Antioxidant U74389G improves glycerol-induced acute renal failure without affecting PPARgamma gene.

Abstract:

:Oxygen metabolites play an important role in the pathogenesis of myoglobinuric acute renal failure (ARF). Previously, we have reported a down regulation of peroxisome proliferator activated receptor gamma (PPARgamma) in glycerol-induced ARF, and the induction of PPARgamma has been shown to provide renal protection. In this study, we determined the protective influence of U74389G, a hydroxyl radical scavenger in myoglobinuric ARF, and its association with PPARgamma-mediated renal protection in the rat. Vascular responses to AII were determined in renal pre-glomerular vessels following the induction of ARF with glycerol (50%, v/v, i.m.). The extent of renal damage and function were assessed with or without pre-treatment with U74389G (10 mg/kg x 21 days). In ARF, AII vasoconstriction was enhanced (97%; p < 0.05), and AII production was doubled. U74389G reduced AII vasoconstriction and production by 42% (p < 0.05) and 40% (p < 0.05), respectively. U74389G reduced proteinuria (85%; p < 0.05), which was four times higher in ARF. Similarly, U74389G enhanced Na+ excretion twofold while reducing plasma creatinine (24%; p < 0.05) and BUN (31%; p < 0.05). U74389G attenuated free radical generation in ARF while nitrite excretion was unchanged. In renal pre-glomerular vessel, PPARgamma expression, activity, and mRNA were significantly lower in ARF rats; this was unchanged with U74389G treatment. On the other hand, U74389G significantly reduced NFkappaB protein expression, which was elevated in ARF by 25% (p < 0.05). We suggest that antioxidant U74389G blunted renal injury and improved renal function in glycerol-induced ARF through the reduction of free radical production and/or inhibition of NFkappaB without affecting PPARgamma.

journal_name

Ren Fail

journal_title

Renal failure

authors

Yousefipour Z,Hercule H,Oyekan AO,Newaz MA

doi

10.1080/08860220701573483

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

903-10

issue

7

eissn

0886-022X

issn

1525-6049

pii

783645613

journal_volume

29

pub_type

杂志文章
  • Cola-colored dialysate as a gastrointestinal sequelae of cardiac surgery in a patient who underwent peritoneal dialysis.

    abstract::The discoloration of effluent peritoneal dialysate, which is transparent in origin, is seen in some particular conditions including chyloperitoneum, calcium channel blocker usage, hemoperitoneum, perforated cholecystitis, iron administration, and hemorrhagic pancreatitis. We report a case of a 60-year-old woman who un...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2012.711731

    authors: Ling EK,Lin BS,Chiang SS,Tsai MH

    更新日期:2012-01-01 00:00:00

  • Test of the recommended dialysis dose on one-year mortality of nondiabetic maintenance hemodialysis patients; observations from a single dialysis unit.

    abstract:BACKGROUND:The optimal delivered dialysis dose has been of a great interest for the last three decades, though a clear cut point has not been reached yet. We aimed to evaluate the relationship between one-year mortality and the delivered dialysis dose, which was recommended by Kidney Disease Outcomes Quality Initiative...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2016.1208515

    authors: Sahutoglu T,Kara E,Ahbap E,Sakaci T,Koc Y,Basturk T,Sevinc M,Akgol C,Ucar ZA,Ozdemir Kayalar A,Caglayan FB,Unsal A

    更新日期:2016-09-01 00:00:00

  • The effect of strict volume control on cognitive functions in chronic hemodialysis patients.

    abstract::Cognitive dysfunction is a well-known complication of chronic renal failure that is evident in 30% of hemodialysis (HD) patients. However, the pathogenesis of this dysfunction is unknown. Left ventricular hypertrophy could develop in hypertensive HD patients without establishing normovolemia. Our aim was to evaluate t...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860220903134548

    authors: Dogukan A,Guler M,Yavuzkir MF,Tekatas A,Poyrazoglu OK,Aygen B,Gunal AI,Yoldas TK

