Intermittent hirudin versus continuous heparin for anticoagulation in continuous renal replacement therapy.

Abstract:

BACKGROUND:Besides possible bleeding complications a further problem in anticoagulation during continuous renal replacement therapy (CRRT) is the development of heparin-induced thrombocytopenia type II (HIT II) where further anticoagulation with heparin is contraindicated. The application of continuous hirudin as alternative for heparin caused bleeding complications by comparable filter efficacy. Aim of this prospective-controlled pilot study was to compare the efficacy and safety of intermittent hirudin and continuous heparin for anticoagulation during CRRT in critically ill patients. METHODS:26 patients receiving CRRT were randomly allocated to two groups: Heparin group (14 patients): continuous administration of 250 IU/h heparin, dose was adjusted in 125 IU/h steps with a targeted activated clotting time (ACT) of 180-210 s. Hirudin group (12 patients): initial bolus application of 2-2-5 microg/kg hirudin, dose was adjusted in 2 microg/kg bolus steps with a targeted ecarin clotting time (ECT) >80 s. Observation time was 96 hours. RESULTS:Measured filter run time was virtually longer for heparin. No bleeding complications were observed in the hirudin group, two bleeding complications in the heparin group. CONCLUSIONS:Intermittent hirudin can be used safely for anticoagulation in CRRT. However, the in tendency better filter survival for heparin elucidates the need for further investigations to find the right dosage equilibrium between filter clotting and bleeding complications.

journal_name

Ren Fail

journal_title

Renal failure

authors

Hein OV,von Heymann C,Diehl T,Ziemer S,Ronco C,Morgera S,Siebert G,Kox WJ,Neumayer HH,Spies C

doi

10.1081/jdi-120039529

subject

Has Abstract

pub_date

2004-05-01 00:00:00

pages

297-303

issue

3

eissn

0886-022X

issn

1525-6049

journal_volume

26

pub_type

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