Abstract:
BACKGROUND:Besides possible bleeding complications a further problem in anticoagulation during continuous renal replacement therapy (CRRT) is the development of heparin-induced thrombocytopenia type II (HIT II) where further anticoagulation with heparin is contraindicated. The application of continuous hirudin as alternative for heparin caused bleeding complications by comparable filter efficacy. Aim of this prospective-controlled pilot study was to compare the efficacy and safety of intermittent hirudin and continuous heparin for anticoagulation during CRRT in critically ill patients. METHODS:26 patients receiving CRRT were randomly allocated to two groups: Heparin group (14 patients): continuous administration of 250 IU/h heparin, dose was adjusted in 125 IU/h steps with a targeted activated clotting time (ACT) of 180-210 s. Hirudin group (12 patients): initial bolus application of 2-2-5 microg/kg hirudin, dose was adjusted in 2 microg/kg bolus steps with a targeted ecarin clotting time (ECT) >80 s. Observation time was 96 hours. RESULTS:Measured filter run time was virtually longer for heparin. No bleeding complications were observed in the hirudin group, two bleeding complications in the heparin group. CONCLUSIONS:Intermittent hirudin can be used safely for anticoagulation in CRRT. However, the in tendency better filter survival for heparin elucidates the need for further investigations to find the right dosage equilibrium between filter clotting and bleeding complications.
journal_name
Ren Failjournal_title
Renal failureauthors
Hein OV,von Heymann C,Diehl T,Ziemer S,Ronco C,Morgera S,Siebert G,Kox WJ,Neumayer HH,Spies Cdoi
10.1081/jdi-120039529subject
Has Abstractpub_date
2004-05-01 00:00:00pages
297-303issue
3eissn
0886-022Xissn
1525-6049journal_volume
26pub_type
临床试验,杂志文章,随机对照试验相关文献
RENAL FAILURE文献大全abstract::Cognitive dysfunction is a well-known complication of chronic renal failure that is evident in 30% of hemodialysis (HD) patients. However, the pathogenesis of this dysfunction is unknown. Left ventricular hypertrophy could develop in hypertensive HD patients without establishing normovolemia. Our aim was to evaluate t...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860220903134548
更新日期:2009-01-01 00:00:00
abstract::The prognosis of uremia patients on continuous ambulatory peritoneal dialysis (CAPD) is related to frequent peritonitis rate. Frequent peritonitis will lead to peritoneum failure, making CAPD unfeasible. We have performed proteomic profiling of peritoneal dialysis effluent samples from a cross-section of CAPD patients...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220802248969
更新日期:2008-01-01 00:00:00
abstract:AIM:The aim of this study was to observe the effects of coupled plasma filtration adsorption (CPFA) on septic patients with multiple organ dysfunction syndrome (MODS). METHODS:A total of 14 patients were randomly divided into two groups, and, respectively, received 10 h of CPFA or high-volume hemofiltration (HVHF). Th...
journal_title:Renal failure
pub_type: 杂志文章,随机对照试验
doi:10.3109/0886022X.2012.684553
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND AND AIM:Trendelenburg positioning (TP) is a common approach used during internal jugular vein (IJV) cannulation. No evidence indicates that TP significantly increases the cross-sectional area (CSA) of the IJV or decreases the overlap between the carotid artery (CA) and the IJV in dialysis patients. The prima...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2015.1073052
更新日期:2015-01-01 00:00:00
abstract::Incidence of acute kidney injury (AKI) in patients with pyogenic liver abscess is rare. In our study we found AKI in 32.6% of patients with liver abscess. Majority of the patients were in their fifties and sixties. As per acute kidney injury network trial criteria, renal failure was in stage 1 in 26.6%, stage 2 in 40%...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2011.569108
更新日期:2011-01-01 00:00:00
abstract::Recently, we demonstrated that furosemide improves renal hemodynamics and attenuates ischemia/reperfusion (I/R)-associated changes in angiogenesis-related gene expression. However, the effect of furosemide on I/R-induced apoptosis is not known. We utilized a rat model of acute ischemic nephropathy to test the hypothes...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220701263671
更新日期:2007-01-01 00:00:00
abstract::The use of colistin in the treatment of multidrug-resistant Gram-negative bacterial infections is restricted due to nephrotoxicity. We investigated the effects of aged black garlic extract (ABGE) on colistin-induced kidney injury in rats. Rats were assigned to four groups. Normal saline was intraperitoneally and intra...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2018.1561375
