Pharmacokinetics and Pharmacodynamics of Emicizumab in Persons with Hemophilia A with Factor VIII Inhibitors: HAVEN 1 Study.

abstract：:Components of the fibrinolytic system were studied in samples of plasma from 15 normal, young women and from 11 women taking oral contraceptives containing 30 micrograms ethinyl oestradiol and 150 micrograms levo-norgestrel. Fibrinolytic activity of euglobulins precipitated at pH 5.9 was higher than normal in the horm...

journal_title：Thrombosis and haemostasis

authors： Jespersen J,Kluft C

更新日期：1985-08-30 00:00:00

abstract：:Vitamin K antagonists (VKAs) remain as the most prescribed drug for treatment and prevention of thrombotic disorders in many countries, despite the recent approval of the new oral anticoagulants (NOACs). Although effectiveness and safety of VKAs are tightly associated to maintaining the patient within the internationa...

journal_title：Thrombosis and haemostasis

authors： Jiménez-Varo E,Cañadas-Garre M,Henriques CI,Pinheiro AM,Gutiérrez-Pimentel MJ,Calleja-Hernández MÁ

更新日期：2014-09-02 00:00:00

abstract：:Bacterial pneumonia, the most common cause of sepsis, is associated with activation of coagulation. Factor XI (FXI), the key component of the intrinsic pathway, can be activated via factor XII (FXII), part of the contact system, or via thrombin. To determine whether intrinsic coagulation is involved in host defence du...

journal_title：Thrombosis and haemostasis

authors： Stroo I,Zeerleder S,Ding C,Luken BM,Roelofs JJTH,de Boer OJ,Meijers JCM,Castellino FJ,van 't Veer C,van der Poll T

更新日期：2017-07-26 00:00:00

abstract：:When compared to normal megakaryocytes, those from a patient with the giant platelet syndrome exhibited numerous cytochemical abnormalities. These reflected disturbances in the metabolism of RNA, glycogen, arginine-rich histone, and various glycolytic enzymes. Ultrastructural studies of the abnormal megakaryocytes als...

journal_title：Thrombosis and haemostasis

authors： Kass L,Leichtman DA,Beals TF,Schnitzer B

更新日期：1977-10-31 00:00:00

abstract：:The aim of the present study was to evaluate the relative performance of five screening methods for APC resistance caused by the factor V:Q506 mutation: the original method Coatest APC Resistance Chromogenix, a modified method using the same reagents but a predilution 1+4 of the plasma in a factor V deficient plasma f...

journal_title：Thrombosis and haemostasis

authors： Freyburger G,Javorschi S,Labrouche S,Bernard P

更新日期：1997-11-01 00:00:00

abstract：:TAK-442 is an oral direct factor Xa inhibitor. We sought to determine the dose-dependent effect of TAK-442 on major bleeding when added to standard treatment in stabilised patients with acute coronary syndrome (ACS). In this phase II double-blind study, 2,753 ACS patients were randomised to TAK-442 or placebo in addit...

journal_title：Thrombosis and haemostasis

authors： Goldstein S,Bates ER,Bhatt DL,Cao C,Holmes D,Kupfer S,Martinez F,Spaeder J,Weitz JI,Ye Z,Zannad F,AXIOM investigators.

更新日期：2014-06-01 00:00:00

abstract：:Use of oral contraceptives (OC) that combine a progestogen with synthetic ethinyl estradiol (EE) is associated with increased risk of venous thromboembolism. NOMAC/E2 is a new monophasic OC that combines nomegestrol acetate (NOMAC), a highly selective progestogen, with 17β-estradiol (E2). The study objective was to co...

journal_title：Thrombosis and haemostasis

authors： Gaussem P,Alhenc-Gelas M,Thomas JL,Bachelot-Loza C,Remones V,Ali FD,Aiach M,Scarabin PY

更新日期：2011-03-01 00:00:00

abstract：:The leech protein hirudin is a potent inhibitor of thrombin, but clinical use of recombinant hirudin is restricted by haemorrhagic risks, and complicated by hirudin's rapid clearance from the circulation. We previously employed albumin fusion to slow hirudin variant 3 (HV3) clearance. In this study, we hypothesized th...

