A comparison of sevelamer hydrochloride with calcium acetate on biomarkers of bone turnover in hemodialysis patients.


OBJECTIVE:To evaluate the influence of sevelamer hydrochloride and calcium acetate on biomarkers of bone turnover in patients with hyperphosphatemia receiving hemodialysis. METHODS:In this prospective, open-label, randomized, active-controlled study, 70 patients (38 men and 32 women) with hyperphosphatemia (serum phosphorus level >6.0 mg/dL) underwent a two-week washout period and were randomly selected to receive sevelamer hydrochloride (n = 37) or calcium acetate (n = 33) for eight weeks. Changes in serum levels of intact parathyroid hormone (iPTH), alkaline phosphatase (Alk-P), phosphorus, and calcium were measured and compared. RESULTS:After eight weeks of treatment, calcium acetate lowered iPTH levels significantly more than sevelamer hydrochloride did (-178.0 vs. -69.0 pg/mL, p = 0.0019). Levels of Alk-P were significantly elevated in patients given sevelamer hydrochloride compared with levels in those given calcium acetate treatment (24.09 vs. 7.45 U/L, p = 0.0014). Changes in serum phosphorus levels did not differ between sevelamer hydrochloride (-1.93 mg/dL) and calcium acetate (-2.5 mg/dL) at the end of the study (p = 0.0514). Changes in the calcium and phosphorous product did not significantly differ between the sevelamer-hydrochloride group (-18.06 mg2/dL2) and the calcium-acetate group (-19.05 mg2/dL2, p = 0.6764). Fifteen patients (45.5%) treated with calcium acetate had hypercalcemia (serum-adjusted calcium level >10.5 mg/dL); the rate was significantly higher than that of patients treated with sevelamer (five [13.5%] of 37, p = 0.0039). CONCLUSION:Treatment with sevelamer hydrochloride had the advantage of maintaining stable iPTH levels and elevating Alk-P levels while lowering serum phosphorus levels and calcium-phosphorous product.


Ren Fail


Renal failure


Liu YL,Lin HH,Yu CC,Kuo HL,Yang YF,Chou CY,Lin PW,Liu JH,Liao PY,Huang CC




Has Abstract


2006-01-01 00:00:00














  • The effects of proteinuria on urinary cystatin-C and glomerular filtration rate calculated by serum cystatin-C.

    abstract:BACKGROUND:The measurement of glomerular filtration rate (GFR) applying serum creatinine (Cr) does not reflect the GFR of patients accurately, and thus recently, studies on the measurement of GFR applying serum cystatin-C (Cys-C) have been conducted. We investigated the relationship between Cys-C and proteinuria in pat...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Kim JS,Kim MK,Lee JY,Han BG,Choi SO,Yang JW

    更新日期:2012-01-01 00:00:00

  • The role of the uncertainty of measurement of serum creatinine concentrations in the diagnosis of acute kidney injury.

    abstract::Uncertainty of measurement is the numeric expression of the errors associated with all measurements taken in clinical laboratories. Serum creatinine concentration is the most common diagnostic marker for acute kidney injury. The goal of this study was to determine the effect of the uncertainty of measurement of serum ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Kin Tekce B,Tekce H,Aktas G,Uyeturk U

    更新日期:2016-01-01 00:00:00

  • Effect of individual health education on hyperphosphatemia in the Hakkas residential area.

    abstract::The Hakka are a sub-ethnicity with unique diet customs in South China. This study investigated hyperphosphatemia in hemodialysis patients in relation to the current Hakka dietary customs and explored health education patterns for hyperphosphatemia control. Two continuous cross-sectional surveys were conducted among th...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Chen Y,Li Z,Liang X,Zhang M,Zhang Y,Xu L,Zhong L,Shi W

    更新日期:2015-01-01 00:00:00

  • 3-aminobenzamide, a poly ADP ribose polymerase inhibitor, attenuates renal ischemia/reperfusion injury.

    abstract:INTRODUCTION:This study was designed to investigate whether 3-amino benzamide (3-AB), a poly (ADP-ribose) polymerase (PARP) inhibitor, has a protective effect on kidney injury induced by renal ischemia/reperfusion (I/R) by decreasing oxidative and nitrosative stress on renal dysfunction and injury. MATERIALS AND METHO...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Oztas E,Guven A,Turk E,Uysal B,Akgul EO,Cayci T,Ersoz N,Korkmaz A

    更新日期:2009-01-01 00:00:00

  • Glomerular alterations in experimental oliguric and nonoliguric acute renal failure.

    abstract::Studies were performed in oliguric and nonoliguric forms of uranyl acetate (UA)-induced and ischemic acute renal failure (ARF) to examine whether a reduction in GFR is correlated with glomerular morphologic alterations. UA-induced nonoliguric and oliguric ARF were induced in rabbits by i.v. injections of 0.9 and 2 mg/...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Kato A,Hishida A,Kobayashi S,Honda N

