Effect of sevelamer on dyslipidemia and chronic inflammation in maintenance hemodialysis patients.

Abstract:

BACKGROUND:Hemodialysis (HD) patients often experience cardiovascular events, that might be related to altered calcium-phosphate metabolism, dyslipidemia, and chronic inflammation in addition to hypertension. Sevelamer, a non-calcium-containing phosphate binder, may improve the lipid profile of HD patients. However, the influence of sevelamer on chronic inflammation has not been clarified. METHODS:We enrolled 36 maintenance HD patients with a serum calcium (Ca) or phosphate (P) level constantly greater than 9.5 mg/dL and 5.5 mg/dL, respectively. The dose of sevelamer was titrated to achieve a serum Ca and P in the target ranges. The study period was 24 weeks. Patients underwent the following measurements: bone mineral markers, lipids, and a high-sensitivity C-reactive protein (hs-CRP). RESULTS:In the 28 patients who completed the study, sevelamer significantly reduced the mean non-high-density lipoprotein cholesterol (non-HDL-C) level by 15% and 20% (p < 0.0001) after 12 and 24 weeks, respectively, in addition to reducing the serum P level and Ca x P product. Similarly, there was a significant reduction of the serum hs-CRP level after 12 and 24 weeks [median at baseline: 1.03 mg/dL (interquartile range 0.26-3.98 mg/dL) versus 0.57 (0.17-1.47) and 0.38 (0.16-1.03), respectively, p = 0.0259]. The reduction rate of hs-CRP was significantly correlated with those of non-HDL-C (r = 0.451, p < 0.0401) and P (r = 0.453, p < 0.0008) CONCLUSION:Hs-CRP levels were reduced by sevelamer administration, as well as non-HDL-C, P, and the Ca x P product. Sevelamer may have an anti-inflammatory effect, in addition to lowering phosphate and lipid levels in HD patients.

journal_name

Ren Fail

journal_title

Renal failure

authors

Yamada K,Fujimoto S,Tokura T,Fukudome K,Ochiai H,Komatsu H,Sato Y,Hara S,Eto T

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

361-5

issue

4

eissn

0886-022X

issn

1525-6049

journal_volume

27

pub_type

杂志文章
  • Transforming growth factor-beta1 (TGF-beta1): a potential recovery signal in the post-ischemic kidney.

    abstract::TGF-beta1 has been demonstrated to be up-regulated in response to ischemic events both in animal models and in man. Demonstration of this up-regulation in the kidney following experimentally induced acute renal failure and in renal transplants complements similar findings in coronary and cerebral ischemia. Activation ...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:10.1081/jdi-120006767

    authors: Docherty NG,Pérez-Barriocanal F,Balboa NE,López-Novoa JM

    更新日期:2002-07-01 00:00:00

  • Psychological aspects of disasters.

    abstract::This article describes several topics necessary for understanding the psychological impact of disasters. Topics discussed include characteristics of disaster that impact psychological response, stages of response, factors influencing individual and collective trauma, and important aspects of psychological intervention...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:10.3109/08860229709109027

    authors: Flynn BW

    更新日期:1997-09-01 00:00:00

  • Protective effect of curcumin on busulfan-induced renal toxicity in male rats.

    abstract:AIM:The aim of this study was to evaluate the effects of curcumin in an experimental model of busulfan-induced renal toxicity with emphasis on importance of histological alterations. METHODS:In this study, we utilized 32 adult male Wistar rats (250 ± 10 g). All the animals were divided into four experimental groups ra...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2020.1818580

    authors: Abdollahifar MA,Ebrahimi V,Aliaghaei A,Raoofi A,Khosravi A,Hasani A,Mehdizadeh A,Asadi M

    更新日期:2020-11-01 00:00:00

  • Rhabdomyolysis, acute renal failure, and multiple focal neuropathies after drinking alcohol soaked with centipede.

