Effects of a stroma-free hemoglobin and perfluorochemical combination on ultrastructure and function of the isolated rat kidney.

Abstract:

:Experimental perfusions of isolated rat kidneys were performed with flow rates adjusted to produce comparable glomerular filtration rates (GFR) in control and experimental groups. The experimental perfusate, consisting of Krebs-Ringer bicarbonate (KRB) containing 3.5% (uncrosslinked) stroma-free hemoglobin (SFH) plus 3.5% of the perfluorochemical (PFC) Fluosol-DA, was found to produce only 48% as much urine as the control perfusate consisting of KRB containing 7% dextran (without either SFH or PFC). Perfusion with the experimental SFH/PFC mixture was associated with mean fractional reabsorptions of sodium 3.3% greater and of potassium 5.1% lesser than perfusion with the control KRB (with dextran) solution (p < .05). The SFH/PFC mixture was localized histochemically to the capillaries and urinary spaces of glomeruli; and to the apical microvilli, basal laminae, and intracytoplasmic vacuoles of proximal renal tubular cells. Since the glomerular filtration rate was not a factor, decremental urine production appears to be associated with increased reabsorption of sodium, excretion of potassium, and proximal tubular uptake of the experimental SFH/PFC mixture by endocytosis.

journal_name

Ren Fail

journal_title

Renal failure

authors

Millis RM,Barber JD,Anderson WA,Dehkordi O

doi

10.3109/08860229509037635

subject

Has Abstract

pub_date

1995-11-01 00:00:00

pages

675-87

issue

6

eissn

0886-022X

issn

1525-6049

journal_volume

17

pub_type

杂志文章
  • Renin-angiotensin system blockade is not associated with hyperkalemia in chronic hemodialysis patients.

    abstract:BACKGROUND:Serious hyperkalemia was reported in 10% of chronic hemodialysis (HD) patients that could lead to arrhythmia and death. Angiotensin-converting enzyme inhibitors (ACE-I) and angiotensin II receptor blockers (ARB) are well accepted for cardio-protective benefits. The relationship between renin-angiotensin syst...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860220903216147

    authors: Lin HH,Yang YF,Chang JK,Ting IW,Kuo HL,Wang IK,Huang CC

    更新日期:2009-01-01 00:00:00

  • The combination of sirolimus and cyclosporine does not delay initial renal graft function recovery.

    abstract:BACKGROUND:Sirolimus has been considered to be a non-nephrotoxic agent. It may delay graft function due to a potential hindrance of the recovery from acute tubular necrosis. It remains controversial as to whether the concomitant administration of sirolimus (SRL) with calcineurin inhibitors delays graft function in Asia...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220701860989

    authors: Hsu HJ,Tian YC,Chen YC,Lai BC,Fang JT,Yang CW,Wu MS

    更新日期:2008-01-01 00:00:00

  • Predictors of mortality in acute renal failure in a developing country: a prospective study.

    abstract::Acute renal failure (ARF) occurs in wide range of conditions, making the evaluation of its prognosis a difficult task. Data regarding prognostic factors in ARF in a general population in developing countries are scarce. The objective of the study was to describe predictors of mortality in ARF that are relevant in the ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220701260651

    authors: Kohli HS,Bhat A,Jairam A,Aravindan AN,Sud K,Jha V,Gupta KL,Sakhuja V

    更新日期:2007-01-01 00:00:00

  • Evaluation and outcome of antenatal hydronephrosis: a prospective study.

    abstract::Antenatal hydronephrosis (AHN), defined as dilatation of renal pelvis and/or calyces, is the most frequently detected antenatal abnormality. However, postnatal management of AHN is controversial. The purpose of this study was to describe the clinical outcomes of infants with AHN and to contribute to the definition of ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2012.676492

    authors: Gökaslan F,Yalçınkaya F,Fitöz S,Özçakar ZB

    更新日期:2012-01-01 00:00:00

  • The subjective sleep quality and heart rate variability in hemodialysis patients.

    abstract:INTRODUCTION:Sleep disturbances and cardiovascular autonomic dysfunction are major complications of hemodialysis (HD). The goal of this study is to identify clinical, heart rate variability (HRV) or laboratory parameters that are independently associated with subjective sleep quality. PATIENT AND METHODS:Forty-six sta...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2010.541578

    authors: Wei CY,Chung TC,Wu SC,Chung CF,Wu WP

    更新日期:2011-01-01 00:00:00

  • Combination of pentoxifylline with angiotensin converting enzyme inhibitors produces an additional reduction in microalbuminuria in hypertensive type 2 diabetic patients.

    abstract:OBJECTIVE:To investigate the anti proteinuric effect of pentoxifylline in diabetic patients, we prospectively studied in 25 hypertensive type 2 diabetic patients with persistent microalbuminuria and normal renal function the impact of combining pentoxifylline with an angiotensin converting enzyme inhibitor, lisinopril,...