更新日期:2019-11-01 00:00:00
abstract::The case of giant renal cyst measuring 30 cm, accompanied by abdominal swelling and erythrocytosis, is presented. A 45-year-old male presented with large abdominal mass, atrophic left kidney, hypertension, and erythrocytosis. The patient underwent multiple preoperative phlebotomies, open extirpation of the cyst, and n...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2011.552148
更新日期:2011-01-01 00:00:00
abstract::Hypertonic glycerol injection is one of the most frequently used models of experimental acute renal failure. Late structural changes such as interstitial fibrosis in the renal cortex and tubular atrophy have been detected after severe acute tubular necrosis (ATN). The aim of this study was to investigate the expressio...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220500244781
更新日期:2005-01-01 00:00:00
abstract::Vascular calcification (VC) is an important promoter of cardiovascular disease (CVD) in patients undergoing peritoneal dialysis (PD). Several indices can be used to evaluate VC, including the abdominal aortic calcification index (AACI) and carotid artery intima-media thickness (IMT); however, simpler and lesser expens...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2020.1762646
更新日期:2020-11-01 00:00:00
abstract:AIMS:The use of hemodialysis temporary dual-lumen catheters is often complicated by infections, which may be a significant cause of death among patients with end stage renal disease (ESRD). The aim of this study was to assess the incidence of bacteremia and bacterial colonization related to non-tunneled, non-cuffed, du...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220701741940
更新日期:2008-01-01 00:00:00
abstract::Studies were performed to reexamine the response of erythropoietin (Epo) production to acute hypoxic stimuli in patients with end-stage renal disease (ESRD). In the absence of acute bleeding or hypoxia, the serum Epo level in ESRD was similar to that of normal subjects despite severe anemia. In 11 dialysis patients wi...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229409044892
更新日期:1994-01-01 00:00:00
abstract::Arteriosclerosis is characterized by stiffening of arteries. The incremental elastic modulus (Einc) measurement is a good marker of arterial wall stiffness. Metabolic, inflammatory and hemodynamic alterations cause structural changes and vascular complications in end stage renal disease. The aim of the present study w...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-120026036
更新日期:2003-11-01 00:00:00
abstract::Diabetic nephropathy (DN) has become the most common pathogenesis of end-stage renal disease. Plasminogen activator inhibitor-1 (PAI-1) plays an important role in the pathogenesis of DN. A meta-analysis was conducted to investigate the association between 4 G/5 G variants in the PAI-1 gene and DN susceptibility. Datab...
journal_title:Renal failure
pub_type: 杂志文章,meta分析
doi:10.3109/0886022X.2013.867783
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:Intima-Media-Thickness of the carotid artery wall (cIMT) is a strong predictor of cardiovascular (CV) disease. The aim of this study was to investigate the significance of cIMT as an independent prognostic factor for CV morbidity and mortality in patients with chronic kidney disease (CKD) and diabetes mellit...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2019.1585372
更新日期:2019-11-01 00:00:00
abstract::During exercise, the plasma urate levels and urinary excretion increase due to the enhanced purine degradation in skeletal muscle. Although urate transporter-1 (URAT1) is the main transporter responsible for the reabsorption of filtered urate, potential changes in its activity and expression during exercise have not b...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2010.494805
更新日期:2010-01-01 00:00:00
abstract:PURPOSE:To describe the epidemiologic features of acute renal failure related to pregnancy (PRARF) and to evaluate its prognostic impact. METHODS:Retrospective study conducted in a Tunisian intensive care unit over a period of 17 years (1995-2011). Women were included if they were more than 20 weeks pregnant and were ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2013.819767
更新日期:2013-10-01 00:00:00
abstract::The characteristics of two established renal cell lines (LLC-PKI and OK) and of primary cultures of rabbit and human proximal tubule cells are described by summarizing the literature about specific properties retained by these cells in culture. Furthermore, comparative biochemical and functional properties are present...