    更新日期:1993-01-01 00:00:00

  • Neutrophil-to-lymphocyte ratio as a predictor of worsening renal function in diabetic patients (3-year follow-up study).

    abstract:BACKGROUND:Previous studies have demonstrated the role of inflammation in diabetic nephropathy (DN). Neutrophil to lymphocyte ratio (NLR) rather than other white cell parameters was found to be a useful inflammatory marker to predict adverse outcomes in medical and surgical conditions. Nevertheless, the value of NLR in...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Azab B,Daoud J,Naeem FB,Nasr R,Ross J,Ghimire P,Siddiqui A,Azzi N,Rihana N,Abdallah M,Azzi N,Patel P,Kleiner M,El-Sayegh S

    更新日期:2012-01-01 00:00:00

  • The effect of strict volume control on cognitive functions in chronic hemodialysis patients.

    abstract::Cognitive dysfunction is a well-known complication of chronic renal failure that is evident in 30% of hemodialysis (HD) patients. However, the pathogenesis of this dysfunction is unknown. Left ventricular hypertrophy could develop in hypertensive HD patients without establishing normovolemia. Our aim was to evaluate t...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Dogukan A,Guler M,Yavuzkir MF,Tekatas A,Poyrazoglu OK,Aygen B,Gunal AI,Yoldas TK

    更新日期:2009-01-01 00:00:00

  • Primary disseminated form of Ewing sarcoma in association with hypercalcemia and acute renal failure.

    abstract::We present a case of an extremely rare form of Ewing sarcoma--primary disseminated, with fulminating course, severe hypercalcemia, extensive calcium deposition in parenchymatous organs, including kidneys, and acute renal failure as a clinical consequence. Correction of hypercalcemia was followed by prompt restoration ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Lozance LA,Zafirovska KG,Bogdanovska SV,Zafirovski GJ

    更新日期:1994-01-01 00:00:00

  • Acute renal failure following bone marrow transplantation.

    abstract::Acute renal failure (ARF) is one of the most frequent and potentially life threatening complications following bone marrow transplantation (BMT). Several renal syndromes that occur are either unique or occur with a disproportionate frequency post-BMT. Clinically ARF can be classified according to the time of onset pos...

    journal_title:Renal failure

    pub_type: 杂志文章,评审


    authors: Pulla B,Barri YM,Anaissie E

    更新日期:1998-05-01 00:00:00

  • The effects of spironolactone on nephron function in patients with diabetic nephropathy.

    abstract::Increasing evidence suggests that circulating aldosterone per se contributes directly to renal and cardiovascular diseases. We sought to evaluate the effects of a three-month treatment with 25 mg spironolactone, an aldosterone receptor antagonist, on nephron function in 20 type II diabetic patients with persistent mic...

    journal_title:Renal failure

    pub_type: 临床试验,杂志文章


    authors: Ustundag A,Tugrul A,Ustundag S,Sut N,Demirkan B

    更新日期:2008-01-01 00:00:00

  • Circulating purine compounds, uric acid, and xanthine oxidase/dehydrogenase relationship in essential hypertension and end stage renal disease.

    abstract::Purine nucleotide liberation and their metabolic rate of interconversion may be important in the development of hypertension and its renal consequences. In the present study, blood triphosphate (ATP), adenosine diphosphate (ADP), and adenosine monophosphate (AMP) breakdown pathway was evaluated in relation to uric aci...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Boban M,Kocic G,Radenkovic S,Pavlovic R,Cvetkovic T,Deljanin-Ilic M,Ilic S,Bobana MD,Djindjic B,Stojanovic D,Sokolovic D,Jevtovic-Stoimenov T

    更新日期:2014-05-01 00:00:00

  • Use of phosphonoformic acid to induce phosphaturia in chronic renal failure in rats.

    abstract::In chronic renal failure (CRF), phosphate (Pi) retention may lead to secondary hyperparathyroidism and progression to end-stage renal disease (ESRD). Dietary phosphorus restriction or phosphate binders can slow progression in experimental CRF. Conversely, diets high in phosphorus can accelerate the progression toward ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Loghman-Adham M,Motock GT

    更新日期:1996-11-01 00:00:00

  • Outcomes and APACHE II predictions for critically ill patients with acute renal failure requiring dialysis.

    abstract:BACKGROUND:Despite the widespread availability of dialytic and intensive care unit technology, the probability of early mortality in critically ill patients with acute renal failure (ARF) is still high, and the evaluation of the patients' prognosis has been difficult. The Acute Physiology and Chronic Health Evaluation ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Chen YC,Hsu HH,Kao KC,Fang JT,Huang CC

