Abstract:
OBJECTIVES:Chronic kidney disease (CKD) is a major risk factor for cardiovascular disease (CVD). We previously reported renal parenchymal damage in autopsy subjects with stroke or abdominal aortic aneurysm. The aim of this study is to evaluate the relationship between renal histology and clinical characteristics of patients with myocardial infarction (MI). METHODS:A total of 699 subjects were autopsied at the National Cerebral and Cardiovascular Center Hospital. We retrospectively evaluated all autopsy cases with MI (n = 123). Estimated glomerular filtration rate (eGFR) was calculated using the Japanese formula. Subjects were classified into four groups: 25 subjects with eGFR ≥ 60 mL/min/1.73 m(2) and no proteinuria (no CKD), 10 subjects with eGFR ≥ 60 and proteinuria (CKD1/2), 65 subjects with 60 > eGFR ≥ 30 (CKD3), and 23 subjects with eGFR < 30 (CKD4/5). Renal parenchymal damage was evaluated using a semi-quantitative histological score (score 0-3) for glomerulosclerosis, interstitial fibrosis, tubular atrophy, arteriolar hyalinosis, and arteriosclerosis of medium-sized artery (maximum score = 15). RESULTS:The mean histological score was significantly higher in patients with CKD3 and CKD4/5 and was associated with age, hypertension, diabetes, kidney function, proteinuria, and other CVD. CONCLUSIONS:In patients with MI, renal parenchymal damage and deteriorating kidney function are closely associated.
journal_name
Ren Failjournal_title
Renal failureauthors
Niizuma S,Nakamura S,Ishibashi-Ueda H,Yoshihara F,Kawano Ydoi
10.3109/0886022X.2011.605531subject
Has Abstractpub_date
2011-01-01 00:00:00pages
847-52issue
9eissn
0886-022Xissn
1525-6049journal_volume
33pub_type
杂志文章相关文献
RENAL FAILURE文献大全abstract::Abstract TGF-β1 plays an important role in the pathogenesis of chronic renal diseases. Although the specific mechanism is unknown, a major factor is the potent fibrogenic activity of TGF-β1 in the chronic progression of renal diseases. TGF-β1 closely correlates with renal fibrosis in cooperation with several fibrosis-...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2014.882713
更新日期:2014-05-01 00:00:00
abstract::Antenatal hydronephrosis (AHN), defined as dilatation of renal pelvis and/or calyces, is the most frequently detected antenatal abnormality. However, postnatal management of AHN is controversial. The purpose of this study was to describe the clinical outcomes of infants with AHN and to contribute to the definition of ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2012.676492
更新日期:2012-01-01 00:00:00
abstract::Renal ischemia reperfusion injury (IRI) is a major problem, currently without treatments in clinical use. This reflects the failure of animal models to mimic the severity of IRI observed in clinical practice. Most described models lack both the ability to inflict a permanent reduction in renal function and the sensiti...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2016.1144024
更新日期:2016-11-01 00:00:00
abstract::Diabetic nephropathy (DN) is a serious complication of diabetes with a poorly defined etiology and limited treatment options. Early intervention is a key to preventing the progression of DN. Dynamin-related protein 1 (DRP1) regulates mitochondrial morphology by promoting its fission and is involved in the pathogenesis...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2015.1034607
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:There are little data on the incidence of acute renal failure (ARF) from India due to the absence of central registry. The etiology, course, and outcome of ARF differ in various parts of India. Significant trend changes were reported even within a same center over a period of time. AIM:To find out the epide...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220600689034
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Determination of fluid overload is important in chronic kidney disease. Early diagnosis and treatment of volume overload may decrease morbidity and mortality. We aimed to determine body composition by using bioelectrical impedance analysis, and studying other clinical characteristics, inferior vena cava diam...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2013.875815
更新日期:2014-05-01 00:00:00
abstract::Although hemodialysis (HD) patients could develop vancomycin-resistant enterococci (VRE) infection, limited studies of VRE-related peritoneal dialysis (PD) peritonitis have been reported. Here, we document a patient who developed peritonitis for the first time with VRE infection after shifting from HD to PD over 4 wee...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2010.509899
