Abstract:
:Substances toxic to the kidney are legion in the modern world. The sheer number and variety, their mutual interactions and, metabolism within the body are a challenge to research. Moreover, the kidney is especially prone to injury owing to its physiology. Acute kidney injury (AKI) induced by poisonous or primarily nephrotoxic substances, may be community acquired with ingestion or inhalation or nosocomial. Many nephrotoxic plants, animal poisons, medications, chemicals and illicit drugs can induce AKI by varying pathophysiological pathways. Moreover, the epidemiology of toxic AKI varies depending on country, regions within countries, socioeconomic status and health care facilities. In this review, we have selected nephrotoxic insults due to medication, plants, animal including snake venom toxicity, environmental, (agri)chemicals and also illicit drugs. We conclude with a section on diagnosis, clinical presentation and management of poisoning accompanied by various organ dysfunction and AKI.
journal_name
Ren Failjournal_title
Renal failureauthors
Petejova N,Martinek A,Zadrazil J,Teplan Vdoi
10.1080/0886022X.2019.1628780subject
Has Abstractpub_date
2019-11-01 00:00:00pages
576-594issue
1eissn
0886-022Xissn
1525-6049journal_volume
41pub_type
杂志文章,评审相关文献
RENAL FAILURE文献大全abstract:BACKGROUND:The syndrome of rapid onset end-stage renal disease (SORO-ESRD) was first described in the journal Renal Failure in 2010. This is an acute precipitate unpredictable yet irreversible ESRD following acute kidney injury (AKI), as distinct from "classic" ESRD where chronic kidney disease (CKD)-ESRD progression w...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2015.1088336
更新日期:2015-01-01 00:00:00
abstract::The Latin American Society of Nephrology and Arterial Hypertension's Dialysis and Transplant Registry was chartered in 1991. It collects information on ESRD and its treatment in 20 countries of the region. The prevalence of patients on renal replacement therapy (RRT) increased from 129 pmp in 1992 to 447 pmp in 2004; ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220600925693
更新日期:2006-01-01 00:00:00
abstract::N-acetylglucosaminidase (NAG) is a lysosomal enzyme produced by renal proximal tubular cells and has been widely used as a marker, which indicates a degree of renal tubular damage. An increase in urinary NAG excretion is though to result from the renal tubular damage. The aim of this study was to evaluate whether even...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-120002662
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:The optimal delivered dialysis dose has been of a great interest for the last three decades, though a clear cut point has not been reached yet. We aimed to evaluate the relationship between one-year mortality and the delivered dialysis dose, which was recommended by Kidney Disease Outcomes Quality Initiative...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2016.1208515
更新日期:2016-09-01 00:00:00
abstract::Abstract TGF-β1 plays an important role in the pathogenesis of chronic renal diseases. Although the specific mechanism is unknown, a major factor is the potent fibrogenic activity of TGF-β1 in the chronic progression of renal diseases. TGF-β1 closely correlates with renal fibrosis in cooperation with several fibrosis-...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2014.882713
更新日期:2014-05-01 00:00:00
abstract::During embryonic life, renal morphogenesis is characterized by a defined period of intense cellular activity, inductive-transformation of undifferentiated cells to polarized epithelia, in-growth of capillaries into an intricate parenchymal epithelial-mesenchymal mass, and finally the maturation into an organ with dive...
