Abstract:
BACKGROUND:Transforming growth factor-beta1 (TGF-beta1), the major fibrogenic growth factor, is implicated in the pathogenesis of renal scarring in experimental and clinical nephropathies as well as in chronic allograft nephropathy. In this study we examined the pattern of changes of TGF-beta1 excretion in the urine and the sites of TGF-beta1 expression in the kidney of transplanted patients during the early post-transplantation period. METHODS:Eighteen renal allograft recipients were included in the study. In all patients urinary TGF-beta1 levels were determined by ELISA in sequential measurements during the first two postoperative months and compared to that of 14 healthy subjects. The renal expression of TGF-beta1 protein was studied in 4 patients that underwent a biopsy of the transplanted kidney at the same period. All patients were treated with prednisolone, cyclosporin, and mycophenolate mofetil. RESULTS:Urinary TGF-beta1 levels were increased during the first postoperative days. Although they were gradually reduced during the first two post-operative months, they remained significantly higher compared to those of normal subjects (580 +/- 148 ng/24 h vs. 310 +/- 140 ng/ 24 h p < 0.01). The decline of urinary TGF-beta1 excretion followed that of serum creatinine. TGF-beta1 protein expression was identified within the cytoplasm of tubular epithelial cells of transplanted patients. CONCLUSIONS:Elevated urinary TGF-beta1 levels are observed during the early post-transplantation period in renal allograft recipients and are maintained high even after restoration of renal function to normal.
journal_name
Ren Failjournal_title
Renal failureauthors
Goumenos DS,Tsakas S,Karavias D,Savidaki I,Karatzas T,Vlachojannis JGdoi
10.1081/jdi-120022547subject
Has Abstractpub_date
2003-07-01 00:00:00pages
561-8issue
4eissn
0886-022Xissn
1525-6049journal_volume
25pub_type
杂志文章相关文献
RENAL FAILURE文献大全abstract:PRINCIPLES:Coumadin-induced renal and retroperitoneal hemorrhages are rare. Clinical and laboratory findings are not specific for the diagnosis. Computed tomography (CT) has some advantages in the evaluation of these patients. The aim of this study is to report our experience regarding renal and retroperitoneal hemorrh...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220500530569
更新日期:2006-01-01 00:00:00
abstract::Acute renal failure (ARF) occurs in wide range of conditions, making the evaluation of its prognosis a difficult task. Data regarding prognostic factors in ARF in a general population in developing countries are scarce. The objective of the study was to describe predictors of mortality in ARF that are relevant in the ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220701260651
更新日期:2007-01-01 00:00:00
abstract::The necessary exposure of blood to biomembranes during hemodialysis has been viewed by many as an immunogenic challenge leading to an acute phase response. In this study we examined the relationship between hemodialysis-induced immune activation and intradialytic hypotension, using the acute phase reactant serum C-rea...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-100107360
更新日期:2001-09-01 00:00:00
abstract::Currently, obesity has reached an epidemic stage and represents a challenge for health authorities across the globe. Certainly, with emergence of obesity epidemic, we started to see an increase in the prevalence of chronic kidney disease (CKD) and nephrolithiasis. Interestingly, epidemiologic studies have shown that t...
