Abstract:
:Currently, obesity has reached an epidemic stage and represents a challenge for health authorities across the globe. Certainly, with emergence of obesity epidemic, we started to see an increase in the prevalence of chronic kidney disease (CKD) and nephrolithiasis. Interestingly, epidemiologic studies have shown that the incident stone risk increases with body mass index (BMI), and no further increase in risk is noticed when the BMI > 30 kg/m(2). Furthermore, metabolic syndrome and diabetes are also associated with an increase in the incidence of renal stones disease. The shared links between these metabolic disorders are insulin resistance. Furthermore, insulin resistance is thought to alter renal acid-base metabolism, resulting in a lower urine pH and increased risk of uric acid stone disease. Obesity is also associated with excess nutritional intake of lithogenic substances such as refined sugars, low fluid intake, calcium, oxalate, and purine-rich foods. Obesity is also associated with an increase in incidence of urinary tract infection. Recent reports suggested that renal stone disease carries risk of myocardial infarction, progression of CKD, and diabetes. Alarmingly, orlistat (obesity medication) and bariatric surgery are associated with hyperoxaluria and associated stone formation and even oxalate nephropathy. Certainly, the many health risks of obesity, including nephrolithiasis, will add more burden on urologists and nephrologists. Shockwave lithotripsy, percutaneous nephrolithotomy, and ureteroscopy are all safe procedures in obese individuals. Further research is urgently needed to address the pathophysiology and management of obesity-induced renal stones disease.
journal_name
Ren Failjournal_title
Renal failureauthors
Ahmed MH,Ahmed HT,Khalil AAdoi
10.3109/0886022X.2012.723777subject
Has Abstractpub_date
2012-01-01 00:00:00pages
1348-54issue
10eissn
0886-022Xissn
1525-6049journal_volume
34pub_type
杂志文章,评审相关文献
RENAL FAILURE文献大全abstract:BACKGROUND:Intima-Media-Thickness of the carotid artery wall (cIMT) is a strong predictor of cardiovascular (CV) disease. The aim of this study was to investigate the significance of cIMT as an independent prognostic factor for CV morbidity and mortality in patients with chronic kidney disease (CKD) and diabetes mellit...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2019.1585372
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:Human urotensin-II (hU-II) is one of the most potent vasoconstrictors in mammals. To our knowledge, there is no study about the role of U-II in childhood glomerulonephritis. We first determined the expression of h U-II in kidneys of children with chronic glomerular diseases. METHODS:Normal human kidneys wer...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220701392108
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Sirolimus has been considered to be a non-nephrotoxic agent. It may delay graft function due to a potential hindrance of the recovery from acute tubular necrosis. It remains controversial as to whether the concomitant administration of sirolimus (SRL) with calcineurin inhibitors delays graft function in Asia...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220701860989
更新日期:2008-01-01 00:00:00
abstract::The hallmark of the professional is continued development and expanded expertise based on acquisition of new knowledge and refinement of clinical skills. Medical knowledge acquisition is a key component of professional development for fellows in training as well as practicing physicians. New medical knowledge may be a...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860220903474428
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVES:To explore the capacity of mutant lactobacilli to remove creatinine (Cr) and urea nitrogen (UN) via the gastrointestinal tract and its effects on renal pathology in the 5/6 nephrectomized rat model of chronic renal failure. METHODS:Sixty Sprague-Dawley rats were randomly divided into a Sham group, a Model g...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2016.1227617
更新日期:2016-10-01 00:00:00
abstract::Herein we present one of the largest single-center reports of the response of hemodialysis patients to a two-vaccine hepatitis B virus vaccination protocol in a European dialysis population. A hepatitis B recombinant DNA vaccine, HBvaxPRO, was given at a dose of 40 µg intramuscularly using a four-dose schedule at 0, 1...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2011.559300
