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Epigenetic mechanisms of macrophage activation in type 2 diabetes.

Abstract：

:The alarming rise of obesity and type 2 diabetes (T2D) has put a tremendous strain on global healthcare systems. Over the past decade extensive research has focused on the role of macrophages as key mediators of inflammation in T2D. The inflammatory environment in the obese adipose tissue and pancreatic β-cell islets creates and perpetuates imbalanced inflammatory macrophage activation. Consequences of this chronic low-grade inflammation include insulin resistance in the adipose tissue and pancreatic β-cell dysfunction. Recently, the emerging field of epigenetics has provided new insights into the pathogenesis of T2D, while also affording potential new opportunities for treatment. In macrophages, epigenetic mechanisms are increasingly being recognized as crucial controllers of their phenotype. Here, we first describe the role of macrophages in T2D. Then we elaborate on epigenetic mechanisms that regulate macrophage activation, thereby focusing on T2D. Next, we highlight how diabetic conditions such as hyperlipidemia and hyperglycemia could induce epigenetic changes that promote an inflammatory macrophage phenotype. In conclusion we discuss possible therapeutic interventions by targeting macrophage epigenetics and speculate on future research directions.

journal_name

Immunobiology

journal_title

Immunobiology

authors

Ahmed M,de Winther MPJ,Van den Bossche J

doi

10.1016/j.imbio.2016.08.011

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

937-943

issue

10

eissn

0171-2985

issn

1878-3279

pii

S0171-2985(16)30358-8

journal_volume

222

pub_type

杂志文章,评审

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