The East Asian Paradox: An Updated Position Statement on the Challenges to the Current Antithrombotic Strategy in Patients with Cardiovascular Disease.

Abstract:

:East Asian patients have reduced anti-ischemic benefits and increased bleeding risk during antithrombotic therapies compared with Caucasian patients. As potent P2Y12 receptor inhibitors (e.g., ticagrelor and prasugrel) and direct oral anticoagulants are commonly used in current daily practice, the unique risk-benefit trade-off in East Asians has been a topic of emerging interest. In this article, we propose updated evidence and future directions of antithrombotic treatment in East Asian patients.

journal_name

Thromb Haemost

authors

Kim HK,Tantry US,Smith SC Jr,Jeong MH,Park SJ,Kim MH,Lim DS,Shin ES,Park DW,Huo Y,Chen SL,Bo Z,Goto S,Kimura T,Yasuda S,Chen WJ,Chan M,Aradi D,Geisler T,Gorog DA,Sibbing D,Lip GYH,Angiolillo DJ,Gurbel PA,J

doi

10.1055/s-0040-1718729

subject

Has Abstract

pub_date

2020-11-10 00:00:00

eissn

0340-6245

issn

2567-689X

pub_type

杂志文章
  • Long-term tolerance and recovery of beta-propiolactone/ultraviolet (beta PL/UV) treated PPSB in chimpanzees.

    abstract::Recent experiments have shown that a preparation of PPSB (factor IX concentrate) derived form beta PL/UV treated plasma was not infectious in chimpanzees with respect to hepatitis B and non-A, non-B. To answer the question whether the beta PL/UV treatment influences the tolerance and efficacy of the PPSB-concentrate, ...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Stephan W,Kotitschke R,Prince AM,Brotman B

    更新日期:1981-08-28 00:00:00

  • Animal models of vulnerable plaque. Clinical context and current status.

    abstract::There is increasing recognition of the importance of vulnerable plaque and acute plaque rupture leading to thrombosis, in the pathogenesis of acute coronary syndromes. This is fueling a number of developments, including novel imaging modalities and potential plaque stabilization therapies. However, to date, no animal ...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,评审

    doi:10.1160/TH03-06-0374

    authors: Lowe HC,Jang IK,Khachigian LM

    更新日期:2003-11-01 00:00:00

  • Red blood cell distribution width is associated with poor clinical outcome in acute cerebral infarction.

    abstract::Increased red blood cell distribution width (RDW), which is a marker of anisocytosis, is associated with mortality and cardiovascular events in the general population and in patients with heart failure or coronary heart disease. We investigated whether RDW in acute cerebral infarction is predictive of functional outco...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH12-03-0165

    authors: Kim J,Kim YD,Song TJ,Park JH,Lee HS,Nam CM,Nam HS,Heo JH

    更新日期:2012-08-01 00:00:00

  • Rituximab for treatment of inhibitors in haemophilia A. A Phase II study.

    abstract::The development of antibodies against infused factor VIII (FVIII) in patients with haemophilia A is a serious complication leading to poorly controlled bleeding and increased morbidity. No treatment has been proven to reduce high titre antibodies in patients who fail immune tolerance induction or are not candidates fo...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,多中心研究

    doi:10.1160/TH14-01-0078

    authors: Leissinger C,Josephson CD,Granger S,Konkle BA,Kruse-Jarres R,Ragni MV,Journeycake JM,Valentino L,Key NS,Gill JC,McCrae KR,Neufeld EJ,Manno C,Raffini L,Saxena K,Torres M,Marder V,Bennett CM,Assmann SF

    更新日期:2014-09-02 00:00:00

  • An experimental model of intracranial hemorrhage during thrombolytic therapy with t-PA.

    abstract::Multiple clinical trials have proven that thrombolytic therapy is an effective treatment for acute myocardial infarction. Spontaneous intracranial hemorrhage (ICH) occurs in a small percentage of patients as a result of the treatment. The etiology of the ICH is unknown and there is currently no established experimenta...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Paoni NF,Steinmetz HG,Gillett N,Refino CJ,Badillo JM,Bunting S

    更新日期:1996-05-01 00:00:00

  • Molecular signature of coronary stent thrombosis: oxidative stress and innate immunity cells.

    abstract::The clinical impact of in-stent thrombosis is high because it is associated with high mortality and 20 % of the patients suffer a recurrent event within the two following years. The aim of this study was to characterise the morphologic and proteomic profile of in-stent thrombi (IST) in comparison to thrombi developed ...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH17-03-069

    authors: Cubedo J,Blasco A,Padro T,Ramaiola I,Juan-Babot O,Goicolea J,Fernández-Díaz JA,Oteo JF,Badimon L

    更新日期:2017-08-30 00:00:00

  • Characterisation of epitopes on human tissue plasminogen activator recognised by a group of monoclonal antibodies.