journal_title：Thrombosis and haemostasis

authors： Sheffield WP,Eltringham-Smith LJ,Gataiance S,Bhakta V

更新日期：2009-05-01 00:00:00

abstract：:Sulodexide, a highly purified glycosaminoglycan, was investigated for treatment of venous leg ulcers. Patients (n = 235) undergoing local treatment including wound care and compression bandaging, were randomised to receive either sulodexide or matching placebo for three months. Primary study endpoint was complete ulce...

journal_title：Thrombosis and haemostasis

authors： Coccheri S,Scondotto G,Agnelli G,Aloisi D,Palazzini E,Zamboni V,Venous arm of the SUAVIS (Sulodexide Arterial Venous Italian Study) Group.

更新日期：2002-06-01 00:00:00

abstract：:Lupus anticoagulants (LA) are immunoglobulins directed to either prothrombin or Beta-2-glycoprotein 1(beta1GPI) bound to phospholipids. Most patients with LA have both beta2GPI- and prothrombin-dependent antibodies. Several recent reports have shown that LA is more strongly associated with thrombosis than anticardioli...

journal_title：Thrombosis and haemostasis

authors： Arnout J,Meijer P,Vermylen J

更新日期：1999-06-01 00:00:00

abstract：:In high-risk and complicated coronary intervention, the risk of acute closure is unpredictable. Thrombus and platelet deposition at the intervention site may also have further effects on subsequent restenosis. In vivo infusion of activated protein C has previously been shown to achieve potent anticoagulation without a...

journal_title：Thrombosis and haemostasis

authors： Foo RS,Gershlick AH,Hogrefe K,Baron JH,Johnston TW,Hussey AJ,Garner I,de Bono DP

更新日期：2000-03-01 00:00:00

abstract：:Clots formed from platelet rich plasma were found to be lysed more readily by low concentrations of pro-urokinase (pro-UK) than clots formed from platelet poor plasma. This was not a non-specific effect since the reverse occurred with tissue plasminogen activator. A mechanical explanation due to platelet-mediated clot...

journal_title：Thrombosis and haemostasis

authors： Loza JP,Gurewich V,Johnstone M,Pannell R

更新日期：1994-03-01 00:00:00

abstract：:Platelet-rich plasma was obtained 24 hr after the race ended from athletes who ran in the London marathon. The platelets were only marginally less sensitive to adrenaline than were those of non-runners using conventional aggregation tests. However, the runners' platelets were much more sensitive to inhibition by prost...

journal_title：Thrombosis and haemostasis

authors： Dix CJ,Hassall DG,Bruckdorfer KR

更新日期：1984-07-29 00:00:00

abstract：:In patients with deep vein thrombosis (DVT), the factors which predispose to concomitant symptomatic pulmonary embolism (PE) have remained uncertain. From a prospective cohort of 5,451 consecutive patients with ultrasound-confirmed DVT, we analyzed 4,211 patients with a known status for presence (n=639) or absence (n=...

journal_title：Thrombosis and haemostasis

authors： Kucher N,Tapson VF,Goldhaber SZ,DVT FREE Steering Committee.

更新日期：2005-03-01 00:00:00

abstract：:The interaction of beta 2-glycoprotein-I (beta 2-G-I), a plasma constituent of unknown function, with blood platelets was studied. The following results were obtained: 1) beta 2-G-I binds to washed human platelets isolated by centrifugation (WP) at one kind of specific, saturable binding sites. The dissociation consta...

journal_title：Thrombosis and haemostasis

authors： Nimpf J,Wurm H,Kostner GM

更新日期：1985-08-30 00:00:00

abstract：:In a previous report we found an inverse correlation between pre-operative platelet count (PlC) levels and the risk of post-operative pulmonary embolism in patients undergoing hip surgery. In the present study, we prospectively evaluated the prognostic significance of pre-operative PlC levels on survival in 180 consec...

