Elevated plasma levels of PAI-1 predict cardiovascular events and cardiovascular mortality in prevalent peritoneal dialysis patients.

Abstract:

BACKGROUND:Elevated plasminogen activator inhibitor-1 (PAI-1) levels are associated with increased cardiovascular (CV) risk in the general population. It has been shown that peritoneal dialysis (PD) patients have increased plasma levels of PAI-1. The aim of this study was to investigate whether PAI-1 independently predicted CV outcome in PD patients. MATERIAL AND METHODS:Seventy-two PD patients (53% females, mean age 49.9 +/- 16.1 years) were studied. Twelve patients who underwent kidney transplantation and 14 patients who transferred to hemodialysis during follow-up were excluded from the analysis. The remaining 46 patients (54% female, mean age 54 +/- 16 years, dialytic age 42 +/- 30 months) were followed a mean time of 45.4 +/- 19.4 months (range 8-71 months). Baseline PAI-1, clinical, and laboratory parameters were assessed in all patients. Survival analyses were made with Kaplan-Meier and Cox regression analysis, with all-cause mortality and CV mortality and CV events (CVEs) as clinical end points. RESULTS:During the follow-up, 29 patients died (17 from CV causes), and 28 fatal and non-fatal CVEs were recorded. The patients were divided according to plasma PAI-1 levels (i.e., 41 ng/mL). The significant independent predictors of all-cause of mortality were age (60 years; p = 0.018), CRP (5 mg/L; p = 0.015), and serum albumin (<3.5 g/L; p = 0.011). Multivariable Cox regression analysis showed that plasma PAI-1 41 ng/mL was independently predictive of higher CV mortality (p = 0.021) and CVEs (p = 0.001). The only other independent predictor of CV mortality was only CRP (5 mg/L; p = 0.008). CONCLUSIONS:Plasma levels of PAI-1 41 ng/mL is a significant predictor of CV mortality and CVEs in PD patients.

journal_name

Ren Fail

journal_title

Renal failure

authors

Arikan H,Koc M,Tuglular S,Ozener C,Akoglu E

doi

10.1080/08860220902963772

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

438-45

issue

6

eissn

0886-022X

issn

1525-6049

pii

10.1080/08860220902963772

journal_volume

31

pub_type

杂志文章
  • Novel lncRNA XLOC_032768 protects against renal tubular epithelial cells apoptosis in renal ischemia-reperfusion injury by regulating FNDC3B/TGF-β1.

    abstract::Renal ischemia-reperfusion injury is a leading cause of acute kidney injury, but its underlying mechanism remains poorly understood and effective therapies are still lacking. Here, we identified lncRNA XLOC_032768 as a novel target in renal ischemia-reperfusion injury by analyzing differentially expressed genes of the...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2020.1818579

    authors: Zhou X,Li Y,Wu C,Yu W,Cheng F

    更新日期:2020-11-01 00:00:00

  • Ureteral anastomosis with a polyimide stent in rat kidney transplantation.

    abstract::Background: Complications associated with ureteral anastomosis in kidney transplantation are highly prevalent, despite the development of various types of stents. The current stent materials and placement methods have several limitations. This study attempts to provide an alternative by investigating ureteral anastomo...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2020.1726386

    authors: Wang T,Yu Z,Chen C,Song Y,Zeng X,Su Y,Yi C

    更新日期:2020-11-01 00:00:00

  • Acute renal failure due to acute rhabdomyolysis precipitated by MAST trousers and diflunisal.

    abstract::This report describes a patient who developed acute rhabdomyolysis and acute renal failure following the application of MAST trousers associated with an overdose of diflunisal. This association has not previously been reported. ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229309069415

    authors: Pilmore H,Walker RJ

    更新日期:1993-01-01 00:00:00

  • Interleukin-22 attenuates renal tubular cells inflammation and fibrosis induced by TGF-β1 through Notch1 signaling pathway.

    abstract::Transforming growth factor-β1 (TGF-β1) is a crucial factor implicated in the development of renal inflammation and tubulointerstitial fibrosis (TIF). The cytokine interleukin 22 (IL-22) was previously reported to involve in the pathogenesis of chronic inflammatory diseases, however recent studies showed that IL-22 cou...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2020.1753538

    authors: Tang R,Xiao X,Lu Y,Li H,Zhou Q,Kwadwo Nuro-Gyina P,Li X

    更新日期:2020-11-01 00:00:00

  • Reversible renal failure due to bilateral renal sarcoma in a patient with acute myeloid leukemia.