    abstract::Seven mouse monoclonal antibodies have been produced against human melanoma tissue plasminogen activator (t-PA). They were specifically bound to 125I t-PA but not 125I urokinase (u-PA) and inhibited t-PA, but not u-PA, activity in plasminogen-rich 125I fibrin wells. Three of the antibodies directly inhibited the amido...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: MacGregor IR,Micklem LR,James K,Pepper DS

    更新日期:1985-02-18 00:00:00

  • Safety and tolerability of an immediate-release formulation of theoral direct thrombin inhibitor AZD0837 in the prevention of stroke and systemic embolism in patients with atrial fibrillation.

    abstract::AZD0837 is an investigational oral anticoagulant which is converted to the active form, AR-H067637, a selective direct thrombin inhibitor. The present study, a multicentre, randomised, parallel-group, dose-guiding study, assessed the safety and tolerability of an immediate-release formulation of AZD0837 compared with ...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1160/TH09-07-0509

    authors: Olsson SB,Rasmussen LH,Tveit A,Jensen E,Wessman P,Panfilov S,Wåhlander K

    更新日期:2010-03-01 00:00:00

  • Tenilsetam prevents early diabetic retinopathy without correcting pericyte loss.

    abstract::Hyperglycemia-induced mitochondrial overproduction of reactive oxygen species leads to the activation of different biochemical pathways involved in endothelial damage of the diabetic retina. Tenilsetam [(+/-)-3-(2-thienyl)-2-piperazinone] is a dicarbonyl scavenger in the millimolar range and a transition metal ion che...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Hoffmann J,Alt A,Lin J,Lochnit G,Schubert U,Schleicher E,Chavakis T,Brownlee M,Van der Woude FJ,Preissner KT,Hammes HP

    更新日期:2006-04-01 00:00:00

  • Baboon models of acute arterial thrombosis.

    abstract::In conclusion, we believe that the baboon offers many advantages as an experimental animal to study vascular disease, thrombus formation and dissolution, the effects of mediating variables, and the relative efficacy of therapeutic interventions. Each specific application for testing therapeutic agents may require test...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,评审

    doi:

    authors: Hanson SR,Harker LA

    更新日期:1987-10-28 00:00:00

  • Non-occlusive bleeding times may improve the value of Ivy bleeding times.

    abstract::The present studies measured bleeding times, without venous occlusion, in a series of patients, whose bleeding times (+ venostasis) consistently exceeded 20 min. During these tests, the amount of blood loss (expressed as mg/min) was also quantitated. To allow comparison, normal controls were studied before and followi...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Zeigler ZR

    更新日期:1990-06-28 00:00:00

  • Inhibition of human and rat platelet aggregation by extracts of Mo-er (Auricularia auricula).

    abstract::Hot water extracts of Mo-er (1 gm by 15 ml of water), an oriental food (Auricularia auricula), inhibit strongly both human and rat platelet ADP-induced aggregation. HPLC analysis of two varieties of Mo-er, A. auricula and A. polytricha (a black tree fungus), shows that they contain adenosine (Ado), 133 and 154 microgr...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Agarwal KC,Russo FX,Parks RE Jr

    更新日期:1982-10-29 00:00:00

  • Human tissue factor pathway inhibitor fused to CD4 binds both FXa and TF/FVIIa at the cell surface.

    abstract::Tissue factor pathway inhibitor (TFPI) is one of the main regulators of the tissue factor (TF) pathway of coagulation. To tether human TFPI to the cell surface, full length or truncated TFPI lacking the third Kunitz domain were fused with domains three and four and the carboxy-terminal sequence of human CD4. Construct...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Riesbeck K,Dorling A,Kemball-Cook G,McVey JH,Jones M,Tuddenham EG,Lechler RI

    更新日期:1997-12-01 00:00:00

  • Prasugrel inhibits platelet-leukocyte interaction and reduces inflammatory markers in a model of endotoxic shock in the mouse.

    abstract::Prasugrel, through its active metabolite, reduces atherothrombosis and its clinical manifestations by inhibiting platelet activation and aggregation. Platelets also contribute to inflammation through interaction with different classes of leukocytes. We investigated whether the inhibitory effect of prasugrel on platele...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH11-12-0867

    authors: Totani L,Dell'Elba G,Martelli N,Di Santo A,Piccoli A,Amore C,Evangelista V

    更新日期:2012-06-01 00:00:00

  • The increased sensitivity of platelets to prostacyclin in marathon runners.

    abstract::Platelet-rich plasma was obtained 24 hr after the race ended from athletes who ran in the London marathon. The platelets were only marginally less sensitive to adrenaline than were those of non-runners using conventional aggregation tests. However, the runners' platelets were much more sensitive to inhibition by prost...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Dix CJ,Hassall DG,Bruckdorfer KR