更新日期:2010-01-01 00:00:00
abstract::The ability to predict the rate of progression of renal parenchymal disease may help in its clinical management. We undertook characterization of urinary macrophages obtained from patients with various renal diseases paying special attention to the differentiation from non-progressive to progressive renal diseases. A ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229809045129
更新日期:1998-03-01 00:00:00
abstract:BACKGROUND:Human urotensin-II (hU-II) is one of the most potent vasoconstrictors in mammals. To our knowledge, there is no study about the role of U-II in childhood glomerulonephritis. We first determined the expression of h U-II in kidneys of children with chronic glomerular diseases. METHODS:Normal human kidneys wer...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220701392108
更新日期:2007-01-01 00:00:00
abstract:AIM:Bio-impedance analysis (BIA) is a preferred method for estimating the volume status. However, it cannot be utilized in daily practice. Since the assessment of the volume status is important and challenging for hemodialysis (HD) patients, the aim of study was to determine the volume status in chronic HD patients usi...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2016.1229968
更新日期:2016-11-01 00:00:00
abstract::Left ventricular (LV) diastolic function was found to be a significant predictor of cardiovascular events and general mortality in dialysis. Studies have indicated that dialysate calcium concentrations were significantly associated with cardiac function. However, the relationship between low calcium dialysate and LV d...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2016.1229986
更新日期:2016-11-01 00:00:00
abstract::The renal functional reserve (RFR) is the ability of the kidneys to increase renal plasma flow and glomerular filtration rate (GFR) in response to protein intake. It is a measure of functional and anatomic integrity of nephrons. It is not known what relation between RFR and kidney Doppler parameters. We aimed to study...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2016.1214052
更新日期:2016-10-01 00:00:00
abstract::Vascular calcification (VC) is an important promoter of cardiovascular disease (CVD) in patients undergoing peritoneal dialysis (PD). Several indices can be used to evaluate VC, including the abdominal aortic calcification index (AACI) and carotid artery intima-media thickness (IMT); however, simpler and lesser expens...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2020.1762646
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:The hemodialysis adequacy is one of the most important issues influencing the survival of patients on maintenance hemodialysis (HD). Assessment of measuring the delivered dialysis dose using clearance x time/volume (Kt/V) index requires multiple blood sampling. New methods for assessment of dialysis dose bas...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220500200262
更新日期:2005-01-01 00:00:00
abstract::Psoriasis, being limited to the skin, is generally a chronic inflammatory disorder. Several glomerular diseases have been distinguished due to renal histological findings of psoriatic patients to date. The underlying pathogenetic mechanisms of these associations remain unclear because of the limited number of cases. W...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860221003778072
更新日期:2010-06-01 00:00:00
abstract::Cold preservation has greatly facilitated the use of cadaveric kidneys for renal transplantation, but, clearly, damage occurs during both the preservation episode and the reperfusion phase (following transplantation). The aims of this study were twofold: to develop an in vivo model that was capable of evaluating renal...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220701813327
更新日期:2008-01-01 00:00:00
abstract::The effect of FK 506 pretreatment on renal ischemia and reperfusion (I/R) injury was investigated. Adult male rats were assigned to one of two groups (20 animals each). Group 1 (controls) received 0.5 mL saline while group 2 received FK 506 (0.3 mg/kg) intravenously 24 h prior to the induction of renal ischemia. After...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229209106630
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:To assess the safety and clinical efficacy of leflunomide (LEF) and prednisone on refractory nephrotic syndrome (RNS). METHODS:A total of 52 patients with RNS were treated for 24 weeks between 2010 and 2014 in our hospital. In the treated group, 26 patients were treated with LEF and prednisone, and, in the c...