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:We investigate the mechanism of neutrophil/lymphocyte ratio (NLR) elevation, a useful prognostic marker in patients with cardiovascular diseases (CVDs). METHODS:In this clinical study, we retrospectively searched for factors associated with NLR elevation in cardiovascular outpatients. In animal experiments u...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2019.1597736
更新日期:2019-11-01 00:00:00
abstract::Previously we have shown that the amount of protein in a dietary regimen prior to the induction of renal ischemia will significantly affect the degree of postischemic acute renal failure (Andrews PM, Bates SB: Kidney Int 30:299-303, 1986). The present investigation was undertaken to determine what effect dietary prote...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229309065566
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:The syndrome of rapid onset end-stage renal disease (SORO-ESRD) was first described in the journal Renal Failure in 2010. This is an acute precipitate unpredictable yet irreversible ESRD following acute kidney injury (AKI), as distinct from "classic" ESRD where chronic kidney disease (CKD)-ESRD progression w...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2015.1088336
更新日期:2015-01-01 00:00:00
abstract::Recent studies show that clinically stable renal transplant recipients have an increased prevalence of hyperhomocysteinemia (hyperHcy), but the mechanism of this disorder has not yet been elucidated. The aim of the present study was to evaluate the factors associated with hyperHcy after a successful renal transplantat...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220500461260
更新日期:2006-01-01 00:00:00
abstract::Depression is common in patients with end-stage renal disease (ESRD) and is associated with increased mortality and morbidity. Several investigators have estimated that depression occurs in about 20% to 30% of dialysis patients. The aim of this study was to investigate the relationship between depression, some laborat...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220500242728
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Acquired cystic kidney disease (ACKD) is a frequent complication in chronic hemodialysis (HD) patients and a risk factor for renal cell carcinoma. Online hemodiafiltration (HDF) provides better clearance of middle molecular weight solutes, but its effect on ACKD has not been investigated. MATERIALS AND METH...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220903003412
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Gastrointestinal complications are frequent in patients with renal disease and are responsible for substantial morbidity and mortality among these patients in developing countries. Many times, these patients are subjected to endoscopic evaluation and mucosal biopsies are taken for definitive diagnosis. This ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2012.731998
更新日期:2013-01-01 00:00:00
abstract::Introduction: This study aimed to investigate the clinical characteristics, risk factors, and outcomes of infection-related hospitalization (IRH) in patients with lupus nephritis (LN) and ANCA glomerulonephritis after intensive immunosuppressive therapy.Methods: Patients diagnosed with LN or ANCA glomerulonephritis wh...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2020.1763400
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Experimental studies have shown that increased levels of parathyroid hormone (PTH) in uremia may cause elevation of intracellular calcium, predisposing to insulin resistance and lipid metabolism abnormalities. Administration of calcium-channel blockers (CCBs) in these models protects against the development ...
journal_title:Renal failure
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of urokinase-type plasminogen activator (uPA) on mesangial matrix in the kidney of diabetic rats and its related mechanisms. METHODS:Diabetic Sprague-Dawley (SD) rats induced by intraperitoneal injection of streptozotocin (STZ) were randomly and evenly divided into two groups: DM + ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2014.934694
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Asymmetric dimethylarginine (ADMA) as a uremia toxin is accumulated in end-stage renal disease (ESRD) patients. Elevated ADMA level has been shown to be predictive of cardiovascular diseases (CVDs) and all-cause mortality in ESRD. Therefore, we investigated the removal of ADMA by different dialysis treatment...
