Abstract:
BACKGROUND:Diabetic nephropathy (DN) is a leading cause of diabetes-related morbidity and mortality. The aim of this study was to evaluate the relationship of AGT M235T and apoprotein E (APO E) gene polymorphism with DN in Turkish patients of Type 2 diabetes, and to compare genotype and allele distributions among DN patients, non-DN patients, and healthy controls. METHODS:AGT M235T and APO E genotype and allele analysis were performed in 111 DN patients, 108 non-DN patients, 106 healthy control subjects for APO E genotype, and 100 for AGT M235T genotype polymorphism. APO E and AGT M235T genotype were determined by RFLP-PCR. RESULTS:The frequencies of APO E ε2/3, ε 3/3, ε 3/4 genotypes were 22.7%, 60%, 60%, respectively, among DN patients and 6.6%, 80%, 10.4%, respectively (p < 0.001), in the non-DN patients. The frequencies of AGT M235T MM, MT, TT genotypes among the same groups were 17%, 46%, 37% and 21%, 63%, 16%, respectively (p < 0.02). Having the ε2/3 genotype and TT genotype increased the risk for DN nephropathy [4.8-fold (95% CI: 1.94-11.67), 2.9-fold (95% CI: 1.27-6.69), respectively]. CONCLUSION:Our study has shown that AGT M235T TT genotype and APO E ε 2/3 genotype may be linked to a risk for DN among Turkish population.
journal_name
Ren Failjournal_title
Renal failureauthors
Reis KA,Ebinç FA,Koç E,Demirci H,Erten Y,Güz G,Derici UB,Bali M,Söylemezoğlu O,Arınsoy T,Sindel Sdoi
10.3109/0886022X.2011.568133subject
Has Abstractpub_date
2011-01-01 00:00:00pages
469-74issue
5eissn
0886-022Xissn
1525-6049journal_volume
33pub_type
杂志文章相关文献
RENAL FAILURE文献大全abstract::Autosomal dominant polycystic disease (ADPKD) is one of the most common monogenic disorders, and globally is among the most common hereditary causes of end stage kidney disease. Until recently, the causes of this disease remained obscure. However, in the past decade there have been enormous advances in the understandi...
journal_title:Renal failure
pub_type: 杂志文章,评审
doi:10.3109/0886022X.2015.1013404
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVES:Few studies mention how to objectively adjust peritoneal dialysis (PD) dwell volume for adult continuous ambulatory peritoneal dialysis (CAPD) patients. We proposed a reference equation composed of parameters from the peritoneal equilibrium test (PET) for adjusting daily dialysate dwell volume to obtain more...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860220903541127
更新日期:2010-01-01 00:00:00
abstract::TGF-beta1 has been demonstrated to be up-regulated in response to ischemic events both in animal models and in man. Demonstration of this up-regulation in the kidney following experimentally induced acute renal failure and in renal transplants complements similar findings in coronary and cerebral ischemia. Activation ...
journal_title:Renal failure
pub_type: 杂志文章,评审
doi:10.1081/jdi-120006767
更新日期:2002-07-01 00:00:00
abstract:BACKGROUND:Patients with chronic kidney disease (CKD) often have CD4+ regulatory T cells (Tregs) dysfunction and chronic inflammation. We aim to investigate the effect, function, and related mechanism of low-dose IL-2 on CD4+ regulatory T cells expansion in vitro from patients with CKD. METHODS:A total of 148 newly di...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2018.1456462
更新日期:2018-11-01 00:00:00
abstract::Herein, we report a case of acute kidney injury (AKI) due to diarrhea-induced acute tubular necrosis (ATN) in a patient with nephrotic syndrome secondary to biopsy-proven collapsing focal and segmental glomerulosclerosis (FSGS). The clinical picture mimicked rapidly progressive glomerulonephritis (RPGN) and motivated ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2010.501931
更新日期:2010-01-01 00:00:00
abstract::Urinary N-acetyl-β-d-glucosaminidase (NAG) has been suggested as a marker for early diabetic nephropathy. This study aimed to prospectively investigate the relationship between asymptomatic leukocyturia (ASL) and NAG in women. One hundred and five female outpatients aged 31-86 years were selected for a 10-year follow-...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2012.713278
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:The syndrome of rapid onset end-stage renal disease (SORO-ESRD) was first described in the journal Renal Failure in 2010. This is an acute precipitate unpredictable yet irreversible ESRD following acute kidney injury (AKI), as distinct from "classic" ESRD where chronic kidney disease (CKD)-ESRD progression w...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2015.1088336
更新日期:2015-01-01 00:00:00
abstract::Introduction: This study aimed to investigate the clinical characteristics, risk factors, and outcomes of infection-related hospitalization (IRH) in patients with lupus nephritis (LN) and ANCA glomerulonephritis after intensive immunosuppressive therapy.Methods: Patients diagnosed with LN or ANCA glomerulonephritis wh...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2020.1763400
更新日期:2020-11-01 00:00:00
abstract::The aim of this investigation was to study the validity of the radionuclide methods in the estimation of kidney function, for prognosis and follow-up of acute renal failure (ARF). In thirty-one ARF patients, the evaluation of glomerular filtration rate (GFR) by 99mTc-DTPA clearance and effective renal plasma flow (ERP...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-100100899
更新日期:2000-01-01 00:00:00
abstract::Uremia induces a suppression of the immune status. A large clinical literature suggests that estradiol (E2) plays a critical role in immune function. A large proportion of women hemodialysis patients faced early menopause and inadequate estrogen levels. The aim of the present study is to evaluate the effect of hormone...
