Specific alterations in gut microbiota in patients with chronic kidney disease: an updated systematic review.


BACKGROUND:Emerging evidence demonstrates that gut dysbiosis is implicated in the pathogenesis of chronic kidney disease (CKD) with underlying mechanisms involving mucosal and/or systematic immunity or metabolic disorders. However, the profile of gut microbiota in patients with CKD has not been completely explored. METHODS:Databases from their date of inception to 31 March 2020 were systematically searched for case-control or cross-sectional studies comparing the gut microbial profiles in adult patients with CKD or end-stage renal disease (ESRD) with those in healthy controls. Quantitative analysis of alterations in gut microbial profiles was conducted. RESULTS:Twenty-five studies with a total of 1436 CKD patients and 918 healthy controls were included. The present study supports the increased abundance of, phylum Proteobacteria and Fusobacteria, genus Escherichia_Shigella, Desulfovibrio, and Streptococcus, while lower abundance of genus Roseburia, Faecalibacterium, Pyramidobacter, Prevotellaceae_UCG-001, and Prevotella_9 in patients with CKD; and increased abundance of phylum Proteobacteria, and genus Streptococcus and Fusobacterium, while lower abundance of Prevotella, Coprococcus, Megamonas, and Faecalibacterium in patients with ESRD. Moreover, higher concentrations of trimethylamine-N-oxide and p-cresyl sulfate and lower concentrations of short-chain fatty acids were observed. Gut permeability in patients with CKD was not determined due to the heterogeneity of selected parameters. CONCLUSIONS:Specific alterations of gut microbial parameters in patients with CKD were identified. However, a full picture of the gut microbiota could not be drawn from the data due to the differences in methodology, and qualitative and incomplete reporting of different studies.


Ren Fail


Renal failure


Zhao J,Ning X,Liu B,Dong R,Bai M,Sun S




Has Abstract


2021-12-01 00:00:00












  • Renal stone disease and obesity: what is important for urologists and nephrologists?

    abstract::Currently, obesity has reached an epidemic stage and represents a challenge for health authorities across the globe. Certainly, with emergence of obesity epidemic, we started to see an increase in the prevalence of chronic kidney disease (CKD) and nephrolithiasis. Interestingly, epidemiologic studies have shown that t...

    journal_title:Renal failure

    pub_type: 杂志文章,评审


    authors: Ahmed MH,Ahmed HT,Khalil AA

    更新日期:2012-01-01 00:00:00

  • Mrna expression of transforming growth factor-alpha and the EGF receptor following nephrotoxic renal injury.

    abstract::We studied gene expression for transforming growth factor (TGF)-alpha, epidermal growth factor (EGF), heparin binding (HB) EGF, and the EGF receptor following acute renal failure induced by mercuric chloride administration to gain insight into potential mechanisms of renal repair. Twenty four hours after HgCl2, 2 mg/k...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Hise MK,Liu L,Salmanullah M,Drachenberg CI,Papadimitriou JC,Rohan RM

    更新日期:2000-01-01 00:00:00

  • Pathophysiology of paraprotein production.

    abstract::Paraproteins or monoclonal proteins are the result of clonal B-cell or plasma cell proliferation of a malignant, premalignant or non-malignant nature. Monoclonal proteins may consist of intact immunoglobulin molecules or of heavy or light chains only. Depending on their rate of production and/or secretion they may acc...

    journal_title:Renal failure

    pub_type: 杂志文章,评审


    authors: Maniatis A

    更新日期:1998-11-01 00:00:00

  • Late onset renal failure and nephrotic syndrome after autologous stem cell transplant for Al amyloidosis.

    abstract::We present a patient with AL amyloidosis who had an autologous stem cell transplant (ASCT) over 9 years ago. She has since then developed slowly progressive renal insufficiency and the nephrotic syndrome. Hematologic evaluation has failed to identify recurrent disease and a renal biopsy demonstrated extensive amyloid ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Rifkin SI,Weinstein SS

    更新日期:2012-01-01 00:00:00

  • The differences of asymmetric dimethylarginine removal by different dialysis treatments.

    abstract:BACKGROUND:Asymmetric dimethylarginine (ADMA) as a uremia toxin is accumulated in end-stage renal disease (ESRD) patients. Elevated ADMA level has been shown to be predictive of cardiovascular diseases (CVDs) and all-cause mortality in ESRD. Therefore, we investigated the removal of ADMA by different dialysis treatment...

    journal_title:Renal failure

    pub_type: 杂志文章,随机对照试验


    authors: Zhang DL,Liu J,Liu S,Zhang Y,Liu WH

    更新日期:2010-01-01 00:00:00

  • Parathyroid hormone levels, calcium-channel blockers, and the dyslipidemia of nondiabetic hemodialysis patients.

