Neutrophil Extracellular Traps Enhance Staphylococcus Aureus Vegetation Formation through Interaction with Platelets in Infective Endocarditis.

abstract：:Protein Z-dependent protease inhibitor (ZPI) is plasma proteinase inhibitor in the serpin superfamily that produces rapid inhibition of factor Xa in the presence of phospholipids, Ca++ and protein Z (PZ). Mouse ZPI cDNA was isolated and cloned from mouse liver RNA using RT-PCR. The cDNA contains 100 nucleotides 5' of ...

journal_title：Thrombosis and haemostasis

authors： Zhang J,Broze GJ Jr

更新日期：2001-05-01 00:00:00

abstract：:A new genetic test has been developed for detection of the mutation known as factor V Leiden. The test employs heteroduplex technology and comprises a single PCR reaction followed immediately by PCR product analysis. It therefore represents the minimum practical route from blood/tissue sample to genetic result. A coho...

journal_title：Thrombosis and haemostasis

authors： Bowen DJ,Standen GR,Granville S,Bowley S,Wood NA,Bidwell J

更新日期：1997-01-01 00:00:00

abstract：:Congenitally abnormal fibrinogen Osaka III with the replacement of gamma Arg-275 by His was found in a 38-year-old female with no bleeding or thrombotic tendency. Release of fibrinopeptide(s) by thrombin or reptilase was normal, but her thrombin or reptilase time in the absence of calcium was markedly prolonged and th...

journal_title：Thrombosis and haemostasis

authors： Yoshida N,Imaoka S,Hirata H,Matsuda M,Asakura S

更新日期：1992-11-10 00:00:00

abstract：:At the moment of hemostasis, the platelet must be able to reorganize its cytoskeleton through a complexly orchestrated signaling cascade that is regulated, in part, by polyphosphoinositides. In the past 6 years, evidence has accumulated that PH domains bind these polyphosphoinositides and play a role in cytoskeletal c...

journal_title：Thrombosis and haemostasis

authors： Ma AD,Abrams CS

更新日期：1999-08-01 00:00:00

abstract：:Bacteraemia and viraemia are characterised by pathogens entering the bloodstream. Endothelial cells are among the first cells coming into contact with the microbes and also some endogenous molecules which are released by tissue damage. As part of the innate immune system, endothelial cells respond to these contacts by...

journal_title：Thrombosis and haemostasis

authors： Opitz B,Eitel J,Meixenberger K,Suttorp N

更新日期：2009-12-01 00:00:00

abstract：:Less than 60 cases of acquired factor (F)XIII deficiencies have been reported, most having distinct clinical features. To illustrate the therapeutic challenges of acquired FXIII inhibitors, we report a case of a 65-year-old patient with no previous bleeding history who suddenly developed massive haemorrhages associate...

journal_title：Thrombosis and haemostasis

authors： Boehlen F,Casini A,Chizzolini C,Mansouri B,Kohler HP,Schroeder V,Reber G,de Moerloose P

更新日期：2013-03-01 00:00:00

abstract：:Antiphospholipid-protein antibodies (APA) are a family of immunoglobulins which have been defined by varying laboratory test systems. Lupus anticoagulants (LA) and anticardiolipin antibodies (ACA) are the two most prominent members of this family of antibodies. LA are detected utilizing various phospholipid (PL) depen...

journal_title：Thrombosis and haemostasis

authors： Triplett DA

更新日期：1995-07-01 00:00:00

abstract：:Venous thromboembolism (VTE) is a central concern in the intensive care unit (ICU). However, little is known about both current practices for VTE prevention in the ICU and the risk for VTE in persons with severe sepsis and septic shock. XPRESS was a randomized, double-blind, placebo-controlled trial of prophylactic he...

journal_title：Thrombosis and haemostasis

authors： Shorr AF,Williams MD

更新日期：2009-01-01 00:00:00

abstract：:The carboxy-terminal region of hirudin (residues 54-65) has previously been shown to inhibit thrombin clotting activity without binding to the catalytic site of the enzyme. In the present study, the effect of hirudin 54-65 on thrombin interaction with specified platelet proteins has been investigated. Hirudin 54-65 wa...

journal_title：Thrombosis and haemostasis

authors： Jandrot-Perrus M,Huisse MG,Krstenansky JL,Bezeaud A,Guillin MC

更新日期：1991-09-02 00:00:00

abstract：:Novel strategies for a tailored risk prediction in chronic heart failure (CHF) are crucial to identify patients at very high risk for an improved patient management and to specify treatment regimens. Endothelial progenitor cells (EPCs) are an important endogenous repair mechanism with the ability to counteract endothe...

journal_title：Thrombosis and haemostasis

authors： Koller L,Hohensinner P,Sulzgruber P,Blum S,Maurer G,Wojta J,Hülsmann M,Niessner A

更新日期：2016-08-01 00:00:00

abstract：:A fully representative and viable platelet population was isolated from the blood of 15 baboons by a multiwash procedure, and labelled with In-111-oxine. The recovery of the total platelet population in the circulation was 85% +/- 9. Mean platelet life span was 146 hr +/- 13. Correcting for plasma radioactivity (alway...

