Abstract:
BACKGROUND:The aim of this study was to evaluate whether neutrophil gelatinase-associated lipocalin (NGAL) and interleukin-18 (IL-18) predict renal disfunction in patients with familial Mediterranean fever (FMF). METHODS:This prospective study consisted of 102 patients with FMF in attack-free period, and 40 matched healthy controls. Of the patients, nine were diagnosed as amyloidosis. The patients were divided into two groups according to eGFR as below 120 mL per minute and above 120 mL per minute. Also, patients were divided into three groups according to the degree of urinary albumin excretion as normoalbuminuric, microalbuminuric, and macroalbuminuric. The serum levels of IL-18 (sIL-18) and NGAL (sNGAL), and urinary levels of IL-18 (uIL-18) and NGAL (uNGAL) were measured by using ELISA kits. RESULTS:The levels of sIL-18, sNGAL, uIL-18, and uNGAL were detected significantly higher in FMF patients, particularly in patients with amyloidosis, when compared to controls. sNGAL, uIL-18, and uNGAL were significantly higher in patients with eGFR < 120 mL per minute than in patients with eGFR ≥ 120 mL per minute. sNGAL, uIL-18, and uNGAL were correlated significantly with urinary albumin excretion, additionally, were inverse correlated with eGFR. The most remarkable findings of this study are of the higher values of sIL-18, sNGAL, uIL-18, and uNGAL in both normoalbuminuric FMF patients and patients with eGFR ≥ 120 mL per minute. CONCLUSIONS:The results of this study suggest that sIL-18, uIL-18, sNGAL, and uNGAL are reliable markers of early renal disfunction in FMF patients, and may let us take measures from the early stage of renal involvement.
journal_name
Ren Failjournal_title
Renal failureauthors
Deveci K,Korkmaz S,Senel S,Deveci H,Sancakdar E,Uslu AU,Deniz A,Alkan F,Seker MM,Sencan Mdoi
10.3109/0886022X.2013.865486subject
Has Abstractpub_date
2014-04-01 00:00:00pages
339-44issue
3eissn
0886-022Xissn
1525-6049journal_volume
36pub_type
杂志文章相关文献
RENAL FAILURE文献大全abstract:BACKGROUND:Spontaneous crescentic glomerulonephritis (SCG)/Kj mice are a candidate for suitable animal model of human pauci-immune crescentic glomerulonephritis (GN). In the present study, we used renal biopsy technique and analyzed time sequence correlations among crescent formation and glomerular neutrophil infiltrat...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-120013958
更新日期:2002-09-01 00:00:00
abstract:BACKGROUND:Besides possible bleeding complications a further problem in anticoagulation during continuous renal replacement therapy (CRRT) is the development of heparin-induced thrombocytopenia type II (HIT II) where further anticoagulation with heparin is contraindicated. The application of continuous hirudin as alter...
journal_title:Renal failure
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1081/jdi-120039529
更新日期:2004-05-01 00:00:00
abstract:BACKGROUND:Chronic heart failure (CHF) and chronic kidney disease (CKD) are serious medical conditions with significant morbidity and mortality and often coexist. Because of perioperative risks in these patients, they may not be considered a candidate for renal transplantation (RTx). MATERIAL AND METHODS:We compare re...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2014.899474
更新日期:2014-07-01 00:00:00
abstract::Cardiac dysfunction portends a poor prognosis in renal failure and vice versa. Functional abnormalities of heart in patients with renal insufficiency were frequently noted. The aim of this study is to assess the relationship between left ventricular systolic and diastolic function and renal function in patients with v...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2011.618792
更新日期:2011-01-01 00:00:00
abstract::Recently, we demonstrated that furosemide improves renal hemodynamics and attenuates ischemia/reperfusion (I/R)-associated changes in angiogenesis-related gene expression. However, the effect of furosemide on I/R-induced apoptosis is not known. We utilized a rat model of acute ischemic nephropathy to test the hypothes...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220701263671
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Contrast-induced nephropathy (CIN) is a complex syndrome of acute nephropathy that occurs following infusion of intravascular contrast agents, and is associated with an increased risk for adverse cardiovascular events. While there is no ideal biomarker for making an early diagnosis of CIN, we hypothesized th...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2015.1077322
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Patients on long-term peritoneal dialysis develop progressive peritoneal fibrosis and loss of mesothelial layer. Regeneration of the mesothelium has been reported in the normal peritoneum but not the fibrotic peritoneum. Moreover, the origin of the regenerated mesothelial cells remains obscure. The aim of th...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220701741619