    abstract:BACKGROUND:Experimental studies have shown that increased levels of parathyroid hormone (PTH) in uremia may cause elevation of intracellular calcium, predisposing to insulin resistance and lipid metabolism abnormalities. Administration of calcium-channel blockers (CCBs) in these models protects against the development ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Zanos S,Mitsopoulos E,Sakellariou G

    更新日期:2005-01-01 00:00:00

  • 3-aminobenzamide, a poly ADP ribose polymerase inhibitor, attenuates renal ischemia/reperfusion injury.

    abstract:INTRODUCTION:This study was designed to investigate whether 3-amino benzamide (3-AB), a poly (ADP-ribose) polymerase (PARP) inhibitor, has a protective effect on kidney injury induced by renal ischemia/reperfusion (I/R) by decreasing oxidative and nitrosative stress on renal dysfunction and injury. MATERIALS AND METHO...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Oztas E,Guven A,Turk E,Uysal B,Akgul EO,Cayci T,Ersoz N,Korkmaz A

    更新日期:2009-01-01 00:00:00

  • Lipoprotein-A and carotid intima media thickness as cardiovascular risk factors in patients of chronic kidney disease.

    abstract::Patients in all stages of chronic kidney disease (CKD) are considered in the "high-risk group" for development of cardiovascular disease (CVD). The study was undertaken in 60 adult patients of chronic renal failure. The patients were divided into three groups: Group I had subjects with CKD (stages 1 and 2); Group II h...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Aggarwal HK,Jain D,Lathar M,Yadav RK,Sawhney A

    更新日期:2010-07-01 00:00:00

  • Effect of concomitant administration of coenzyme Q10 with sitagliptin on experimentally induced diabetic nephropathy in rats.

    abstract::This study was aimed to investigate the therapeutic potential of coenzyme Q10 and its combination with sitagliptin in experimentally induced diabetic nephropathy. The diabetic rats were treated with coenzyme Q10 or sitagliptin and their concomitant administration. Various parameters of renal function like serum creati...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Maheshwari R,Balaraman R,Sen AK,Shukla D,Seth A

    更新日期:2017-11-01 00:00:00

  • The role of aluminum in the pathogenesis of anemia in an outpatient hemodialysis population.

    abstract::Anemia is a well-defined complication of aluminum overload in chronic dialysis patients which may be present before other manifestations of aluminum toxicity are obvious. Causes of anemia in chronic renal failure are multiple, and at the present time there is no marker for aluminum-induced anemia. Deferoxamine (DFO) t...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Yuan B,Klein MH,Contiguglia RS,Mishell JL,Seligman PA,Miller NL,Molitoris BA,Alfrey AC,Shapiro JI

    更新日期:1989-01-01 00:00:00

  • Chronic renal disease in Kuwaiti nationals: a prospective study during the past 4 years.

    abstract::Our study is a prospective one conducted at Al-Amiri Hospital and including all new cases of chronic renal disease (CRD) seen at the capital area of Kuwait between 1 January 1999 and 30 December 2003. Diagnosis of CRD was based on clinical, laboratory, and radiological features. Kidney biopsies were done when indicate...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: El-Reshaid W,El-Reshaid K,Kapoor M,Hakim A

    更新日期:2005-01-01 00:00:00

  • Higher thrombin activatable fibrinolysis inhibitor levels are associated with inflammation in attack-free familial Mediterranean fever patients.

    abstract:BACKGROUND:Coagulation abnormalities have been reported in familial Mediterranean fever (FMF) patients with amyloidosis and nephrotic syndrome; but there is not enough data about the continuity of the thrombogenic activity in FMF patients in clinical remission. The purpose of this study was to assess thrombin activatab...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Bavbek N,Ceri M,Akdeniz D,Kargili A,Duranay M,Erdemli K,Akcay A,Guz G

    更新日期:2014-06-01 00:00:00

  • Acute renal failure in leptospirosis in Uruguay.

    abstract::The present study was carried out to describe epidemiology and clinical pattern of acute renal failure caused by leptospirosis in Uruguay. For these purposes, all literature published in Uruguay was reviewed. Three studies were analyzed: 2 series of patients and 1 case report that summarize 26 cases. The incidence of ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Lombardi R

    更新日期:1997-03-01 00:00:00

  • The effect of alfuzosin on renal resistive index, urinary electrolytes and β2 microglobulin levels and TGF β-1 levels of kidney tissue in rats with unilateral ureteropelvic junction obstruction.

