Regeneration of peritoneal mesothelium in a rat model of peritoneal fibrosis.


BACKGROUND:Patients on long-term peritoneal dialysis develop progressive peritoneal fibrosis and loss of mesothelial layer. Regeneration of the mesothelium has been reported in the normal peritoneum but not the fibrotic peritoneum. Moreover, the origin of the regenerated mesothelial cells remains obscure. The aim of this study was to investigate mesothelial regeneration in fibrotic peritoneum induced by chlorhexidine gluconate. METHODS:Peritoneal fibrosis was induced by injection of CG into the peritoneal cavity of Wistar rats. After injection, the abdomen was opened, and the parietal fibrotic peritoneum with mesothelial cells was stripped from the abdominal wall, and then the abdominal incision was closed. Rats were sacrificed, and peritoneal tissues were dissected out at 0, 1, 3, 5, or 7 days after the stripping procedure. RESULTS:Spindle-shaped cells with microvilli appeared on the surface of stripped peritoneum at day 3 after denudation. Immunohistochemistry identified staining for vimentin, a marker of mesoderm cells, in the spindle-shaped cells at days 3, 5, and 7. Expression of alpha-SMA was observed in the same cells at days 3 and 5, but not 7. Expression of cytokeratin and HBME-1, markers for mesothelial cells, in these cells was delayed until day 7. CONCLUSIONS:Mesothelium can regenerate on the fibrotic peritoneum. The regenerated mesothelial cells seem to originate from vimentin-positive mesenchymal cells.


Ren Fail


Renal failure


Nishioka Y,Miyazaki M,Abe K,Furusu A,Harada T,Ozono Y,Taguchi T,Koji T,Kohno S




Has Abstract


2008-01-01 00:00:00














  • Advanced glycation end products and soluble receptor as markers of oxidative stress in children on hemodialysis.

    abstract:BACKGROUND:Advanced glycation end products (AGEs) have biological properties that may contribute to the mortality of children on hemodialysis (HD). This study examines the relationship of LMW fluorescence AGEs, oxidized LDL (ox-LDL), soluble receptor AGE (sRAGE) as markers of oxidative stress in children with end stage...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: El-Saeed GS,Fadel F,Elshamaa MF,Galal RE,Elghoroury EA,Nasr SA,Thabet EH,Abdelrahman SM

    更新日期:2015-01-01 00:00:00

  • Diagnostic value of the aminopeptidase N, N-acetyl-beta-D-glucosaminidase and dipeptidylpeptidase IV in evaluating tubular dysfunction in patients with glomerulopathies.

    abstract:AIM:The aim of the present study was to investigate the value of the urine cell glycoprotein 1 (PC-1), aminopeptidase N (APN), N-acetyl-beta-D-glucosaminidase (NAGA), and dipeptidylpeptidase IV (DPP IV) in the evaluation of tubular damage in patients with primary glomerulonephritis, diabetic nephropathy, and lupus neph...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Mitic B,Lazarevic G,Vlahovic P,Rajic M,Stefanovic V

    更新日期:2008-01-01 00:00:00

  • Acute cyclosporin A renal dysfunction in dogs reversed by calcium antagonists and antiplatelet agents.

    abstract::The aim of this study was to assess the effect of nifedipine and piracetam alone or in combination in the protection of renal function and morphology after cyclosporin A (CyA) administration. Thirty healthy mongrel dogs with a mean body weight of 15 kg were sacrificed. Six animals (group C) were given CyA 20 mg/kg bod...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Grekas D,Alivanis P,Kalekou H,Papayianni K,Karamouzis M,Tourkantonis A

    更新日期:1992-01-01 00:00:00

  • Test of the recommended dialysis dose on one-year mortality of nondiabetic maintenance hemodialysis patients; observations from a single dialysis unit.

    abstract:BACKGROUND:The optimal delivered dialysis dose has been of a great interest for the last three decades, though a clear cut point has not been reached yet. We aimed to evaluate the relationship between one-year mortality and the delivered dialysis dose, which was recommended by Kidney Disease Outcomes Quality Initiative...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Sahutoglu T,Kara E,Ahbap E,Sakaci T,Koc Y,Basturk T,Sevinc M,Akgol C,Ucar ZA,Ozdemir Kayalar A,Caglayan FB,Unsal A

    更新日期:2016-09-01 00:00:00

  • Neutrophil-lymphocyte ratio predicts cardiovascular and all-cause mortality in hemodialysis patients.

    abstract::Neutrophil-lymphocyte ratio (NLR) is a marker of systemic inflammation that has been shown to predict mortality in patients with malignancies, ischemic heart disease and peripheral vascular disease. Its prognostic value in hemodialysis patients is unclear. The aims of this study were to: (i) explore the relationship b...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Neuen BL,Leather N,Greenwood AM,Gunnarsson R,Cho Y,Mantha ML

