Abstract:
:The nephrotoxicity of amikacin (AK) was prevented with pentoxifylline (PTX) in a rat model. Rats were received a single injection of AK (1.2 g/kg, i.p.) with or without PTX pretreatment (25 mg/kg, orally). Renal morphology was investigated by light microscopy. Tissue samples and trunk blood were also obtained to determine renal malondialdehyde (MDA), blood urea nitrogen (BUN), and creatinine (Cr) levels. MDA production was found to be higher in AK group. PTX administration caused a significant decrease in MDA production. Morphological damage in rats given AK was severe in the kidney, whereas in rats given AK plus PTX, no histological changes occurred. It is concluded that PTX could be useful for reducing the nephrotoxic effects of AK.
journal_name
Ren Failjournal_title
Renal failureauthors
Ozer MK,Asci H,Oncu M,Yesilot S,Savran M,Bayram D,Cicek Edoi
10.1080/08860220802595492subject
Has Abstractpub_date
2009-01-01 00:00:00pages
134-9issue
2eissn
0886-022Xissn
1525-6049pii
908658190journal_volume
31pub_type
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