Transforming growth factor-beta1 (TGF-beta1): a potential recovery signal in the post-ischemic kidney.

Abstract:

:TGF-beta1 has been demonstrated to be up-regulated in response to ischemic events both in animal models and in man. Demonstration of this up-regulation in the kidney following experimentally induced acute renal failure and in renal transplants complements similar findings in coronary and cerebral ischemia. Activation of TGF-beta1 occurs as a direct consequence of hypoxia, angiotensin II signaling and loss of extra cellular matrix (ECM) integrity, all of which occur in renal ischemia-reperfusion injury. TGF-beta1 thus up-regulates the synthesis of extracellular matrix components such as fibronectin and collagen IV providing a basis for the restoration of epithelial coverage in the regenerating tubule. TGF-beta1 also regulates epithelial tubular cell proliferation and differentiation. This response is quickly closed down in response to recovery of the kidney. This review examines the evidence linking TGF-beta1 activity to recovery from renal ischemia thereby constructing a hypothesis for the beneficial role of TGF-beta1 in the post ischemic kidney.

journal_name

Ren Fail

journal_title

Renal failure

authors

Docherty NG,Pérez-Barriocanal F,Balboa NE,López-Novoa JM

doi

10.1081/jdi-120006767

subject

Has Abstract

pub_date

2002-07-01 00:00:00

pages

391-406

issue

4

eissn

0886-022X

issn

1525-6049

journal_volume

24

pub_type

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