Abstract:
BACKGROUND:Morphine is an opioid analgesic drug often used for pain relief in cancer patients. However, there is growing evidence that morphine may modulate tumor growth, progression and metastasis. Unfortunately, the results obtained by these studies are still contradictory. METHODS:In this study, we investigated the effect of morphine in human clear cell renal cell carcinoma 786-O, RLC-310 cells and whether morphine affects on tumor growth in human clear cell renal cell carcinoma 786-O, RLC-310 cells. The cell proliferation was determined by MTT assay, cell proliferation, migration and invasion assays. Immunofluorescence staining and Q-PCR was used to determine the Survivin expression. RESULTS:It was shown that morphine enhances proliferation of 786-O, RLC-310 cells, whereas morphine promoted the growth and aggressive phenotype of 786-O and RLC-310 cells in vitro though Survivin-dependent signaling. CONCLUSIONS:Our data showed that morphine promotes RCC growth and increases RCC progression via over-expression of Survivin.
journal_name
Ren Failjournal_title
Renal failureauthors
Ma Y,Ren Z,Ma S,Yan W,He M,Wang D,Ding Pdoi
10.1080/0886022X.2016.1256322subject
Has Abstractpub_date
2017-11-01 00:00:00pages
258-264issue
1eissn
0886-022Xissn
1525-6049journal_volume
39pub_type
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