    更新日期:2009-01-01 00:00:00

  • Polyneuropathy due to cyclosporine A in patients with renal transplantation: a case report.

    abstract:BACKGROUND:Calcineurin inhibitor cyclosporine A (CsA) is a potent immunosuppressive agent. The side effects of CsA include nephrotoxicity, hypertension, hypertrichosis, infection, hyperpotassemia, and, to a lower extent, neuropathy. OBJECTIVES:In this case report, we aimed to present a renal transplant patient with po...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2011.573893

    authors: Sayin R,Soyoral YU,Erkoc R

    更新日期:2011-01-01 00:00:00

  • Psychological aspects of disasters.

    abstract::This article describes several topics necessary for understanding the psychological impact of disasters. Topics discussed include characteristics of disaster that impact psychological response, stages of response, factors influencing individual and collective trauma, and important aspects of psychological intervention...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:10.3109/08860229709109027

    authors: Flynn BW

    更新日期:1997-09-01 00:00:00

  • Long-term efficacy and safety of quadruple therapy in childhood diffuse proliferative lupus nephritis.

    abstract::In this study, we evaluated the frequency, clinical presentation, treatment protocols, prognostic factors, and outcome in children with diffuse proliferative lupus nephritis (DPLN). Between June 1990 and December 2004, 46 patients were diagnosed to have systemic lupus erythematosus (SLE), and 26 of them (56.5%) were f...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220802132171

    authors: Demircin G,Oner A,Erdoğan O,Delibaş A,Baysun S,Bülbül M,Bek K,Oksal A

    更新日期:2008-01-01 00:00:00

  • Role of glutathione for cisplatin nephrotoxicity in young and adult rats.

    abstract::Investigations were done in 10- and 55-day-old Wistar rats. Glutathione (GSH) level in kidney was decreased by 8 mmol buthionine sulfoximine (BSO)/100 g BW. There was no effect on the renal function and nephrotoxicity of cisplatin (0.6 mg CP/100 g BW) in adult rats. In young rats BSO treatment was followed by nephroto...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229309046144

    authors: Appenroth D,Winnefeld K

    更新日期:1993-01-01 00:00:00

  • Histopathological changes of rat kidney with exposure to chronic thinner inhalation.

    abstract:INTRODUCTION:Organic solvents are liquid substances commonly used in everyday life at home and in industrial workplaces. These solvents are found primarily in paint as thinner. Because other narcotics are hard to find, thinner is used as a narcotic especially among youngsters of low socioeconomic level. The aim of this...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2010.536290

    authors: Toros AB,Toros SZ,Aker F,Ersoz F,Derin A,Kesici B,Ozel L

    更新日期:2011-01-01 00:00:00

  • Coumadin-induced renal and retroperitoneal hemorrhage.

    abstract:PRINCIPLES:Coumadin-induced renal and retroperitoneal hemorrhages are rare. Clinical and laboratory findings are not specific for the diagnosis. Computed tomography (CT) has some advantages in the evaluation of these patients. The aim of this study is to report our experience regarding renal and retroperitoneal hemorrh...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220500530569

    authors: Danaci M,Kesici GE,Kesici H,Polat C,Belet U

    更新日期:2006-01-01 00:00:00

  • Effect of arachidonic acid metabolic inhibitors on hypoxia/reoxygenation-induced renal cell injury.

    abstract::The present study was undertaken to examine the role of arachidonic acid (AA) metabolites in hypoxia/reoxygenation (H/R)-induced renal cell injury in rabbit renal cortical slices using AA metabolic inhibitors. Inhibitors of cyclooxygenase (indomethacin and diclofenac sodium) and lipoxygenase pathways (nordihydroguaiar...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-100100860

    authors: Kim YK,Hwang MY,Woo JS,Jung JS,Lee SH

    更新日期:2000-03-01 00:00:00

  • Lack of relation between serum parathyroid hormone levels and erythrocyte osmotic fragility in pediatric patients on peritoneal dialysis.