    abstract::Many Chinese like to drink alcohol soaked with creatures for promoting health. This study reports a 49-year-old male who presented with multiple focal neuropathies of the upper limbs, coagulopathy, erythematous swelling of the bilateral upper extremities and trunk with bullous skin lesions, and rhabdomyolysis associat...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-120028562

    authors: Wang IK,Hsu SP,Chi CC,Lee KF,Lin PY,Chang HW,Chuang FR

    更新日期:2004-01-01 00:00:00

  • The subjective sleep quality and heart rate variability in hemodialysis patients.

    abstract:INTRODUCTION:Sleep disturbances and cardiovascular autonomic dysfunction are major complications of hemodialysis (HD). The goal of this study is to identify clinical, heart rate variability (HRV) or laboratory parameters that are independently associated with subjective sleep quality. PATIENT AND METHODS:Forty-six sta...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2010.541578

    authors: Wei CY,Chung TC,Wu SC,Chung CF,Wu WP

    更新日期:2011-01-01 00:00:00

  • Spontaneous blastogenesis profiles and IL-2 receptor expression on kidney allograft.

    abstract::To examine immune activation rate of interstitial and glomeruli infiltrating MNC in different conditions of human renal allograft function deterioration, 33 renal transplant biopsies were performed 1-30 months after transplantations. Forty-one patients observed were on immunosuppressives: Pr, Aza, CsA following renal ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229309054973

    authors: Savin M,Basta-Jovanovic G,Veljovic R,Sindjic M

    更新日期:1993-01-01 00:00:00

  • Occult HBV infection in continuous ambulatory peritoneal dialysis and hemodialysis patients.

    abstract:AIM:Occult hepatitis B virus (HBV) infection can be defined as the presence of HBV DNA in the liver and/or blood in the absence of detectable serum hepatitis B surface antigen (HBs Ag). There is a high prevalence of occult HBV infection in dialysis patients. This study investigated the prevalence of occult HBV infectio...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860220903391242

    authors: Sav T,Gursoy S,Torun E,Sav NM,Unal A,Oymak O,Utas C

    更新日期:2010-01-01 00:00:00

  • Acute kidney injury in patients with pyogenic liver abscess.

    abstract::Incidence of acute kidney injury (AKI) in patients with pyogenic liver abscess is rare. In our study we found AKI in 32.6% of patients with liver abscess. Majority of the patients were in their fifties and sixties. As per acute kidney injury network trial criteria, renal failure was in stage 1 in 26.6%, stage 2 in 40%...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2011.569108

    authors: Sriramnaveen P,Sridhar A,Sandeep Y,Krishnakishore C,Sainaresh V,Manjusha Y,Sivakumar V

    更新日期:2011-01-01 00:00:00

  • Kidney function and histological damage in autopsy subjects with myocardial infarction.

    abstract:OBJECTIVES:Chronic kidney disease (CKD) is a major risk factor for cardiovascular disease (CVD). We previously reported renal parenchymal damage in autopsy subjects with stroke or abdominal aortic aneurysm. The aim of this study is to evaluate the relationship between renal histology and clinical characteristics of pat...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2011.605531

    authors: Niizuma S,Nakamura S,Ishibashi-Ueda H,Yoshihara F,Kawano Y

    更新日期:2011-01-01 00:00:00

  • The influence of low calcium dialysate on left ventricular diastolic function in peritoneal dialysis patients.

    abstract::Left ventricular (LV) diastolic function was found to be a significant predictor of cardiovascular events and general mortality in dialysis. Studies have indicated that dialysate calcium concentrations were significantly associated with cardiac function. However, the relationship between low calcium dialysate and LV d...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2016.1229986

    authors: Wang Z,Wen Y,Liang J,Liang X,Shi W

    更新日期:2016-11-01 00:00:00

  • Effects of uric acid-lowering therapy on the progression of chronic kidney disease: a systematic review and meta-analysis.

    abstract:OBJECTIVES:Whether uric acid levels were associated with the progression of chronic kidney disease (CKD) remained controversial. This meta-analysis was aimed to assess the effect of lowering serum uric acid therapy on the progression of CKD to clarify the role of uric acid in the progression of CKD indirectly. METHODS...