    abstract:BACKGROUND:In this study, it was aimed to determine the effects of alfuzosin on experimentally generated unilateral partial ureteropelvic junction obstruction (UPO) in rats. MATERIALS AND METHODS:Thirty Long-Evans rats were randomly allocated into five groups. In control group (C), nothing was performed; in group Sham...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Kose F,Turkyilmaz Z,Sonmez K,Karabulut R,Poyraz A,Gulbahar O,Aral A,Damar C,Kaya C,Can Basaklar A

    更新日期:2016-09-01 00:00:00

  • Valvular calcification and left ventricular modifying in peritoneal dialysis patients.

    abstract:BACKGROUND:Cardiac valve calcification (CVC) and left ventricular (LV) alterations are frequent complication in end-stage renal disease (ESRD). We determined the prevalence of CVC and LV hypertrophy (LVH) in ESRD patients before renal replacement therapy and 12 months after peritoneal dialysis (PD). METHODS:A prospect...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Rebić D,Rašić S,Hamzić-Mehmedbašić A,Džemidžić J,Kurtalić E

    更新日期:2015-01-01 00:00:00

  • Combination of pentoxifylline with angiotensin converting enzyme inhibitors produces an additional reduction in microalbuminuria in hypertensive type 2 diabetic patients.

    abstract:OBJECTIVE:To investigate the anti proteinuric effect of pentoxifylline in diabetic patients, we prospectively studied in 25 hypertensive type 2 diabetic patients with persistent microalbuminuria and normal renal function the impact of combining pentoxifylline with an angiotensin converting enzyme inhibitor, lisinopril,...

    journal_title:Renal failure

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Harmankaya O,Seber S,Yilmaz M

    更新日期:2003-05-01 00:00:00

  • Renal artery stenosis of solitary kidney: the dilemma.

    abstract:BACKGROUND:Renal artery stenosis is an important cause of hypertension and renal failure. When present in a solitary kidney, it is associated with extremely high morbidity and mortality. Although guidelines suggest an aggressive approach by revascularization in these cases, available evidence is too weak and contradict...

    journal_title:Renal failure

    pub_type: 杂志文章,评审


    authors: Feldman L,Beberashvili I,Averbukh Z,Weissgarten J

    更新日期:2004-09-01 00:00:00

  • Retroperitoneal fibrosis secondary to different etiologies (hemilaminectomy and hypothyroidism): reports of two cases.

    abstract::Retroperitoneal fibrosis (RF) is a clinical entity characterized by the progressive proliferation of connective tissue that rarely forms a mass involving the periaortic area of the abdomen, which may be idiopathic as well as a result of an inflammatory process after aneurysmal dilatation of the aorta. This fibrotic ti...

    journal_title:Renal failure

    pub_type: 杂志文章,评审


    authors: Dişel U,Alpay NR,Paydas S

    更新日期:2007-01-01 00:00:00

  • Role of CT scan in diagnosis of renal lymphangiectasia: our single-center experience.

    abstract:BACKGROUND:Renal lymphangiectasia is rarely reported benign renal disorder of lymphatic malformation. Though found incidentally; it presents with nonspecific symptoms and shows characteristic findings in radiological imaging studies. AIM:Here, we report eight patients with symptoms, laboratory and imaging findings com...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Pandya VK,Sutariya HC,Gandhi SP,Khemchandani SI,Patel HV,Shah MK

    更新日期:2017-11-01 00:00:00

  • Increased urinary excretion of N-acetylglucosaminidase in subjects with impaired glucose tolerance.

    abstract::N-acetylglucosaminidase (NAG) is a lysosomal enzyme produced by renal proximal tubular cells and has been widely used as a marker, which indicates a degree of renal tubular damage. An increase in urinary NAG excretion is though to result from the renal tubular damage. The aim of this study was to evaluate whether even...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Fujita H,Narita T,Morii T,Shimotomai T,Yoshioka N,Kakei M,Ito S

    更新日期:2002-01-01 00:00:00

  • Erythropoietin production in patients with chronic renal failure.

    abstract::Studies were performed to reexamine the response of erythropoietin (Epo) production to acute hypoxic stimuli in patients with end-stage renal disease (ESRD). In the absence of acute bleeding or hypoxia, the serum Epo level in ESRD was similar to that of normal subjects despite severe anemia. In 11 dialysis patients wi...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Kato A,Hishida A,Kumagai H,Furuya R,Nakajima T,Honda N

    更新日期:1994-01-01 00:00:00

  • Wider intraoperative glycemic fluctuation increases risk of acute kidney injury after pediatric cardiac surgery.

    abstract:OBJECTIVE:The association between poor intraoperative glycemic control and postoperative acute kidney injury (AKI) in adult cardiac surgery has been observed, but data in the pediatrics remain unknown. We performed a hypothesis that intraoperative hyperglycemia and/or wider glycemic fluctuation were associated with the...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Hu GH,Duan L,Jiang M,Zhang CL,Duan YY