    abstract::A 68-year-old male presented with acute myeloid leukemia, renal failure, hypokalemia, and enlarged kidneys on renal ultrasound. Renal biopsy revealed massive leukemic infiltration of the kidney. After systemic chemotherapy, the patient developed tumor lysis syndrome followed by a phase of proximal tubule dysfunction p...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220902972187

    authors: Rüger W,Kruip MJ,Betjes MG

    更新日期:2009-01-01 00:00:00

  • Frequency, types, and direct related costs of medication errors in an academic nephrology ward in Iran.

    abstract::Medication errors are ongoing problems among hospitalized patients especially those with multiple co-morbidities and polypharmacy such as patients with renal diseases. This study evaluated the frequency, types and direct related cost of medication errors in nephrology ward and the role played by clinical pharmacists. ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2014.934650

    authors: Gharekhani A,Kanani N,Khalili H,Dashti-Khavidaki S

    更新日期:2014-09-01 00:00:00

  • Infectious complications of prosthetic arteriovenous grafts for hemodialysis: prevention is better than cure.

    abstract::Synthetic arteriovenous grafts for hemodialysis constitute the second choice in comparison with native arteriovenous fistulas. Lower patency rates and significantly more frequent infections are the main disadvantages of hemodialysis grafts over fistulas. Infectious complications could vary between a simple local eryth...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2014.883910

    authors: Galanopoulos G,Lambidis C

    更新日期:2014-05-01 00:00:00

  • Valvular calcification and left ventricular modifying in peritoneal dialysis patients.

    abstract:BACKGROUND:Cardiac valve calcification (CVC) and left ventricular (LV) alterations are frequent complication in end-stage renal disease (ESRD). We determined the prevalence of CVC and LV hypertrophy (LVH) in ESRD patients before renal replacement therapy and 12 months after peritoneal dialysis (PD). METHODS:A prospect...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2015.1073495

    authors: Rebić D,Rašić S,Hamzić-Mehmedbašić A,Džemidžić J,Kurtalić E

    更新日期:2015-01-01 00:00:00

  • Inhibition to DRP1 translocation can mitigate p38 MAPK-signaling pathway activation in GMC induced by hyperglycemia.

    abstract::Diabetic nephropathy (DN) is a serious complication of diabetes with a poorly defined etiology and limited treatment options. Early intervention is a key to preventing the progression of DN. Dynamin-related protein 1 (DRP1) regulates mitochondrial morphology by promoting its fission and is involved in the pathogenesis...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2015.1034607

    authors: Zhang L,Ji L,Tang X,Chen X,Li Z,Mi X,Yang L

    更新日期:2015-06-01 00:00:00

  • Causes and prognosis of nontraumatic acute renal failure requiring dialysis in adult patients with and without diabetes.

    abstract::Despite advanced techniques of renal replacement therapy the overall mortality of patients with ARF is still high. The majority of patients with ARF requiring dialysis are those with nontraumatic ARF. In a retrospective study we compared the causes of nontraumatic ARF, the risk factors for the development of renal fai...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-120028542

    authors: Schmekal B,Pichler R,Biesenbach G

    更新日期:2004-01-01 00:00:00

  • Acute renal failure in leptospirosis in Uruguay.

    abstract::The present study was carried out to describe epidemiology and clinical pattern of acute renal failure caused by leptospirosis in Uruguay. For these purposes, all literature published in Uruguay was reviewed. Three studies were analyzed: 2 series of patients and 1 case report that summarize 26 cases. The incidence of ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229709026295

    authors: Lombardi R

    更新日期:1997-03-01 00:00:00

  • Malnutrition in the elderly patient on dialysis.

    abstract::Approximately one-third of all dialysis patients have mild to moderate malnutrition, while 6-8% have severe malnutrition, which is associated with increased morbidity and mortality rates and numerous pre-existing factors directly correlated with, or existing prior to, replacement hemodialysis. However, moderate to sev...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:10.1080/08860220802669891

    authors: Lacquaniti A,Bolignano D,Campo S,Perrone C,Donato V,Fazio MR,Buemi A,Sturiale A,Buemi M

    更新日期:2009-01-01 00:00:00

  • Update on role of direct renin inhibitor in diabetic kidney disease.

    abstract:BACKGROUND:Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease (ESRD). Renin-angiotensin-aldosterone system (RAAS) plays a critical role in the development of DKD with angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) being the mainstay of treatment. System...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:10.3109/0886022X.2014.900425

    authors: Dhakarwal P,Agrawal V,Kumar A,Goli KM,Agrawal V

    更新日期:2014-07-01 00:00:00

  • Predictors of mortality in acute renal failure in a developing country: a prospective study.