    更新日期:2016-01-01 00:00:00

  • Exercise-induced changes in renal URAT1 activity and expression in rats.

    abstract::During exercise, the plasma urate levels and urinary excretion increase due to the enhanced purine degradation in skeletal muscle. Although urate transporter-1 (URAT1) is the main transporter responsible for the reabsorption of filtered urate, potential changes in its activity and expression during exercise have not b...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Cirrik S,Yavuzer BU,Oner G

    更新日期:2010-01-01 00:00:00

  • Hemodynamic maladjustment and disease progression in nephrosis with FSGS.

    abstract::Idiopathic nephrotic syndrome (NS) associated with focal segmental glomerulosclerosis (FSGS) and severe renal function impairment is usually refractory to the conventional treatment and progresses to end-stage renal disease. Herein, we reported 10 patients with NS-FSGS who had initially had CCr 34 +/- 12 mL/min/1.73 m...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Futrakul N,Siriviriyakul P,Deekajorndej T,Futrakul P

    更新日期:2004-05-01 00:00:00

  • Indwelling hemodialysis catheterization by transthoracic way.

    abstract::Chronic kidney failure can be described as a chronic and progressive disfunction in metabolic-endocrine function and in adjustment of fluid-electrolyte balance of kidney, as a result of reducing of glomerular filtration value. Besides being a medical issue, chronic kidney failure affects social, economic, and psycholo...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Yildiz Z,Tort M,Çalik ES,Arslan Ü,Kaygin MA

    更新日期:2015-04-01 00:00:00

  • Protective effect of N-benzoyl-beta-alanine against cisplatin nephrotoxicity in rats.

    abstract::Prophylactic effects of N-benzoyl-beta-alanine (betamipron, BP), one of a series of N-acyl amino acids, were examined against cisplatin-induced nephrotoxicity. Male Wistar rats were injected i.p. with 6 mg/kg of cisplatin combined with an i.p. BP dose given at various times and various doses. Rats were sacrificed 5 da...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Tokunaga J,Kobayashi M,Nakamura C,Kitagawa A,Arimori K,Nakano M

    更新日期:1996-03-01 00:00:00

  • Nutritional status in stage V dialyzed patient versus CKD patient on conservative therapy across different economic status.

    abstract:BACKGROUND:This aim of this multi-centric cross-sectional study was to assess the nutritional status in Indian chronic kidney disease (CKD) patients and to compare the nutritional indicators between stage 5 dialyzed (CKD-D) patients below the poverty line (BPL), and stage 3-4 non-dialyzed (CKD-ND) patients above (APL) ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Vijayan M,Abraham G,Alex ME,Vijayshree N,Reddy Y,Fernando E,Mathew M,Nair S,Yuvaraj A

    更新日期:2014-04-01 00:00:00

  • Specific alterations in gut microbiota in patients with chronic kidney disease: an updated systematic review.

    abstract:BACKGROUND:Emerging evidence demonstrates that gut dysbiosis is implicated in the pathogenesis of chronic kidney disease (CKD) with underlying mechanisms involving mucosal and/or systematic immunity or metabolic disorders. However, the profile of gut microbiota in patients with CKD has not been completely explored. ME...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Zhao J,Ning X,Liu B,Dong R,Bai M,Sun S

    更新日期:2021-12-01 00:00:00

  • Syndrome of rapid onset ESRD accounted for high hemodialysis catheter use--results of a 13-year Mayo Clinic incident hemodialysis study.

    abstract:BACKGROUND:The syndrome of rapid onset end-stage renal disease (SORO-ESRD) was first described in the journal Renal Failure in 2010. This is an acute precipitate unpredictable yet irreversible ESRD following acute kidney injury (AKI), as distinct from "classic" ESRD where chronic kidney disease (CKD)-ESRD progression w...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Onuigbo M,Agbasi N

    更新日期:2015-01-01 00:00:00

  • Renal proximal tubule cell cultures for studying drug-induced nephrotoxicity and modulation of phenotype expression by medium components.

    abstract::The characteristics of two established renal cell lines (LLC-PKI and OK) and of primary cultures of rabbit and human proximal tubule cells are described by summarizing the literature about specific properties retained by these cells in culture. Furthermore, comparative biochemical and functional properties are present...

    journal_title:Renal failure

    pub_type: 杂志文章,评审


    authors: Toutain H,Morin JP

    更新日期:1992-01-01 00:00:00

  • Normal mesenteric lymph ameliorates acute kidney injury following lipopolysaccharide challenge in mice.

