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Epidemiologic investigation of serum levels of the soluble forms of CD25, CD54 and CD58, and T cell responsiveness after stimulation via the CD2-dependent pathway in a random sample of the general population.

Abstract：

:A sero-epidemiologic correlation study on immune parameters which would correlate with the frequency of common colds (FCC) had been conducted in 1992. There, an inverse relationship between circulating adhesion molecules CD54 and CD58 and FCC was found. Eighteen months later we performed an analogous assessment in order to verify the previous findings and to carry out additional experiments including in vitro proliferative responses of T cells and their production of various cytokines (IFN-gamma, IL-2, IL-6 and IL-10). The additional examinations showed that individuals with frequent common colds exert a higher T cell proliferation and higher production of cytokines than persons which experience never or few common cold infections. These findings could be confirmed statistically. Taken together, the results suggest consistently in individuals with frequent common colds an association with low serum levels of the immunosuppressive soluble adhesion molecules sCD54 and sCD58, high proliferation of unstimulated and stimulated T cells and secretion of higher concentrations of cytokines (IFN-gamma, IL-2, IL-6 and IL-10) into the cell culture supernatants.

journal_name

Immunobiology

journal_title

Immunobiology

authors

Becker N,Krause G,Rensch K,Meuer SC

doi

10.1016/S0171-2985(96)80005-2

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

47-60

issue

1

eissn

0171-2985

issn

1878-3279

pii

S0171-2985(96)80005-2

journal_volume

195

pub_type

杂志文章

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