Abstract:
AIM:Estimation of eGFR in children with normal kidney function using the Schwartz equations results in underestimating real GFR. MATERIALS AND METHODS:We propose modification of three Schwartz equations - two based on creatinine concentration (eGFRScrBS bedside) and (eGFRScr) and one 3-marker based on creatinine, urea and cystatin C concentrations (eGFRS3M). The iohexol test (reference method) was performed 417 times in 353 children >2 years with mean GFR: 98 ± 31.6 ml/min/1.73m(2). The assessment included also the Filler and Zappitelli equations. The modification was performed using methods: (1) based on equation, eGFRcor = a [eGFR - T] + T, where T = 50, if eGFR > T, and a equals for: eGFRScrBS 1.4043, for eGFRScr 2.0048, for eGFRS3M 1.2951, and (2) based on correction of all coefficients of the original equation. RESULTS:For comparison of all the results and for children with GFR< 60, 60-90, 90-135 and > 135 ml/min/1.73m(2) the correlation coefficient, relative error (RE) and root mean square relative error (RMSRE) was employed and revealed improvement of RE from 25.9 to 6.8 and 3.9% (depending on the correction method) for eGFRScr; from 19 to 8.1 and 3.9% for eGFRScrBS and: from 11.6% to 2.0 and 2.3% for eGFRS3M (respectively). The RMSRE values changed from 30 to 21.3 and 19.8% for eGFRScr, from 25.1 to 21.6 and 19.8% for eGFRScrBS and from 19.1 to 15.8 and 15.3 % for eGFRS3M. CONCLUSIONS:Modifications of Schwartz equations at GFR > 60 ml/min/1.73m(2) significantly improves the accuracy of calculating eGFR. The 3-markers equation is more accurate and should be employed frequently.
journal_name
Ren Failjournal_title
Renal failureauthors
Zachwieja K,Korohoda P,Kwinta-Rybicka J,Miklaszewska M,Moczulska A,Bugajska J,Berska J,Drożdż D,Pietrzyk JAdoi
10.3109/0886022X.2016.1163152subject
Has Abstractpub_date
2016-06-01 00:00:00pages
787-98issue
5eissn
0886-022Xissn
1525-6049journal_volume
38pub_type
杂志文章相关文献
RENAL FAILURE文献大全abstract::Studies were performed to reexamine the response of erythropoietin (Epo) production to acute hypoxic stimuli in patients with end-stage renal disease (ESRD). In the absence of acute bleeding or hypoxia, the serum Epo level in ESRD was similar to that of normal subjects despite severe anemia. In 11 dialysis patients wi...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229409044892
更新日期:1994-01-01 00:00:00
abstract::Insidious progressive renal damage caused by type 1 diabetes mellitus (T1DM) begins in childhood before it becomes manifest in adult ages. Heat shock proteins (HSPs) regulate the cell response to any hazardous factors to prevent cell structure. The aim of the study is to determine whether urine levels of HSPs increase...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2015.1136893
更新日期:2016-01-01 00:00:00
abstract::At least 372 people developed crush syndrome after they were injured by the Great Hanshin-Awaji Earthquake. Of these, 23 were transferred to Osaka City General Hospital from the disaster area. The serum creatinine kinase (CK) of each of the 23 patients exceeded 10,000 IU/L. Sixteen of these patients were treated with ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229709109037
更新日期:1997-09-01 00:00:00
abstract:BACKGROUND:The complement system has been recently proposed to play an important role in the pathogenesis of ANCA-associated vasculitis (AAV). This study evaluated the value of serum and kidney deposited C3 in predicting renal outcomes in AAV. METHODS:This was a retrospective study of 47 patients with AAV, who were ca...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2020.1803086
更新日期:2020-11-01 00:00:00
abstract::Iron accumulates within proximal tubular lysosomes in several models of renal disease and may play a role in the progression of proteinuric chronic renal disease by the generation of reactive oxygen species. In this study, tubular iron was examined at an ultrastructural level by energy dispersive x-ray spectrometry in...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229409044877
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:The goal of this study was to define the clinical and histological differences in new-onset IgA nephropathy between young adults and the elderly. METHODS:We retrospectively examined renal biopsy findings, clinical features at presentation and outcomes in 82 young adults (mean age 30.3+/-10.2 years) and 17 e...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860221003611687
更新日期:2010-01-01 00:00:00