    abstract:BACKGROUND:The kidney is one of the prior damaged organs subjected to severe infection and sepsis shock. Our previous studies have shown that the normal mesenteric lymph (NML) obtained from healthy dogs could alleviate multiple organ injuries following endotoxic shock. In the current study, we further investigated the ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Zhao ZG,Zhang LM,Song W,Du HB,Cui H,Niu CY

    更新日期:2014-09-01 00:00:00

  • Current evidence on the use of anti-RAAS agents in congenital or acquired solitary kidney.

    abstract:RATIONAL:The inhibition of renin-angiotensin-aldosterone system (RAAS) is a major strategy for slowing the progression of chronic kidney disease (CKD). The utility of anti-RAAS agents in patients with congenital or acquired solitary kidney is still controversial. OBJECTIVE:A systematic literature review was conducted....

    journal_title:Renal failure

    pub_type: 杂志文章,评审


    authors: Simeoni M,Armeni A,Summaria C,Cerantonio A,Fuiano G

    更新日期:2017-11-01 00:00:00

  • Effect of arachidonic acid metabolic inhibitors on hypoxia/reoxygenation-induced renal cell injury.

    abstract::The present study was undertaken to examine the role of arachidonic acid (AA) metabolites in hypoxia/reoxygenation (H/R)-induced renal cell injury in rabbit renal cortical slices using AA metabolic inhibitors. Inhibitors of cyclooxygenase (indomethacin and diclofenac sodium) and lipoxygenase pathways (nordihydroguaiar...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Kim YK,Hwang MY,Woo JS,Jung JS,Lee SH

    更新日期:2000-03-01 00:00:00

  • Paradoxical body and kidney growth in potassium deficiency.

    abstract::In the growing animal, K deficiency (KD) retards body growth, but paradoxically stimulates renal growth. If KD persists, interstitial infiltrates appear and eventually tubulointerstitial fibrosis develops. In patients with chronic KD, renal cysts may form and with time tubulointerstitial disease with renal failure dev...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Fervenza F,Tsao T,Rabkin R

    更新日期:2001-05-01 00:00:00

  • Urinary transforming growth factor-beta1 excretion in renal allograft recipients during the early post-transplantation period.

    abstract:BACKGROUND:Transforming growth factor-beta1 (TGF-beta1), the major fibrogenic growth factor, is implicated in the pathogenesis of renal scarring in experimental and clinical nephropathies as well as in chronic allograft nephropathy. In this study we examined the pattern of changes of TGF-beta1 excretion in the urine an...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Goumenos DS,Tsakas S,Karavias D,Savidaki I,Karatzas T,Vlachojannis JG

    更新日期:2003-07-01 00:00:00

  • The predictive value of 131I-hippurate clearance in the prognosis of acute renal failure.

    abstract::The aim of this investigation was to study the validity of the radionuclide methods in the estimation of kidney function, for prognosis and follow-up of acute renal failure (ARF). In thirty-one ARF patients, the evaluation of glomerular filtration rate (GFR) by 99mTc-DTPA clearance and effective renal plasma flow (ERP...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Ilic S,Rajic M,Vlajkovic M,Bogicevic M,Stefanovic V

    更新日期:2000-01-01 00:00:00

  • Influenza vaccination in chronic hemodialysis patients. The effect of zinc supplementation.

    abstract::Since influenza increases the mortality of chronically ill patients we decided to study the effectiveness of influenza vaccination in hemodialysis (HD) patients. Nineteen HD patients aged from 20 to 60 years, on unrestricted diet and with no febrile episode, were studied. Blood samples were collected before the intram...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Grekas D,Alivanis P,Kotzadamis N,Kiriazopoulou V,Pyrpasopoulos M,Tourkantonis A

    更新日期:1992-01-01 00:00:00

  • The differences of asymmetric dimethylarginine removal by different dialysis treatments.

    abstract:BACKGROUND:Asymmetric dimethylarginine (ADMA) as a uremia toxin is accumulated in end-stage renal disease (ESRD) patients. Elevated ADMA level has been shown to be predictive of cardiovascular diseases (CVDs) and all-cause mortality in ESRD. Therefore, we investigated the removal of ADMA by different dialysis treatment...

    journal_title:Renal failure

    pub_type: 杂志文章,随机对照试验


    authors: Zhang DL,Liu J,Liu S,Zhang Y,Liu WH

    更新日期:2010-01-01 00:00:00

  • Effects of a stroma-free hemoglobin and perfluorochemical combination on ultrastructure and function of the isolated rat kidney.