    更新日期:2018-11-01 00:00:00

  • Influence of dialysis modality and membrane flux on quality of life in hemodialysis patients.

    abstract:BACKGROUND:The quality of life in patients undergoing hemodialysis is significantly disturbed. There are data that hemodiafiltration (HDF) may be more effective than conventional hemodialysis in the removal of uremic toxins and may reduce frequency and severity of intradialytic and postdialysis adverse symptoms in pati...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Knezevic MZ,Djordjevic VV,Radovanovic-Velickovic RM,Stankovic JJ,Cvetkovic TP,Djordjevic VM

    更新日期:2012-01-01 00:00:00

  • Renal functional reserve and renal hemodynamics in hypertensive patients.

    abstract::The renal functional reserve (RFR) is the ability of the kidneys to increase renal plasma flow and glomerular filtration rate (GFR) in response to protein intake. It is a measure of functional and anatomic integrity of nephrons. It is not known what relation between RFR and kidney Doppler parameters. We aimed to study...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Gaipov A,Solak Y,Zhampeissov N,Dzholdasbekova A,Popova N,Molnar MZ,Tuganbekova S,Iskandirova E

    更新日期:2016-10-01 00:00:00

  • Effect of dialysis on erythrocyte membrane of chronically hemodialyzed patients.

    abstract::The present work examines the role of uremia and the effect of dialysis treatment on red blood cells (RBCs) membrane properties of hemodialysis patients. The results showed that, the uremic patients had a lower values of erythrocyte deformability than that of healthy control subject. The median osmotic fragility (MOF)...

    journal_title:Renal failure

    pub_type: 临床试验,杂志文章


    authors: Ibrahim FF,Ghannam MM,Ali FM

    更新日期:2002-11-01 00:00:00

  • Community-based study on elderly CKD subjects and the associated risk factors.

    abstract:OBJECTIVE:To investigate the prevalence and risk factors for chronic kidney disease (CKD) among community elderly population in Shanghai, China, in order to provide early diagnosis and treatment of CKD, and improve the quality of life for elderly people. METHODS:In all, 24,886 residents (≥65 years old) were selected f...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Huang YP,Zheng T,Zhang DH,Chen LY,Mao PJ

    更新日期:2016-11-01 00:00:00

  • Thrombotic thrombocytopenic purpura (TTP): initial treatment with plasma exchange plus steroids and immunosuppressive agents for relapsing cases.

    abstract:BACKGROUND:The thrombotic thrombocytopenic purpura (TTP) is a rare disorder with a high mortality rate if untreated or delayed therapy. Whether immediate diagnosis and promptly treated with plasma exchange can change the grave prognosis? METHOD:Retrospective analysis was performed on clinical characteristics and treat...

    journal_title:Renal failure

    pub_type: 临床试验,杂志文章


    authors: Yang CW,Chen YC,Dunn P,Chang MY,Fang JT,Huang CC

    更新日期:2003-01-01 00:00:00

  • Exercise-induced changes in renal URAT1 activity and expression in rats.

    abstract::During exercise, the plasma urate levels and urinary excretion increase due to the enhanced purine degradation in skeletal muscle. Although urate transporter-1 (URAT1) is the main transporter responsible for the reabsorption of filtered urate, potential changes in its activity and expression during exercise have not b...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Cirrik S,Yavuzer BU,Oner G

    更新日期:2010-01-01 00:00:00

  • A prospective study of hepatitis B vaccination - a comparison of responders versus nonresponders.

    abstract::Herein we present one of the largest single-center reports of the response of hemodialysis patients to a two-vaccine hepatitis B virus vaccination protocol in a European dialysis population. A hepatitis B recombinant DNA vaccine, HBvaxPRO, was given at a dose of 40 µg intramuscularly using a four-dose schedule at 0, 1...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Brown CM,Donlon S,O'Kelly P,Casey AM,Collier C,Conlon PJ,Walshe JJ

    更新日期:2011-01-01 00:00:00

  • Invasive fungal infections in renal transplant patients: a single center study.

    abstract:BACKGROUND:Timely diagnosis of invasive fungal infections (IFI) in renal transplant (RT) patients on immunosuppression is often difficult, jeopardizing their life and graft. We reported IFI and their causative fungal agents in post-RT patients. MATERIALS AND METHODS:This was a retrospective 6-year clinical study carri...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Patel MH,Patel RD,Vanikar AV,Kanodia KV,Suthar KS,Nigam LK,Patel HV,Patel AH,Kute VB,Trivedi HL

    更新日期:2017-11-01 00:00:00