abstract::Purpose: Typically, IgA nephropathy is a slowly progressive type of glomerulonephritis. High-grade proteinuria and hypertension are predictors of reduced kidney function. However, we found some normotensive patients with mild proteinuria could exhibit impaired renal function at the time of IgAN diagnosis. We therefore...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2019.1654512
更新日期:2019-11-01 00:00:00
abstract::Injectable vitamin D agents are commonly used to manage secondary hyperparathyroidism in dialysis patients. Yet, there are few data documenting the trends and geographic variations in the use of these agents in large, representative samples. We sought to describe patterns and variations in the use of vitamin D formula...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2012.734260
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of osteopenia and osteoporosis in HD patients at our center; to investigate whether HCV infection affects BMD in hemodialysis patients; to test for correlations between bone mineral density (BMD) and clinical and laboratory parameters in this population. SUBJECTS AND METHODS:The s...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-120038501
更新日期:2004-03-01 00:00:00
abstract::We report a case of rapidly progressive diabetic nephropathy, from little diabetic change on renal biopsy to severe, nodular, diabetic nephrosclerosis over 32 months. The patient was taking an angiotensin converting enzyme inhibitor and had a mean arterial pressure of 95 mm Hg over this time period. Her dietary protei...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229709037223
更新日期:1997-11-01 00:00:00
abstract::Aldosterone is reported to promote fibrosis of multiple organs. Recent studies showed that Na+-H+ exchanger isoform 1 (NHE1) was involved in mineralocorticoid-induced tissue fibrosis. The present study examined the role of NHE1 in aldosterone-induced glomerulosclerosis in rats. SD male rats were subjected to 5/6 nephr...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860220903134571
更新日期:2009-01-01 00:00:00
abstract::The characteristics of two established renal cell lines (LLC-PKI and OK) and of primary cultures of rabbit and human proximal tubule cells are described by summarizing the literature about specific properties retained by these cells in culture. Furthermore, comparative biochemical and functional properties are present...
journal_title:Renal failure
pub_type: 杂志文章,评审
doi:10.3109/08860229209106645
更新日期:1992-01-01 00:00:00
abstract::Cognitive dysfunction is a well-known complication of chronic renal failure that is evident in 30% of hemodialysis (HD) patients. However, the pathogenesis of this dysfunction is unknown. Left ventricular hypertrophy could develop in hypertensive HD patients without establishing normovolemia. Our aim was to evaluate t...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860220903134548
更新日期:2009-01-01 00:00:00
abstract::During exercise, the plasma urate levels and urinary excretion increase due to the enhanced purine degradation in skeletal muscle. Although urate transporter-1 (URAT1) is the main transporter responsible for the reabsorption of filtered urate, potential changes in its activity and expression during exercise have not b...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2010.494805
更新日期:2010-01-01 00:00:00
abstract::In this prospective study, we aimed to determine the protective antioxidant role of alpha-lipoic acid (ALA) on development of contrast-induced nephropathy (CIN) in diabetic patients undergoing coronary angiography. Seventy-eight diabetic patients undergoing coronary angiography were included. Thirty-nine patients were...
journal_title:Renal failure
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/0886022X.2013.790298
更新日期:2013-01-01 00:00:00
abstract::The study of urinary proteins is an important tool in the screening and diagnosis of patients with renal impairment. Quantification of total proteins, although useful, can provide only limited information. Gel electrophoresis of urine samples may provide more detailed information. ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229909085105
更新日期:1999-05-01 00:00:00
abstract:OBJECTIVE:To investigate the anti proteinuric effect of pentoxifylline in diabetic patients, we prospectively studied in 25 hypertensive type 2 diabetic patients with persistent microalbuminuria and normal renal function the impact of combining pentoxifylline with an angiotensin converting enzyme inhibitor, lisinopril,...