    更新日期:1984-07-29 00:00:00

  • Fibrinogen Matsumoto V: a variant with Aalpha19 Arg-->Gly (AGG-->GGG). Comparison between fibrin polymerization stimulated by thrombin or reptilase and fibrin monomer polymerization.

    abstract::Fibrinogen Matsumoto V (M-V) is a dysfibrinogen identified in a 52-year-old woman with systemic lupus erythematous. The triplet AGG encoding the amino acid residue Aalpha19 was replaced by GGG, resulting in the substitution of Arg-->Gly. Residue Aalpha19 has been shown to be one of the most important amino acids in th...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Tanaka H,Terasawa F,Ito T,Tokunaga S,Ishida F,Kitano K,Kiyosawa K,Okumura N

    更新日期:2001-01-01 00:00:00

  • Dysfunction of annexin A2 contributes to hyperglycaemia-induced loss of human endothelial cell surface fibrinolytic activity.

    abstract::Hyperglycaemia impairs fibrinolytic activity on the surface of endothelial cells, but the underlying mechanisms are not fully understood. In this study, we tested the hypothesis that hyperglycaemia causes dysfunction of the endothelial membrane protein annexin A2, thereby leading to an overall reduction of fibrinolyti...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH12-12-0944

    authors: Dai H,Yu Z,Fan X,Liu N,Yan M,Chen Z,Lo EH,Hajjar KA,Wang X

    更新日期:2013-06-01 00:00:00

  • Effects of Native Fucosylated Glycosaminoglycan, Its Depolymerized Derivatives on Intrinsic Factor Xase, Coagulation, Thrombosis, and Hemorrhagic Risk.

    abstract::A native fucosylated glycosaminoglycan from sea cucumber Holothuria fuscopunctata (nHG), mainly branched with Fuc3S4S, exhibited potent anticoagulant activity by intrinsic tenase iXase (FIXa-FVIIIa complex) and antithrombin-dependent factor IIa (FIIa) inhibition, but also had the effects of FXII activation and platele...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1055/s-0040-1708480

    authors: Zhou L,Gao N,Sun H,Xiao C,Yang L,Lin L,Yin R,Li Z,Zhang H,Ji X,Zhao J

    更新日期:2020-04-01 00:00:00

  • Palmitoylation at Cys595 is essential for PECAM-1 localisation into membrane microdomains and for efficient PECAM-1-mediated cytoprotection.

    abstract::The Ig-ITIM superfamily member, PECAM-1 acts as a negative regulator of ITAM-signalling pathways in platelets involving GPVI/FcR gamma chain and Fc?RIIa. This negative feedback loop involves regulation of collagen and GPVI-dependent aggregation events, platelet-thrombus-growth on immobilised collagen under flow and Fc...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Sardjono CT,Harbour SN,Yip JC,Paddock C,Tridandapani S,Newman PJ,Jackson DE

    更新日期:2006-12-01 00:00:00

  • Paediatric cerebral sinus vein thrombosis. A multi-center, case-controlled study.

    abstract::The etiology and pathophysiology of cerebral sinus venous thrombosis (CSVT) in the paediatric population is still poorly understood, and the role of thrombophilic risk factors remains to be elucidated. In our multi-center case-controlled study we studied 46 patients with CSVT diagnosed from April 1996 to December 2003...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,多中心研究

    doi:10.1160/TH04-03-0182

    authors: Kenet G,Waldman D,Lubetsky A,Kornbrut N,Khalil A,Koren A,Wolach B,Fattal A,Kapelushnik J,Tamary H,Yacobovitch J,Raveh E,Revel-Vilk S,Toren A,Brenner B

    更新日期:2004-10-01 00:00:00

  • Patients with severe factor XI deficiency have a reduced incidence of deep-vein thrombosis.

    abstract::Factor XI (FXI) plays a dual role in haemostasis and thrombosis. It contributes to thrombin generation and promotes inhibition of fibrinolysis. Severe FXI deficiency was shown to confer protection against arterial and venous thrombosis in animal models without compromising haemostasis. We have previously shown that pa...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH10-05-0307

    authors: Salomon O,Steinberg DM,Zucker M,Varon D,Zivelin A,Seligsohn U

    更新日期:2011-02-01 00:00:00

  • Risk of pregnancy-related venous thrombosis in carriers of severe inherited thrombophilia.

    abstract::Homozygous carriers of factor V Leiden have an approximately 80-fold increased risk of venous thrombosis. Also double heterozygous carriers of both the factor V Leiden and the prothrombin gene mutations are at high thrombotic risk. The magnitude of the risk of venous thrombosis in pregnant women with the two severe th...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,多中心研究

    doi:

    authors: Martinelli I,Legnani C,Bucciarelli P,Grandone E,De Stefano V,Mannucci PM