    abstract::Secondary hyperparathyroidism and anemia are the hallmarks in uremic patients. It is suggested that parathyroid hormone increases erythrocyte osmotic fragility and induces hemolysis. The present study was undertaken to examine the possible relationship between erythrocyte osmotic fragility and secondary hyperparathyro...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-200037140

    authors: Koşan C,Sever L,Arisoy N

    更新日期:2004-11-01 00:00:00

  • Intermittent hirudin versus continuous heparin for anticoagulation in continuous renal replacement therapy.

    abstract:BACKGROUND:Besides possible bleeding complications a further problem in anticoagulation during continuous renal replacement therapy (CRRT) is the development of heparin-induced thrombocytopenia type II (HIT II) where further anticoagulation with heparin is contraindicated. The application of continuous hirudin as alter...

    journal_title:Renal failure

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1081/jdi-120039529

    authors: Hein OV,von Heymann C,Diehl T,Ziemer S,Ronco C,Morgera S,Siebert G,Kox WJ,Neumayer HH,Spies C

    更新日期:2004-05-01 00:00:00

  • Safety and efficacy of mizoribine treatment in nephrotic syndrome complicated with hepatitis B virus infection: a clinical study.

    abstract::Objective The objective of this study is to explore the efficacy and safety of mizoribine (MZR) in treating nephrotic syndrome patients afflicted with hepatitis B virus (HBV). Methods The present study included 36 nephrotic syndrome patients accompanied with HBV infection. A draft of MZR (150-200 mg/d), methylpredniso...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2016.1158035

    authors: Liu J,Zhang K,Ji Y,Zhang W,Li W,Yong Q,Wang J,Sun J,Zhang H

    更新日期:2016-06-01 00:00:00

  • Effects of pentoxifylline on amikacin-induced nephrotoxicity in rats.

    abstract::The nephrotoxicity of amikacin (AK) was prevented with pentoxifylline (PTX) in a rat model. Rats were received a single injection of AK (1.2 g/kg, i.p.) with or without PTX pretreatment (25 mg/kg, orally). Renal morphology was investigated by light microscopy. Tissue samples and trunk blood were also obtained to deter...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220802595492

    authors: Ozer MK,Asci H,Oncu M,Yesilot S,Savran M,Bayram D,Cicek E

    更新日期:2009-01-01 00:00:00

  • Hypocomplementemia is associated with more severe renal disease and worse renal outcomes in patients with ANCA-associated vasculitis: a retrospective cohort study.

    abstract:BACKGROUND:The complement system has been recently proposed to play an important role in the pathogenesis of ANCA-associated vasculitis (AAV). This study evaluated the value of serum and kidney deposited C3 in predicting renal outcomes in AAV. METHODS:This was a retrospective study of 47 patients with AAV, who were ca...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2020.1803086

    authors: Chalkia A,Thomas K,Giannou P,Panagiotopoulos A,Hadziyannis E,Kapota A,Gakiopoulou H,Vassilopoulos D,Petras D

    更新日期:2020-11-01 00:00:00

  • Postoperative hemolytic uremic syndrome with renal cortical necrosis following laparoscopic hemicolectomy.

    abstract::Non-Shiga-like toxin-producing Escherichia coli (STEC) or atypical hemolytic uremic syndrome (aHUS) is observed in 5-10% of all hemolytic uremic syndrome (HUS) cases, and usually develops secondary to infections, malignancies, drugs, transplantation, pregnancy, and autoimmune disease. However, there has been no report...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2013.780978

    authors: Lee JW,Won NH,Cho E,Kim MG,Jo SK,Cho WY,Kim HK

    更新日期:2013-01-01 00:00:00

  • Erythropoietin production in patients with chronic renal failure.

