The effects of N-acetyl-L-cysteine on the female reproductive performance and nephrotoxicity in rats.

Abstract:

:This study was designed to investigate whether the treatment with the N-acetyl-L-cysteine prior to the administration of chemotherapy drug would prevent from nephrotoxicity and the loss of reproductive performance induced from chemotherapy treatment. Female rats were divided into five equal groups of six each: 1/control group; 2/rats i.p administered saline solution; 3/rats i.p administered holoxan (50 mg/kg b.wt); 4/rats i.p administered N-acetyl-L-cysteine (160 mg/kg b.wt); 5/rats i.p administered holoxan and N-acetyl-L-cysteine at the same doses. After medications, females rats were allowed to mate with males and the pregnant rats were sacrificed on day 18 of gestation. Premating treatment with holoxan showed reduction (p < 0.05) in reproductive performance. Whereas administration of N-acetyl-L-cysteine prior to treatment with holoxan and then concurrently with it modulated significantly fertility index, progesterone level, decreasing postimplantation loss, resorbed fetuses and improved fetal growth. Additionally, holoxan elevated the renal nicotinamide dinucleotide phosphate (NADPH) oxidase activity, oxidative stress, renal functions and caused histological changes in renal tissue. N-Acetyl-L-cysteine treatment reduced (p < 0.05) renal tissue NADPH oxidase, nitric oxide, malondialdehyde and improved super oxide dismutase (SOD) depletion, elevated levels phosphate, total protein and calcium as well as prevented renal histological damages. N-Acetyl-L-cysteine can confer protection against nitrosative and oxidative stresses in renal tissue induced by holoxan by suppressing NADPH oxidase activation, malondialdehyde, nitric oxide and restoring SOD activity which led to the reduction of reactive oxygen species production and subsequently might effectively improve the gonadal hormone disturbance and reproductive functions.

journal_name

Ren Fail

journal_title

Renal failure

authors

Helal MA

doi

10.3109/0886022X.2015.1127742

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

311-20

issue

2

eissn

0886-022X

issn

1525-6049

journal_volume

38

pub_type

杂志文章
  • Unilateral renal venous thrombosis secondary to the use of vibration belt in a young woman.

    abstract::We report on the isolated unilateral renal venous thrombosis (RVT) detected in a young patient who used vibration belt to stay thin. Apart from her sickle cell trait, the patient presented no other clinical situations associated with RVT. ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2012.712848

    authors: Balal M,Paydas S,Inal M

    更新日期:2012-01-01 00:00:00

  • Impact of immunofluorescence on the histological pattern of pediatric kidney biopsies from northern Pakistan.

    abstract::Kidney biopsy is an investigation for diagnosis and prognosis of a variety of nephritides. It also influences therapeutic options. Immunofluorescence (IMF) greatly adds in identifying the pathologies which may not be obvious on light microscopy (L/M), such as IgM, IgA nephropathy, pauci-immune glomerulonephritis, and ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2011.589944

    authors: Ali A,Ali MU,Ali MA

    更新日期:2011-01-01 00:00:00

  • Inhibitory factors of serum opsonic activity in serum from patients with chronic renal failure.

    abstract::We investigated the mechanism of impaired serum opsonic activity in patients suffering from chronic renal failure (CRF). Prehemodialysis pooled serum from CRF patients was fractionated using Sephadex G-50 gel chromatography, and the effects of the obtained fractions on serum opsonic activity were examined using lumino...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229709026268

    authors: Kikuchi T,Nigawara K,Sugawara K,Nakaji S,Abe T,Satoh H

    更新日期:1997-01-01 00:00:00

  • Clinical and ultrasonographical characterization of childhood cystic kidney diseases in Egypt.