journal_title:Renal failure
pub_type: 杂志文章,随机对照试验
doi:10.3109/0886022X.2016.1172917
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:The syndrome of rapid onset end-stage renal disease (SORO-ESRD) was first described in the journal Renal Failure in 2010. This is an acute precipitate unpredictable yet irreversible ESRD following acute kidney injury (AKI), as distinct from "classic" ESRD where chronic kidney disease (CKD)-ESRD progression w...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2015.1088336
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Spontaneous crescentic glomerulonephritis (SCG)/Kj mice are a candidate for suitable animal model of human pauci-immune crescentic glomerulonephritis (GN). In the present study, we used renal biopsy technique and analyzed time sequence correlations among crescent formation and glomerular neutrophil infiltrat...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-120013958
更新日期:2002-09-01 00:00:00
abstract::In this study, we evaluated the frequency, clinical presentation, treatment protocols, prognostic factors, and outcome in children with diffuse proliferative lupus nephritis (DPLN). Between June 1990 and December 2004, 46 patients were diagnosed to have systemic lupus erythematosus (SLE), and 26 of them (56.5%) were f...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220802132171
更新日期:2008-01-01 00:00:00
abstract::The clinical course of 15 patients with Wegener's granulomatosis (WG) and eight patients with microscopic polyangiitis (MPA) from one nephrological clinical center is presented for the period from 1984 to 1993, when testing for antineutrophil cytoplasmic antibodies (ANCA) was gradually introduced into routine clinical...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229809045141
更新日期:1998-05-01 00:00:00
abstract::Australia was an early pioneer of national integrated programs for the management of end-stage renal disease (ESRD). From being a leader in numbers of patients per population treated, it is now in the top 15. The Australian program has a high proportion of living patients with functioning transplants and a high propor...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229409044855
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Experimental studies have shown that increased levels of parathyroid hormone (PTH) in uremia may cause elevation of intracellular calcium, predisposing to insulin resistance and lipid metabolism abnormalities. Administration of calcium-channel blockers (CCBs) in these models protects against the development ...
journal_title:Renal failure
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Although adequate peritoneal dialysis is not well defined, Kt/Vurea has been used as an index, and various values have been proposed. However, conflicting evidence existed regarding the appropriateness of using Kt/Vurea to define dialysis adequacy and its optimal value. Therefore, the present study performed...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220601166586
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Hemodialysis (HD) patients often experience cardiovascular events, that might be related to altered calcium-phosphate metabolism, dyslipidemia, and chronic inflammation in addition to hypertension. Sevelamer, a non-calcium-containing phosphate binder, may improve the lipid profile of HD patients. However, th...
journal_title:Renal failure
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::There are conflicting results in studies concerning the best marker for liver histopathological features of HCV infection in HD patients. We planned a prospective study to follow HCV viremia and laboratory parameters of HD patients and correlate these with clinic features and histopathological findings. We included 68...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-100108192
更新日期:2001-11-01 00:00:00
abstract::The aim of this investigation was to study the validity of the radionuclide methods in the estimation of kidney function, for prognosis and follow-up of acute renal failure (ARF). In thirty-one ARF patients, the evaluation of glomerular filtration rate (GFR) by 99mTc-DTPA clearance and effective renal plasma flow (ERP...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-100100899
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the influence of sevelamer hydrochloride and calcium acetate on biomarkers of bone turnover in patients with hyperphosphatemia receiving hemodialysis. METHODS:In this prospective, open-label, randomized, active-controlled study, 70 patients (38 men and 32 women) with hyperphosphatemia (serum phos...
journal_title:Renal failure
pub_type: 杂志文章,随机对照试验
doi:10.1080/08860220600925388
更新日期:2006-01-01 00:00:00
abstract::Injectable vitamin D agents are commonly used to manage secondary hyperparathyroidism in dialysis patients. Yet, there are few data documenting the trends and geographic variations in the use of these agents in large, representative samples. We sought to describe patterns and variations in the use of vitamin D formula...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2012.734260
更新日期:2013-01-01 00:00:00