Valvular calcification and left ventricular modifying in peritoneal dialysis patients.

Abstract:

BACKGROUND:Cardiac valve calcification (CVC) and left ventricular (LV) alterations are frequent complication in end-stage renal disease (ESRD). We determined the prevalence of CVC and LV hypertrophy (LVH) in ESRD patients before renal replacement therapy and 12 months after peritoneal dialysis (PD). METHODS:A prospective longitudinal of 50 incident PD patients was studied. Demographic and clinical data were recorded and blood assayed at baseline and after 1-year of follow-up. CVC and LVH were evaluated by M-mode two-dimensional echocardiography. RESULTS:CVC of the mitral and aortic valves and of both valves were noted in 30, 18 and 10% of patients, respectively. After 12 months of PD regimen, 20% patients had aortic, 24% mitral and 8% had calcification of both valves. After one year of PD, LVH was 62 and 36% in patients with and without CVC, respectively (p < 0.05). Endothelin-1 is an independent predictor of CVC at the baseline, while nitric oxide is inversely an independent predictor at the end of follow-up. CONCLUSIONS:CVC is associated with LVH in PD patients. These findings identified a potential role for monitored markers to be incorporated into therapeutic strategies aimed at detection and treatment of cardiovascular complications and prevention strategies.

journal_name

Ren Fail

journal_title

Renal failure

authors

Rebić D,Rašić S,Hamzić-Mehmedbašić A,Džemidžić J,Kurtalić E

doi

10.3109/0886022X.2015.1073495

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

1316-22

issue

8

eissn

0886-022X

issn

1525-6049

journal_volume

37

pub_type

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