    abstract:BACKGROUND:Renal cystic disorders (RCD) constitute an important and leading cause of end-stage renal disease (ESRD) in children. It can be acquired or inherited; isolated or associated with extrarenal manifestations. The precise diagnosis represents a difficult clinical challenge. METHODS:The aim of this study was to ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2014.883996

    authors: Soliman NA,Nabhan MM,Bazaraa HM,Badr AM,Shaheen M

    更新日期:2014-06-01 00:00:00

  • Lack of relation between serum parathyroid hormone levels and erythrocyte osmotic fragility in pediatric patients on peritoneal dialysis.

    abstract::Secondary hyperparathyroidism and anemia are the hallmarks in uremic patients. It is suggested that parathyroid hormone increases erythrocyte osmotic fragility and induces hemolysis. The present study was undertaken to examine the possible relationship between erythrocyte osmotic fragility and secondary hyperparathyro...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-200037140

    authors: Koşan C,Sever L,Arisoy N

    更新日期:2004-11-01 00:00:00

  • Biological effects of lentivirus-mediated shRNA targeting collagen type I on the mesangial cells of rats.

    abstract:AIM:To investigate the effects of lentivirus-mediated shRNA targeting collagen type I on the mesangial cells of rats and the feasibility of lentivirus-mediated shRNA delivery through renal parenchyma injection. METHODS:Anti-collagen type I shRNA lentiviral vector was constructed, and rat mesangial cells were transfect...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2011.559679

    authors: Zhou C,Shan Y,Zhao H,He P

    更新日期:2011-01-01 00:00:00

  • Renal artery stenosis of solitary kidney: the dilemma.

    abstract:BACKGROUND:Renal artery stenosis is an important cause of hypertension and renal failure. When present in a solitary kidney, it is associated with extremely high morbidity and mortality. Although guidelines suggest an aggressive approach by revascularization in these cases, available evidence is too weak and contradict...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:10.1081/jdi-200031740

    authors: Feldman L,Beberashvili I,Averbukh Z,Weissgarten J

    更新日期:2004-09-01 00:00:00

  • The role of Na+-H+ exchanger isoform 1 in aldosterone-induced glomerulosclerosis in vivo.

    abstract::Aldosterone is reported to promote fibrosis of multiple organs. Recent studies showed that Na+-H+ exchanger isoform 1 (NHE1) was involved in mineralocorticoid-induced tissue fibrosis. The present study examined the role of NHE1 in aldosterone-induced glomerulosclerosis in rats. SD male rats were subjected to 5/6 nephr...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860220903134571

    authors: Zhang M,Chen J,Liu S,You L,Lin S,Gu Y

    更新日期:2009-01-01 00:00:00

  • Infection-related hospitalization after intensive immunosuppressive therapy among lupus nephritis and ANCA glomerulonephritis patients.

    abstract::Introduction: This study aimed to investigate the clinical characteristics, risk factors, and outcomes of infection-related hospitalization (IRH) in patients with lupus nephritis (LN) and ANCA glomerulonephritis after intensive immunosuppressive therapy.Methods: Patients diagnosed with LN or ANCA glomerulonephritis wh...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2020.1763400

    authors: Yin P,Li J,Wen Q,Qiu Y,Liang W,Wang J,Yu J,Zhong Z,Yang X,Yu X,Ye Q,Huang F

    更新日期:2020-11-01 00:00:00

  • The role of Silodosin as a new medical expulsive therapy for ureteral stones: a meta-analysis.

    abstract::To evaluate the efficacy of Silodosin as a medical expulsive therapy of ureteral stones, we searched PubMed, EMBASE, the Cochrane Library, and CBM up to June 2015. All randomized controlled trials (RCTs) were identified in which patients were randomized to receive Silodosin versus placebo or other therapies for ureter...

    journal_title:Renal failure

    pub_type: 杂志文章,meta分析,评审

    doi:10.1080/0886022X.2016.1215221

    authors: Ding H,Ning Z,Dai Y,Shang P,Yang L

    更新日期:2016-10-01 00:00:00

  • Long-term efficacy and safety of quadruple therapy in childhood diffuse proliferative lupus nephritis.