journal_title：Thrombosis and haemostasis

authors： Monreal M,Fernandez-Llamazares J,Piñol M,Julian JF,Broggi M,Escola D,Abad A

更新日期：1998-05-01 00:00:00

abstract：:We have evaluated the effect of plasminogen activators (t-PA and urokinase) on an experimental model of disseminated intravascular coagulation (DIC) in rabbits by injection of 20 micrograms/kg/h of E. coli lipopolysaccharide during 6 h t-PA (0.2 mg/kg and 0.7 mg/kg), urokinase (3000 U/kg/h) and saline (control) were g...

journal_title：Thrombosis and haemostasis

authors： Paloma MJ,Páramo JA,Rocha E

更新日期：1995-12-01 00:00:00

abstract：:Acute myocardial infarction (AMI) is associated with activation of various cells, including platelets that form monocyte-platelet complexes (MPCs). Here, we analysed MPC in vivo and in vitro and investigated the abilities of different monocyte subclasses to form MPC, the characteristics of the cells involved in MPC fo...

journal_title：Thrombosis and haemostasis

authors： Loguinova M,Pinegina N,Kogan V,Vagida M,Arakelyan A,Shpektor A,Margolis L,Vasilieva E

更新日期：2018-11-01 00:00:00

abstract：:Despite great efforts in stroke research, disability and recurrence rates in ischaemic stroke remain unacceptably high. To address this issue, one potential target for novel therapeutics is the glycoprotein von Willebrand factor (vWF), which increases in thrombogenicity especially under high shear rates as it bridges ...

journal_title：Thrombosis and haemostasis

authors： Buchtele N,Schwameis M,Gilbert JC,Schörgenhofer C,Jilma B

更新日期：2018-06-01 00:00:00

abstract：:Fibrinogen Matsumoto V (M-V) is a dysfibrinogen identified in a 52-year-old woman with systemic lupus erythematous. The triplet AGG encoding the amino acid residue Aalpha19 was replaced by GGG, resulting in the substitution of Arg-->Gly. Residue Aalpha19 has been shown to be one of the most important amino acids in th...

journal_title：Thrombosis and haemostasis

authors： Tanaka H,Terasawa F,Ito T,Tokunaga S,Ishida F,Kitano K,Kiyosawa K,Okumura N

更新日期：2001-01-01 00:00:00

abstract：:The cloning of the cDNA encoding von Willebrand factor (vWF) has revealed that it is synthesized as a large precursor (pre-pro-vWF) molecule and it is now clear that the prosequence or vWAgII is responsible for the intracellular multimerization of vWF. We have cloned the complete vWF cDNA and expressed it using a reco...

journal_title：Thrombosis and haemostasis

authors： Meulien P,Nishino M,Mazurier C,Dott K,Piétu G,Jorieux S,Pavirani A,Girma JP,Oufkir D,Courtney M

更新日期：1992-01-23 00:00:00

abstract：:Our initial finding that CD40- and CD40 ligand (CD40L)-deficient mice displayed prolonged tail bleeding and platelet function analyzer (PFA-100) closure times prompted us to further investigate the role of the CD40-CD40L dyad in primary hemostasis and platelet function. Recombinant human soluble CD40L (rhsCD40L), chem...

journal_title：Thrombosis and haemostasis

authors： Langer F,Ingersoll SB,Amirkhosravi A,Meyer T,Siddiqui FA,Ahmad S,Walker JM,Amaya M,Desai H,Francis JL

更新日期：2005-06-01 00:00:00

abstract：:Idarucizumab, a Fab fragment directed against dabigatran, produced rapid and complete reversal of the anticoagulation effect of dabigatran in animals and in healthy volunteers. The Study of the REVERSal Effects of Idarucizumab in Patients on Active Dabigatran (RE-VERSE AD™) is a global phase 3 prospective cohort study...