journal_title:Renal failure
pub_type: 杂志文章,随机对照试验
doi:10.3109/0886022X.2010.502281
更新日期:2010-01-01 00:00:00
abstract::The risk of tuberculosis (TB) is significantly increased in chronic kidney disease (CKD). Data on TB in CKD in the UK are sparse; most information stems from countries with high background prevalence. The aim of this study was to estimate the incidence of TB in CKD patients in South East London and to describe the epi...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2015.1128290
更新日期:2016-01-01 00:00:00
abstract::The present study was undertaken to examine the role of arachidonic acid (AA) metabolites in hypoxia/reoxygenation (H/R)-induced renal cell injury in rabbit renal cortical slices using AA metabolic inhibitors. Inhibitors of cyclooxygenase (indomethacin and diclofenac sodium) and lipoxygenase pathways (nordihydroguaiar...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-100100860
更新日期:2000-03-01 00:00:00
abstract::The effect of ticlopidine on rats with adriamycin nephropathy was observed during 26 weeks. In the ticlopidine-treated nephrotic animals (TNG), proteinuria was less than in the untreated nephrotic animals (NG), but this difference was significant only at week 6 (TNG = 47.27 +/- 16.52 versus NG = 100.08 +/- 13.83 mg/24...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229909045185
更新日期:1999-09-01 00:00:00
abstract::Spontaneous nontraumatic rupture of the kidney (Wunderlich syndrome) is an extremely uncommon condition on hemodialysis. We report a case of 44-year-old hemodialysis patient presented with hemorrhagic shock and a right quadrant abdominal pain to the emergency department. There was no history of trauma. A kidney ruptur...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2012.706887
更新日期:2012-01-01 00:00:00
abstract::Podocyte injury is a vital factor, which induces massive proteinuria. Studies have shown that tacrolimus (TAC) protected podocyte via stabilizing cytoskeleton. Our latest study indicates that calcineurin binding protein 1 (Cabin1) undergoes nuclear translocation during podocytes injury. Whether TAC targets on Cabin1 d...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2016.1148936
更新日期:2016-01-01 00:00:00
abstract::Secondary hyperparathyroidism and anemia are the hallmarks in uremic patients. It is suggested that parathyroid hormone increases erythrocyte osmotic fragility and induces hemolysis. The present study was undertaken to examine the possible relationship between erythrocyte osmotic fragility and secondary hyperparathyro...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-200037140
更新日期:2004-11-01 00:00:00
abstract:OBJECTIVE:In order to evaluate the clinical and pathological characteristics of diuretics associated acute kidney injury (AKI) and its management. METHODS:We performed a retrospective study including 131 cases that diagnosed as diuretics associated AKI from 1 January 1999 to 1 January 2010 in Ruijin Hospital affiliate...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2014.917560
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVE:The present study investigated whether hemodialysis (HD) patients exhibit future memory impairment (PM; the capability of remembering to perform expected future actions) and exploring relevant factors of PM task performance. METHODS:Sixty HD patients and 60 healthy controls matched by age are enrolled in the...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2020.1835673
更新日期:2020-11-01 00:00:00
abstract::Electrolyte disorders can alter cardiac ionic currents and depending on the changes can promote proarrhythmic effects. Potassium (K(+)) is the most common intracellular cation related to arrhythmic disorders. Hyperkalemia is mainly seen in the setting of impaired renal function. Severe hyperkalemia may lead to rhythm ...
journal_title:Renal failure
pub_type: 信件
doi:10.3109/0886022X.2011.653752
更新日期:2012-01-01 00:00:00
abstract::Ciprofloxacin has been associated with several side effects including interstitial nephritis and hemolytic anemia. The combination of both side effects is extremely rare. In this report, we describe a case of ciprofloxacin-induced interstitial nephritis and autoimmune hemolytic anemia. Hemolytic anemia improved after ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-120022557
更新日期:2003-07-01 00:00:00
abstract:INTRODUCTION:Organic solvents are liquid substances commonly used in everyday life at home and in industrial workplaces. These solvents are found primarily in paint as thinner. Because other narcotics are hard to find, thinner is used as a narcotic especially among youngsters of low socioeconomic level. The aim of this...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2010.536290
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:An increased red blood cell (RBC) phosphatidylserine (PS) exposure in uremic patients was found that could promote macrophage recognition and decrease RBC survival time. Furthermore, a reduced red cell life span was found to contribute anemia in patients with renal failure. It is therefore possible to hypoth...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220600839647
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:The pathogenesis of the development of IgA nephropathy has not been clear up to now. At present, some studies revealed that the mTOR pathway may participate in IgA nephropathy; however, the mechanism has not been systematically studied. In this study, we established an IgAN rat model to investigate the prote...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2019.1577257
更新日期:2019-11-01 00:00:00