Abstract:
:Purine nucleotide liberation and their metabolic rate of interconversion may be important in the development of hypertension and its renal consequences. In the present study, blood triphosphate (ATP), adenosine diphosphate (ADP), and adenosine monophosphate (AMP) breakdown pathway was evaluated in relation to uric acid concentration and xanthine dehydrogenase/xanthine oxidase (XDH/XO) in patients with essential hypertension, patients with chronic renal diseases on dialysis, and control individuals. The pattern of nucleotide catabolism was significantly shifted toward catabolic compounds, including ADP, AMP, and uric acid in patients on dialysis program. A significant fall of ATP was more expressed in a group of patients on dialysis program, compared with the control value (p<0.001), while ADP and AMP were significantly increased in both groups of patients compared with control healthy individuals (p<0.001), together with their final degradation product, uric acid (p<0.001). The index of ATP/ADP and ATP/uric acid showed gradual significant fall in both the groups, compared with the control value (p<0.001), near five times in a group on dialysis. Total XOD was up-regulated significantly in a group with essential hypertension, more than in a group on dialysis. The activity of XO, which dominantly contributes reactive oxygen species (ROS) production, significantly increased in dialysis group, more than in a group with essential hypertension. In conclusion, the examination of the role of circulating purine nucleotides and uric acid in pathogenesis of hypertension and possible development of renal disease, together with XO role in ROS production, may help in modulating their liberation and ROS production in slowing progression from hypertension to renal failure.
journal_name
Ren Failjournal_title
Renal failureauthors
Boban M,Kocic G,Radenkovic S,Pavlovic R,Cvetkovic T,Deljanin-Ilic M,Ilic S,Bobana MD,Djindjic B,Stojanovic D,Sokolovic D,Jevtovic-Stoimenov Tdoi
10.3109/0886022X.2014.882240subject
Has Abstractpub_date
2014-05-01 00:00:00pages
613-8issue
4eissn
0886-022Xissn
1525-6049journal_volume
36pub_type
杂志文章相关文献
RENAL FAILURE文献大全abstract:BACKGROUND:Renal lymphangiectasia is rarely reported benign renal disorder of lymphatic malformation. Though found incidentally; it presents with nonspecific symptoms and shows characteristic findings in radiological imaging studies. AIM:Here, we report eight patients with symptoms, laboratory and imaging findings com...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2017.1337584
更新日期:2017-11-01 00:00:00
abstract::Dyslipoproteinemia and oxidative modification of low-density lipoprotein (oxLDL) contribute to the development of oxidative stress and atherosclerosis in chronic kidney disease (CKD). On the contrary, high-density lipoprotein cholesterol (HDL-C), especially HDL3-C subtype, has protective effect against oxidative damag...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2011.641515
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:There are controversial reports in the prevalence of abnormal nighttime blood pressure fall in renal patients. It has been evaluated nocturnal BP in renal patients using 24 h blood pressure monitoring (ABPM) in comparison with nontreated control subjects either normotensives or hypertensives. DESIGN AND METH...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-120024297
更新日期:2003-09-01 00:00:00
abstract::This study was designed to investigate whether the treatment with the N-acetyl-L-cysteine prior to the administration of chemotherapy drug would prevent from nephrotoxicity and the loss of reproductive performance induced from chemotherapy treatment. Female rats were divided into five equal groups of six each: 1/contr...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2015.1127742
更新日期:2016-01-01 00:00:00
abstract::A 68-year-old male presented with acute myeloid leukemia, renal failure, hypokalemia, and enlarged kidneys on renal ultrasound. Renal biopsy revealed massive leukemic infiltration of the kidney. After systemic chemotherapy, the patient developed tumor lysis syndrome followed by a phase of proximal tubule dysfunction p...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220902972187
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:The goal of this study was to define the clinical and histological differences in new-onset IgA nephropathy between young adults and the elderly. METHODS:We retrospectively examined renal biopsy findings, clinical features at presentation and outcomes in 82 young adults (mean age 30.3+/-10.2 years) and 17 e...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860221003611687