    journal_title:Renal failure

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1081/jdi-120021159

    authors: Harmankaya O,Seber S,Yilmaz M

    更新日期:2003-05-01 00:00:00

  • Long-term online hemodiafiltration does not reduce the frequency and severity of acquired cystic kidney disease in hemodialysis patients.

    abstract:BACKGROUND:Acquired cystic kidney disease (ACKD) is a frequent complication in chronic hemodialysis (HD) patients and a risk factor for renal cell carcinoma. Online hemodiafiltration (HDF) provides better clearance of middle molecular weight solutes, but its effect on ACKD has not been investigated. MATERIALS AND METH...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220903003412

    authors: Weng CJ,Chang MY,Chen YC,Tian YC,Fang JT,Yang CW

    更新日期:2009-01-01 00:00:00

  • Unilateral nephrectomy and progression of renal failure.

    abstract::Extensive ablation of renal mass in experimental animals leads to progressive glomerulosclerosis and chronic renal failure (CRF). Clinical studies are far from answering the question whether patients with reduced renal mass are at risk of developing progressive CRF. The aim of our study was to examine the morphologica...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229309054954

    authors: Buccianti G,Lorenz M,Cresseri D,Bianchi ML,Valenti G,Cicchetti F,Francucci BM

    更新日期:1993-01-01 00:00:00

  • The effects of spironolactone on nephron function in patients with diabetic nephropathy.

    abstract::Increasing evidence suggests that circulating aldosterone per se contributes directly to renal and cardiovascular diseases. We sought to evaluate the effects of a three-month treatment with 25 mg spironolactone, an aldosterone receptor antagonist, on nephron function in 20 type II diabetic patients with persistent mic...

    journal_title:Renal failure

    pub_type: 临床试验,杂志文章

    doi:10.1080/08860220802389342

    authors: Ustundag A,Tugrul A,Ustundag S,Sut N,Demirkan B

    更新日期:2008-01-01 00:00:00

  • Associations between endothelial nitric oxide synthase polymorphisms and risk of diabetic nephropathy: an updated meta-analysis.

    abstract:BACKGROUND:Genetic polymorphism of endothelial nitric oxide synthase (eNOS) has been implicated in the risk of diabetic nephropathy (DN), but the published findings were inconsistent. We performed a comprehensive meta-analysis to derive a more precise estimation of the association between genetic polymorphisms of eNOS ...

    journal_title:Renal failure

    pub_type: 杂志文章,meta分析

    doi:10.3109/0886022X.2015.1062339

    authors: Zhang Y,Xiao HQ,Zeng XT,Zuo HX,Xu YC

    更新日期:2015-11-01 00:00:00

  • Can continuous intraperitoneal infusion of 125I-iothalamate and 131I-hippuran be used for measurement of GFR in conscious rats?

    abstract::We previously described a method to measure GFR in conscious spontaneously voiding rats. This method circumvents the need for anesthesia and for bladder instrumentation. It's main principle is the correction of renal 125I-iothalamate clearance for incomplete urine collection by the ratio of plasma and renal clearance ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229809045109

    authors: de Vries PA,Navis G,de Jong PE,de Zeeuw D

    更新日期:1998-03-01 00:00:00

  • Do neutrophil gelatinase-associated lipocalin and interleukin-18 predict renal dysfunction in patients with familial Mediterranean fever and amyloidosis?

    abstract:BACKGROUND:The aim of this study was to evaluate whether neutrophil gelatinase-associated lipocalin (NGAL) and interleukin-18 (IL-18) predict renal disfunction in patients with familial Mediterranean fever (FMF). METHODS:This prospective study consisted of 102 patients with FMF in attack-free period, and 40 matched he...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2013.865486

    authors: Deveci K,Korkmaz S,Senel S,Deveci H,Sancakdar E,Uslu AU,Deniz A,Alkan F,Seker MM,Sencan M

    更新日期:2014-04-01 00:00:00

  • Protective effect of N-benzoyl-beta-alanine against cisplatin nephrotoxicity in rats.

    abstract::Prophylactic effects of N-benzoyl-beta-alanine (betamipron, BP), one of a series of N-acyl amino acids, were examined against cisplatin-induced nephrotoxicity. Male Wistar rats were injected i.p. with 6 mg/kg of cisplatin combined with an i.p. BP dose given at various times and various doses. Rats were sacrificed 5 da...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229609052792

    authors: Tokunaga J,Kobayashi M,Nakamura C,Kitagawa A,Arimori K,Nakano M

    更新日期:1996-03-01 00:00:00

  • Successful use of rituximab in fibrillary glomerulopathy.

