Specific alterations in gut microbiota in patients with chronic kidney disease: an updated systematic review.


BACKGROUND:Emerging evidence demonstrates that gut dysbiosis is implicated in the pathogenesis of chronic kidney disease (CKD) with underlying mechanisms involving mucosal and/or systematic immunity or metabolic disorders. However, the profile of gut microbiota in patients with CKD has not been completely explored. METHODS:Databases from their date of inception to 31 March 2020 were systematically searched for case-control or cross-sectional studies comparing the gut microbial profiles in adult patients with CKD or end-stage renal disease (ESRD) with those in healthy controls. Quantitative analysis of alterations in gut microbial profiles was conducted. RESULTS:Twenty-five studies with a total of 1436 CKD patients and 918 healthy controls were included. The present study supports the increased abundance of, phylum Proteobacteria and Fusobacteria, genus Escherichia_Shigella, Desulfovibrio, and Streptococcus, while lower abundance of genus Roseburia, Faecalibacterium, Pyramidobacter, Prevotellaceae_UCG-001, and Prevotella_9 in patients with CKD; and increased abundance of phylum Proteobacteria, and genus Streptococcus and Fusobacterium, while lower abundance of Prevotella, Coprococcus, Megamonas, and Faecalibacterium in patients with ESRD. Moreover, higher concentrations of trimethylamine-N-oxide and p-cresyl sulfate and lower concentrations of short-chain fatty acids were observed. Gut permeability in patients with CKD was not determined due to the heterogeneity of selected parameters. CONCLUSIONS:Specific alterations of gut microbial parameters in patients with CKD were identified. However, a full picture of the gut microbiota could not be drawn from the data due to the differences in methodology, and qualitative and incomplete reporting of different studies.


Ren Fail


Renal failure


Zhao J,Ning X,Liu B,Dong R,Bai M,Sun S




Has Abstract


2021-12-01 00:00:00












  • Influence of different stages of experimental chronic kidney disease on rats locomotor and postural skeletal muscles microcirculation.

    abstract:BACKGROUND:Chronic kidney disease (CKD) is associated with muscle excess fatigue and diminished maximal whole body oxygen consumption, which in part could be depended on poor muscle microcirculatory network. The aim of this study was to assume the influence of different stages of CKD on microcirculation vessels in func...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Flisiński M,Brymora A,Elminowska-Wenda G,Bogucka J,Walasik K,Stefańska A,Odrowaz-Sypniewska G,Manitius J

    更新日期:2008-01-01 00:00:00

  • The incidence of acute kidney injury in patients with traumatic brain injury.

    abstract::There is limited information on the incidence of acute kidney injury (AKI) in patients with traumatic brain injury (TBI) although AKI may contribute to morbidity and mortality. We investigated the incidence of AKI in patients with moderate and severe TBI and the association of AKI with risk factors and outcomes in the...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Moore EM,Bellomo R,Nichol A,Harley N,Macisaac C,Cooper DJ

    更新日期:2010-01-01 00:00:00

  • Pathophysiology of paraprotein production.

    abstract::Paraproteins or monoclonal proteins are the result of clonal B-cell or plasma cell proliferation of a malignant, premalignant or non-malignant nature. Monoclonal proteins may consist of intact immunoglobulin molecules or of heavy or light chains only. Depending on their rate of production and/or secretion they may acc...

    journal_title:Renal failure

    pub_type: 杂志文章,评审


    authors: Maniatis A

    更新日期:1998-11-01 00:00:00

  • Urotensin-II immunoreactivity in children with chronic glomerulonephritis.

    abstract:BACKGROUND:Human urotensin-II (hU-II) is one of the most potent vasoconstrictors in mammals. To our knowledge, there is no study about the role of U-II in childhood glomerulonephritis. We first determined the expression of h U-II in kidneys of children with chronic glomerular diseases. METHODS:Normal human kidneys wer...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Balat A,Karakök M,Yilmaz K,Kibar Y

    更新日期:2007-01-01 00:00:00

  • Unilateral nephrectomy and progression of renal failure.

    abstract::Extensive ablation of renal mass in experimental animals leads to progressive glomerulosclerosis and chronic renal failure (CRF). Clinical studies are far from answering the question whether patients with reduced renal mass are at risk of developing progressive CRF. The aim of our study was to examine the morphologica...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Buccianti G,Lorenz M,Cresseri D,Bianchi ML,Valenti G,Cicchetti F,Francucci BM

    更新日期:1993-01-01 00:00:00

  • Ginsenoside-Rg1 inhibits endoplasmic reticulum stress-induced apoptosis after unilateral ureteral obstruction in rats.