    abstract::Studies were performed to reexamine the response of erythropoietin (Epo) production to acute hypoxic stimuli in patients with end-stage renal disease (ESRD). In the absence of acute bleeding or hypoxia, the serum Epo level in ESRD was similar to that of normal subjects despite severe anemia. In 11 dialysis patients wi...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229409044892

    authors: Kato A,Hishida A,Kumagai H,Furuya R,Nakajima T,Honda N

    更新日期:1994-01-01 00:00:00

  • Acute renal failure following bone marrow transplantation.

    abstract::Acute renal failure (ARF) is one of the most frequent and potentially life threatening complications following bone marrow transplantation (BMT). Several renal syndromes that occur are either unique or occur with a disproportionate frequency post-BMT. Clinically ARF can be classified according to the time of onset pos...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:10.3109/08860229809045131

    authors: Pulla B,Barri YM,Anaissie E

    更新日期:1998-05-01 00:00:00

  • The effect of renal replacement therapies on serum gastrointestinal system hormones.

    abstract:BACKGROUND:The kidney is a major site for the inactivation, degradation, and clearance of a variety of peptide hormones. It has been shown that the uremia increases or decreases gastrointestinal system (GIS) hormones. Moreover, studies investigating the serum GIS hormones levels in chronic renal failure (CRF) were cond...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220701643799

    authors: Borazan A,Cavdar Z,Saglam F

    更新日期:2007-01-01 00:00:00

  • Association of the angiotensinogen M235T and APO E gene polymorphisms in Turkish type 2 diabetic patients with and without nephropathy.

    abstract:BACKGROUND:Diabetic nephropathy (DN) is a leading cause of diabetes-related morbidity and mortality. The aim of this study was to evaluate the relationship of AGT M235T and apoprotein E (APO E) gene polymorphism with DN in Turkish patients of Type 2 diabetes, and to compare genotype and allele distributions among DN pa...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2011.568133

    authors: Reis KA,Ebinç FA,Koç E,Demirci H,Erten Y,Güz G,Derici UB,Bali M,Söylemezoğlu O,Arınsoy T,Sindel S

    更新日期:2011-01-01 00:00:00

  • Urinary excretion of vitamin A in critically ill patients complicated with acute renal failure.

    abstract:OBJECTIVE:Study the possible excretion of vitamin A in urine of critically ill patients complicated with acute renal failure. PATIENTS AND METHODS:Nine Intensive Care Unit patients, age 71.2 +/- 15.7 (mean +/- SD) with acute renal failure were studied. Urinary retinol, creatinine, protein, albumin, and serum creatinin...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-200031729

    authors: Gavrilov V,Weksler N,Ahmed A,Gorodischer R

    更新日期:2004-09-01 00:00:00

  • Valvular calcification and left ventricular modifying in peritoneal dialysis patients.

    abstract:BACKGROUND:Cardiac valve calcification (CVC) and left ventricular (LV) alterations are frequent complication in end-stage renal disease (ESRD). We determined the prevalence of CVC and LV hypertrophy (LVH) in ESRD patients before renal replacement therapy and 12 months after peritoneal dialysis (PD). METHODS:A prospect...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2015.1073495

    authors: Rebić D,Rašić S,Hamzić-Mehmedbašić A,Džemidžić J,Kurtalić E

    更新日期:2015-01-01 00:00:00

  • The influence of mutant lactobacilli on serum creatinine and urea nitrogen concentrations and renal pathology in 5/6 nephrectomized rats.

    abstract:OBJECTIVES:To explore the capacity of mutant lactobacilli to remove creatinine (Cr) and urea nitrogen (UN) via the gastrointestinal tract and its effects on renal pathology in the 5/6 nephrectomized rat model of chronic renal failure. METHODS:Sixty Sprague-Dawley rats were randomly divided into a Sham group, a Model g...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2016.1227617

    authors: Wang F,Jiang YS,Liu F

    更新日期:2016-10-01 00:00:00

  • Acute renal failure: clinical outcome and causes of death.