journal_title:Renal failure
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::Patients with end-stage renal disease, including those treated with peritoneal dialysis, have a high risk for death, particularly from cardiovascular causes. Plasma fatty acid (FA) composition is used as an indicator of disease risk, because its alteration has been related to metabolic disease and cardiovascular disea...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2011.601831
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Chronic kidney disease (CKD) is a world-wide public health problem. Hypertension is both a cause and a complication of CKD, and a risk factor for progression of kidney disease. The effect of salt intake on blood pressure (BP) and the salt sensitivity in non-dialysis patients with CKD were studied. METHODS:O...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2013.866008
更新日期:2014-04-01 00:00:00
abstract::Glycine has been shown to protect against cisplatin (CP) nephrotoxicity in rats and to enhance the in vitro expression of heat-shock protein (hsp) 70 in renal epithelial cells following sublethal heat shock. We hypothesized that the protective effect of glycine against CP nephrotoxicity may be due to an up-regulation ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229709026258
更新日期:1997-01-01 00:00:00
abstract::A 68-year-old male presented with acute myeloid leukemia, renal failure, hypokalemia, and enlarged kidneys on renal ultrasound. Renal biopsy revealed massive leukemic infiltration of the kidney. After systemic chemotherapy, the patient developed tumor lysis syndrome followed by a phase of proximal tubule dysfunction p...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220902972187
更新日期:2009-01-01 00:00:00
abstract::The plasma metallothionein concentration was studied in renal transplant patients. These patients are submitted to an attack of free radicals catalyzed by metals such as copper, zinc, cadmium, and others. The function of metallothionein is to bind toxic metals inhibiting the attack of free radicals and oxidative stres...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-120024287
更新日期:2003-09-01 00:00:00
abstract::In this prospective study, we aimed to determine the protective antioxidant role of alpha-lipoic acid (ALA) on development of contrast-induced nephropathy (CIN) in diabetic patients undergoing coronary angiography. Seventy-eight diabetic patients undergoing coronary angiography were included. Thirty-nine patients were...
journal_title:Renal failure
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/0886022X.2013.790298
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Despite the widespread availability of dialytic and intensive care unit technology, the probability of early mortality in critically ill patients with acute renal failure (ARF) is still high, and the evaluation of the patients' prognosis has been difficult. The Acute Physiology and Chronic Health Evaluation ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-100001284
更新日期:2001-01-01 00:00:00
abstract::Diabetic nephropathy (DN) has become the most common pathogenesis of end-stage renal disease. Plasminogen activator inhibitor-1 (PAI-1) plays an important role in the pathogenesis of DN. A meta-analysis was conducted to investigate the association between 4 G/5 G variants in the PAI-1 gene and DN susceptibility. Datab...