更新日期:2010-01-01 00:00:00
abstract::To evaluate the role of the inducible nitric oxide synthase (iNOS), selective nuclear factor-kB (NF-kB), and p38-mitogene-activated protein kinase (p38-MAPK) on hyperoxaluria-induced oxidative stress and stone formation in rat kidneys. The rats were divided into five groups: group 1, control group; group 2: ethylene g...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220902963871
更新日期:2009-01-01 00:00:00
abstract::Cold preservation has greatly facilitated the use of cadaveric kidneys for renal transplantation, but, clearly, damage occurs during both the preservation episode and the reperfusion phase (following transplantation). The aims of this study were twofold: to develop an in vivo model that was capable of evaluating renal...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220701813327
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Determination of fluid overload is important in chronic kidney disease. Early diagnosis and treatment of volume overload may decrease morbidity and mortality. We aimed to determine body composition by using bioelectrical impedance analysis, and studying other clinical characteristics, inferior vena cava diam...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2013.875815
更新日期:2014-05-01 00:00:00
abstract::Background: Complications associated with ureteral anastomosis in kidney transplantation are highly prevalent, despite the development of various types of stents. The current stent materials and placement methods have several limitations. This study attempts to provide an alternative by investigating ureteral anastomo...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2020.1726386
更新日期:2020-11-01 00:00:00
abstract::Renal ischemia-reperfusion injury is a leading cause of acute kidney injury, but its underlying mechanism remains poorly understood and effective therapies are still lacking. Here, we identified lncRNA XLOC_032768 as a novel target in renal ischemia-reperfusion injury by analyzing differentially expressed genes of the...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2020.1818579
更新日期:2020-11-01 00:00:00
abstract::Medication errors are ongoing problems among hospitalized patients especially those with multiple co-morbidities and polypharmacy such as patients with renal diseases. This study evaluated the frequency, types and direct related cost of medication errors in nephrology ward and the role played by clinical pharmacists. ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2014.934650
更新日期:2014-09-01 00:00:00
abstract::The characteristics of two established renal cell lines (LLC-PKI and OK) and of primary cultures of rabbit and human proximal tubule cells are described by summarizing the literature about specific properties retained by these cells in culture. Furthermore, comparative biochemical and functional properties are present...
journal_title:Renal failure
pub_type: 杂志文章,评审
doi:10.3109/08860229209106645
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND: Urine beta2-microglobulin (beta2-MG) was mainly used as a tubular marker of Balkan endemic nephropathy (BEN) but recently alpha1-microglobulin (alpha1-MG) was proposed for the diagnosis of BEN. In this study, the potential of urine beta2-MG, alpha1-MG, albumin, and total protein in the differentiation of BE...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2011.552152
更新日期:2011-01-01 00:00:00
abstract:AIM:To investigate the effects of lentivirus-mediated shRNA targeting collagen type I on the mesangial cells of rats and the feasibility of lentivirus-mediated shRNA delivery through renal parenchyma injection. METHODS:Anti-collagen type I shRNA lentiviral vector was constructed, and rat mesangial cells were transfect...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2011.559679
更新日期:2011-01-01 00:00:00
abstract::Psoriasis, being limited to the skin, is generally a chronic inflammatory disorder. Several glomerular diseases have been distinguished due to renal histological findings of psoriatic patients to date. The underlying pathogenetic mechanisms of these associations remain unclear because of the limited number of cases. W...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860221003778072
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:To evaluate the influence of sevelamer hydrochloride and calcium acetate on biomarkers of bone turnover in patients with hyperphosphatemia receiving hemodialysis. METHODS:In this prospective, open-label, randomized, active-controlled study, 70 patients (38 men and 32 women) with hyperphosphatemia (serum phos...
