant role in regulating immune homeostasis in autoimmune disorders. To understand immunopathogenesis of P...

journal_title：Immunobiology

authors： Asothai R,Anand V,Das D,Antil PS,Khandpur S,Sharma VK,Sharma A

更新日期：2015-10-01 00:00:00

abstract：:Pregnancy is known to induce a transient depression of maternal cell-mediated immunity, to prevent rejection of the fetus, while at the same time it keeps adequate maternal host defense mechanisms to fight infection. Presently, the aim of this paper was to investigate a possible endocrine and immunologic alteration ob...

journal_title：Immunobiology

authors： Brazão V,Kuehn CC,dos Santos CD,da Costa CM,Júnior JC,Carraro-Abrahão AA

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:To investigate the close association between different antiphospholipid antibodies (aPL) caused by infection and their appearance together with a prolonged activated partial thromboplastin time (aPTT). METHODS:Sera from 122 children were evaluated in this study. Thirty-seven children with mild to medium prol...

journal_title：Immunobiology

authors： Frauenknecht K,Lackner K,von Landenberg P

更新日期：2005-01-01 00:00:00

abstract：:Canine visceral leishmaniasis (CVL) is known to affect the cellular immunity of infected dogs, through impairing lymphoproliferation and microbicidal mechanisms. This study examined heme oxygenase-1 (HO-1) and its metabolites, oxidative stress and IL-10 levels in CVL and investigated correlations between these paramet...

journal_title：Immunobiology

authors： Almeida BF,Silva KL,Chiku VM,Leal AA,Venturin GL,Narciso LG,Fink MF,Eugênio FR,Santos PS,Ciarlini PC,Lima VM

更新日期：2017-05-01 00:00:00

abstract：:The humoral immune response against alpha(1-->3) dextran (Dex) in BALB/c mice is characterized by the formation of predominantly IgM antibodies bearing the J558 idiotype. IgG antibodies do not appear in euthymic mice. In athymic animals, however, the response proceeds to a vigorous IgG production. In euthymic mice for...

journal_title：Immunobiology

authors： Specht C,Junker R,Krüger A,Rademaekers A,Redlich H,Kölsch E

更新日期：1999-09-01 00:00:00

abstract：:The inability of spontaneous and some laboratory-induced tumors to stimulate the immune system has continuously raised the question of the validity of using immunological maneuvers in order to control tumor growth. In this project we suggest that a tumor which is nonimmunogenic still has an immunogenic potential that ...

journal_title：Immunobiology

authors： Klein BY,Sharon R,Tarcic N,Naor D

更新日期：1982-10-01 00:00:00

abstract：PROBLEM:NK lymphocytes play critical yet poorly defined role in implantation and during development in early pregnancy. METHODS OF STUDY:Recently, we showed that the proportion of NK that expressed CD69⁺ after incubation with K562 (CD69(stim)) cells reflected the NK population excitation potential. In the present stud...

journal_title：Immunobiology

authors： Dons'koi BV,Chernyshov VP,Sirenko VY,Strelko GV,Osypchuk DV

更新日期：2014-03-01 00:00:00

abstract：:The century-old tuberculosis vaccine BCG has been the focus of renewed interest due to its well-documented ability to protect against various non-TB pathogens. Much of these broad spectrum protective effects are attributed to trained immunity, the epigenetic and metabolic reprogramming of innate immune cells. As BCG v...

journal_title：Immunobiology

authors： Moulson AJ,Av-Gay Y

更新日期：2020-12-24 00:00:00

abstract：:By fusion of C3H/HeJ splenic adherent mononuclear cells enriched for macrophages with HPRT-deficient C57L/J HH- hepatoma cells, we have generated six macrophage-hepatoma hybrid clones. The hybrid nature of isolated clones was demonstrated by karyotypic analysis. The hybrid clones were screened for macrophage propertie...

journal_title：Immunobiology

authors： Chou YK,Stanley W,Virella G,Kilpatrick JM,Fudenberg HH

更新日期：1987-08-01 00:00:00

abstract：:Equine dendritic cells (eqDC) can be generated from peripheral blood monocytes by propagation in GM-CSF and IL-4. Despite similarities with the generation of human DC, we found significant improvements for eqDC generation and functional influences on eqDC maturation. The fractionation of peripheral blood mononuclear c...

journal_title：Immunobiology

authors： Dietze B,Cierpka E,Schäfer M,Schill W,Lutz MB

更新日期：2008-01-01 00:00:00