Renal dysfunctions in glomerulonephropathy with rapidly declined renal failure.

Abstract:

:Eight patients aged between 5 and 26 years developed rapid deterioration of renal function and became oliguric/anuric with duration ranging from 1 to 21 days. The initial functional assessment revealed severe degree of glomerular, tubular, and vascular dysfunctions. The magnitude of renal dysfunction was quantified and expressed in terms of a clinical score. The degree of glomerular and tubular dysfunctions were inversely proportional to the renal plasma flow and peritubular capillary blood flow (PTCB), respectively. Similar findings have been observed in a variety of severe glomerulonephropathies. In this aspect, it is likely that the reduction of peritubular capillary blood flow and tubulointerstitial disease are interrelated. Further evidence to support the primary role of reduction of PTCB in inducing tubulointerstitial disease is provided by the following: (a) Reduction of PTCB is documented in mesangial proliferative nephrosis with steroid resistance prior to the detection of tubulointerstitial disease. (b) Ischemic insult can induce tubulointerstitial disease in experimental setting of renal artery occlusion in animal, (c) Improved tubular function can be achieved following the increase in PTCB with the enhanced renal perfusion therapy.

journal_name

Ren Fail

journal_title

Renal failure

authors

Futrakul N,Pochanugool C,Sitprija V,Singkhwa V,Futrakul P,Yenrudi S,Sensirivatana R,Watana D,Poshyachinda M

doi

10.3109/08860229609047678

subject

Has Abstract

pub_date

1996-07-01 00:00:00

pages

557-65

issue

4

eissn

0886-022X

issn

1525-6049

journal_volume

18

pub_type

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