    abstract:AIM:Endoplasmic reticulum (ER) stress and unfolded protein response (UPR) are implicated in many fibrotic diseases, including renal fibrosis. Whether Ginsenoside-Rg1 (G-Rg1) could attenuate renal fibrosis via suppression of ER stress and UPR has not been reported. The aim of this study was to explore the effect of G-Rg...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Li SS,Ye JM,Deng ZY,Yu LX,Gu XX,Liu QF

    更新日期:2015-06-01 00:00:00

  • Case-based education at the 2009 pediatric nephrology fellows conference.

    abstract::The hallmark of the professional is continued development and expanded expertise based on acquisition of new knowledge and refinement of clinical skills. Medical knowledge acquisition is a key component of professional development for fellows in training as well as practicing physicians. New medical knowledge may be a...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Mahan JD,Ferris ME

    更新日期:2010-01-01 00:00:00

  • Osteoprotegerin and bone mineral density in hemodiafiltration patients.

    abstract::A newly identified cytokine, osteoprotegerin (OPG) appears to be involved in the regulation of bone remodeling. In vitro studies suggest that OPG, a soluble member of the TNF receptor family of proteins, inhibits osteoclastogenesis by interrupting the intercellular signaling between osteoblastic stromal cells and oste...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Crisafulli A,Romeo A,Floccari F,Aloisi E,Atteritano M,Cincotta M,Aloisi C,Pizzoleo MA,Ruello A,Artemisia A,Valenti A,Frisina N,Teti D,Buemi M

    更新日期:2005-01-01 00:00:00

  • Diuretics associated acute kidney injury: clinical and pathological analysis.

    abstract:OBJECTIVE:In order to evaluate the clinical and pathological characteristics of diuretics associated acute kidney injury (AKI) and its management. METHODS:We performed a retrospective study including 131 cases that diagnosed as diuretics associated AKI from 1 January 1999 to 1 January 2010 in Ruijin Hospital affiliate...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Wu X,Zhang W,Ren H,Chen X,Xie J,Chen N

    更新日期:2014-08-01 00:00:00

  • Clinicopathologic characteristics and outcomes of lupus nephritis with positive antineutrophil cytoplasmic antibody.

    abstract::Aims: The aim was to determine whether anti-neutrophil cytoplasmic antibody (ANCA)-positive serology in patients with lupus nephritis (LN) is associated with different clinicopathologic features and outcomes.Methods: In our retrospective analysis, 283 patients were enrolled between 2013 and 2018. Thirty-six patients w...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Wang S,Shang J,Xiao J,Zhao Z

    更新日期:2020-11-01 00:00:00

  • Thrombotic thrombocytopenic purpura (TTP): initial treatment with plasma exchange plus steroids and immunosuppressive agents for relapsing cases.

    abstract:BACKGROUND:The thrombotic thrombocytopenic purpura (TTP) is a rare disorder with a high mortality rate if untreated or delayed therapy. Whether immediate diagnosis and promptly treated with plasma exchange can change the grave prognosis? METHOD:Retrospective analysis was performed on clinical characteristics and treat...

    journal_title:Renal failure

    pub_type: 临床试验,杂志文章


    authors: Yang CW,Chen YC,Dunn P,Chang MY,Fang JT,Huang CC

    更新日期:2003-01-01 00:00:00

  • The effect of renal replacement therapies on serum gastrointestinal system hormones.

    abstract:BACKGROUND:The kidney is a major site for the inactivation, degradation, and clearance of a variety of peptide hormones. It has been shown that the uremia increases or decreases gastrointestinal system (GIS) hormones. Moreover, studies investigating the serum GIS hormones levels in chronic renal failure (CRF) were cond...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Borazan A,Cavdar Z,Saglam F

    更新日期:2007-01-01 00:00:00

  • Peritoneal dialysis requirements following open-heart surgery in children with congenital heart disease.

    abstract::This article reviews our experience with 111 pediatric patients following open-heart surgery over 1-year period. Peritoneal dialysis was required in 34 of 111 children (30.6%). We randomly selected 33 patients who did not require peritoneal dialysis as control group. The indications of dialysis were oligoanuria and/or...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Baskin E,Gulleroglu KS,Saygili A,Aslamaci S,Varan B,Tokel K

    更新日期:2010-01-01 00:00:00

  • Protective effect of N-benzoyl-beta-alanine against cisplatin nephrotoxicity in rats.

