Pathophysiology of paraprotein production.

Abstract:

:Paraproteins or monoclonal proteins are the result of clonal B-cell or plasma cell proliferation of a malignant, premalignant or non-malignant nature. Monoclonal proteins may consist of intact immunoglobulin molecules or of heavy or light chains only. Depending on their rate of production and/or secretion they may accumulate in the serum and/or urine of patients. Their presence in the circulation may remain silent, as in monoclonal gammopathy of undetermined significance (MGUS), or may lead to clinical syndromes such as Hyperviscosity, Acrocyanosis, Cold hemagglutination, hemolysis and hemorrhagic manifestations. Their tissue deposition may be localized, with the kidney being the most frequent target as in Myeloma Cast Nephropathy or systemic, as in AL amyloidosis where heart, liver, nerves, tongue are usual targets, in addition to the kidneys.

journal_name

Ren Fail

journal_title

Renal failure

authors

Maniatis A

doi

10.3109/08860229809045179

subject

Has Abstract

pub_date

1998-11-01 00:00:00

pages

821-8

issue

6

eissn

0886-022X

issn

1525-6049

journal_volume

20

pub_type

杂志文章,评审
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    abstract::Aldosterone is reported to promote fibrosis of multiple organs. Recent studies showed that Na+-H+ exchanger isoform 1 (NHE1) was involved in mineralocorticoid-induced tissue fibrosis. The present study examined the role of NHE1 in aldosterone-induced glomerulosclerosis in rats. SD male rats were subjected to 5/6 nephr...

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    doi:10.3109/08860220903134571

    authors: Zhang M,Chen J,Liu S,You L,Lin S,Gu Y

    更新日期:2009-01-01 00:00:00

  • Long-term effects of small doses of calcitriol in hemodialysis patients with moderate secondary hyperparathyroidism.

    abstract::Prevention of secondary hyperparathyroidism (SHPTH) and treatment of the moderate cases by small p.os doses of Vitamin D has not been thoroughly investigated on the long term, while large doses of Vitamin D have been successful in the short term treatment of this entity. We administered calcitriol p.os 0.5-1.0 microgr...

    journal_title:Renal failure

    pub_type: 临床试验,杂志文章

    doi:10.3109/08860229909066984

    authors: Vlassopoulos D,Noussias C,Revenas K,Hadjilouka-Mantaka A,Arvanitis D,Tzortzis G,Hadjiconstantinou V

    更新日期:1999-03-01 00:00:00

  • Proteomic analysis of peritoneal dialysate fluid in patients with dialysis-related peritonitis.

    abstract::The prognosis of uremia patients on continuous ambulatory peritoneal dialysis (CAPD) is related to frequent peritonitis rate. Frequent peritonitis will lead to peritoneum failure, making CAPD unfeasible. We have performed proteomic profiling of peritoneal dialysis effluent samples from a cross-section of CAPD patients...

    journal_title:Renal failure

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    doi:10.1080/08860220802248969

    authors: Lin WT,Tsai CC,Chen CY,Lee WJ,Su CC,Wu YJ

    更新日期:2008-01-01 00:00:00

  • Classic heat stroke in a case of simple hypohydrosis with "bad prognostic indicators" but a remarkable recovery.

    abstract::Heat stroke occurs in the desert area of Saudi Arabia quite frequently and manifest in different patterns including coagulopathy. Frequently encountered complications include renal or hepatic failure, rhabdomyolysis, acute respiratory distress syndrome (ARDS), disseminated intravascular coagulation (DIC), and seizure....

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-100107370

    authors: Sinha AK,Ghacha R,Youmbissi JT,Khursany IA

    更新日期:2001-09-01 00:00:00

  • Elevated plasma levels of PAI-1 predict cardiovascular events and cardiovascular mortality in prevalent peritoneal dialysis patients.

    abstract:BACKGROUND:Elevated plasminogen activator inhibitor-1 (PAI-1) levels are associated with increased cardiovascular (CV) risk in the general population. It has been shown that peritoneal dialysis (PD) patients have increased plasma levels of PAI-1. The aim of this study was to investigate whether PAI-1 independently pred...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220902963772

    authors: Arikan H,Koc M,Tuglular S,Ozener C,Akoglu E

    更新日期:2009-01-01 00:00:00

  • Postoperative hemolytic uremic syndrome with renal cortical necrosis following laparoscopic hemicolectomy.