journal_title：Thrombosis and haemostasis

authors： Kotzé HF,Lötter MG,Badenhorst PN,Heyns AD

更新日期：1985-06-24 00:00:00

abstract：:Sixty-four Chinese women were studied for the effects of injecting once-a-month contraceptive norethisterone enanthate/estradiol valerate between 2 to 4 1/2 years on certain coagulation and fibrinolytic parameters, and 59 women not receiving any steroidal contraception were controls. In both groups there was no signif...

journal_title：Thrombosis and haemostasis

authors： Meng YX,Jiang HY,Lu FY

更新日期：1990-12-28 00:00:00

abstract：:Stress may counteract responses to antiplatelet drug treatment. We investigated if adding clopidogrel to aspirin treatment could attenutate stress-induced platelet activation and myocardial ischemia in patients with coronary artery disease (CAD). Thirty-one male patients with documented CAD-treated with aspirin (75-16...

journal_title：Thrombosis and haemostasis

authors： Perneby C,Wallén NH,Hofman-Bang C,Tornvall P,Ivert T,Li N,Hjemdahl P

更新日期：2007-12-01 00:00:00

abstract：:We have evaluated the effect of plasminogen activators (t-PA and urokinase) on an experimental model of disseminated intravascular coagulation (DIC) in rabbits by injection of 20 micrograms/kg/h of E. coli lipopolysaccharide during 6 h t-PA (0.2 mg/kg and 0.7 mg/kg), urokinase (3000 U/kg/h) and saline (control) were g...

journal_title：Thrombosis and haemostasis

authors： Paloma MJ,Páramo JA,Rocha E

更新日期：1995-12-01 00:00:00

abstract：:Fresh retracted clots are known to be poorly lysable by fibrinolytic agents. We have studied whether lysis of retracted clots could be enhanced by bulk transport in comparison to pure diffusion of plasma containing urokinase (400 IU/ml) into the clots. Cylindrical retracted blood clots were occlusively glued by a poly...

journal_title：Thrombosis and haemostasis

authors： Blinc A,Keber D,Lahajnar G,Stegnar M,Zidansek A,Demsar F

更新日期：1992-12-07 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is characterised by increased pressure in the pulmonary arteries leading to right-sided ventricular failure, and death. Identification of factors that affect patient survival is important to improve patient management and outcomes. The first registry to evaluate survival and devel...

journal_title：Thrombosis and haemostasis

authors： Benza RL,Gomberg-Maitland M,Frost AE,Frantz RP,Humbert M,McGoon MD

更新日期：2012-12-01 00:00:00

abstract：:Thirty-one non-hemophilic patients with acquired antibodies to factor VIII were entered into a prospective, randomized, multi-institutional trial to determine the safety and efficacy of prednisone (P), cyclophosphamide (C), or the combination in the treatment of this disorder. Patients were eligible if they had antibo...

journal_title：Thrombosis and haemostasis

authors： Green D,Rademaker AW,Briët E

更新日期：1993-11-15 00:00:00

abstract：:Sepsis triggers a complex series of pathophysiologic events involving inflammatory responses and coagulation abnormalities. While circulating blood platelets are well-characterized for their contributions to coagulation, increasingly platelet-dependent effects on inflammation are being recognized. Here, we focus on th...

journal_title：Thrombosis and haemostasis

authors： Asfari A,Dent JA,Corken A,Herington D,Kaliki V,Sra N,Hefley G,Pasala S,Prodhan P,Ware J

更新日期：2019-03-01 00:00:00

abstract：:Standard pharmacokinetic (PK) assessments are demanding for persons with hemophilia A, requiring a 72hr washout and 5-11 timed blood samples. A no-washout, single-clinic visit, sparse sampling population PK (PPK) protocol is an attractive alternative. Here, we compared PK parameters obtained with a traditional washout...

journal_title：Thrombosis and haemostasis

authors： Blanchette V,Zunino L,Grassmann V,Barnes C,Carcao M,Curtain J,Jackson SC,Khoo L,Komrska V,Lillicrap D,Morfini M,Romanova G,Stephens D,Zapotocka E,Rand ML,Blatny J

更新日期：2021-01-27 00:00:00

abstract：:Myocardial infarction results from a platelet-rich occlusive coronary thrombus. Platelet membrane glycoprotein IIb/IIIa plays an important role in platelet adhesion and aggregation. Two polymorphisms of the gene encoding the IIIa subunit. PLA1 and PLA2, have been identified. We investigated the frequency of these poly...

journal_title：Thrombosis and haemostasis

authors： Durante-Mangoni E,Davies GJ,Ahmed N,Ruggiero G,Tuddenham EG

更新日期：1998-08-01 00:00:00

abstract：:Lupus anticoagulants (LA) are immunoglobulins directed to either prothrombin or Beta-2-glycoprotein 1(beta1GPI) bound to phospholipids. Most patients with LA have both beta2GPI- and prothrombin-dependent antibodies. Several recent reports have shown that LA is more strongly associated with thrombosis than anticardioli...

