Abstract：
:Integration of cellular and humoral arms of the innate immune response is fundamental to the development of powerful effector functions in host defence as well as aberrant immune responses. Here, we provide evidence in support of the relationship between complement activation and NK cell functional modulation. We demonstrate that human NK cells and both CD56(bright)CD16(-) and CD56(dim)CD16(+) populations express receptors known to detect the biologically active peptides C3a and C5a (i.e. C3aR, C5aR, C5L2) and the covalently-bound fragments C3b and metabolites iC3b and C3d which serve in immune adhesion (e.g. CR3, CR4). We also show that several pathogen- or tumour/inflammation-related stimuli differentially regulated those complement receptor expression. Furthermore, our results suggest that C3 fragments (C3a, iC3b) have a negative regulatory effect on IFN-γ production in NK cells. This work provides extensive information of human complement receptors relevant to the integrated actions of complement and NK cells which has been suggested by animal studies. The observations may act as a resource that allows further understanding and exploitation of role of complement in human health and immune mediated diseases.
journal_name
Immunobiologyjournal_title
Immunobiologyauthors
Min X,Liu C,Wei Y,Wang N,Yuan G,Liu D,Li Z,Zhou W,Li Kdoi
10.1016/j.imbio.2014.03.018subject
Has Abstractpub_date
2014-09-01 00:00:00pages
671-9issue
9eissn
0171-2985issn
1878-3279pii
S0171-2985(14)00066-7journal_volume
219pub_type
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