    abstract::Acute renal failure (ARF) is a frequent complication in hospitalized patients and is strongly related to increase in mortality. In order to analyze the clinical outcome and the prognostic factors in hospital-acquired ARF, a prospective study was performed. Data from 200 patients with established ARF during the period ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229709026285

    authors: Barretti P,Soares VA

    更新日期:1997-03-01 00:00:00

  • Evaluation of renal clinicopathological changes in IgA nephropathy by urinary podocytes excretion and podocalyxin expression.

    abstract:OBJECTIVE:To explore the association of urinary podocyte excretion and renal expression of podocyte-specific marker podocalyxin (PCX) with clinicopathological changes in immunoglobulin A nephropathy (IgAN). METHODS:Morning urine samples from IgAN patients and healthy controls were collected. The expression of glomerul...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2011.643352

    authors: Jiang WL,Peng YM,Liu YH,Liu H,Chen GC,Xu XQ,Zhu XJ,Liu FY

    更新日期:2012-01-01 00:00:00

  • Neutrophil gelatinase-associated lipocalin as a follow-up marker in critically ill pediatric patients with established acute kidney injury.

    abstract:AIM:To assess the utility of neutrophil gelatinase-associated lipocalin (NGAL) in both urine and serum as a follow-up marker for the discrimination of prerenal acute kidney injury (AKI) from intrinsic AKI in critically ill pediatric patients with established AKI at the time of patient presentation. PATIENTS AND METHOD...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2013.764273

    authors: Polat M,Fidan K,Derinöz O,Gönen S,Söylemezoglu O

    更新日期:2013-01-01 00:00:00

  • Effects of pomegranate juice on hyperoxaluria-induced oxidative stress in the rat kidneys.

    abstract::To evaluate the role of the inducible nitric oxide synthase (iNOS), selective nuclear factor-kB (NF-kB), and p38-mitogene-activated protein kinase (p38-MAPK) on hyperoxaluria-induced oxidative stress and stone formation in rat kidneys. The rats were divided into five groups: group 1, control group; group 2: ethylene g...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220902963871

    authors: Ilbey YO,Ozbek E,Simsek A,Cekmen M,Somay A,Tasci AI

    更新日期:2009-01-01 00:00:00

  • Trends and variations in intravenous vitamin D use among hemodialysis patients in the United States.

    abstract::Injectable vitamin D agents are commonly used to manage secondary hyperparathyroidism in dialysis patients. Yet, there are few data documenting the trends and geographic variations in the use of these agents in large, representative samples. We sought to describe patterns and variations in the use of vitamin D formula...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2012.734260

    authors: Beaubrun AC,Brookhart MA,Sleath B,Wang L,Kshirsagar AV

    更新日期:2013-01-01 00:00:00

  • Predictive value of bedside effective renal plasma flow for renal recovery in severe acute renal failure.

    abstract::Single injection, single blood sample, effective renal plasma flow (ERPF) estimated by 131I-orthoiodohippurate can be performed accurately and conveniently without urine collection at the bedside. The purpose of this study was to determine if ERPF early in the course of severe acute renal failure (ARF) predicts recove...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860228709056321

    authors: Holland MD,Galla JH,Dubovsky EV,Luke RG

    更新日期:1987-01-01 00:00:00

  • Association of CYP3A variants with kidney transplant outcomes.

    abstract::Cyclosporine is used extensively in kidney transplantation and is a substrate for cytochrome P450 enzymes. The role of cytochrome p450 polymorphisms in kidney transplant outcome has not yet been fully elucidated. We investigate the clinical impact of single nucleotide polymorphisms in CYP3A4, CYP3A5, PPARα, and POR*28...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2015.1007013

    authors: Traynor C,Conlon P Jr,Phelan PJ,O'Kelly P,Elens L,McCormack M,Cavalleri G,Comber H,van Schaik RH,Conlon PJ

    更新日期:2015-05-01 00:00:00