PREVAPIX-ALL: Apixaban Compared to Standard of Care for Prevention of Venous Thrombosis in Paediatric Acute Lymphoblastic Leukaemia (ALL)-Rationale and Design.

abstract：:The evidence is reviewed and a model presented for two distinct receptors being involved in platelet activation induced by alpha-thrombin: a high affinity thrombin receptor constituting approximately 50 copies of a supercomplexed form of GPIb coupled to phospholipase A2 and a moderate affinity receptor constituting ap...

journal_title：Thrombosis and haemostasis

authors： Jamieson GA

更新日期：1997-07-01 00:00:00

abstract：:We have tried to offer a unifying hypothesis tying vessel wall narrowing in atherosclerotic plaques to plaque rupture and healing (Fig. 7). This hypothesis is supported by evidence that smooth muscle cells are capable of interacting with a fibrin clot, specifically contracting a fibrin clot, and that inhibition of coa...

journal_title：Thrombosis and haemostasis

authors： Yee KO,Schwartz SM

更新日期：1999-08-01 00:00:00

abstract：:Antithrombin (AT) is a native plasma protein that acts as the main inhibitor of enzymes generated by the coagulation cascade. In extreme thrombotic conditions, consumption of plasma AT can make treatment with AT-associated heparin therapies less effective. Supplementation with recombinant human AT (rhAT) has shown pro...

journal_title：Thrombosis and haemostasis

authors： Berry LR,Thong B,Chan AK

更新日期：2009-08-01 00:00:00

abstract：:Vitamin K-dependent proteins are currently purified from pooled human plasma or produced in mammalian cell culture systems by recombinant DNA technology. Transgenic animals may provide an additional expression system for the production of these therapeutic proteins. Mice have been used to test hybrid genes which direc...

journal_title：Thrombosis and haemostasis

authors： Luboń H,Paleyanda RK

更新日期：1997-07-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a potent mitogen for endothelial cells and plays a central role in angiogenesis and vasculogenesis. Therefore, VEGF and its receptors VEGFR-1 and VEGFR-2 are prime targets for anti-angiogenic intervention which is thought to be one of the most promising approaches in cancer...

journal_title：Thrombosis and haemostasis

authors： Piossek C,Thierauch KH,Schneider-Mergener J,Volkmer-Engert R,Bachmann MF,Korff T,Augustin HG,Germeroth L

更新日期：2003-09-01 00:00:00

abstract：:Subcutaneous heparin is the treatment of choice for women requiring anticoagulant therapy during pregnancy. However, heparin therapy presents a management problem at delivery because of its potential to cause a persistent anticoagulant effect and thus increase the risk of bleeding. In order to avoid therapeutic compli...

journal_title：Thrombosis and haemostasis

authors： Anderson DR,Ginsberg JS,Burrows R,Brill-Edwards P

更新日期：1991-03-04 00:00:00

abstract：:Current thrombolytic strategies have a number of important shortcomings including resistance to recanalization and development of acute reocclusion. The purpose of this study was to investigate whether the lysis of venous thrombi by streptokinase could be enhanced by SR 46349, a novel 5-HT2 receptor antagonist, or clo...

journal_title：Thrombosis and haemostasis

authors： Herbert JM,Bernat A,Sainte-Marie M,Dol F,Rinaldi M

更新日期：1993-03-01 00:00:00

abstract：:Increased fibrinogen concentration is a well known phenomenon following acute ischemic stroke. However, the natural course of this hyperfibrinogenemia is uncertain. We aimed to clarify whether it is of a transient or more persistent nature in patients who harbor an underlying morbid biology of atherothrombo-inflammati...

journal_title：Thrombosis and haemostasis

authors： Shenhar-Tsarfaty S,Ben Assayag E,Bova I,Shopin L,Cohen M,Berliner S,Shapira I,Bornstein NM

更新日期：2008-01-01 00:00:00

abstract：:We reported previously that plasma fibrinogen was significantly higher in U.S. Caucasians than in Japanese, which may contribute to the higher mortality rate of coronary heart disease in the United States than in Japan. To examine the contribution of genetic variations to the race difference in plasma fibrinogen level...

journal_title：Thrombosis and haemostasis

authors： Iso H,Folsom AR,Winkelmann JC,Koike K,Harada S,Greenberg B,Sato S,Shimamoto T,Iida M,Komachi Y

更新日期：1995-01-01 00:00:00

abstract：:Thrombocytopenia and platelet dysfunction induced by extracorporeal blood circulation are thought to contribute to postsurgical bleeding complications in neonates undergoing cardiac surgery with cardiopulmonary bypass (CPB). In this study, we examined how changes in platelet function relate to changes in platelet coun...

journal_title：Thrombosis and haemostasis

authors： Zwifelhofer NMJ,Bercovitz RS,Cole R,Yan K,Simpson PM,Moroi A,Newman PJ,Niebler RA,Scott JP,Stuth EAD,Woods RK,Benson DW,Newman DK