journal_title:Renal failure
pub_type: 杂志文章,评审
doi:10.3109/08860229209106645
更新日期:1992-01-01 00:00:00
abstract::Rhabdomyolysis is common clinical and laboratory syndrome resulting from skeletal muscle injury and acute renal failure is the most important complication. Acute renal failure is common in critically ill medical patients. The aim of our study was to determine the prevalence of rhabdomyolysis induced acute renal failur...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229909094161
更新日期:1999-11-01 00:00:00
abstract:BACKGROUND:Emerging evidence demonstrates that gut dysbiosis is implicated in the pathogenesis of chronic kidney disease (CKD) with underlying mechanisms involving mucosal and/or systematic immunity or metabolic disorders. However, the profile of gut microbiota in patients with CKD has not been completely explored. ME...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2020.1864404
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Previous studies have demonstrated the role of inflammation in diabetic nephropathy (DN). Neutrophil to lymphocyte ratio (NLR) rather than other white cell parameters was found to be a useful inflammatory marker to predict adverse outcomes in medical and surgical conditions. Nevertheless, the value of NLR in...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2012.668741
更新日期:2012-01-01 00:00:00
abstract::Patients with end-stage renal disease, including those treated with peritoneal dialysis, have a high risk for death, particularly from cardiovascular causes. Plasma fatty acid (FA) composition is used as an indicator of disease risk, because its alteration has been related to metabolic disease and cardiovascular disea...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2011.601831
更新日期:2011-01-01 00:00:00
abstract::Creatol (CTL) is a hydroxyl radical adduct of creatinine (Cr). The serum methylguanidine (MG) level and the MG/Cr molar ratio are reported to be biomarkers for oxidative stress. The aim of this study was to examine whether urinary excretion of CTL, another oxidative stress-related marker, is increased in patients with...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220701219863
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:The complement system has been recently proposed to play an important role in the pathogenesis of ANCA-associated vasculitis (AAV). This study evaluated the value of serum and kidney deposited C3 in predicting renal outcomes in AAV. METHODS:This was a retrospective study of 47 patients with AAV, who were ca...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2020.1803086
更新日期:2020-11-01 00:00:00
abstract::The study of urinary proteins is an important tool in the screening and diagnosis of patients with renal impairment. Quantification of total proteins, although useful, can provide only limited information. Gel electrophoresis of urine samples may provide more detailed information. ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229909085105
更新日期:1999-05-01 00:00:00
abstract::Neutrophil-lymphocyte ratio (NLR) is a marker of systemic inflammation that has been shown to predict mortality in patients with malignancies, ischemic heart disease and peripheral vascular disease. Its prognostic value in hemodialysis patients is unclear. The aims of this study were to: (i) explore the relationship b...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2015.1104990
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Calcineurin inhibitor cyclosporine A (CsA) is a potent immunosuppressive agent. The side effects of CsA include nephrotoxicity, hypertension, hypertrichosis, infection, hyperpotassemia, and, to a lower extent, neuropathy. OBJECTIVES:In this case report, we aimed to present a renal transplant patient with po...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2011.573893
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION:This study was designed to investigate whether 3-amino benzamide (3-AB), a poly (ADP-ribose) polymerase (PARP) inhibitor, has a protective effect on kidney injury induced by renal ischemia/reperfusion (I/R) by decreasing oxidative and nitrosative stress on renal dysfunction and injury. MATERIALS AND METHO...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220902882741
更新日期:2009-01-01 00:00:00
abstract::Aldosterone is reported to promote fibrosis of multiple organs. Recent studies showed that Na+-H+ exchanger isoform 1 (NHE1) was involved in mineralocorticoid-induced tissue fibrosis. The present study examined the role of NHE1 in aldosterone-induced glomerulosclerosis in rats. SD male rats were subjected to 5/6 nephr...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860220903134571
更新日期:2009-01-01 00:00:00
abstract::Renal ischemia reperfusion injury (IRI) is a major problem, currently without treatments in clinical use. This reflects the failure of animal models to mimic the severity of IRI observed in clinical practice. Most described models lack both the ability to inflict a permanent reduction in renal function and the sensiti...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2016.1144024
更新日期:2016-11-01 00:00:00