FK 506 reduces the injury experienced following renal ischemia and reperfusion.

Abstract:

:The effect of FK 506 pretreatment on renal ischemia and reperfusion (I/R) injury was investigated. Adult male rats were assigned to one of two groups (20 animals each). Group 1 (controls) received 0.5 mL saline while group 2 received FK 506 (0.3 mg/kg) intravenously 24 h prior to the induction of renal ischemia. After a 60-min period of ischemia of the right kidney, a left nephrectomy was performed. Blood for BUN, creatinine, and tumor necrosis factor (TNF) was obtained prior to ischemia and on days 1, 2, 3, 5, 7, and 10. All surviving animals were sacrificed at day 10. FK 506 pretreatment reduced the serum levels of BUN (p less than .02), creatinine (p less than .02) and TNF (p less than .05) as compared to that seen in controls. Based upon these data, it appears that: (a) renal ischemia induces the release of TNF; (b) FK 506 pretreatment inhibits TNF production; and (c) FK 506 reduces renal injury association with I/R.

journal_name

Ren Fail

journal_title

Renal failure

authors

Van Thiel DH,Sakr M,Zetti G,McClain C

doi

10.3109/08860229209106630

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

285-8

issue

3

eissn

0886-022X

issn

1525-6049

journal_volume

14

pub_type

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