journal_title:Renal failure
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1081/jdi-120021159
更新日期:2003-05-01 00:00:00
abstract::Diabetic nephropathy (DN) is the most common cause of end-stage renal disease worldwide. The pathophysiologic mechanisms of diabetic nephropathy are incompletely understood but include overproduction of various growth factors and cytokines. Upregulation of vascular endothelial growth factor (VEGF) is a pathogenic even...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2014.900404
更新日期:2014-07-01 00:00:00
abstract::Idiopathic nephrotic syndrome (NS) associated with focal segmental glomerulosclerosis (FSGS) and severe renal function impairment is usually refractory to the conventional treatment and progresses to end-stage renal disease. Herein, we reported 10 patients with NS-FSGS who had initially had CCr 34 +/- 12 mL/min/1.73 m...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-120039520
更新日期:2004-05-01 00:00:00
abstract::Acute renal failure (ARF) occurs in wide range of conditions, making the evaluation of its prognosis a difficult task. Data regarding prognostic factors in ARF in a general population in developing countries are scarce. The objective of the study was to describe predictors of mortality in ARF that are relevant in the ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220701260651
更新日期:2007-01-01 00:00:00
abstract::The hallmark of the professional is continued development and expanded expertise based on acquisition of new knowledge and refinement of clinical skills. Medical knowledge acquisition is a key component of professional development for fellows in training as well as practicing physicians. New medical knowledge may be a...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860220903474428
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:This study was designed to investigate whether 3-amino benzamide (3-AB), a poly (ADP-ribose) polymerase (PARP) inhibitor, has a protective effect on kidney injury induced by renal ischemia/reperfusion (I/R) by decreasing oxidative and nitrosative stress on renal dysfunction and injury. MATERIALS AND METHO...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220902882741
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to determine the effect of oral cholecalciferol treatment on vascular calcification, left ventricular mass index (LVMI) and other cardiac functions in dialysis patients. DESIGN AND METHODS:A six-month course of oral cholecalciferol treatment was recommended to dialysis patients with...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2015.1010416
更新日期:2015-05-01 00:00:00
abstract::Gentamicin-induced nephrotoxicity results in necrosis of proximal tubular epithelial cells. In mammals, the injured nephron can be repaired by migration and division of surviving cells. We examined this repair process in the fresh-water goldfish, Carassius auratus. Fish were given a single intraperitoneal injection of...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229509026246
更新日期:1995-03-01 00:00:00
abstract::TGF-beta1 has been demonstrated to be up-regulated in response to ischemic events both in animal models and in man. Demonstration of this up-regulation in the kidney following experimentally induced acute renal failure and in renal transplants complements similar findings in coronary and cerebral ischemia. Activation ...
journal_title:Renal failure
pub_type: 杂志文章,评审
doi:10.1081/jdi-120006767
更新日期:2002-07-01 00:00:00
abstract::This study was aimed to investigate the therapeutic potential of coenzyme Q10 and its combination with sitagliptin in experimentally induced diabetic nephropathy. The diabetic rats were treated with coenzyme Q10 or sitagliptin and their concomitant administration. Various parameters of renal function like serum creati...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2016.1254659
更新日期:2017-11-01 00:00:00
abstract::The risk of tuberculosis (TB) is significantly increased in chronic kidney disease (CKD). Data on TB in CKD in the UK are sparse; most information stems from countries with high background prevalence. The aim of this study was to estimate the incidence of TB in CKD patients in South East London and to describe the epi...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2015.1128290
更新日期:2016-01-01 00:00:00
abstract:AIM:Bio-impedance analysis (BIA) is a preferred method for estimating the volume status. However, it cannot be utilized in daily practice. Since the assessment of the volume status is important and challenging for hemodialysis (HD) patients, the aim of study was to determine the volume status in chronic HD patients usi...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2016.1229968
更新日期:2016-11-01 00:00:00
abstract::Depression is common in patients with end-stage renal disease (ESRD) and is associated with increased mortality and morbidity. Several investigators have estimated that depression occurs in about 20% to 30% of dialysis patients. The aim of this study was to investigate the relationship between depression, some laborat...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220500242728
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVES:Chronic kidney disease (CKD) is a major risk factor for cardiovascular disease (CVD). We previously reported renal parenchymal damage in autopsy subjects with stroke or abdominal aortic aneurysm. The aim of this study is to evaluate the relationship between renal histology and clinical characteristics of pat...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2011.605531
更新日期:2011-01-01 00:00:00