    journal_title:Renal failure

    pub_type: 杂志文章,meta分析,评审

    doi:10.1080/0886022X.2018.1456463

    authors: Liu X,Zhai T,Ma R,Luo C,Wang H,Liu L

    更新日期:2018-11-01 00:00:00

  • Acute toxic kidney injury.

    abstract::Substances toxic to the kidney are legion in the modern world. The sheer number and variety, their mutual interactions and, metabolism within the body are a challenge to research. Moreover, the kidney is especially prone to injury owing to its physiology. Acute kidney injury (AKI) induced by poisonous or primarily nep...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:10.1080/0886022X.2019.1628780

    authors: Petejova N,Martinek A,Zadrazil J,Teplan V

    更新日期:2019-11-01 00:00:00

  • Relation between exhaled nitric oxide and left ventricular performance in chronic hemodialysis patients.

    abstract:INTRODUCTION:End-stage renal disease is the most debilitating condition for patients with renal diseases. Cardiovascular disease is the leading cause of death in these patients. It has been shown that nitric oxide (NO) increases in renal failure and hemodialysis patients and could be correlated with cardiovascular dise...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2013.830225

    authors: Ansarin K,Toufan M,Namdar H,Etemadi J,Habibzadeh A,Valinejad M,Shoja MM,Ghabili K

    更新日期:2014-02-01 00:00:00

  • Calcium antagonists and renal protection.

    abstract::A growing body of evidence supports the notion that calcium antagonists exert a renal protective effect. Calcium antagonists may play an important future role in renal hemodynamics related to their reversal of renal vasoconstrictors. Calcium antagonists are also capable of blocking intracellular calcium overload induc...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:10.3109/08860229309054944

    authors: Neumayer HH,Gellert J,Luft FC

    更新日期:1993-01-01 00:00:00

  • Renal cortical necrosis is a disappearing entity in obstetric acute kidney injury in developing countries: our three decade of experience from India.

    abstract:RATIONAL:Obstetrical complications are the commonest causes of Renal Cortical Necrosis (RCN). However, the overall incidence of RCN in obstetric acute kidney injury in developing countries has been decreasing in recent years. OBJECTIVE:The aim of this study was to evaluate the changing profile of RCN in obstetric AKI ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2015.1062340

    authors: Prakash J,Pant P,Singh AK,Sriniwas S,Singh VP,Singh U

    更新日期:2015-08-01 00:00:00

  • Trends and variations in intravenous vitamin D use among hemodialysis patients in the United States.

    abstract::Injectable vitamin D agents are commonly used to manage secondary hyperparathyroidism in dialysis patients. Yet, there are few data documenting the trends and geographic variations in the use of these agents in large, representative samples. We sought to describe patterns and variations in the use of vitamin D formula...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2012.734260

    authors: Beaubrun AC,Brookhart MA,Sleath B,Wang L,Kshirsagar AV

    更新日期:2013-01-01 00:00:00

  • The influence of mutant lactobacilli on serum creatinine and urea nitrogen concentrations and renal pathology in 5/6 nephrectomized rats.

    abstract:OBJECTIVES:To explore the capacity of mutant lactobacilli to remove creatinine (Cr) and urea nitrogen (UN) via the gastrointestinal tract and its effects on renal pathology in the 5/6 nephrectomized rat model of chronic renal failure. METHODS:Sixty Sprague-Dawley rats were randomly divided into a Sham group, a Model g...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2016.1227617

    authors: Wang F,Jiang YS,Liu F

    更新日期:2016-10-01 00:00:00

  • What has changed in the prevalence of hypertension in dialyzed children during the last decade?

    abstract:BACKGROUND:Hypertension very often accompanies progression of chronic kidney disease (CKD) in children. A cross-sectional analysis of hypertension prevalence in dialyzed children in Poland was designed with a comparison with the data previously recorded 10 years earlier. METHODS:Two cohorts of children were analyzed: ...

