Abstract:
AIM:The aim of this study was to observe the effects of coupled plasma filtration adsorption (CPFA) on septic patients with multiple organ dysfunction syndrome (MODS). METHODS:A total of 14 patients were randomly divided into two groups, and, respectively, received 10 h of CPFA or high-volume hemofiltration (HVHF). The mean arterial pressure (MAP), electrolytes and acid-base balance, the sequential organ failure assessment (SOFA) score, and the acute physiology and chronic health evaluation II (APACHE II) score were analyzed. Serum levels of high-mobility group box-1 (HMGB-1) protein, tumor necrosis factor-α (TNF-α), and intercellular adhesion molecule-1 (ICAM-1) were also measured by enzyme-linked immunosorbent assay. RESULTS:After CPFA and HVHF, temporary reduction in blood urea nitrogen and serum creatinine, electrolytes and acid-base metabolism balance were well maintained. Both the SOFA and the APACHE II scores were markedly reduced after CPFA (p < 0.01), while only the SOFA score was significantly decreased after HVHF (p < 0.05). After 10-h treatment with CPFA, the MAP and oxygen index (PaO(2)/FiO(2)) were significantly higher than those at 0 h. Furthermore, the serum levels of HMGB-1, ICAM-1, and TNF-α decreased after 10 h of CPFA (p < 0.05), while the serum levels of HMGB-1 declined at 5 h of HVHF, but rebounded at 10 h, and the serum levels of TNF-α and ICAM-1 were no significant change after treatment with HVHF. CONCLUSIONS:The study indicated that CPFA could be superior to HVHF in improving the clinical manifestations and eliminating inflammatory mediators, which had implications in the optimal treatment of septic patients with MODS.
journal_name
Ren Failjournal_title
Renal failureauthors
Hu D,Sun S,Zhu B,Mei Z,Wang L,Zhu S,Zhao Wdoi
10.3109/0886022X.2012.684553subject
Has Abstractpub_date
2012-01-01 00:00:00pages
834-9issue
7eissn
0886-022Xissn
1525-6049journal_volume
34pub_type
杂志文章,随机对照试验相关文献
RENAL FAILURE文献大全abstract::This study was designed to evaluate the role of nitric oxide (NO) in FK506-induced nephrotoxicity by administering an inhibitor of NO synthesis, N omega-nitro-L-arginine methyl ester (L-NAME) to rats treated with FK506. After one week of treatment with FK506 (3.2 mg/kg/day, intramuscularly) and/or L-NAME (5 mg/100 mL ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-100001279
更新日期:2001-01-01 00:00:00
abstract::The aim of our study was to analyze the clinical course and outcome of acute renal failure (ARF) in patients with hemorrhagic fever with renal syndrome (HFRS). From 1983 to 1995, we treated 33 patients (27 males, 6 females) aged from 16 to 71 years. Half of patients were connected with work at a farm or in a forest. T...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229609047688
更新日期:1996-07-01 00:00:00
abstract:BACKGROUND:Hypertension very often accompanies progression of chronic kidney disease (CKD) in children. A cross-sectional analysis of hypertension prevalence in dialyzed children in Poland was designed with a comparison with the data previously recorded 10 years earlier. METHODS:Two cohorts of children were analyzed: ...
journal_title:Renal failure
pub_type: 杂志文章,多中心研究
doi:10.1080/0886022X.2016.1260033
更新日期:2017-11-01 00:00:00
abstract::The role of the kidney in the control of blood pressure has been convincingly demonstrated by several studies. Recent evidence has suggested that subtle acquired tubulointerstitial injury may cause a defect in sodium excretion function, thus leading to salt-sensitive hypertension. There are no reports, however, examin...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220600779058
更新日期:2006-01-01 00:00:00
abstract::Eight patients aged between 5 and 26 years developed rapid deterioration of renal function and became oliguric/anuric with duration ranging from 1 to 21 days. The initial functional assessment revealed severe degree of glomerular, tubular, and vascular dysfunctions. The magnitude of renal dysfunction was quantified an...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229609047678
更新日期:1996-07-01 00:00:00
abstract:BACKGROUND:Besides possible bleeding complications a further problem in anticoagulation during continuous renal replacement therapy (CRRT) is the development of heparin-induced thrombocytopenia type II (HIT II) where further anticoagulation with heparin is contraindicated. The application of continuous hirudin as alter...