    abstract::Experimental perfusions of isolated rat kidneys were performed with flow rates adjusted to produce comparable glomerular filtration rates (GFR) in control and experimental groups. The experimental perfusate, consisting of Krebs-Ringer bicarbonate (KRB) containing 3.5% (uncrosslinked) stroma-free hemoglobin (SFH) plus ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Millis RM,Barber JD,Anderson WA,Dehkordi O

    更新日期:1995-11-01 00:00:00

  • Role of serotonin in the regulation of renal proximal tubular epithelial cells.

    abstract::In various renal injuries, tissue damage occurs and platelet activation is observed. Recent studies suggest that some factors, such as serotonin, are released into microenvironment upon platelet activation following renal injury. In the present study, we aimed to investigate whether platelets and platelet-released ser...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Erikci A,Ucar G,Yabanoglu-Ciftci S

    更新日期:2016-08-01 00:00:00

  • Familial Mediterranean fever and membranous glomerulonephritis: report of a case.

    abstract::Familial Mediterranean fever (FMF) is an autosomal recessive genetic disease characterized by recurrent attacks of fever and painful episodes of sterile polyserositis. Kidney involvement may occur as a result of secondary amyloidosis during the course of FMF. Previously, different types of glomerulopathies such as IgM...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Ceri M,Unverdi S,Altay M,Unverdi H,Ensari A,Duranay M

    更新日期:2010-01-01 00:00:00

  • Acute ischemic renal failure: review of experimental studies on pathophysiology and potential protective interventions.

    abstract::More than 70% of acute renal failure in man is of circulatory nature and results from hypoxic injury to the kidney. Since intrarenal hemodynamic and metabolic events cannot be accurately assessed in human acute renal failure, various experimental models of renal hypoperfusion or complete interruption of renal blood su...

    journal_title:Renal failure

    pub_type: 杂志文章,评审


    authors: Mohaupt M,Kramer HJ

    更新日期:1989-01-01 00:00:00

  • A biotechnological T-shirt monitors the patient's heart during hemodialysis.

    abstract::Uremic patients are characterized by a "pro-arrhythmic substrate." Arrhythmia appearance during hemodialysis (HD) is an unexpected event with a high incidence of mortality and morbidity and difficult to record in patients repeatedly checked using electrocardiogram (ECG). Furthermore the carrying out of this important ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Lacquaniti A,Donato V,Lucisano S,Buemi A,Buemi M

    更新日期:2012-01-01 00:00:00

  • Effect of hormone replacement therapy on CD4+ and CD8+ numbers, CD4+/CD8+ ratio, and immunoglobulin levels in hemodialysis patients.

    abstract::Uremia induces a suppression of the immune status. A large clinical literature suggests that estradiol (E2) plays a critical role in immune function. A large proportion of women hemodialysis patients faced early menopause and inadequate estrogen levels. The aim of the present study is to evaluate the effect of hormone...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Dogan E,Erkoc R,Demir C,Sayarlioglu H,Dilek I,Sayarlioglu M

    更新日期:2005-01-01 00:00:00

  • Serological and molecular survey of toxoplasmosis in renal transplant recipients and hemodialysis patients in Kashan and Qom regions, central Iran.

    abstract::Toxoplasma gondii is one of the important opportunistic pathogen among solid-organ transplant recipients and hemodialysis patients (HD). This study was aimed to detect toxoplasmosis among 50 renal transplant recipients (RTR), 135 HD and 120 healthy individuals in two cities (Kashan and Qom) that located in the center ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Rasti S,Hassanzadeh M,Soliemani A,Hooshyar H,Mousavi SG,Nikoueinejad H,Abdoli A

    更新日期:2016-07-01 00:00:00

  • Ten years' experience in subtotal parathyroidectomy of hemodialysis patients.

    abstract::Secondary hyperparathyroidism (SHP) is a frequent complication of long-term dialysis patients, and surgical parathyroidectomy remains necessary in patients resistant to medical therapy. The present paper reports single center results in subtotal parathyroidectomy, presenting diagnostic procedure, indications for parat...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Jovanovic DB,Pejanovic S,Vukovic L,Djukanovic L,Jankovic R,Kalezic N,Paunovic I,Zivaljevic V

    更新日期:2005-01-01 00:00:00

  • Classic heat stroke in a case of simple hypohydrosis with "bad prognostic indicators" but a remarkable recovery.

    abstract::Heat stroke occurs in the desert area of Saudi Arabia quite frequently and manifest in different patterns including coagulopathy. Frequently encountered complications include renal or hepatic failure, rhabdomyolysis, acute respiratory distress syndrome (ARDS), disseminated intravascular coagulation (DIC), and seizure....

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Sinha AK,Ghacha R,Youmbissi JT,Khursany IA

    更新日期:2001-09-01 00:00:00