    更新日期:2001-01-01 00:00:00

  • Enhanced urinary adiponectin excretion in IgA-nephropathy patients with proteinuria.

    abstract::Adiponectin is secreted specifically by adipose tissue. It was reported that the serum adiponectin level was markedly increased in patients with end-stage renal disease and was positively associated with abnormal renal function in type 2 diabetes. Recently, we found that urinary adiponectin level was significantly inc...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Shimotomai T,Kakei M,Narita T,Koshimura J,Hosoba M,Kato M,Komatsuda A,Ito S

    更新日期:2005-01-01 00:00:00

  • Analgesic use, parents' clan, and coffee intake are three independent risk factors of chronic kidney disease in middle and elderly-aged population: a community-based study.

    abstract::Chronic kidney disease (CKD) is a world-wide public health problem. The purpose of this study was to identify the role of some controversial potential risk factors in development of CKD. "Community Complex Health Screening" is a large-scale, free, health program for individuals ≥40 years of age that has been available...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Hsu YC,Lee PH,Lei CC,Shih YH,Lin CL

    更新日期:2014-04-01 00:00:00

  • Acute renal failure and pregnancy: a seventeen-year experience of a Tunisian intensive care unit.

    abstract:PURPOSE:To describe the epidemiologic features of acute renal failure related to pregnancy (PRARF) and to evaluate its prognostic impact. METHODS:Retrospective study conducted in a Tunisian intensive care unit over a period of 17 years (1995-2011). Women were included if they were more than 20 weeks pregnant and were ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Bouaziz M,Chaari A,Turki O,Dammak H,Chelly H,Ammar R,Nasri A,Ben Algia N,Bahloul M,Ben Hamida C

    更新日期:2013-10-01 00:00:00

  • Significant benefits after renal transplantation in patients with chronic heart failure and chronic kidney disease.

    abstract:BACKGROUND:Chronic heart failure (CHF) and chronic kidney disease (CKD) are serious medical conditions with significant morbidity and mortality and often coexist. Because of perioperative risks in these patients, they may not be considered a candidate for renal transplantation (RTx). MATERIAL AND METHODS:We compare re...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Kute VB,Vanikar AV,Patel HV,Gumber MR,Shah PR,Engineer DP,Balwani MR,Gautam RS,Modi PR,Shah VR,Trivedi HL

    更新日期:2014-07-01 00:00:00

  • The role of erythrocytes phosphatidylserine exposure in anemia in peritoneal dialysis patients.

    abstract:BACKGROUND:An increased red blood cell (RBC) phosphatidylserine (PS) exposure in uremic patients was found that could promote macrophage recognition and decrease RBC survival time. Furthermore, a reduced red cell life span was found to contribute anemia in patients with renal failure. It is therefore possible to hypoth...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Bi SH,Cheng LT,Wang T

    更新日期:2006-01-01 00:00:00

  • A systematic review on randomized control trials on rennin angiotensin aldosterone system inhibitors role in managing hypertension among hemodialysis patients.

    abstract::Randomized control trials (RCTs) are considered as most rigors way of determining the cause-effect relationship of a treatment and outcome. Activation of rennin angiotensin aldosterone system (RAAS) is an important contributor to hypertension in hemodialysis patients. The prevalence of hypertension in hemodialysis pat...

    journal_title:Renal failure

    pub_type: 杂志文章,评审


    authors: Aftab RA,Khan AH,Adnan AS,Jannah N

    更新日期:2016-01-01 00:00:00

  • The subjective sleep quality and heart rate variability in hemodialysis patients.

    abstract:INTRODUCTION:Sleep disturbances and cardiovascular autonomic dysfunction are major complications of hemodialysis (HD). The goal of this study is to identify clinical, heart rate variability (HRV) or laboratory parameters that are independently associated with subjective sleep quality. PATIENT AND METHODS:Forty-six sta...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Wei CY,Chung TC,Wu SC,Chung CF,Wu WP

    更新日期:2011-01-01 00:00:00

  • Intensification of peritoneal dialysis improves valacyclovir neurotoxicity.

    abstract::Valacyclovir induced neurotoxicity is a life-threatening complication, usually starting 24-48 h after drug-peak serum concentrations. The elderly with impaired renal function seem to be the most susceptible group to valacyclovir neurotoxicity. Although hemodialysis is considered the best method for rapid drug removal,...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Pipili C,Pantelias K,Deda E,Tsiamalos P,Kostis E,Grapsa E

    更新日期:2013-01-01 00:00:00

  • Neutrophil/lymphocyte ratio elevation in renal dysfunction is caused by distortion of leukocyte hematopoiesis in bone marrow.