    abstract::Acute renal failure (ARF) occurs in wide range of conditions, making the evaluation of its prognosis a difficult task. Data regarding prognostic factors in ARF in a general population in developing countries are scarce. The objective of the study was to describe predictors of mortality in ARF that are relevant in the ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220701260651

    authors: Kohli HS,Bhat A,Jairam A,Aravindan AN,Sud K,Jha V,Gupta KL,Sakhuja V

    更新日期:2007-01-01 00:00:00

  • New options in the treatment of autosomal dominant polycystic kidney disease.

    abstract::Autosomal dominant polycystic disease (ADPKD) is one of the most common monogenic disorders, and globally is among the most common hereditary causes of end stage kidney disease. Until recently, the causes of this disease remained obscure. However, in the past decade there have been enormous advances in the understandi...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:10.3109/0886022X.2015.1013404

    authors: Kazancioglu R,Gursu M

    更新日期:2015-05-01 00:00:00

  • High mobility group box 1 and tumor growth factor β: useful biomarkers in pediatric patients receiving peritoneal dialysis.

    abstract:BACKGROUND:Peritonitis, the most important limitation of peritoneal dialysis (PD), could be detected by biomarkers in dialysate effluent, representing a noninvasive method to indirectly assess the peritoneum status. The aim of our study was to test high mobility group box 1 (HMGB1) in PD patients, evaluating its role a...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2016.1216711

    authors: Chimenz R,Lacquaniti A,Colavita L,Chirico V,Fede C,Buemi M,Fede C

    更新日期:2016-10-01 00:00:00

  • A case of idiopathic granulomatous interstitial nephritis with an unusually large granuloma.

    abstract::Granulomatous interstitial nephritis (GIN) is a rare disease. Contributing factors such as drugs, sarcoidosis, infections, and paraproteinemia have been reported, and when no obvious contributing factors can be identified, the disease is classified as idiopathic GIN. We managed a patient with idiopathic GIN with an un...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860220903391218

    authors: Kim SJ,Hee Sung S

    更新日期:2010-01-01 00:00:00

  • Ten years' experience in subtotal parathyroidectomy of hemodialysis patients.

    abstract::Secondary hyperparathyroidism (SHP) is a frequent complication of long-term dialysis patients, and surgical parathyroidectomy remains necessary in patients resistant to medical therapy. The present paper reports single center results in subtotal parathyroidectomy, presenting diagnostic procedure, indications for parat...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:

    authors: Jovanovic DB,Pejanovic S,Vukovic L,Djukanovic L,Jankovic R,Kalezic N,Paunovic I,Zivaljevic V

    更新日期:2005-01-01 00:00:00

  • Efficacy of adefovir dipivoxil combined with a corticosteroid in 38 cases of nephrotic syndrome induced by hepatitis B virus-associated glomerulonephritis.

    abstract:OBJECTIVE:To investigate the treatment efficacy of adefovir dipivoxil combined with a corticosteroid on hepatitis B virus-associated glomerulonephritis (HBV-GN). METHODS:A total of 38 patients with nephrotic syndrome induced by HBV-GN were treated for 36 weeks between 2010 and 2012. RESULTS:The efficacy analysis show...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2014.952745

    authors: Li H,Yuan X,Qiu L,Zhou Q,Xiao P

    更新日期:2014-10-01 00:00:00

  • Differential susceptibility to gentamicin toxicity within the proximal convoluted tubule.

    abstract::The proximal convoluted tubule (PCT) is the major target for injury in gentamicin nephrotoxicity but the necrosis is often patchy and focal. The PCT is structurally, functionally, and metabolically heterogeneous, and the possibility of differential vulnerability to gentamicin-induced necrosis based on this heterogenei...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229009087122

    authors: Shanley PF,Burke TJ

    更新日期:1990-01-01 00:00:00

  • Isolation, characterization, and evaluation of metallothionein in renal transplant patients.

    abstract::The plasma metallothionein concentration was studied in renal transplant patients. These patients are submitted to an attack of free radicals catalyzed by metals such as copper, zinc, cadmium, and others. The function of metallothionein is to bind toxic metals inhibiting the attack of free radicals and oxidative stres...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-120024287

    authors: Martín Mateo MC,Herreros C,Melero R,Bustamante J

    更新日期:2003-09-01 00:00:00

  • Continuous arteriovenous hemodiafiltration in the acute treatment of hyperammonaemia due to ornithine transcarbamylase deficiency.

    abstract:BACKGROUND:Acute hyperammonemia caused by urea cycle disorder is a medical emergency for which immediate managements should be taken to minimize permanent brain damage. Among different enzyme defects, ornithine transcarbamylase deficiency (OTC) is one of the most common enzyme defect in urea cycle disorders. We utilize...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-100101968

    authors: Chen CY,Chen YC,Fang JT,Huang CC

    更新日期:2000-11-01 00:00:00

  • Modification of the Schwartz equations for children increases their accuracy at eGFR > 60 mL/min/1.73 m(2).