更新日期：2020-01-01 00:00:00

abstract：:In order to assess the value of I.P.G. for the diagnosis of D.V.T. in general practice, an I.P.G. was carried out by a skilled technician in 255 consecutive patients with suspected D.V.T. at home. Ascending venography was carried out in 185 of these patients. In addition, blood for assay of AT III, platelet count, fib...

journal_title：Thrombosis and haemostasis

authors： Peters SH,Jonker JJ,de Boer AC,den Ottolander GJ

更新日期：1982-12-27 00:00:00

abstract：:The transforming growth factor-beta (TGFbeta) family of growth factors are major regulators of wound repair, scar formation, and fibrosis. One of the prominent features of TGFbeta biology is the fact that this growth factor is secreted as a latent precursor, which may be directed to and stored at specific sites in the...

journal_title：Thrombosis and haemostasis

authors： Brunner G,Blakytny R

更新日期：2004-08-01 00:00:00

abstract：:Catabolism of coagulation factor VIII (FVIII) is mediated by low-density lipoprotein receptor-related protein (LRP). The ligand-binding sites of LRP are formed by complement-type repeats (CR), and CR clusters II and IV bind most of LRP ligands. FVIII contains two major LRP-binding sites located in the A2 and A3 domain...

journal_title：Thrombosis and haemostasis

authors： Sarafanov AG,Makogonenko EM,Andersen OM,Mikhailenko IA,Ananyeva NM,Khrenov AV,Shima M,Strickland DK,Saenko EL

更新日期：2007-12-01 00:00:00

abstract：:Limited data are available on the role of monocytes in cardiac repair. In the present study, we evaluated the dynamic alterations of monocytes with reparative and angiogenic potential in patients with myocardial infarction(MI). Reparative CXCR4+ monocytes, and CD34+ and KDR+ monocytes with angiogenic potential derived...

journal_title：Thrombosis and haemostasis

authors： Shantsila E,Tapp LD,Wrigley BJ,Montoro-García S,Lip GY

更新日期：2013-02-01 00:00:00

abstract：:Tissue-type plasminogen activator (t-PA) is a fibrin-specific agent which is used to treat acute myocardial infarction. Pharmacokinetically, t-PA is characterized by a rapid clearance from the circulation. In a previous study, we constructed variant forms of t-PA with genetic modifications at the fibronectin finger-li...

journal_title：Thrombosis and haemostasis

authors： Yahara H,Matsumoto K,Maruyama H,Nagaoka T,Ikenaka Y,Yajima K,Fukao H,Ueshima S,Matsuo O

更新日期：1994-12-01 00:00:00

abstract：:Per cent aggregation, release and content of adenine nucleotides, and specific radioactivity were evaluated in citrated platelet-rich plasma (PRP) prepared from paired samples of maternal and cord blood. Platelets of newborn infants aggregated normally in response to highdose ADP (20 muM), strong collagen suspensions,...

journal_title：Thrombosis and haemostasis

authors： Corby DG,Zuck TF

更新日期：1976-08-31 00:00:00

abstract：:Platelet aggregation and adenine nucleotides in platelets have been studied in thirteen patients with myeloproliferative disorders. ADP induced aggregation was abnormal in two patients, but collagen induced aggregation was impaired in 11 patients. The concentrations of ATP and ADP in resting platelets in the patients ...

journal_title：Thrombosis and haemostasis

authors： Nishimura J,Okamoto S,Ibayashi H

更新日期：1979-06-30 00:00:00

abstract：:We have established a new, enzyme-linked immunosorbent assay (ELISA) for the detection of ADAMTS13 antigen using purified polyclonal rabbit anti-human ADAMTS13 IgG. Normal plasma ADAMTS13 antigen levels span a concentration of 740-1420 ng/ml (median 1080 ng/ml) resulting in an ADAMTS13 activity to antigen ratio of 0.4...

journal_title：Thrombosis and haemostasis

authors： Rieger M,Ferrari S,Kremer Hovinga JA,Konetschny C,Herzog A,Koller L,Weber A,Remuzzi G,Dockal M,Plaimauer B,Scheiflinger F

更新日期：2006-02-01 00:00:00

abstract：:In this study, the clot accumulation properties of liposome-coupled plasminogen were compared to those of free (non-liposomal) plasminogen in an in vitro, closed-loop, flow-system. After introduction of a clot into the closed system, double-radiolabelled plasminogen-liposomes were administered and the accumulation of ...

journal_title：Thrombosis and haemostasis

authors： Heeremans JL,Prevost R,Feitsma H,Kluft C,Crommelin DJ

更新日期：1998-01-01 00:00:00

abstract：:The endothelial barrier of the vasculature is of utmost importance for separating the blood stream from underlying tissues. This barrier is formed by tight and adherens junctions (TJ and AJ) that form intercellular endothelial contacts. TJ and AJ are integral membrane structures that are connected to the actin cytoske...

journal_title：Thrombosis and haemostasis

authors： García-Ponce A,Citalán-Madrid AF,Velázquez-Avila M,Vargas-Robles H,Schnoor M