    journal_title:Renal failure

    pub_type: 杂志文章,多中心研究

    doi:10.1080/0886022X.2016.1260033

    authors: Tkaczyk M,Stańczyk M,Miklaszewska M,Zachwieja K,Wierciński R,Stankiewicz R,Firszt-Adamczyk A,Zachwieja J,Borzęcka H,Zagożdżon I,Leszczyńska B,Medyńska A,Adamczyk P,Szczepańska M,Fendler W

    更新日期:2017-11-01 00:00:00

  • Impact of pretreatment with carnitine and tadalafil on contrast-induced nephropathy in CKD patients.

    abstract::Objective: The present study assesses whether phosphodiesterase type 5 (PDE-5) inhibitor or carnitine exert nephroprotective effects against clinical contrast-induced nephropathy (CIN).Materials and Methods: The present study consisted of three groups of CKD patients. The first group was control group, who were treate...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2019.1669459

    authors: Armaly Z,Artol S,Jabbour AR,Saffouri A,Habashi N,Abd Elkadir A,Ghattas N,Farah R,Kinaneh S,Nseir W

    更新日期:2019-11-01 00:00:00

  • Influence of dialysis modality and membrane flux on quality of life in hemodialysis patients.

    abstract:BACKGROUND:The quality of life in patients undergoing hemodialysis is significantly disturbed. There are data that hemodiafiltration (HDF) may be more effective than conventional hemodialysis in the removal of uremic toxins and may reduce frequency and severity of intradialytic and postdialysis adverse symptoms in pati...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2012.684555

    authors: Knezevic MZ,Djordjevic VV,Radovanovic-Velickovic RM,Stankovic JJ,Cvetkovic TP,Djordjevic VM

    更新日期:2012-01-01 00:00:00

  • Bilateral renal hypoplasia and cystic dysplasia: a new phenotype of Thomas syndrome or a new syndrome?

    abstract::Thomas syndrome is a rare syndrome including Potter sequence, renal anomalies, heart defects, cleft palate with other oropharyngeal anomalies. Here, we report a newborn with Potter sequence, bilateral renal hypoplasia and cystic dysplasia, multiple cardiovascular malformations, long large ears, frontal bossing, small ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2011.585414

    authors: Ozkaya H,Akcan AB,Aydemir G,Aydınöz S,Kul M,Karademir F,Süleymanoğlu S

    更新日期:2011-01-01 00:00:00

  • Significant benefits after renal transplantation in patients with chronic heart failure and chronic kidney disease.

    abstract:BACKGROUND:Chronic heart failure (CHF) and chronic kidney disease (CKD) are serious medical conditions with significant morbidity and mortality and often coexist. Because of perioperative risks in these patients, they may not be considered a candidate for renal transplantation (RTx). MATERIAL AND METHODS:We compare re...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2014.899474

    authors: Kute VB,Vanikar AV,Patel HV,Gumber MR,Shah PR,Engineer DP,Balwani MR,Gautam RS,Modi PR,Shah VR,Trivedi HL

    更新日期:2014-07-01 00:00:00

  • Relationship of serum cystatin C with C-reactive protein and apolipoprotein A1 in patients on hemodialysis.

    abstract::Cystatin C is considered an indicator of acute renal failure and also a risk factor of cardiovascular disease. This study was undertaken to examine the relationship of serum cystatin C with C-reactive protein (CRP), lipids, and lipid-related compounds in patients on hemodialysis (HD). Cystatin C, CRP, total cholestero...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220802212973

    authors: Samouilidou EC,Grapsa E

    更新日期:2008-01-01 00:00:00

  • miR-15a-5p suppresses peritoneal fibrosis induced by peritoneal dialysis via targeting VEGF in rats.