journal_title:Renal failure
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1081/jdi-120039529
更新日期:2004-05-01 00:00:00
abstract:OBJECTIVE:We compared the Bergstrom's and Randerson's formula for PNA determination, and compared the normalization of PNA by ideal body weight (IBW) and standard body weight (SBW) as estimated by the Watson's formula. METHODS. We studied 208 Chinese PD patients. Two 24-h dialysate and urine collections were performed ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-120018724
更新日期:2003-03-01 00:00:00
abstract::The effect of ticlopidine on rats with adriamycin nephropathy was observed during 26 weeks. In the ticlopidine-treated nephrotic animals (TNG), proteinuria was less than in the untreated nephrotic animals (NG), but this difference was significant only at week 6 (TNG = 47.27 +/- 16.52 versus NG = 100.08 +/- 13.83 mg/24...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229909045185
更新日期:1999-09-01 00:00:00
abstract::During embryonic life, renal morphogenesis is characterized by a defined period of intense cellular activity, inductive-transformation of undifferentiated cells to polarized epithelia, in-growth of capillaries into an intricate parenchymal epithelial-mesenchymal mass, and finally the maturation into an organ with dive...
journal_title:Renal failure
pub_type: 杂志文章,评审
doi:10.3109/08860229809045119
更新日期:1998-03-01 00:00:00
abstract::Ten-Eleven Translocation (TET) proteins oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytonsie (5hmC). Our recent work found a decline in global 5hmC level in mouse kidney insulted by ischemia reperfusion (IR). However, the genomic distribution of 5hmC in mouse kidney and its relationship with gene expression remai...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2016.1172973
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:The optimal delivered dialysis dose has been of a great interest for the last three decades, though a clear cut point has not been reached yet. We aimed to evaluate the relationship between one-year mortality and the delivered dialysis dose, which was recommended by Kidney Disease Outcomes Quality Initiative...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2016.1208515
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Contrast-induced nephropathy (CIN) is a complex syndrome of acute nephropathy that occurs following infusion of intravascular contrast agents, and is associated with an increased risk for adverse cardiovascular events. While there is no ideal biomarker for making an early diagnosis of CIN, we hypothesized th...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2015.1077322
更新日期:2015-01-01 00:00:00
abstract::Nontraumatic rhabdomyolysis is an important but under-recognized cause of acute renal failure. In alcoholics, rhabdomyolysis most frequently develop following muscle necrosis during alcohol-induced coma, but has also been described rarely in those without prolonged coma or seizures. We describe a patient who developed...
journal_title:Renal failure
pub_type: 杂志文章,评审
doi:10.3109/08860229909045195
更新日期:1999-09-01 00:00:00
abstract::To evaluate the role of the inducible nitric oxide synthase (iNOS), selective nuclear factor-kB (NF-kB), and p38-mitogene-activated protein kinase (p38-MAPK) on hyperoxaluria-induced oxidative stress and stone formation in rat kidneys. The rats were divided into five groups: group 1, control group; group 2: ethylene g...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220902963871
更新日期:2009-01-01 00:00:00
abstract::Diabetic nephropathy (DN) is the most common cause of end-stage renal disease worldwide. The pathophysiologic mechanisms of diabetic nephropathy are incompletely understood but include overproduction of various growth factors and cytokines. Upregulation of vascular endothelial growth factor (VEGF) is a pathogenic even...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2014.900404
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:The kidney is one of the prior damaged organs subjected to severe infection and sepsis shock. Our previous studies have shown that the normal mesenteric lymph (NML) obtained from healthy dogs could alleviate multiple organ injuries following endotoxic shock. In the current study, we further investigated the ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2014.938585
更新日期:2014-09-01 00:00:00
abstract::Nontraumatic rhabdomyolysis may be associated with severe metabolic disturbances. In particular, previous literature has described a 8-20% incidence of acute renal failure in rhabdomyolysis. The aim of this study was to evaluate our experience on 11 patients with acute renal failure treated by high-efficiency daily he...
journal_title:Renal failure
pub_type: 临床试验,杂志文章
doi:10.3109/08860229709047729
更新日期:1997-05-01 00:00:00
abstract::The present study was carried out to describe epidemiology and clinical pattern of acute renal failure caused by leptospirosis in Uruguay. For these purposes, all literature published in Uruguay was reviewed. Three studies were analyzed: 2 series of patients and 1 case report that summarize 26 cases. The incidence of ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229709026295
更新日期:1997-03-01 00:00:00
abstract::Continuous efforts have been made to find out precise and simple method for determination of glomerular filtration rate (GFR). Cystatin C (cysteine proteinase inhibitor = CyC) is a low molecular weight (LMW) protein which is produced constantly by all nucleated cells independently of different pathological conditions ...