journal_title:Renal failure
pub_type: 杂志文章,评审
doi:10.3109/08860229809045119
更新日期:1998-03-01 00:00:00
abstract::Renal involvement is an unusual but significant Behcet´s disease (BD) complication and AA amyloidosis appears to be the most common etiology. IL-6 is a pro-inflammatory cytokine with an important role in AA amyloidosis development. Tocilizumab (TCZ) is a humanized anti-IL-6 receptor antibody that has emerged as an eff...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2013.773913
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Emerging evidence demonstrates that gut dysbiosis is implicated in the pathogenesis of chronic kidney disease (CKD) with underlying mechanisms involving mucosal and/or systematic immunity or metabolic disorders. However, the profile of gut microbiota in patients with CKD has not been completely explored. ME...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2020.1864404
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Interleukin 17 (IL-17) plays an important role in the pathogenesis of autoimmune diseases and might be associated with IgA nephropathy (IgAN). This study aimed to investigate the effect of IL-17 on autoimmune pathogenesis in IgA nephropathy. METHODS:DAKIKI cells were cultured and stimulated with IL-17 to pe...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2017.1419972
更新日期:2018-11-01 00:00:00
abstract::Uremia induces a suppression of the immune status. A large clinical literature suggests that estradiol (E2) plays a critical role in immune function. A large proportion of women hemodialysis patients faced early menopause and inadequate estrogen levels. The aim of the present study is to evaluate the effect of hormone...
journal_title:Renal failure
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract:AIM:To investigate the therapeutic effects of oral carbonic adsorbent on rats with early-stage renal failure. METHODS:The early-stage renal failure model was established with three-fourth subtotal nephrectomy Wistar rats. Four weeks after the subtotal nephrectomy, the rats were randomly divided into four groups: (1) a...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2014.986006
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:The kidney is one of the prior damaged organs subjected to severe infection and sepsis shock. Our previous studies have shown that the normal mesenteric lymph (NML) obtained from healthy dogs could alleviate multiple organ injuries following endotoxic shock. In the current study, we further investigated the ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2014.938585
更新日期:2014-09-01 00:00:00
abstract::Medication errors are ongoing problems among hospitalized patients especially those with multiple co-morbidities and polypharmacy such as patients with renal diseases. This study evaluated the frequency, types and direct related cost of medication errors in nephrology ward and the role played by clinical pharmacists. ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2014.934650
更新日期:2014-09-01 00:00:00
abstract::The aim of our study was to analyze the clinical course and outcome of acute renal failure (ARF) in patients with hemorrhagic fever with renal syndrome (HFRS). From 1983 to 1995, we treated 33 patients (27 males, 6 females) aged from 16 to 71 years. Half of patients were connected with work at a farm or in a forest. T...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229609047688
更新日期:1996-07-01 00:00:00
abstract:PRINCIPLES:Coumadin-induced renal and retroperitoneal hemorrhages are rare. Clinical and laboratory findings are not specific for the diagnosis. Computed tomography (CT) has some advantages in the evaluation of these patients. The aim of this study is to report our experience regarding renal and retroperitoneal hemorrh...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220500530569
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to establish a predictive postoperative nomogram for acute kidney injury (AKI) after intracranial aneurysm clipping surgery, in order to early identify patients with high postoperative AKI risk. METHODS:This is a retrospective study, which included patients who underwent intracranial...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2020.1838299
更新日期:2020-11-01 00:00:00
abstract::A 44-year-old man with acute renal failure and antineutrophil cytoplasmic antibodies (ANCA) positivity was described. The first renal biopsy specimen showed tubulointerstitial nephritis (TIN) with normal glomeruli. However, delayed recovery of renal function with low-dose steroid treatment for TIN prompted a second re...
journal_title:Renal failure
pub_type: 杂志文章,评审
doi:10.1080/08860220500531559
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Chronic kidney disease (CKD) is associated with muscle excess fatigue and diminished maximal whole body oxygen consumption, which in part could be depended on poor muscle microcirculatory network. The aim of this study was to assume the influence of different stages of CKD on microcirculation vessels in func...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220801985694
更新日期:2008-01-01 00:00:00
abstract::There are conflicting results in studies concerning the best marker for liver histopathological features of HCV infection in HD patients. We planned a prospective study to follow HCV viremia and laboratory parameters of HD patients and correlate these with clinic features and histopathological findings. We included 68...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-100108192
更新日期:2001-11-01 00:00:00
abstract:BACKGROUND:Hemodialysis (HD) patients often experience cardiovascular events, that might be related to altered calcium-phosphate metabolism, dyslipidemia, and chronic inflammation in addition to hypertension. Sevelamer, a non-calcium-containing phosphate binder, may improve the lipid profile of HD patients. However, th...