更新日期：2015-01-01 00:00:00

abstract：:Prothrombin complex concentrates (PCCs) and fresh-frozen plasma (FFP) have been clinically used for acute warfarin reversal. The recovery of prothrombin time (PT) or international normalised ratio (INR) is often reported as an endpoint, but haemostatic efficacies of PCCs and FFP may not be fully reflected in static cl...

journal_title：Thrombosis and haemostasis

authors： Ogawa S,Szlam F,Ohnishi T,Molinaro RJ,Hosokawa K,Tanaka KA

更新日期：2011-12-01 00:00:00

abstract：:Tissue factor (TF) is the primary initiator of the coagulation cascade and is thought to play a key role in the generation of arterial thrombosis. Recent studies have suggested that TF mediates inflammatory processes in the arterial wall and may be an important regulator of intimal hyperplasia. We have employed geneti...

journal_title：Thrombosis and haemostasis

authors： Pyo RT,Sato Y,Mackman N,Taubman MB

更新日期：2004-09-01 00:00:00

abstract：:Cystic fibrosis (CF) is characterized by a persistent inflammatory state, which can be secondary to chronic pulmonary infection and may affect vascular endothelium. We measured circulating levels of von Willebrand factor (vWF), tissue-plasminogen activator (t-PA), and P-selectin in 20 CF patients and 20 healthy subjec...

journal_title：Thrombosis and haemostasis

authors： Romano M,Collura M,Lapichino L,Pardo F,Falco A,Chiesa PL,Caimi G,Davì G

更新日期：2001-12-01 00:00:00

abstract：:By the use of a fluorogenic thrombin substrate and continuous calibration of each individual sample, it is now possible to obtain a thrombin generation (TG) curve (or thrombogram) in plasma, with or without platelets, in an easy routine procedure at high throughput and with an acceptable experimental error (<5%). Evid...

journal_title：Thrombosis and haemostasis

authors： Hemker HC,Al Dieri R,De Smedt E,Béguin S

更新日期：2006-11-01 00:00:00

abstract：:There is much debate over the appropriateness of prescribing prolonged anticoagulation to heterozygous carriers of factor V Leiden suffering a first episode of deep vein thrombosis (DVT). We, thus used meta-analysis to estimate from six eligible studies the summary odds-ratio of recurrent DVT in carriers of factor V L...

journal_title：Thrombosis and haemostasis

authors： Marchetti M,Pistorio A,Barosi G

更新日期：2000-11-01 00:00:00

abstract：:We analyzed the protein C gene (PROC) with the denaturing gradient gel electrophoresis (DGGE) scanning strategy in a series of 129 patients with suspected protein C (PC) deficiency (93 with low plasma PC levels and 36 with borderline level). At least one sequence variation was found in 104 of the 129 patients. Thirty-...

journal_title：Thrombosis and haemostasis

authors： Alhenc-Gelas M,Gandrille S,Aubry ML,Aiach M

更新日期：2000-01-01 00:00:00

abstract：:Platelet activation may contribute to the increased risk of thrombotic complications in patients with antiphospholipid antibodies (aPL). The increased urinary excretion of 11-dehydro-thromboxane B2 (11-DH-TXB2) reported in patients with lupus anticoagulant (LA) and/or anticardiolipin antibodies (aCL) reflects in vivo ...

journal_title：Thrombosis and haemostasis

authors： Forastiero R,Martinuzzo M,Carreras LO,Maclouf J

更新日期：1998-01-01 00:00:00

abstract：:In hereditary angioedema (HAE), normal C1-inhibitor (C1-INH) is low and the contact system activated. Recently, the findings of a tissue factor mutant selectively deficient in promoting the conversion of FVII to FVIIa, but with retained cofactor for FVIIa, made it possible to examine reliably the pre-existing content ...

journal_title：Thrombosis and haemostasis

authors： Nielsen EW,Morrissey J,Olsen JO,Osterud B

更新日期：1995-10-01 00:00:00

abstract：:The influence of changes in liver blood flow on the clearance of rt-PA was studied both in healthy subjects and in a perfused rat liver model. Liver blood flow in healthy subjects was documented indirectly by the clearance of indocyanine green (ICG). Exercise reduced liver blood flow on average by 57% with a 95% confi...

journal_title：Thrombosis and haemostasis

authors： de Boer A,Kluft C,Kroon JM,Kasper FJ,Schoemaker HC,Pruis J,Breimer DD,Soons PA,Emeis JJ,Cohen AF

更新日期：1992-01-23 00:00:00

abstract：:Probands from 15 unrelated families with hereditary protein S deficiency type I, that is having a plasma total protein S concentration fifty percent of normal, were screened for abnormalities in their protein S genes by Southern analysis. Two probands were found to have a deviating DNA pattern with the restriction enz...

journal_title：Thrombosis and haemostasis

authors： Ploos van Amstel HK,Reitsma PH,Hamulyák K,de Die-Smulders CE,Mannucci PM,Bertina RM

更新日期：1989-11-24 00:00:00