journal_title:Renal failure
pub_type: 杂志文章,随机对照试验
doi:10.1080/08860220600925388
更新日期:2006-01-01 00:00:00
abstract::Acetaminophen (APAP), also known as paracetamol, is the commonest cause of toxic ingestion in the world. Because overdose of APAP has life-threatening effects on kidney, treatment of APAP-induced nephrotoxicity has life-saving importance. Aim of the study was to evaluate the efficacy of medical ozone therapy in experi...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860221003646352
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Elevated plasminogen activator inhibitor-1 (PAI-1) levels are associated with increased cardiovascular (CV) risk in the general population. It has been shown that peritoneal dialysis (PD) patients have increased plasma levels of PAI-1. The aim of this study was to investigate whether PAI-1 independently pred...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220902963772
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Patients on maintenance hemodialysis (HD) face an increased risk of atherosclerosis, a crucial problem and the leading cause of cardiovascular morbidity and mortality. This study was designed to evaluate the effects of zinc supplementation on paraoxonase (PON) enzyme activity in patients on HD. MET...
journal_title:Renal failure
pub_type: 杂志文章,随机对照试验
doi:10.3109/0886022X.2012.717479
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Emerging evidence demonstrates that gut dysbiosis is implicated in the pathogenesis of chronic kidney disease (CKD) with underlying mechanisms involving mucosal and/or systematic immunity or metabolic disorders. However, the profile of gut microbiota in patients with CKD has not been completely explored. ME...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2020.1864404
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate whether neutrophil gelatinase-associated lipocalin (NGAL) and interleukin-18 (IL-18) predict renal disfunction in patients with familial Mediterranean fever (FMF). METHODS:This prospective study consisted of 102 patients with FMF in attack-free period, and 40 matched he...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2013.865486
更新日期:2014-04-01 00:00:00
abstract::Previously we have shown that the amount of protein in a dietary regimen prior to the induction of renal ischemia will significantly affect the degree of postischemic acute renal failure (Andrews PM, Bates SB: Kidney Int 30:299-303, 1986). The present investigation was undertaken to determine what effect dietary prote...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229309065566
更新日期:1993-01-01 00:00:00
abstract::The concentrations of urea, creatinine, and uric acid were measured in edema fluid and plasma during hemodialysis and 18 h after hemodialysis. The concentrations of these solutes in plasma were 15-17% lower than in the edema fluid after hemodialysis. Eighteen hours after hemodialysis, however, the concentrations in pl...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229209039118
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to establish a predictive postoperative nomogram for acute kidney injury (AKI) after intracranial aneurysm clipping surgery, in order to early identify patients with high postoperative AKI risk. METHODS:This is a retrospective study, which included patients who underwent intracranial...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2020.1838299
更新日期:2020-11-01 00:00:00
abstract::Randomized control trials (RCTs) are considered as most rigors way of determining the cause-effect relationship of a treatment and outcome. Activation of rennin angiotensin aldosterone system (RAAS) is an important contributor to hypertension in hemodialysis patients. The prevalence of hypertension in hemodialysis pat...
journal_title:Renal failure
pub_type: 杂志文章,评审
doi:10.3109/0886022X.2016.1138833
更新日期:2016-01-01 00:00:00
abstract::Diabetic nephropathy (DN) is a serious complication of diabetes with a poorly defined etiology and limited treatment options. Early intervention is a key to preventing the progression of DN. Dynamin-related protein 1 (DRP1) regulates mitochondrial morphology by promoting its fission and is involved in the pathogenesis...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2015.1034607
更新日期:2015-06-01 00:00:00
abstract::There is limited information on the incidence of acute kidney injury (AKI) in patients with traumatic brain injury (TBI) although AKI may contribute to morbidity and mortality. We investigated the incidence of AKI in patients with moderate and severe TBI and the association of AKI with risk factors and outcomes in the...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2010.510234
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND AND AIM:Trendelenburg positioning (TP) is a common approach used during internal jugular vein (IJV) cannulation. No evidence indicates that TP significantly increases the cross-sectional area (CSA) of the IJV or decreases the overlap between the carotid artery (CA) and the IJV in dialysis patients. The prima...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2015.1073052
更新日期:2015-01-01 00:00:00
abstract::Amidinotransferase (transamidinase, L-arginine: glycine amidinotransferase, EC 2.1.4.1) is an enzyme that catalyses the first step in creatine synthesis primarily in the kidney and pancreas. The kidney is also the primary target organ for the toxic effect of mercury. Therefore, we studied the effect of acute uremic sy...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-200037149
更新日期:2004-11-01 00:00:00