    abstract::Fibrillary glomerulopathy (FG) can occur either alone or co-existing with other proteinuric glomerular disorders. FG has been associated with poor renal outcomes leading to End Stage Renal Disease (ESRD). Since FG is a relatively rare disorder, limited information is available concerning treatment protocols. We presen...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2014.918832

    authors: Chaudhary A,Gyamlani G,Cossey NL,Walker PD,Wall BM

    更新日期:2014-08-01 00:00:00

  • Low prevalence of hepatitis C virus infection in hemodialysis units: effect of isolation?

    abstract::Hepatitis C virus (HCV) infection has recently become the major cause of chronic liver disease among patients on chronic hemodialysis. The use of erythropoietin for treatment of anemia has reduced the number of blood transfusions, but the frequency of HCV infection has not declined in hemodialysis units. The exact mod...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-120013968

    authors: Harmankaya O,Cetin B,Obek A,Seber E

    更新日期:2002-09-01 00:00:00

  • Relation between urinary cytology abnormalities and cyclosporine A therapy in bone marrow transplant recipients.

    abstract::The aim of the study was to determine the relationship, if any, between abnormalities in urinary cytology and the administration of cyclosporine A in bone marrow transplant recipients. Specific attention was given to the presence of tubular cells with round inclusions (TCRI). Two bone marrow transplant recipient group...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229809045154

    authors: Sucic M,Boban D,Markovic-Glamocak M,Bogdanic V,Nemet D,Labar B,Cvoriscec D,Plavsic F,Stoos-Veic T,Mrsic M

    更新日期:1998-07-01 00:00:00

  • Clinicopathologic characteristics and outcomes of lupus nephritis with positive antineutrophil cytoplasmic antibody.

    abstract::Aims: The aim was to determine whether anti-neutrophil cytoplasmic antibody (ANCA)-positive serology in patients with lupus nephritis (LN) is associated with different clinicopathologic features and outcomes.Methods: In our retrospective analysis, 283 patients were enrolled between 2013 and 2018. Thirty-six patients w...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2020.1735416

    authors: Wang S,Shang J,Xiao J,Zhao Z

    更新日期:2020-11-01 00:00:00

  • Community-based study on elderly CKD subjects and the associated risk factors.

    abstract:OBJECTIVE:To investigate the prevalence and risk factors for chronic kidney disease (CKD) among community elderly population in Shanghai, China, in order to provide early diagnosis and treatment of CKD, and improve the quality of life for elderly people. METHODS:In all, 24,886 residents (≥65 years old) were selected f...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2016.1229987

    authors: Huang YP,Zheng T,Zhang DH,Chen LY,Mao PJ

    更新日期:2016-11-01 00:00:00

  • The SHR as a small animal model for radiocontrast renal failure. Relation of nephrotoxicity to animal's age, gender, strain, and dose of radiocontrast.

    abstract::The male spontaneously hypertensive rat (SHR), as it ages, suffers many of the renal and cardiovascular complications that are recognized in humans as risk factors for radiocontrast (RC) agent induced renal failure (RF). Knowledge of this led us to test this strain of rats as a small animal model for RC-induced renal ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229709037213

    authors: Duarte CG,Zhang J,Ellis S

    更新日期:1997-11-01 00:00:00

  • Lysosomal iron accumulation in diabetic nephropathy.

    abstract::Iron accumulates within proximal tubular lysosomes in several models of renal disease and may play a role in the progression of proteinuric chronic renal disease by the generation of reactive oxygen species. In this study, tubular iron was examined at an ultrastructural level by energy dispersive x-ray spectrometry in...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229409044877

    authors: Nankivell BJ,Tay YC,Boadle RA,Harris DC

    更新日期:1994-01-01 00:00:00

  • Most common intoxication in nephrology ward organophosphate poisoning.

    abstract:OBJECTIVES:In Taiwan, the widespread use of organophosphates (OPs) in agricultural and household environments results in numerous OP poisoning. To better understand the clinical significance of associated parameters on respiratory failure and patient outcome, we evaluate patients admitted to the Nephrology ward in our ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-120039816

    authors: Lin CL,Yang CT,Pan KY,Huang CC

    更新日期:2004-07-01 00:00:00

  • Long-term efficacy and safety of quadruple therapy in childhood diffuse proliferative lupus nephritis.

    abstract::In this study, we evaluated the frequency, clinical presentation, treatment protocols, prognostic factors, and outcome in children with diffuse proliferative lupus nephritis (DPLN). Between June 1990 and December 2004, 46 patients were diagnosed to have systemic lupus erythematosus (SLE), and 26 of them (56.5%) were f...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220802132171

    authors: Demircin G,Oner A,Erdoğan O,Delibaş A,Baysun S,Bülbül M,Bek K,Oksal A

    更新日期:2008-01-01 00:00:00

  • Neutrophil-to-lymphocyte ratio as a predictor of worsening renal function in diabetic patients (3-year follow-up study).