    abstract::In this study, we evaluated the frequency, clinical presentation, treatment protocols, prognostic factors, and outcome in children with diffuse proliferative lupus nephritis (DPLN). Between June 1990 and December 2004, 46 patients were diagnosed to have systemic lupus erythematosus (SLE), and 26 of them (56.5%) were f...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220802132171

    authors: Demircin G,Oner A,Erdoğan O,Delibaş A,Baysun S,Bülbül M,Bek K,Oksal A

    更新日期:2008-01-01 00:00:00

  • Ozone therapy ameliorates tubulointerstitial inflammation by regulating TLR4 in adenine-induced CKD rats.

    abstract::Tubulointerstitium inflammation is a common pathway aggravating chronic kidney disease (CKD) progression and the mechanism is partly associated with excessive activation of toll-like receptor 4 (TLR4) in tubulointerstitium. Ozone therapy is demonstrated to alleviate inflammation in some experiments. The aim of this st...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2016.1143757

    authors: Chen Z,Liu X,Yu G,Chen H,Wang L,Wang Z,Qiu T,Weng X

    更新日期:2016-06-01 00:00:00

  • Osmotic diuretics and hemodilution in postischemic renal failure.

    abstract::In the acute phase of ischemic renal failure, the severe depression of the glomerular filtration rate (GFR) is due to obstruction of the tubules by cells and cell debris rejected from the proximal tubules, a blockade which can be prevented at least partly, by treatment with osmotic diuretics. The isosthenuria, the sec...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229209106632

    authors: Wolgast M,Bayati A,Hellberg O,Källskog O,Nygren K

    更新日期:1992-01-01 00:00:00

  • Histopathological changes of rat kidney with exposure to chronic thinner inhalation.

    abstract:INTRODUCTION:Organic solvents are liquid substances commonly used in everyday life at home and in industrial workplaces. These solvents are found primarily in paint as thinner. Because other narcotics are hard to find, thinner is used as a narcotic especially among youngsters of low socioeconomic level. The aim of this...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2010.536290

    authors: Toros AB,Toros SZ,Aker F,Ersoz F,Derin A,Kesici B,Ozel L

    更新日期:2011-01-01 00:00:00

  • Intensification of peritoneal dialysis improves valacyclovir neurotoxicity.

    abstract::Valacyclovir induced neurotoxicity is a life-threatening complication, usually starting 24-48 h after drug-peak serum concentrations. The elderly with impaired renal function seem to be the most susceptible group to valacyclovir neurotoxicity. Although hemodialysis is considered the best method for rapid drug removal,...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2012.743914

    authors: Pipili C,Pantelias K,Deda E,Tsiamalos P,Kostis E,Grapsa E

    更新日期:2013-01-01 00:00:00

  • Evaluation of renal clinicopathological changes in IgA nephropathy by urinary podocytes excretion and podocalyxin expression.

    abstract:OBJECTIVE:To explore the association of urinary podocyte excretion and renal expression of podocyte-specific marker podocalyxin (PCX) with clinicopathological changes in immunoglobulin A nephropathy (IgAN). METHODS:Morning urine samples from IgAN patients and healthy controls were collected. The expression of glomerul...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2011.643352

    authors: Jiang WL,Peng YM,Liu YH,Liu H,Chen GC,Xu XQ,Zhu XJ,Liu FY

    更新日期:2012-01-01 00:00:00

  • Neutrophil-to-lymphocyte ratio as a predictor of worsening renal function in diabetic patients (3-year follow-up study).

    abstract:BACKGROUND:Previous studies have demonstrated the role of inflammation in diabetic nephropathy (DN). Neutrophil to lymphocyte ratio (NLR) rather than other white cell parameters was found to be a useful inflammatory marker to predict adverse outcomes in medical and surgical conditions. Nevertheless, the value of NLR in...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2012.668741

    authors: Azab B,Daoud J,Naeem FB,Nasr R,Ross J,Ghimire P,Siddiqui A,Azzi N,Rihana N,Abdallah M,Azzi N,Patel P,Kleiner M,El-Sayegh S