    abstract:OBJECTIVE:We investigate the mechanism of neutrophil/lymphocyte ratio (NLR) elevation, a useful prognostic marker in patients with cardiovascular diseases (CVDs). METHODS:In this clinical study, we retrospectively searched for factors associated with NLR elevation in cardiovascular outpatients. In animal experiments u...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Ito S,Ohno Y,Tanaka T,Kobuchi S,Ayajiki K,Manabe E,Masuyama T,Jun-Ichi S,Tsujino T

    更新日期:2019-11-01 00:00:00

  • A modified relief of unilateral ureteral obstruction model.

    abstract::Objectives: To improve the mouse model of relief for unilateral ureteral obstruction (RUUO) and explore the pathological process of renal fibrosis after the obstruction was relieved. Methods: C57BL/6 mice in model group were randomly divided into RUUO group, improved RUUO group, and UUO group. After leaving Unilateral...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Song J,Liu J,Luo J,Zhang Q,Xia Y,Shao Q,Sun C,Jiang C,Zhang M,Zhu W

    更新日期:2019-11-01 00:00:00

  • Adenylate cyclase responses and biochemical characterization of primary rabbit proximal tubular cell cultures and LLC-PK1 cells.

    abstract::Freshly isolated rabbit proximal tubules (PT), confluent primary rabbit proximal tubule cultures (PTC) and LLC-PK1 cells were characterised. Brushborder enzyme activities were lower in PTC than in LLC-PK1: ratios were 0.026 for alkaline phosphatase (AP), 0.458 for alanine aminopeptidase (AAP) and 0.514 for gamma-gluta...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Toutain H,Courjault F,Vauclin-Jacques N,Morin JP

    更新日期:1990-01-01 00:00:00

  • Oxidation of albumin is enhanced in the presence of uremic toxins.

    abstract::Albumin has been considered a "sacrificial plasma antioxidant" due to the high reactivity of the protein sulfhydryl groups with oxidants such as hydrogen peroxide (H2O2) and hypochlorous acid (HOCl). Based on its large quantity and high turnover. It is considered as one of the most important plasma antioxidants for pr...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Wratten ML,Sereni L,Tetta C

    更新日期:2001-05-01 00:00:00

  • The influence of l-carnitine supplementation on hematocrit and hemoglobin levels in patients with end stage renal failure on CAPD.

    abstract::The influence of L-carnitine supplementation on hematocrit (Hct) and hemoglobin (Hb) levels, in patients suffering from end stage renal disease (ESRD) on maintenance hemodialysis, are well known from several studies. The data concerning the serum levels of carnitine, in patients with ESRD on continuous ambulatory peri...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Sotirakopoulos N,Athanasiou G,Tsitsios T,Mavromatidis K

    更新日期:2002-07-01 00:00:00

  • Neutrophil gelatinase-associated lipocalin as a follow-up marker in critically ill pediatric patients with established acute kidney injury.

    abstract:AIM:To assess the utility of neutrophil gelatinase-associated lipocalin (NGAL) in both urine and serum as a follow-up marker for the discrimination of prerenal acute kidney injury (AKI) from intrinsic AKI in critically ill pediatric patients with established AKI at the time of patient presentation. PATIENTS AND METHOD...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Polat M,Fidan K,Derinöz O,Gönen S,Söylemezoglu O

    更新日期:2013-01-01 00:00:00

  • Long-term intravenous calcitriol in secondary hyperparathyroidism: the role of technetium-99m-MIBI scintigraphy in predicting the response to treatment.

    abstract:BACKGROUND:Despite the effectiveness of intravenous calcitriol in suppressing parathyroid hormone secretion in patients with uremic hyperparathyroidism, 50% of the patients remain refractory to this treatment. There are conflicting reports regarding the factors that can predict the response to treatment. Technetium-99m...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Owda AK,Mousa D,Abdallah AH,Hawas FA,Al-Harbi W,Fedail H,At-Shoail G,Al-Sulaiman MH,Al-Khader AA

    更新日期:2002-03-01 00:00:00

  • Comparison of insulin resistance in the various stages of chronic kidney disease and inflammation.

    abstract:OBJECTIVE:In this study, we compared predialysis and dialysis patients with the controls in terms of insulin resistance and evaluated the association with inflammation that is a risk factor for cardiovascular disease. MATERIALS AND METHODS:A total of 134 non-diabetic patients with controls (n=33), predialysis (n=29) a...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Akalın N,Köroğlu M,Harmankaya Ö,Akay H,Kumbasar B

    更新日期:2015-03-01 00:00:00

  • Renal failure and nephrotoxic drug-induced disturbances in rat kidney tissue.

    abstract::The injection to rats of glycerol, cisplatin, uranyl acetate, sodium dichromate, and mercuric chloride is followed on the third day by acute renal failure. A new approach for quantitative estimation of disturbance of excretory renal function is presented. The decrease in renal function due to uranyl acetate was 77%; s...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Natochin YV,Bakhteeva VT,Karpenko LA

    更新日期:1994-11-01 00:00:00