    abstract::Prophylactic effects of N-benzoyl-beta-alanine (betamipron, BP), one of a series of N-acyl amino acids, were examined against cisplatin-induced nephrotoxicity. Male Wistar rats were injected i.p. with 6 mg/kg of cisplatin combined with an i.p. BP dose given at various times and various doses. Rats were sacrificed 5 da...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Tokunaga J,Kobayashi M,Nakamura C,Kitagawa A,Arimori K,Nakano M

    更新日期:1996-03-01 00:00:00

  • Toward the optimal clinical use of the fraction excretion of solutes in oliguric azotemia.

    abstract::While the fractional excretion of solutes have long been considered excellent research tools to investigate tubular physiology, their clinical use has become common over the last 40 years in the diagnoses of many disorders; however, none have reached the clinical utility of the fractional excretion of sodium in the ab...

    journal_title:Renal failure

    pub_type: 杂志文章,评审


    authors: Diskin CJ,Stokes TJ,Dansby LM,Radcliff L,Carter TB

    更新日期:2010-01-01 00:00:00

  • Novel lncRNA XLOC_032768 protects against renal tubular epithelial cells apoptosis in renal ischemia-reperfusion injury by regulating FNDC3B/TGF-β1.

    abstract::Renal ischemia-reperfusion injury is a leading cause of acute kidney injury, but its underlying mechanism remains poorly understood and effective therapies are still lacking. Here, we identified lncRNA XLOC_032768 as a novel target in renal ischemia-reperfusion injury by analyzing differentially expressed genes of the...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Zhou X,Li Y,Wu C,Yu W,Cheng F

    更新日期:2020-11-01 00:00:00

  • Clinical and ultrasonographical characterization of childhood cystic kidney diseases in Egypt.

    abstract:BACKGROUND:Renal cystic disorders (RCD) constitute an important and leading cause of end-stage renal disease (ESRD) in children. It can be acquired or inherited; isolated or associated with extrarenal manifestations. The precise diagnosis represents a difficult clinical challenge. METHODS:The aim of this study was to ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Soliman NA,Nabhan MM,Bazaraa HM,Badr AM,Shaheen M

    更新日期:2014-06-01 00:00:00

  • Monitor lizard bite-induced acute kidney injury--a case report.

    abstract::Envenomations by venomous lizards are rare. Monitor lizard bite-induced acute kidney injury (AKI) is a previously unreported complication in humans. A 55-year-old female was bitten on her right leg during farming activity by a monitor lizard (Varanus bengalensis). The patient experienced severe local pain and bleeding...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Vikrant S,Verma BS

    更新日期:2014-04-01 00:00:00

  • Frequency, types, and direct related costs of medication errors in an academic nephrology ward in Iran.

    abstract::Medication errors are ongoing problems among hospitalized patients especially those with multiple co-morbidities and polypharmacy such as patients with renal diseases. This study evaluated the frequency, types and direct related cost of medication errors in nephrology ward and the role played by clinical pharmacists. ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Gharekhani A,Kanani N,Khalili H,Dashti-Khavidaki S

    更新日期:2014-09-01 00:00:00

  • Influenza vaccination in chronic hemodialysis patients. The effect of zinc supplementation.

    abstract::Since influenza increases the mortality of chronically ill patients we decided to study the effectiveness of influenza vaccination in hemodialysis (HD) patients. Nineteen HD patients aged from 20 to 60 years, on unrestricted diet and with no febrile episode, were studied. Blood samples were collected before the intram...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Grekas D,Alivanis P,Kotzadamis N,Kiriazopoulou V,Pyrpasopoulos M,Tourkantonis A

    更新日期:1992-01-01 00:00:00

  • Neutrophil-to-lymphocyte ratio as a predictor of worsening renal function in diabetic patients (3-year follow-up study).

    abstract:BACKGROUND:Previous studies have demonstrated the role of inflammation in diabetic nephropathy (DN). Neutrophil to lymphocyte ratio (NLR) rather than other white cell parameters was found to be a useful inflammatory marker to predict adverse outcomes in medical and surgical conditions. Nevertheless, the value of NLR in...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Azab B,Daoud J,Naeem FB,Nasr R,Ross J,Ghimire P,Siddiqui A,Azzi N,Rihana N,Abdallah M,Azzi N,Patel P,Kleiner M,El-Sayegh S

    更新日期:2012-01-01 00:00:00

  • Serological and molecular survey of toxoplasmosis in renal transplant recipients and hemodialysis patients in Kashan and Qom regions, central Iran.

    abstract::Toxoplasma gondii is one of the important opportunistic pathogen among solid-organ transplant recipients and hemodialysis patients (HD). This study was aimed to detect toxoplasmosis among 50 renal transplant recipients (RTR), 135 HD and 120 healthy individuals in two cities (Kashan and Qom) that located in the center ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Rasti S,Hassanzadeh M,Soliemani A,Hooshyar H,Mousavi SG,Nikoueinejad H,Abdoli A