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Patients with chronic kidney disease (CKD) often have CD4+ regulatory T cells (Tregs) dysfunction and chronic inflammation. We aim to investigate the effect, function, and related mechanism of low-dose IL-2 on CD4+ regulatory T cells expansion in vitro from patients with CKD. METHODS:A total of 148 newly di...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2018.1456462
更新日期:2018-11-01 00:00:00
abstract:AIM:To assess the utility of neutrophil gelatinase-associated lipocalin (NGAL) in both urine and serum as a follow-up marker for the discrimination of prerenal acute kidney injury (AKI) from intrinsic AKI in critically ill pediatric patients with established AKI at the time of patient presentation. PATIENTS AND METHOD...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2013.764273
更新日期:2013-01-01 00:00:00
abstract::Cyclosporine is used extensively in kidney transplantation and is a substrate for cytochrome P450 enzymes. The role of cytochrome p450 polymorphisms in kidney transplant outcome has not yet been fully elucidated. We investigate the clinical impact of single nucleotide polymorphisms in CYP3A4, CYP3A5, PPARα, and POR*28...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2015.1007013
更新日期:2015-05-01 00:00:00
abstract::Abstract TGF-β1 plays an important role in the pathogenesis of chronic renal diseases. Although the specific mechanism is unknown, a major factor is the potent fibrogenic activity of TGF-β1 in the chronic progression of renal diseases. TGF-β1 closely correlates with renal fibrosis in cooperation with several fibrosis-...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2014.882713
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND AND AIM:Trendelenburg positioning (TP) is a common approach used during internal jugular vein (IJV) cannulation. No evidence indicates that TP significantly increases the cross-sectional area (CSA) of the IJV or decreases the overlap between the carotid artery (CA) and the IJV in dialysis patients. The prima...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2015.1073052
更新日期:2015-01-01 00:00:00
abstract::Rhabdomyolysis ranges from an asymptomatic illness with elevated creatine kinase levels to a life-threatening condition associated with extreme elevations in creatine kinase, electrolyte imbalances, acute renal failure, and disseminated intravascular coagulation. The most common causes are crush injury, overexertion, ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2013.832856
更新日期:2014-02-01 00:00:00
abstract:INTRODUCTION:Sleep disturbances and cardiovascular autonomic dysfunction are major complications of hemodialysis (HD). The goal of this study is to identify clinical, heart rate variability (HRV) or laboratory parameters that are independently associated with subjective sleep quality. PATIENT AND METHODS:Forty-six sta...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2010.541578
更新日期:2011-01-01 00:00:00
abstract:AIM:Returning to society plays an important role in improving the quality of life in maintenance hemodialysis (MHD) patients, and retention of employment is one of the core enablers. The study is to assess the employment status and to determine the variables for unemployment in Chinese MHD patients. METHODS:Prevalent ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2017.1361834
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:To investigate the prevalence and risk factors for chronic kidney disease (CKD) among community elderly population in Shanghai, China, in order to provide early diagnosis and treatment of CKD, and improve the quality of life for elderly people. METHODS:In all, 24,886 residents (≥65 years old) were selected f...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2016.1229987
更新日期:2016-11-01 00:00:00
abstract::From unpublished experience of clinicians in the rural tropics, the combination of furosemide and dopamine is beneficial in the management of mild acute renal failure in tropical disease. We studied two groups of patients with leptospirosis and mild acute renal failure whose serum creatinine ranged from 2.4 to 5 mg/dL...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220601095850
更新日期:2007-01-01 00:00:00
abstract:AIMS:The use of hemodialysis temporary dual-lumen catheters is often complicated by infections, which may be a significant cause of death among patients with end stage renal disease (ESRD). The aim of this study was to assess the incidence of bacteremia and bacterial colonization related to non-tunneled, non-cuffed, du...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220701741940