    更新日期:2012-01-01 00:00:00

  • Clinical course and symptomatic prediagnostic period of patients with Wegener's granulomatosis and microscopic polyangiitis.

    abstract::The clinical course of 15 patients with Wegener's granulomatosis (WG) and eight patients with microscopic polyangiitis (MPA) from one nephrological clinical center is presented for the period from 1984 to 1993, when testing for antineutrophil cytoplasmic antibodies (ANCA) was gradually introduced into routine clinical...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229809045141

    authors: Schleiffer T,Burkhard B,Klooker P,Brass H

    更新日期:1998-05-01 00:00:00

  • Acute renal failure due to nontraumatic rhabdomyolysis following binge drinking.

    abstract::Nontraumatic rhabdomyolysis is an important but under-recognized cause of acute renal failure. In alcoholics, rhabdomyolysis most frequently develop following muscle necrosis during alcohol-induced coma, but has also been described rarely in those without prolonged coma or seizures. We describe a patient who developed...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:10.3109/08860229909045195

    authors: Muthukumar T,Jha V,Sud A,Wanchoo A,Bambery P,Sakhuja V

    更新日期:1999-09-01 00:00:00

  • Association between VEGF receptors and baseline peritoneal transport status in new peritoneal dialysis patients.

    abstract:BACKGROUND:Peritoneal transport status is important not only for prescription, but also as a prognostic index. Flt-1 and Flk-1, the major vascular endothelial growth factor receptors involved in angiogenesis and hyperpermeability, may play a potent role in determining peritoneal transport characteristics. However, the ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2012.669322

    authors: Zhang AH,Wang G,Zhang DL,Zhang QD,Liu S,Liao Y,Yin Y,Liu WH

    更新日期:2012-01-01 00:00:00

  • The aqueous extract of aged black garlic ameliorates colistin-induced acute kidney injury in rats.

    abstract::The use of colistin in the treatment of multidrug-resistant Gram-negative bacterial infections is restricted due to nephrotoxicity. We investigated the effects of aged black garlic extract (ABGE) on colistin-induced kidney injury in rats. Rats were assigned to four groups. Normal saline was intraperitoneally and intra...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2018.1561375

    authors: Lee TW,Bae E,Kim JH,Jang HN,Cho HS,Chang SH,Park DJ

    更新日期:2019-11-01 00:00:00

  • Pathophysiology of paraprotein production.

    abstract::Paraproteins or monoclonal proteins are the result of clonal B-cell or plasma cell proliferation of a malignant, premalignant or non-malignant nature. Monoclonal proteins may consist of intact immunoglobulin molecules or of heavy or light chains only. Depending on their rate of production and/or secretion they may acc...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:10.3109/08860229809045179

    authors: Maniatis A

    更新日期:1998-11-01 00:00:00

  • Posttreatment with aminoguanidine attenuates renal ischemia/reperfusion injury in rats.

    abstract::Acute renal failure secondary to ischemia/reperfusion (I/R) injury is associated with significant mortality and morbidity. Aminoguanidine (AG), an inducible nitric oxide synthase inhibitor with antioxidant properties, has been reported beneficial in renal I/R injury. The aim of the present study was to investigate the...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220802546313

    authors: Onem Y,Ipcioglu OM,Haholu A,Sen H,Aydinoz S,Suleymanoglu S,Bilgi O,Akyol I

    更新日期:2009-01-01 00:00:00

  • Rapid-onset diabetic nephropathy in type II diabetes mellitus.

    abstract::We report a case of rapidly progressive diabetic nephropathy, from little diabetic change on renal biopsy to severe, nodular, diabetic nephrosclerosis over 32 months. The patient was taking an angiotensin converting enzyme inhibitor and had a mean arterial pressure of 95 mm Hg over this time period. Her dietary protei...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229709037223

    authors: Dillon JJ,Sedmak DD,Cosio FG

    更新日期:1997-11-01 00:00:00

  • Factors related to pulse wave velocity and augmentation index in chronic hemodialysis patients.