    更新日期:2016-07-01 00:00:00

  • Update on role of direct renin inhibitor in diabetic kidney disease.

    abstract:BACKGROUND:Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease (ESRD). Renin-angiotensin-aldosterone system (RAAS) plays a critical role in the development of DKD with angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) being the mainstay of treatment. System...

    journal_title:Renal failure

    pub_type: 杂志文章,评审


    authors: Dhakarwal P,Agrawal V,Kumar A,Goli KM,Agrawal V

    更新日期:2014-07-01 00:00:00

  • Role of ticlopidine on adriamycin-induced nephropathy.

    abstract::The effect of ticlopidine on rats with adriamycin nephropathy was observed during 26 weeks. In the ticlopidine-treated nephrotic animals (TNG), proteinuria was less than in the untreated nephrotic animals (NG), but this difference was significant only at week 6 (TNG = 47.27 +/- 16.52 versus NG = 100.08 +/- 13.83 mg/24...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Riyuzo MC,Soares VA

    更新日期:1999-09-01 00:00:00

  • Assessment of protein nitrogen appearance in Chinese peritoneal dialysis patients-which method to use?

    abstract:OBJECTIVE:We compared the Bergstrom's and Randerson's formula for PNA determination, and compared the normalization of PNA by ideal body weight (IBW) and standard body weight (SBW) as estimated by the Watson's formula. METHODS. We studied 208 Chinese PD patients. Two 24-h dialysate and urine collections were performed ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Szeto CC,Chow KM,Leung CB,Wong TY,Li PK

    更新日期:2003-03-01 00:00:00

  • Acute toxic kidney injury.

    abstract::Substances toxic to the kidney are legion in the modern world. The sheer number and variety, their mutual interactions and, metabolism within the body are a challenge to research. Moreover, the kidney is especially prone to injury owing to its physiology. Acute kidney injury (AKI) induced by poisonous or primarily nep...

    journal_title:Renal failure

    pub_type: 杂志文章,评审


    authors: Petejova N,Martinek A,Zadrazil J,Teplan V

    更新日期:2019-11-01 00:00:00

  • Successful treatment of severe iron intoxication with gastrointestinal decontamination, deferoxamine, and hemodialysis.

    abstract::Acute iron poisoning is a common and potentially serious problem in the pediatric population. Early recognition and treatment is crucial for a better outcome and to prevent morbidity and mortality. An 18-year-old female, who had accidental ingestion of 50 tablets of ferrous sulfate (100 mg of elemental iron per 335 mg...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Gumber MR,Kute VB,Shah PR,Vanikar AV,Patel HV,Balwani MR,Ghuge PP,Trivedi HL

    更新日期:2013-01-01 00:00:00

  • Long-term intravenous calcitriol in secondary hyperparathyroidism: the role of technetium-99m-MIBI scintigraphy in predicting the response to treatment.

    abstract:BACKGROUND:Despite the effectiveness of intravenous calcitriol in suppressing parathyroid hormone secretion in patients with uremic hyperparathyroidism, 50% of the patients remain refractory to this treatment. There are conflicting reports regarding the factors that can predict the response to treatment. Technetium-99m...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Owda AK,Mousa D,Abdallah AH,Hawas FA,Al-Harbi W,Fedail H,At-Shoail G,Al-Sulaiman MH,Al-Khader AA

    更新日期:2002-03-01 00:00:00

  • Radial augmentation index may be an effective predictor of vascular calcification in patients on peritoneal dialysis.

    abstract::Vascular calcification (VC) is an important promoter of cardiovascular disease (CVD) in patients undergoing peritoneal dialysis (PD). Several indices can be used to evaluate VC, including the abdominal aortic calcification index (AACI) and carotid artery intima-media thickness (IMT); however, simpler and lesser expens...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Yang N,Yang W,Cui W,Zhou D,Du X,Li L

    更新日期:2020-11-01 00:00:00

  • Effect of glycine on cisplatin nephrotoxicity and heat-shock protein 70 expression in the rat kidney.

    abstract::Glycine has been shown to protect against cisplatin (CP) nephrotoxicity in rats and to enhance the in vitro expression of heat-shock protein (hsp) 70 in renal epithelial cells following sublethal heat shock. We hypothesized that the protective effect of glycine against CP nephrotoxicity may be due to an up-regulation ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Musio F,Carome MA,Bohen EM,Sabnis S,Yuan CM

    更新日期:1997-01-01 00:00:00