    abstract:BACKGROUND:Previous studies have demonstrated the role of inflammation in diabetic nephropathy (DN). Neutrophil to lymphocyte ratio (NLR) rather than other white cell parameters was found to be a useful inflammatory marker to predict adverse outcomes in medical and surgical conditions. Nevertheless, the value of NLR in...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2012.668741

    authors: Azab B,Daoud J,Naeem FB,Nasr R,Ross J,Ghimire P,Siddiqui A,Azzi N,Rihana N,Abdallah M,Azzi N,Patel P,Kleiner M,El-Sayegh S

    更新日期:2012-01-01 00:00:00

  • Unilateral renal venous thrombosis secondary to the use of vibration belt in a young woman.

    abstract::We report on the isolated unilateral renal venous thrombosis (RVT) detected in a young patient who used vibration belt to stay thin. Apart from her sickle cell trait, the patient presented no other clinical situations associated with RVT. ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2012.712848

    authors: Balal M,Paydas S,Inal M

    更新日期:2012-01-01 00:00:00

  • Vancomycin-resistant enterococci peritonitis development after shifting from hemodialysis to peritoneal dialysis.

    abstract::Although hemodialysis (HD) patients could develop vancomycin-resistant enterococci (VRE) infection, limited studies of VRE-related peritoneal dialysis (PD) peritonitis have been reported. Here, we document a patient who developed peritonitis for the first time with VRE infection after shifting from HD to PD over 4 wee...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2010.509899

    authors: Chang CM,Liang CC,Yeh HC,Yang YF,Wang IK,Lin HH,Huang CC

    更新日期:2010-01-01 00:00:00

  • Low-dose IL-2 expands CD4+ regulatory T cells with a suppressive function in vitro via the STAT5-dependent pathway in patients with chronic kidney diseases.

    abstract:BACKGROUND:Patients with chronic kidney disease (CKD) often have CD4+ regulatory T cells (Tregs) dysfunction and chronic inflammation. We aim to investigate the effect, function, and related mechanism of low-dose IL-2 on CD4+ regulatory T cells expansion in vitro from patients with CKD. METHODS:A total of 148 newly di...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2018.1456462

    authors: Li Y,Liu X,Wang W,Wang S,Zhang J,Jiang S,Wang Y,Li L,Li J,Zhang Y,Huang H

    更新日期:2018-11-01 00:00:00

  • Evaluation of the protective effect of agmatine against cisplatin nephrotoxicity with 99mTc-DMSA renal scintigraphy and cystatin-C.

    abstract:BACKGROUND:The aim of the current study was to investigate whether agmatine (AGM) has a protective effect against cisplatin-induced nephrotoxicity. MATERIALS AND METHODS:Thirty-two rats were randomly divided into four groups: (1) Saline (control); (2) Cisplatin (CDDP; 7.5 mg/kg intraperitoneally); (3) Agmatine (AGM; 1...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2016.1227919

    authors: Salihoglu YS,Elri T,Gulle K,Can M,Aras M,Ozacmak HS,Cabuk M

    更新日期:2016-10-01 00:00:00

  • The course of hypercalciuria and related markers of bone metabolism parameters associated with corticosteroid treatment.

    abstract:BACKGROUND AND OBJECTIVE:Prolonged corticosteroid (CS) use induces osteoporosis; the pathogenesis of this condition is multifactorial and includes CS-induced hypercalciuria. We investigated the course of hypercalciuria and related markers of bone metabolism parameters during and after the CS treatment. MATERIALS AND M...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2011.648596

    authors: Duzen O,Erkoc R,Begenik H,Soyoral YU,Aldemir MN

    更新日期:2012-01-01 00:00:00

  • Postpartum acute kidney injury: a review of 99 cases.

    abstract::Postpartum acute kidney injury (PPAKI) constitutes an important cause of obstetric AKI. It is associated with high maternal and fetal mortality in developing nations. The aim of this study is to survey the etiology and outcomes of PPAKI in a tertiary care Indian hospital. Ninety-nine patients, without prior comorbidit...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2016.1164015

    authors: Eswarappa M,Madhyastha PR,Puri S,Varma V,Bhandari A,Chennabassappa G

    更新日期:2016-07-01 00:00:00

  • Bacterial colonization in hemodialysis temporary dual lumen catheters: a prospective study.

    abstract:AIMS:The use of hemodialysis temporary dual-lumen catheters is often complicated by infections, which may be a significant cause of death among patients with end stage renal disease (ESRD). The aim of this study was to assess the incidence of bacteremia and bacterial colonization related to non-tunneled, non-cuffed, du...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220701741940

    authors: de Freitas LW,Neto MM,Nascimento MM,Figueiredo JF

    更新日期:2008-01-01 00:00:00