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Cytokine treatment of macrophage suppression of T cell activation.

Abstract：

:High Mphi:T cell ratios suppress the immune response to the retroviral superantigen Mls by IFNgamma-triggered production of the arg- and trp-consuming enzymes iNOS and IDO. Attempts to reverse suppression by treatment with pro-inflammatory cytokines revealed that IL-6 improved the T cell response to Mls and the pro-hematopoietic cyokines IL-3 and GM-CSF increased suppression. GM-CSF treatment increased Mphi expression of CD80, a ligand for the immune suppressive B7H1 and CTLA-4 receptors. These results illustrate potential strategies for reversing the suppression of cell-mediated immunity characteristic of the high Mphi:T cell ratios found in many tumors.

journal_name

Immunobiology

journal_title

Immunobiology

authors

Silberman D,Bucknum A,Kozlowski M,Matlack R,Riggs J

doi

10.1016/j.imbio.2009.01.015

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

70-80

issue

1

eissn

0171-2985

issn

1878-3279

pii

S0171-2985(09)00036-9

journal_volume

215

pub_type

杂志文章

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