journal_title:Renal failure
pub_type: 杂志文章,评审
doi:10.3109/0886022X.2012.723777
更新日期:2012-01-01 00:00:00
abstract::The main objectives of this study were to evaluate the health-related physical fitness for the patients with end-stage renal disease on hemodialysis and determine the suitability of Eurofit Test Battery for adults to decide their health-related physical fitness level. Eighteen patients with end-stage renal disease (ES...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220701641330
更新日期:2007-01-01 00:00:00
abstract::Prophylactic effects of N-benzoyl-beta-alanine (betamipron, BP), one of a series of N-acyl amino acids, were examined against cisplatin-induced nephrotoxicity. Male Wistar rats were injected i.p. with 6 mg/kg of cisplatin combined with an i.p. BP dose given at various times and various doses. Rats were sacrificed 5 da...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229609052792
更新日期:1996-03-01 00:00:00
abstract::The aim of our study was to analyze the clinical course and outcome of acute renal failure (ARF) in patients with hemorrhagic fever with renal syndrome (HFRS). From 1983 to 1995, we treated 33 patients (27 males, 6 females) aged from 16 to 71 years. Half of patients were connected with work at a farm or in a forest. T...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229609047688
更新日期:1996-07-01 00:00:00
abstract::Australia was an early pioneer of national integrated programs for the management of end-stage renal disease (ESRD). From being a leader in numbers of patients per population treated, it is now in the top 15. The Australian program has a high proportion of living patients with functioning transplants and a high propor...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229409044855
更新日期:1994-01-01 00:00:00
abstract:AIM:To investigate the effects of lentivirus-mediated shRNA targeting collagen type I on the mesangial cells of rats and the feasibility of lentivirus-mediated shRNA delivery through renal parenchyma injection. METHODS:Anti-collagen type I shRNA lentiviral vector was constructed, and rat mesangial cells were transfect...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2011.559679
更新日期:2011-01-01 00:00:00
abstract::Secondary hyperparathyroidism is one of the most common complications of chronic renal failure (CRF). Its pathogenesis is multifactorial and still not completely understood. Pathological mechanism of hypocalcemia, hyperphosphatemia and calcitriol deficiency are basic characteristics of CRF and main reason for morpholo...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-100103500
更新日期:2001-03-01 00:00:00
abstract:AIM:To investigate the therapeutic effects of oral carbonic adsorbent on rats with early-stage renal failure. METHODS:The early-stage renal failure model was established with three-fourth subtotal nephrectomy Wistar rats. Four weeks after the subtotal nephrectomy, the rats were randomly divided into four groups: (1) a...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2014.986006
更新日期:2015-03-01 00:00:00
abstract:AIM:Novel coronavirus pneumonia (COVID-19) has become pandemic. It brings serious threat to hemodialysis (HD) patients. Therefore, we carried out a study on the clinical characteristics of HD patients with COVID-19. METHODS:We retrospectively analyzed the data of 31 HD patients with COVID-19. The clinical features of ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2020.1796705
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE:We compared the Bergstrom's and Randerson's formula for PNA determination, and compared the normalization of PNA by ideal body weight (IBW) and standard body weight (SBW) as estimated by the Watson's formula. METHODS. We studied 208 Chinese PD patients. Two 24-h dialysate and urine collections were performed ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-120018724
更新日期:2003-03-01 00:00:00
abstract:OBJECTIVE:To investigate the anti proteinuric effect of pentoxifylline in diabetic patients, we prospectively studied in 25 hypertensive type 2 diabetic patients with persistent microalbuminuria and normal renal function the impact of combining pentoxifylline with an angiotensin converting enzyme inhibitor, lisinopril,...
journal_title:Renal failure
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1081/jdi-120021159
更新日期:2003-05-01 00:00:00
abstract:OBJECTIVE:Study the possible excretion of vitamin A in urine of critically ill patients complicated with acute renal failure. PATIENTS AND METHODS:Nine Intensive Care Unit patients, age 71.2 +/- 15.7 (mean +/- SD) with acute renal failure were studied. Urinary retinol, creatinine, protein, albumin, and serum creatinin...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-200031729
更新日期:2004-09-01 00:00:00
abstract:RATIONAL:Obstetrical complications are the commonest causes of Renal Cortical Necrosis (RCN). However, the overall incidence of RCN in obstetric acute kidney injury in developing countries has been decreasing in recent years. OBJECTIVE:The aim of this study was to evaluate the changing profile of RCN in obstetric AKI ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2015.1062340
更新日期:2015-08-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of osteopenia and osteoporosis in HD patients at our center; to investigate whether HCV infection affects BMD in hemodialysis patients; to test for correlations between bone mineral density (BMD) and clinical and laboratory parameters in this population. SUBJECTS AND METHODS:The s...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-120038501
更新日期:2004-03-01 00:00:00
abstract::Non-Shiga-like toxin-producing Escherichia coli (STEC) or atypical hemolytic uremic syndrome (aHUS) is observed in 5-10% of all hemolytic uremic syndrome (HUS) cases, and usually develops secondary to infections, malignancies, drugs, transplantation, pregnancy, and autoimmune disease. However, there has been no report...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2013.780978
更新日期:2013-01-01 00:00:00
abstract:AIM:The aim of this study was to observe the effects of coupled plasma filtration adsorption (CPFA) on septic patients with multiple organ dysfunction syndrome (MODS). METHODS:A total of 14 patients were randomly divided into two groups, and, respectively, received 10 h of CPFA or high-volume hemofiltration (HVHF). Th...