journal_title：Thrombosis and haemostasis

authors： Arnout J,Meijer P,Vermylen J

更新日期：1999-06-01 00:00:00

abstract：:The correlation between homocysteine and vascular disease has been assessed in several clinical studies that demonstrated that elevation of plasma total homocysteine (tHcy) was an independent risk factor for atheriosclerotic disease. Major advances of homocysteine metabolism disorders have been made during the last fe...

journal_title：Thrombosis and haemostasis

authors： Di Minno MN,Tremoli E,Coppola A,Lupoli R,Di Minno G

更新日期：2010-05-01 00:00:00

abstract：:Osteoprotegerin (OPG) regulates bone metabolism by reducing the activation of osteoclasts, but may also be involved in blood vessel calcification and atherosclerosis. Within endothelial cells OPG is stored in Weibel-Palade bodies (WPBs). Blood kinetics of OPG are essentially unknown. We aimed to assess these using two...

journal_title：Thrombosis and haemostasis

authors： Buchtele N,Kovacevic KD,Brostjan C,Schwameis M,Hayden H,Derhaschnig U,Firbas C,Jilma B,Schoergenhofer C

更新日期：2020-07-01 00:00:00

abstract：:Accumulating evidence suggests an immune-modulatory role for platelets (PLT) and PLT-derived microvesicles. In particular, ectosomes, i.e. vesicles budding from PLT surface, have been shown to exert immunosuppressive activities on phagocytes. Here we investigated the effects mediated by PLT-derived ectosomes (PLT-Ecto...

journal_title：Thrombosis and haemostasis

authors： Sadallah S,Amicarella F,Eken C,Iezzi G,Schifferli JA

更新日期：2014-12-01 00:00:00

abstract：:There is much debate over the appropriateness of prescribing prolonged anticoagulation to heterozygous carriers of factor V Leiden suffering a first episode of deep vein thrombosis (DVT). We, thus used meta-analysis to estimate from six eligible studies the summary odds-ratio of recurrent DVT in carriers of factor V L...

journal_title：Thrombosis and haemostasis

authors： Marchetti M,Pistorio A,Barosi G

更新日期：2000-11-01 00:00:00

abstract：:Developmental haemostasis is a concept, now universally accepted, introduced by Andrew et al. in the late 1980's. However, coagulation analysers and reagents have changed significantly over the past 15 years. Coagulation testing is known to be sensitive to changes in individual reagents and analysers. We hypothesised ...

journal_title：Thrombosis and haemostasis

authors： Monagle P,Barnes C,Ignjatovic V,Furmedge J,Newall F,Chan A,De Rosa L,Hamilton S,Ragg P,Robinson S,Auldist A,Crock C,Roy N,Rowlands S

更新日期：2006-02-01 00:00:00

abstract：:Positively charged macromolecule, polylysine (mol. wt. 15,000; 23,000; 180,000) could induce the platelet aggregation in low concentration but high concentration was required in the case of neutral macromolecule, dextran (mol. wt. 40,000; 250,000; 2,000,000). The larger molecules of polylysine and dextran were more ef...

journal_title：Thrombosis and haemostasis

authors： Taketomi Y,Kuramoto A

更新日期：1978-08-31 00:00:00

abstract：:Aspirin prevents thrombotic events by inhibiting platelet cyclooxygenase-1 (COX-1), thus reducing thromboxane A2 formation and platelet aggregation. The C50T polymorphism of COX-1 is associated with an impaired inhibition of both thromboxane production and in-vitro platelet aggregation by aspirin. We studied whether t...

journal_title：Thrombosis and haemostasis

authors： Clappers N,van Oijen MG,Sundaresan S,Brouwer MA,Te Morsche RH,Keuper W,Peters WH,Drenth JP,Verheugt FW

更新日期：2008-07-01 00:00:00

abstract：:We have developed a simple assay that measures the circulating activated protein C (APC) in plasma. The assay requires collection of duplicate blood samples, one in citrate plus heparin and the other in citrate plus inhibitors of the enzyme. In the heparin tube, APC reacts completely and irreversibly with its major pl...

journal_title：Thrombosis and haemostasis

authors： Espana F,Zuazu I,Vicente V,Estellés A,Marco P,Aznar J

更新日期：1996-01-01 00:00:00

abstract：:Recent clinical studies have shown that the interruption of platelet function appears to be effective for treatment of coronary occlusive diseases. For this purpose, a Fab fragment of humanized anti-platelet glycoprotein (GP) IIb/IIIa monoclonal antibody (YM 337) that exhibited an in vivo antithrombotic effect without...

journal_title：Thrombosis and haemostasis

authors： Kuwahara M,Sugimoto M,Tsuji S,Miyata S,Nishio K,Kaku S,Suzuki K,Kawasaki T,Yoshioka A

更新日期：1998-07-01 00:00:00