    abstract:AIM:When peritoneal fibrosis (PF) causes ultrafiltration failure in peritoneal dialysis (PD) patients, PD has to be discontinued. Currently, there is no effective way to relieve PF. In this study, we aimed to determine whether miR-15a-5p is involved in PF and to determine the underlying mechanism. METHODS:Six normal r...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2020.1811123

    authors: He Q,Wen L,Wang L,Zhang Y,Yu W,Zhang F,Zhang W,Xiao J,Wen X,Zhao Z

    更新日期:2020-11-01 00:00:00

  • Test of the recommended dialysis dose on one-year mortality of nondiabetic maintenance hemodialysis patients; observations from a single dialysis unit.

    abstract:BACKGROUND:The optimal delivered dialysis dose has been of a great interest for the last three decades, though a clear cut point has not been reached yet. We aimed to evaluate the relationship between one-year mortality and the delivered dialysis dose, which was recommended by Kidney Disease Outcomes Quality Initiative...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2016.1208515

    authors: Sahutoglu T,Kara E,Ahbap E,Sakaci T,Koc Y,Basturk T,Sevinc M,Akgol C,Ucar ZA,Ozdemir Kayalar A,Caglayan FB,Unsal A

    更新日期:2016-09-01 00:00:00

  • Pheochromocytoma presenting with rhabdomyolysis and acute renal failure: a case report.

    abstract::Rhabdomyolysis ranges from an asymptomatic illness with elevated creatine kinase levels to a life-threatening condition associated with extreme elevations in creatine kinase, electrolyte imbalances, acute renal failure, and disseminated intravascular coagulation. The most common causes are crush injury, overexertion, ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2013.832856

    authors: Celik H,Celik O,Guldiken S,Inal V,Puyan FO,Tugrul A

    更新日期:2014-02-01 00:00:00

  • Mortality risk factors in chronic renal failure patients after coronary artery bypass grafting.

    abstract::Perioperative risk during coronary artery bypass grafting (CABG) is high in patients with chronic renal disease. We aimed to determine postoperative two-year mortality and identify the preoperative risk factors of mortality during CABG surgery in hemodialysis (HD)-dependent and HD-non-dependent CRF patients. We includ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220701573525

    authors: Akman B,Bilgic A,Sasak G,Sezer S,Sezgin A,Arat Z,Ozdemir FN,Haberal M

    更新日期:2007-01-01 00:00:00

  • Community-based study on elderly CKD subjects and the associated risk factors.

    abstract:OBJECTIVE:To investigate the prevalence and risk factors for chronic kidney disease (CKD) among community elderly population in Shanghai, China, in order to provide early diagnosis and treatment of CKD, and improve the quality of life for elderly people. METHODS:In all, 24,886 residents (≥65 years old) were selected f...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2016.1229987

    authors: Huang YP,Zheng T,Zhang DH,Chen LY,Mao PJ

    更新日期:2016-11-01 00:00:00

  • Transformation from tubulointerstitial nephritis to crescentic glomerulonephritis: an unusual presentation of ANCA-associated renal vasculitis.

    abstract::A 44-year-old man with acute renal failure and antineutrophil cytoplasmic antibodies (ANCA) positivity was described. The first renal biopsy specimen showed tubulointerstitial nephritis (TIN) with normal glomeruli. However, delayed recovery of renal function with low-dose steroid treatment for TIN prompted a second re...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:10.1080/08860220500531559

    authors: Wen YK,Chen ML

    更新日期:2006-01-01 00:00:00

  • The differences of asymmetric dimethylarginine removal by different dialysis treatments.

    abstract:BACKGROUND:Asymmetric dimethylarginine (ADMA) as a uremia toxin is accumulated in end-stage renal disease (ESRD) patients. Elevated ADMA level has been shown to be predictive of cardiovascular diseases (CVDs) and all-cause mortality in ESRD. Therefore, we investigated the removal of ADMA by different dialysis treatment...

    journal_title:Renal failure

    pub_type: 杂志文章,随机对照试验

    doi:10.3109/0886022X.2010.502281

    authors: Zhang DL,Liu J,Liu S,Zhang Y,Liu WH

    更新日期:2010-01-01 00:00:00