journal_title:Renal failure
pub_type: 杂志文章,随机对照试验
doi:10.3109/0886022X.2012.684553
更新日期:2012-01-01 00:00:00
abstract:BACKGROUNDS/AIMS:Renal ischemia-reperfusion (IR) induces organ damage in remote organs. The aim of this study was to assess the role of leukocytes in the induction of liver damage after renal IR injury. METHODS:Inbred mice were subjected to either sham operation or bilateral renal IR injury (60 min ischemia followed b...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2010.541585
更新日期:2011-01-01 00:00:00
abstract::Secondary hyperparathyroidism and anemia are the hallmarks in uremic patients. It is suggested that parathyroid hormone increases erythrocyte osmotic fragility and induces hemolysis. The present study was undertaken to examine the possible relationship between erythrocyte osmotic fragility and secondary hyperparathyro...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-200037140
更新日期:2004-11-01 00:00:00
abstract::This article reviews our experience with 111 pediatric patients following open-heart surgery over 1-year period. Peritoneal dialysis was required in 34 of 111 children (30.6%). We randomly selected 33 patients who did not require peritoneal dialysis as control group. The indications of dialysis were oligoanuria and/or...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2010.493980
更新日期:2010-01-01 00:00:00
abstract::Albumin has been considered a "sacrificial plasma antioxidant" due to the high reactivity of the protein sulfhydryl groups with oxidants such as hydrogen peroxide (H2O2) and hypochlorous acid (HOCl). Based on its large quantity and high turnover. It is considered as one of the most important plasma antioxidants for pr...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-100104738
更新日期:2001-05-01 00:00:00
abstract:PURPOSE:Oxidative stress due to hyperglycemia is a major cause of diabetes complications. The aim of this study was to evaluate the effects of pomegranate seed oil (PSO) on serum biochemical parameters, cardiomyopathy and nephropathy induced by diabetes mellitus. METHOD:W/A adult rats were divided into four groups (12...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2016.1207053
更新日期:2016-09-01 00:00:00
abstract::We present a patient with AL amyloidosis who had an autologous stem cell transplant (ASCT) over 9 years ago. She has since then developed slowly progressive renal insufficiency and the nephrotic syndrome. Hematologic evaluation has failed to identify recurrent disease and a renal biopsy demonstrated extensive amyloid ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2012.669320
更新日期:2012-01-01 00:00:00
abstract::Anticoagulants are commonly used to prolong circuit life during continuous hemofiltration. However, a clear correlation between routinely performed blood coagulability tests and circuit life has not been demonstrated. This lack of correlation may derive from the limited ability of such tests to describe the likelihood...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-100100873
更新日期:2000-05-01 00:00:00
abstract::Arteriosclerosis is characterized by stiffening of arteries. The incremental elastic modulus (Einc) measurement is a good marker of arterial wall stiffness. Metabolic, inflammatory and hemodynamic alterations cause structural changes and vascular complications in end stage renal disease. The aim of the present study w...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-120026036
更新日期:2003-11-01 00:00:00
abstract::Randomized control trials (RCTs) are considered as most rigors way of determining the cause-effect relationship of a treatment and outcome. Activation of rennin angiotensin aldosterone system (RAAS) is an important contributor to hypertension in hemodialysis patients. The prevalence of hypertension in hemodialysis pat...
journal_title:Renal failure
pub_type: 杂志文章,评审
doi:10.3109/0886022X.2016.1138833
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To explore the association of urinary podocyte excretion and renal expression of podocyte-specific marker podocalyxin (PCX) with clinicopathological changes in immunoglobulin A nephropathy (IgAN). METHODS:Morning urine samples from IgAN patients and healthy controls were collected. The expression of glomerul...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2011.643352
更新日期:2012-01-01 00:00:00
abstract:AIM:The aim of this study was to evaluate the effects of curcumin in an experimental model of busulfan-induced renal toxicity with emphasis on importance of histological alterations. METHODS:In this study, we utilized 32 adult male Wistar rats (250 ± 10 g). All the animals were divided into four experimental groups ra...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2020.1818580
更新日期:2020-11-01 00:00:00