journal_title:Renal failure
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::Left ventricular hypertrophy (LVH) is a common abnormality in hemodialysis (HD) patients. Mitochondrial dysfunction contributes to the progression of LVH. As an inner mitochondrial membrane structural protein, mitofilin plays a key role in maintaining mitochondrial structure and function. The aim of this study was to ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2018.1456455
更新日期:2018-11-01 00:00:00
abstract::Currently, obesity has reached an epidemic stage and represents a challenge for health authorities across the globe. Certainly, with emergence of obesity epidemic, we started to see an increase in the prevalence of chronic kidney disease (CKD) and nephrolithiasis. Interestingly, epidemiologic studies have shown that t...
journal_title:Renal failure
pub_type: 杂志文章,评审
doi:10.3109/0886022X.2012.723777
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:In order to evaluate the clinical and pathological characteristics of diuretics associated acute kidney injury (AKI) and its management. METHODS:We performed a retrospective study including 131 cases that diagnosed as diuretics associated AKI from 1 January 1999 to 1 January 2010 in Ruijin Hospital affiliate...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2014.917560
更新日期:2014-08-01 00:00:00
abstract:INTRODUCTION:In this study, the cause of rapidly deteriorating renal functions in a follow-up period of a 65-year-old female patient, who applied with nephrotic syndrome findings and diagnosed as membranous nephropathy, is presented. CASE REPORT:A 65-year-old patient with findings of nephrotic syndrome had normal kidn...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220802064804
更新日期:2008-01-01 00:00:00
abstract::Renal ischemia reperfusion injury (IRI) is a major problem, currently without treatments in clinical use. This reflects the failure of animal models to mimic the severity of IRI observed in clinical practice. Most described models lack both the ability to inflict a permanent reduction in renal function and the sensiti...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2016.1144024
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVES:Whether uric acid levels were associated with the progression of chronic kidney disease (CKD) remained controversial. This meta-analysis was aimed to assess the effect of lowering serum uric acid therapy on the progression of CKD to clarify the role of uric acid in the progression of CKD indirectly. METHODS...
journal_title:Renal failure
pub_type: 杂志文章,meta分析,评审
doi:10.1080/0886022X.2018.1456463
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Fabry disease (FD) is an X-linked lysosomal storage disorder caused by the mutation of the GLA gene, encoding the α-galactosidase, which is responsible for the catabolism of neutral glycosphingolipids. Microalbuminuria or low-grade proteinuria, and continuously progressive renal failure are common manifestat...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2020.1818578
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Psychological problems such as depression and anxiety are common in hemodialysis patients. In several studies, exercise programs were effective in relieving depression or anxiety in these patients, although not all agree. PURPOSE:In this study, we evaluated the effects of an exercise program on exercise cap...
journal_title:Renal failure
pub_type: 临床试验,杂志文章
doi:10.1081/jdi-120005367
更新日期:2002-05-01 00:00:00
abstract:RATIONAL:Obstetrical complications are the commonest causes of Renal Cortical Necrosis (RCN). However, the overall incidence of RCN in obstetric acute kidney injury in developing countries has been decreasing in recent years. OBJECTIVE:The aim of this study was to evaluate the changing profile of RCN in obstetric AKI ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2015.1062340
更新日期:2015-08-01 00:00:00
abstract::Heat stroke occurs in the desert area of Saudi Arabia quite frequently and manifest in different patterns including coagulopathy. Frequently encountered complications include renal or hepatic failure, rhabdomyolysis, acute respiratory distress syndrome (ARDS), disseminated intravascular coagulation (DIC), and seizure....
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-100107370
更新日期:2001-09-01 00:00:00