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:This study was designed to investigate whether 3-amino benzamide (3-AB), a poly (ADP-ribose) polymerase (PARP) inhibitor, has a protective effect on kidney injury induced by renal ischemia/reperfusion (I/R) by decreasing oxidative and nitrosative stress on renal dysfunction and injury. MATERIALS AND METHO...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220902882741
更新日期:2009-01-01 00:00:00
abstract::Albumin has been considered a "sacrificial plasma antioxidant" due to the high reactivity of the protein sulfhydryl groups with oxidants such as hydrogen peroxide (H2O2) and hypochlorous acid (HOCl). Based on its large quantity and high turnover. It is considered as one of the most important plasma antioxidants for pr...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-100104738
更新日期:2001-05-01 00:00:00
abstract::We report on the isolated unilateral renal venous thrombosis (RVT) detected in a young patient who used vibration belt to stay thin. Apart from her sickle cell trait, the patient presented no other clinical situations associated with RVT. ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2012.712848
更新日期:2012-01-01 00:00:00
abstract::Although hemodialysis (HD) patients could develop vancomycin-resistant enterococci (VRE) infection, limited studies of VRE-related peritoneal dialysis (PD) peritonitis have been reported. Here, we document a patient who developed peritonitis for the first time with VRE infection after shifting from HD to PD over 4 wee...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2010.509899
更新日期:2010-01-01 00:00:00
abstract::Oxidative stress is one of the important mechanisms of cisplatin-induced nephrotoxicity. Therefore, this study was designed to explore the potential protective effects of morin and/or hesperidin on oxidative stress in cisplatin-induced nephrotoxicity. This study was performed on 42 Wistar rats. Rats were divided into ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2016.1209383
更新日期:2016-09-01 00:00:00
abstract::Diabetic nephropathy (DN) has become the most common pathogenesis of end-stage renal disease. Plasminogen activator inhibitor-1 (PAI-1) plays an important role in the pathogenesis of DN. A meta-analysis was conducted to investigate the association between 4 G/5 G variants in the PAI-1 gene and DN susceptibility. Datab...
journal_title:Renal failure
pub_type: 杂志文章,meta分析
doi:10.3109/0886022X.2013.867783
更新日期:2014-04-01 00:00:00
abstract::In vascular smooth muscle, calcium overload is a highly pathogenic event, which increases with advancing age. An increase in the calcium content of arterial wall may be produced in rats by treatment with vitamin D3. The aim of this study was to evaluate the renal clearance of sulfanilamide (a model organic anion, pref...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-120021150
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND:The kidney is one of the prior damaged organs subjected to severe infection and sepsis shock. Our previous studies have shown that the normal mesenteric lymph (NML) obtained from healthy dogs could alleviate multiple organ injuries following endotoxic shock. In the current study, we further investigated the ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2014.938585
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVES:In Taiwan, the widespread use of organophosphates (OPs) in agricultural and household environments results in numerous OP poisoning. To better understand the clinical significance of associated parameters on respiratory failure and patient outcome, we evaluate patients admitted to the Nephrology ward in our ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-120039816
更新日期:2004-07-01 00:00:00
abstract:AIM:The relation of chronic kidney disease (CKD) with metabolic, psychiatric and endocrinologic disorder is well-known. Depressive mood and sexual dysfunction are frequently observed as renal functions deteriorate. We aimed to analyze the relationship of sexual dysfunction, depressive mood and life quality in patients ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2014.990348
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:A nephrologist in the millennium offers comprehensive care to renal failure patients. Interventional nephrology plays a major role in this new approach. Overton Brooks Veterans Affairs Medical Center (OBVAMC) is the first federal health care provider in the nation offering such services. Lack of intervention...
journal_title:Renal failure
pub_type: 杂志文章,评审
doi:
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Determination of fluid overload is important in chronic kidney disease. Early diagnosis and treatment of volume overload may decrease morbidity and mortality. We aimed to determine body composition by using bioelectrical impedance analysis, and studying other clinical characteristics, inferior vena cava diam...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2013.875815
更新日期:2014-05-01 00:00:00