    abstract:BACKGROUND:Augmentation index (AIx) and pulse wave velocity (PWV) are early markers of atherosclerotic vascular changes and also have been shown to be predictive of cardiovascular disease and total mortality. The aim of our study was to evaluate the relationship between PWV and AIx-HR75, which is the corrected form of ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2011.615967

    authors: Celik G,Demirci MS,Tumuklu M,Ascı G,Sipahi S,Toz H,Bascı A,Ok E

    更新日期:2011-01-01 00:00:00

  • High mobility group box 1 and tumor growth factor β: useful biomarkers in pediatric patients receiving peritoneal dialysis.

    abstract:BACKGROUND:Peritonitis, the most important limitation of peritoneal dialysis (PD), could be detected by biomarkers in dialysate effluent, representing a noninvasive method to indirectly assess the peritoneum status. The aim of our study was to test high mobility group box 1 (HMGB1) in PD patients, evaluating its role a...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2016.1216711

    authors: Chimenz R,Lacquaniti A,Colavita L,Chirico V,Fede C,Buemi M,Fede C

    更新日期:2016-10-01 00:00:00

  • Endothelin-1 and nitric oxide in patients on chronic hemodialysis.

    abstract:AIM:To establish the role of endothelin-1 and nitric oxide in the pathogenesis of hypertension in patients on chronic hemodialysis by correlating endothelin-1 and NO plasma concentrations to the level of arterial hypertension with respect to angiotensin-converting enzyme (ACE) inhibitor therapy. METHODS:We determined ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220802356218

    authors: Tomić M,Galesić K,Markota I

    更新日期:2008-01-01 00:00:00

  • Associations between endothelial nitric oxide synthase polymorphisms and risk of diabetic nephropathy: an updated meta-analysis.

    abstract:BACKGROUND:Genetic polymorphism of endothelial nitric oxide synthase (eNOS) has been implicated in the risk of diabetic nephropathy (DN), but the published findings were inconsistent. We performed a comprehensive meta-analysis to derive a more precise estimation of the association between genetic polymorphisms of eNOS ...

    journal_title:Renal failure

    pub_type: 杂志文章,meta分析

    doi:10.3109/0886022X.2015.1062339

    authors: Zhang Y,Xiao HQ,Zeng XT,Zuo HX,Xu YC

    更新日期:2015-11-01 00:00:00

  • What has changed in the prevalence of hypertension in dialyzed children during the last decade?

    abstract:BACKGROUND:Hypertension very often accompanies progression of chronic kidney disease (CKD) in children. A cross-sectional analysis of hypertension prevalence in dialyzed children in Poland was designed with a comparison with the data previously recorded 10 years earlier. METHODS:Two cohorts of children were analyzed: ...

    journal_title:Renal failure

    pub_type: 杂志文章,多中心研究

    doi:10.1080/0886022X.2016.1260033

    authors: Tkaczyk M,Stańczyk M,Miklaszewska M,Zachwieja K,Wierciński R,Stankiewicz R,Firszt-Adamczyk A,Zachwieja J,Borzęcka H,Zagożdżon I,Leszczyńska B,Medyńska A,Adamczyk P,Szczepańska M,Fendler W

    更新日期:2017-11-01 00:00:00

  • Outcomes of normotensive IgA nephropathy patients with mild proteinuria who have impaired renal function.

    abstract::Purpose: Typically, IgA nephropathy is a slowly progressive type of glomerulonephritis. High-grade proteinuria and hypertension are predictors of reduced kidney function. However, we found some normotensive patients with mild proteinuria could exhibit impaired renal function at the time of IgAN diagnosis. We therefore...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2019.1654512

    authors: Tan M,Fang J,Xu Q,Zhang C,Zou G,Wang M,Li W

    更新日期:2019-11-01 00:00:00