    abstract:AIM:Estimation of eGFR in children with normal kidney function using the Schwartz equations results in underestimating real GFR. MATERIALS AND METHODS:We propose modification of three Schwartz equations - two based on creatinine concentration (eGFRScrBS bedside) and (eGFRScr) and one 3-marker based on creatinine, urea...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2016.1163152

    authors: Zachwieja K,Korohoda P,Kwinta-Rybicka J,Miklaszewska M,Moczulska A,Bugajska J,Berska J,Drożdż D,Pietrzyk JA

    更新日期:2016-06-01 00:00:00

  • Assessment of protein nitrogen appearance in Chinese peritoneal dialysis patients-which method to use?

    abstract:OBJECTIVE:We compared the Bergstrom's and Randerson's formula for PNA determination, and compared the normalization of PNA by ideal body weight (IBW) and standard body weight (SBW) as estimated by the Watson's formula. METHODS. We studied 208 Chinese PD patients. Two 24-h dialysate and urine collections were performed ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-120018724

    authors: Szeto CC,Chow KM,Leung CB,Wong TY,Li PK

    更新日期:2003-03-01 00:00:00

  • Resolving erythrocytosis and hypertension after open surgical extirpation of giant renal cyst measuring 30 cm: case report.

    abstract::The case of giant renal cyst measuring 30 cm, accompanied by abdominal swelling and erythrocytosis, is presented. A 45-year-old male presented with large abdominal mass, atrophic left kidney, hypertension, and erythrocytosis. The patient underwent multiple preoperative phlebotomies, open extirpation of the cyst, and n...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2011.552148

    authors: Pejcic T,Hadzi-Djokic J,Markovic B,Naumovic R

    更新日期:2011-01-01 00:00:00

  • The protective effect and mechanism of rapamycin in the rat model of IgA nephropathy.

    abstract:BACKGROUND:The pathogenesis of the development of IgA nephropathy has not been clear up to now. At present, some studies revealed that the mTOR pathway may participate in IgA nephropathy; however, the mechanism has not been systematically studied. In this study, we established an IgAN rat model to investigate the prote...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2019.1577257

    authors: Guo N,Liu S,Bow LM,Cui X,Zhang L,Xu S,Lu S,Tian J

    更新日期:2019-11-01 00:00:00

  • Predictive value of bedside effective renal plasma flow for renal recovery in severe acute renal failure.

    abstract::Single injection, single blood sample, effective renal plasma flow (ERPF) estimated by 131I-orthoiodohippurate can be performed accurately and conveniently without urine collection at the bedside. The purpose of this study was to determine if ERPF early in the course of severe acute renal failure (ARF) predicts recove...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860228709056321

    authors: Holland MD,Galla JH,Dubovsky EV,Luke RG

    更新日期:1987-01-01 00:00:00

  • 3-aminobenzamide, a poly ADP ribose polymerase inhibitor, attenuates renal ischemia/reperfusion injury.

    abstract:INTRODUCTION:This study was designed to investigate whether 3-amino benzamide (3-AB), a poly (ADP-ribose) polymerase (PARP) inhibitor, has a protective effect on kidney injury induced by renal ischemia/reperfusion (I/R) by decreasing oxidative and nitrosative stress on renal dysfunction and injury. MATERIALS AND METHO...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220902882741

    authors: Oztas E,Guven A,Turk E,Uysal B,Akgul EO,Cayci T,Ersoz N,Korkmaz A

    更新日期:2009-01-01 00:00:00

  • Two novel mutations affecting the same splice site of PKD1 correlate with different phenotypes in ADPKD.

    abstract::Genetic heterogeneity is the main factor for significant variation in the course of autosomal dominant polycystic kidney disease (ADPKD). PKD1 patients have more severe renal outcomes compared with PKD2 patients. Co-inheritance of a mutation in both genes is associated with more severe phenotypes than that found with ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2014.890010

    authors: Yu C,Li J,Yuan Z,Liu S,Zou L

    更新日期:2014-06-01 00:00:00

  • Early detection of acute tubular injury with diffusion-weighted magnetic resonance imaging in a rat model of myohemoglobinuric acute renal failure.

    abstract::We evaluated the feasibility of magnetic resonance imaging (MRI) for early detection of tubular injury by monitoring changes in the apparent diffusion coefficient (ADC) of renal water in a rat model of myohemoglobinuric glycerol-induced acute renal failure (ARF). Diffusion-weighted MRI was performed concurrently with ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229609052773

    authors: Vexler VS,Roberts TP,Rosenau W

    更新日期:1996-01-01 00:00:00