journal_title:Renal failure
pub_type: 临床试验,杂志文章
doi:10.1081/jdi-120017475
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Morphine is an opioid analgesic drug often used for pain relief in cancer patients. However, there is growing evidence that morphine may modulate tumor growth, progression and metastasis. Unfortunately, the results obtained by these studies are still contradictory. METHODS:In this study, we investigated the...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2016.1256322
更新日期:2017-11-01 00:00:00
abstract::A multidisciplinary approach represents the best method to interact with patients. Neoplastic and renal diseases are closely related to each other because of an increased risk of cancer among individuals with end-stage renal disease and because of the high prevalence of renal failure in cancer patients. Physicians sho...
journal_title:Renal failure
pub_type: 杂志文章,评审
doi:10.3109/0886022X.2015.1068514
更新日期:2015-01-01 00:00:00
abstract::Psoriasis, being limited to the skin, is generally a chronic inflammatory disorder. Several glomerular diseases have been distinguished due to renal histological findings of psoriatic patients to date. The underlying pathogenetic mechanisms of these associations remain unclear because of the limited number of cases. W...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860221003778072
更新日期:2010-06-01 00:00:00
abstract::In various renal injuries, tissue damage occurs and platelet activation is observed. Recent studies suggest that some factors, such as serotonin, are released into microenvironment upon platelet activation following renal injury. In the present study, we aimed to investigate whether platelets and platelet-released ser...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2016.1194165
更新日期:2016-08-01 00:00:00
abstract::Acute renal failure (ARF) is a frequent complication in hospitalized patients and is strongly related to increase in mortality. In order to analyze the clinical outcome and the prognostic factors in hospital-acquired ARF, a prospective study was performed. Data from 200 patients with established ARF during the period ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229709026285
更新日期:1997-03-01 00:00:00
abstract::Single injection, single blood sample, effective renal plasma flow (ERPF) estimated by 131I-orthoiodohippurate can be performed accurately and conveniently without urine collection at the bedside. The purpose of this study was to determine if ERPF early in the course of severe acute renal failure (ARF) predicts recove...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860228709056321
更新日期:1987-01-01 00:00:00
abstract::Acute iron poisoning is a common and potentially serious problem in the pediatric population. Early recognition and treatment is crucial for a better outcome and to prevent morbidity and mortality. An 18-year-old female, who had accidental ingestion of 50 tablets of ferrous sulfate (100 mg of elemental iron per 335 mg...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2013.790299
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Long-term peritoneal exposure to high glucose in the peritoneal dialysis (PD) solution may potentiate the development of peritoneal fibrosis in PD patients. The most important factor leading to peritoneal fibrosis may be injury of human peritoneal mesothelial cells (HPMC). Little is known about senescence of...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2011.623497
更新日期:2012-01-01 00:00:00
abstract::Prevention of secondary hyperparathyroidism (SHPTH) and treatment of the moderate cases by small p.os doses of Vitamin D has not been thoroughly investigated on the long term, while large doses of Vitamin D have been successful in the short term treatment of this entity. We administered calcitriol p.os 0.5-1.0 microgr...
journal_title:Renal failure
pub_type: 临床试验,杂志文章
doi:10.3109/08860229909066984
更新日期:1999-03-01 00:00:00
abstract:BACKGROUND:Fabry disease (FD) is an X-linked lysosomal storage disorder caused by the mutation of the GLA gene, encoding the α-galactosidase, which is responsible for the catabolism of neutral glycosphingolipids. Microalbuminuria or low-grade proteinuria, and continuously progressive renal failure are common manifestat...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2020.1818578
更新日期:2020-11-01 00:00:00
abstract:UNLABELLED:Conventional urea kinetic modeling and peritoneal equilibration test (PET) were performed on 73 patients undergoing CAPD in order to determine factors influencing morbidity. Dialysis adequacy (KT/V, creatinine clearance, efficacy number) and nutrition (PCR, nPCR, creatinine generation rate, body mass index, ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229509037622
更新日期:1995-09-01 00:00:00