journal_title:Renal failure
pub_type: 杂志文章,meta分析
doi:10.3109/0886022X.2013.867783
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:The optimal delivered dialysis dose has been of a great interest for the last three decades, though a clear cut point has not been reached yet. We aimed to evaluate the relationship between one-year mortality and the delivered dialysis dose, which was recommended by Kidney Disease Outcomes Quality Initiative...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2016.1208515
更新日期:2016-09-01 00:00:00
abstract::Background: Renal interstitial fibrosis is a common pathway of chronic kidney disease to end-stage renal disease, which is characterized by an imbalance between the synthesis and degradation of the collagen-rich extracellular matrix (ECM). While, discoidin domain receptor 2 (DDR2) can be activated when it binds to som...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2019.1621759
更新日期:2019-11-01 00:00:00
abstract::Retroperitoneal fibrosis (RF) is a clinical entity characterized by the progressive proliferation of connective tissue that rarely forms a mass involving the periaortic area of the abdomen, which may be idiopathic as well as a result of an inflammatory process after aneurysmal dilatation of the aorta. This fibrotic ti...
journal_title:Renal failure
pub_type: 杂志文章,评审
doi:10.1080/08860220701392322
更新日期:2007-01-01 00:00:00
abstract::A 44-year-old man with acute renal failure and antineutrophil cytoplasmic antibodies (ANCA) positivity was described. The first renal biopsy specimen showed tubulointerstitial nephritis (TIN) with normal glomeruli. However, delayed recovery of renal function with low-dose steroid treatment for TIN prompted a second re...
journal_title:Renal failure
pub_type: 杂志文章,评审
doi:10.1080/08860220500531559
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Previous studies have demonstrated the role of inflammation in diabetic nephropathy (DN). Neutrophil to lymphocyte ratio (NLR) rather than other white cell parameters was found to be a useful inflammatory marker to predict adverse outcomes in medical and surgical conditions. Nevertheless, the value of NLR in...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2012.668741
更新日期:2012-01-01 00:00:00
abstract:AIM:The aim of this study was to observe the effects of coupled plasma filtration adsorption (CPFA) on septic patients with multiple organ dysfunction syndrome (MODS). METHODS:A total of 14 patients were randomly divided into two groups, and, respectively, received 10 h of CPFA or high-volume hemofiltration (HVHF). Th...
journal_title:Renal failure
pub_type: 杂志文章,随机对照试验
doi:10.3109/0886022X.2012.684553
更新日期:2012-01-01 00:00:00
abstract::Fibrillary glomerulopathy (FG) can occur either alone or co-existing with other proteinuric glomerular disorders. FG has been associated with poor renal outcomes leading to End Stage Renal Disease (ESRD). Since FG is a relatively rare disorder, limited information is available concerning treatment protocols. We presen...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2014.918832
更新日期:2014-08-01 00:00:00
abstract::Experimental perfusions of isolated rat kidneys were performed with flow rates adjusted to produce comparable glomerular filtration rates (GFR) in control and experimental groups. The experimental perfusate, consisting of Krebs-Ringer bicarbonate (KRB) containing 3.5% (uncrosslinked) stroma-free hemoglobin (SFH) plus ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229509037635
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND:The goal of this study was to define the clinical and histological differences in new-onset IgA nephropathy between young adults and the elderly. METHODS:We retrospectively examined renal biopsy findings, clinical features at presentation and outcomes in 82 young adults (mean age 30.3+/-10.2 years) and 17 e...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860221003611687
更新日期:2010-01-01 00:00:00
abstract::Several studies have shown that hepatocyte growth factor (HGF) ameliorates chronic renal failure, but its mechanism of action is unclear. This study was designed to test the delivery of HGF in the PCI-neo vector, using the 5/6 nephrectomized rat as a model for chronic renal failure, and to confirm that this protective...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2013.867797
更新日期:2014-04-01 00:00:00
abstract::Renal involvement is an unusual but significant Behcet´s disease (BD) complication and AA amyloidosis appears to be the most common etiology. IL-6 is a pro-inflammatory cytokine with an important role in AA amyloidosis development. Tocilizumab (TCZ) is a humanized anti-IL-6 receptor antibody that has emerged as an eff...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2013.773913
更新日期:2013-01-01 00:00:00
abstract::Incidence of acute kidney injury (AKI) in patients with pyogenic liver abscess is rare. In our study we found AKI in 32.6% of patients with liver abscess. Majority of the patients were in their fifties and sixties. As per acute kidney injury network trial criteria, renal failure was in stage 1 in 26.6%, stage 2 in 40%...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2011.569108
更新日期:2011-01-01 00:00:00