Impact of pretreatment with carnitine and tadalafil on contrast-induced nephropathy in CKD patients.

Abstract:

:Objective: The present study assesses whether phosphodiesterase type 5 (PDE-5) inhibitor or carnitine exert nephroprotective effects against clinical contrast-induced nephropathy (CIN).Materials and Methods: The present study consisted of three groups of CKD patients. The first group was control group, who were treated with N-acetyl-L-cysteine 1 day before and on the day of radiocontrast administration. The second one was carnitine group, where the patients were infused with carnitine over 10 min 2 h prior to the radiocontrast administration and 24 h post CT. The third one was PDE-5 inhibitor group, where patients were given tadalafil 2 h prior to the administration of the radiocontrast and in the subsequent day. Urine and blood samples were collected before and at the following time sequence: 2, 6, 12, 24, 48, and 120 h after the contrast administration, for creatinine and NGAL determination.Results: Pretreated with N-acetyl-L-cysteine prior to administration of contrast media (CM) to CKD patients caused a significant increase in urinary but not of plasma neutrophil gelatinase-associated lipocalin (NGAL) and serum creatinine (SCr). In contrast, pretreatment with carnitine prevented the increase in urinary NGAL and reduced SCr below basal levels. Similarly, tadalafil administration diminished the elevation of CM-induced urinary NGAL.Conclusions: These results indicate that carnitine and PDE-5 inhibitors may comprise potential therapeutic maneuvers for CIN.

journal_name

Ren Fail

journal_title

Renal failure

authors

Armaly Z,Artol S,Jabbour AR,Saffouri A,Habashi N,Abd Elkadir A,Ghattas N,Farah R,Kinaneh S,Nseir W

doi

10.1080/0886022X.2019.1669459

subject

Has Abstract

pub_date

2019-11-01 00:00:00

pages

976-986

issue

1

eissn

0886-022X

issn

1525-6049

journal_volume

41

pub_type

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