Abstract:
:Renal ischemia-reperfusion injury is a leading cause of acute kidney injury, but its underlying mechanism remains poorly understood and effective therapies are still lacking. Here, we identified lncRNA XLOC_032768 as a novel target in renal ischemia-reperfusion injury by analyzing differentially expressed genes of the transcriptome data. PCR results show that XLOC_032768 was markedly downregulated in the kidney during renal ischemia-reperfusion in mice and in cultured kidney cells during hypoxia. Upon induction in vitro, XLOC_032768 overexpression repressed the expression of fibronectin type III domain containing 3B (FNDC3B) and tubular epithelial cells apoptosis. Administration of XLOC_032768 preserved FNDC3B expression and attenuated renal tubular epithelial cells apoptosis, resulting in protection against kidney injury in mice. Knockdown of FNDC3B markedly reduced the expression of TGF-β1 and apoptosis of renal tubular cells. Thus, XLOC_032768/FNDC3B/TGF-β1signaling pathway in ischemia-reperfusion injury may be targeted for therapy.
journal_name
Ren Failjournal_title
Renal failureauthors
Zhou X,Li Y,Wu C,Yu W,Cheng Fdoi
10.1080/0886022X.2020.1818579subject
Has Abstractpub_date
2020-11-01 00:00:00pages
994-1003issue
1eissn
0886-022Xissn
1525-6049journal_volume
42pub_type
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