journal_title：Thrombosis and haemostasis

authors： Pollack CV Jr,Reilly PA,Bernstein R,Dubiel R,Eikelboom J,Glund S,Huisman MV,Hylek E,Kam CW,Kamphuisen PW,Kreuzer J,Levy JH,Sellke F,Stangier J,Steiner T,Wang B,Weitz JI

更新日期：2015-07-01 00:00:00

abstract：:Unfractionated heparin is the most commonly used anticoagulant in ST-elevation myocardial infarction (STEMI) and its effect can be monitored with activated partial thromboplastin time (aPTT). However, the optimal aPTT range during heparin therapy after primary percutaneous coronary intervention (PCI) is yet to be defi...

journal_title：Thrombosis and haemostasis

authors： Kikkert WJ,van Nes SH,Lieve KV,Dangas GD,van Straalen J,Vis M,Baan J Jr,Koch KT,de Winter RJ,Piek JJ,Tijssen JG,Henriques JP

更新日期：2013-05-01 00:00:00

abstract：:Hyperhomocysteinemia is a risk factor of venous thromboembolism. The risk of recurrence in patients with hyperhomocysteinemia is unknown, and the optimal therapy for these patients after acute venous thromboembolism is uncertain. In a multicenter study, 264 patients with an objectively documented single episode of idi...

journal_title：Thrombosis and haemostasis

authors： Eichinger S,Stümpflen A,Hirschl M,Bialonczyk C,Herkner K,Stain M,Schneider B,Pabinger I,Lechner K,Kyrle PA

更新日期：1998-10-01 00:00:00

abstract：:A suggestive locus on chromosome 8 could be shown to be associated with familial high factor VIII (FVIII) levels in venous thromboembolism. The ADAMDEC 1 gene is a candidate expressing an ectodomain sheddase. However, the ectodomain of the clearance receptor for FVIII, the low-density lipoprotein receptor-related prot...

journal_title：Thrombosis and haemostasis

authors： Berger M,Moscatelli H,Kulle B,Luxembourg B,Blouin K,Spannagl M,Lindhoff-Last E,Schambeck CM

更新日期：2008-05-01 00:00:00

abstract：:Viper venoms contain a variety of platelet binding proteins including those which bind to platelet GPIb/GPIX. Most of these proteins inhibit von Willebrand factor mediated platelet agglutination. Here we report the primary structures of unique members of this family, alboaggregins A and B, isolated from Trimeresurus a...

journal_title：Thrombosis and haemostasis

authors： Kowalska MA,Tan L,Holt JC,Peng M,Karczewski J,Calvete JJ,Niewiarowski S

更新日期：1998-03-01 00:00:00

abstract：:Examination of the entire von Willebrand factor (VWF) gene for mutations, particularly in types 1 and 3 von Willebrand disease (VWD) is becoming more widely practised. The sequence of the entire VWF gene will soon be compiled as a single sequence. For these reasons, a clearly defined nomenclature to use for numbering ...

journal_title：Thrombosis and haemostasis

authors： Goodeve AC,Eikenboom JC,Ginsburg D,Hilbert L,Mazurier C,Peake IR,Sadler JE,Rodeghiero F,ISTH SSC Subcommittee on von Willebrand factor.

更新日期：2001-05-01 00:00:00

abstract：:Extracellular RNA (eRNA), released from cells under conditions of injury or vascular disease, acts as potent prothrombotic factor and promotes vascular hyperpermeability related to oedema formation in vivo. In this study, we aimed to investigate the mechanism by which eRNA triggers inflammatory processes, particularl...

journal_title：Thrombosis and haemostasis

authors： Fischer S,Grantzow T,Pagel JI,Tschernatsch M,Sperandio M,Preissner KT,Deindl E

更新日期：2012-10-01 00:00:00

abstract：:Lenalidomide, a derivate of thalidomide, has recently been approved in Europe for the treatment of patients with multiple myeloma. Although the substance has a better effect/side-effect profile, especially with regard to teratogenicity and neurotoxicity, the rate of therapy-induced thrombosis seems comparable to thali...

journal_title：Thrombosis and haemostasis

authors： Gieseler F

更新日期：2008-06-01 00:00:00