    更新日期:2001-09-01 00:00:00

  • The endothelial cell and the factor VIII bypassing activity of prothrombin complex concentrate.

    abstract::Some classical hemophiliacs have a paradoxical hemostatic response to prothrombin complex concentrate (PCC). We hypothesized that vascular endothelial cells (EC) may contribute to this "factor VIII bypassing activity". When PCC were incubated with suspensions or monolayer cultures of EC, they acquired the ability to p...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Teitel JM,Ni HY,Freedman JJ,Garvey MB

    更新日期:1988-10-31 00:00:00

  • Vulnerable atherosclerotic plaque metalloproteinases and foam cell phenotypes.

    abstract::Plaque rupture underlies most myocardial infarctions. Plaques vulnerable to rupture have thin fibrous caps, an excess of macrophages over vascular smooth muscle cells, large lipid cores, and depletion of collagen and other matrix proteins form the cap and lipid core. Production of matrix metalloproteinases from macrop...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Newby AC,George SJ,Ismail Y,Johnson JL,Sala-Newby GB,Thomas AC

    更新日期:2009-06-01 00:00:00

  • Standardisation of factor VIII--V. Calibration of the 2nd International Standard for Factor VIII and von Willebrand factor activities in plasma.

    abstract::The proposed 2nd International Standard for Factor VIII and von Willebrand Factor activities in plasma, NIBSC code 87/718, was assayed against the 1st IRP, 80/511, and against fresh normal plasma, in 21 laboratories. There were no significant differences between the various assay methods for factor VIII antigen, von W...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Heath AB,Barrowcliffe TW

    更新日期:1992-08-03 00:00:00

  • A long-acting PAI-1 inhibitor reduces thrombus formation.

    abstract::Plasminogen activator inhibitor 1 (PAI-1) is the main inhibitor of tissue-type and urokinase-type plasminogen activators (t/uPA) and plays an important role in fibrinolysis. Inhibition of PAI-1 activity prevents thrombosis and accelerates fibrinolysis, indicating that PAI-1 inhibitors may be used as effective antithro...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH16-11-0891

    authors: Peng S,Xue G,Gong L,Fang C,Chen J,Yuan C,Chen Z,Yao L,Furie B,Huang M

    更新日期:2017-06-28 00:00:00

  • Characterisation of a monoclonal antibody to von Willebrand factor as a potent inhibitor of ristocetin-mediated platelet interaction and platelet adhesion.

    abstract::We studied a murine monoclonal antibody (211 A6) to von Willebrand factor (vWF) with a view to investigating structure-relationship of plasma vWF. The specificity of this antibody has been substantiated by ELISA tests and indirect immunofluorescence. It reacts with purified vWF, normal plasma but not with plasma or pl...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Jorieux S,de Romeuf C,Samor B,Goudemand M,Mazurier C

    更新日期:1987-06-03 00:00:00

  • Increase in plasma concentration of plasminogen activator inhibitor, fibrinogen, von Willebrand factor, factor VIII:C and in erythrocyte sedimentation rate with age.

    abstract::Elderly patients have previously been shown to have an increased plasma concentration of tissue plasminogen activator (t-PA) antigen (t-PA Ag). Since the concentration of t-PA Ag depends on both free t-PA and t-PA complexed with inhibitors, mainly plasminogen activator inhibitor (PA inhibitor), we have investigated th...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Aillaud MF,Pignol F,Alessi MC,Harle JR,Escande M,Mongin M,Juhan-Vague I

    更新日期:1986-06-30 00:00:00

  • G4120, an Arg-Gly-Asp containing pentapeptide, enhances arterial eversion graft recanalization with recombinant tissue-type plasminogen activator in dogs.

    abstract::The effects of G4120, a cyclic Arg-Gly-Asp (RGD) containing peptide which inhibits fibrinogen binding to the platelet receptor GPIIb/IIIa, on thrombolysis with recombinant tissue-type plasminogen activator (rt-PA) were investigated in a combined arterial and venous thrombosis model in heparinized dogs. The arterial th...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Lu HR,Gold HK,Wu Z,Yasuda T,Pauwels P,Rapold HJ,Napier M,Bunting S,Collen D

    更新日期:1992-06-01 00:00:00

  • Newly diagnosed malignancy in patients with venous thromboembolism. Search or wait and see?

    abstract::The incidence of newly diagnosed malignancy is increased in patients with unexplained venous thromboembolism during the first year after a thromboembolic event in comparison to controls (odds ratio, 3.9-36). Extensive screening with computed tomography, endoscopy and tumor markers can identify most of these undetected...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,评审

    doi:

    authors: Prins MH,Hettiarachchi RJ,Lensing AW,Hirsh J

    更新日期:1997-07-01 00:00:00