Abstract:
:Investigating the expression of lipoteichoic acid (LTA) from Listeria monocytogenes, we found two distinct structural variants of LTA (LTA1 and LTA2) using NMR and MS technology. While both LTA consisted of a poly-glycerophosphate backbone (differing in length) bound via a disaccharide to a diacyl-glycerol moiety, one LTA type (LTA2) possessed a second diacyl-glycerol moiety linked to the disaccharide via a phosphodiester. As examined in vitro, LTA2 in contrast to LTA1 failed to activate the L-ficolin dependent pathway of complement. Most interestingly, growth temperature had a strong influence on the expression levels of LTA1 and LTA2 in the cell wall: while the amount of LTA1 was comparable, the expression of LTA2 was low when Listeria had grown at room temperature (ratio of LTA1 to LTA2 was 1:0.06), but increased when Listeria had been cultivated at 37°C (ratio of LTA1 to LTA2 was 1:0.68). The observed shift in LTA expression, probably accompanying the switch from the saprophytic to the virulent entity, indicates an important adaptation to the different structural requirements inside the host cells.
journal_name
Immunobiologyjournal_title
Immunobiologyauthors
Dehus O,Pfitzenmaier M,Stuebs G,Fischer N,Schwaeble W,Morath S,Hartung T,Geyer A,Hermann Cdoi
10.1016/j.imbio.2010.03.008subject
Has Abstractpub_date
2011-01-01 00:00:00pages
24-31issue
1-2eissn
0171-2985issn
1878-3279pii
S0171-2985(10)00031-8journal_volume
216pub_type
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