    abstract::Non-Shiga-like toxin-producing Escherichia coli (STEC) or atypical hemolytic uremic syndrome (aHUS) is observed in 5-10% of all hemolytic uremic syndrome (HUS) cases, and usually develops secondary to infections, malignancies, drugs, transplantation, pregnancy, and autoimmune disease. However, there has been no report...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2013.780978

    authors: Lee JW,Won NH,Cho E,Kim MG,Jo SK,Cho WY,Kim HK

    更新日期:2013-01-01 00:00:00

  • Endothelin-1 and nitric oxide in patients on chronic hemodialysis.

    abstract:AIM:To establish the role of endothelin-1 and nitric oxide in the pathogenesis of hypertension in patients on chronic hemodialysis by correlating endothelin-1 and NO plasma concentrations to the level of arterial hypertension with respect to angiotensin-converting enzyme (ACE) inhibitor therapy. METHODS:We determined ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220802356218

    authors: Tomić M,Galesić K,Markota I

    更新日期:2008-01-01 00:00:00

  • Differences in new-onset IgA nephropathy between young adults and the elderly.

    abstract:BACKGROUND:The goal of this study was to define the clinical and histological differences in new-onset IgA nephropathy between young adults and the elderly. METHODS:We retrospectively examined renal biopsy findings, clinical features at presentation and outcomes in 82 young adults (mean age 30.3+/-10.2 years) and 17 e...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860221003611687

    authors: Wen YK,Chen ML

    更新日期:2010-01-01 00:00:00

  • Toward the optimal clinical use of the fraction excretion of solutes in oliguric azotemia.

    abstract::While the fractional excretion of solutes have long been considered excellent research tools to investigate tubular physiology, their clinical use has become common over the last 40 years in the diagnoses of many disorders; however, none have reached the clinical utility of the fractional excretion of sodium in the ab...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:10.3109/0886022X.2010.517353

    authors: Diskin CJ,Stokes TJ,Dansby LM,Radcliff L,Carter TB

    更新日期:2010-01-01 00:00:00

  • Improvement of endothelial dysfunction with simvastatin in patients with autosomal dominant polycystic kidney disease.

    abstract::Cardiovascular problems are a major cause of morbidity and mortality in patients with autosomal dominant polycystic kidney disease (ADPKD). Endothelial dysfunction (ED), which is an early manifestation of vascular injury, has been shown in patients with ADPKD. Statins have a beneficial effect in the reversal of ED. Th...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220601038892

    authors: Namli S,Oflaz H,Turgut F,Alisir S,Tufan F,Ucar A,Mercanoglu F,Ecder T

    更新日期:2007-01-01 00:00:00

  • Use of phosphonoformic acid to induce phosphaturia in chronic renal failure in rats.

    abstract::In chronic renal failure (CRF), phosphate (Pi) retention may lead to secondary hyperparathyroidism and progression to end-stage renal disease (ESRD). Dietary phosphorus restriction or phosphate binders can slow progression in experimental CRF. Conversely, diets high in phosphorus can accelerate the progression toward ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229609047712

    authors: Loghman-Adham M,Motock GT

    更新日期:1996-11-01 00:00:00

  • Bcıı--RFLP profiles for serum amiloid A1 and mutated MEFV gene prevalence in chronic renal failure patients requiring long-term hemodialysis.

    abstract:BACKGROUND AND AIM:There is an increased mortality risk in long-term hemodialysis patients of renal failure due to the chronic inflammation. The relationship between the chronic renal failure (CRF) and the role of familial genetic markers remains incompletely understood. In the current study, it was aimed to find out t...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2014.982954

    authors: Ozdemir O,Kayatas M,Cetinkaya S,Yildirim ME,Silan F,Kurtulgan HK,Koksal B,Urfali M,Candan F

    更新日期:2015-03-01 00:00:00

  • Antioxidant U74389G improves glycerol-induced acute renal failure without affecting PPARgamma gene.

    abstract::Oxygen metabolites play an important role in the pathogenesis of myoglobinuric acute renal failure (ARF). Previously, we have reported a down regulation of peroxisome proliferator activated receptor gamma (PPARgamma) in glycerol-induced ARF, and the induction of PPARgamma has been shown to provide renal protection. In...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220701573483

    authors: Yousefipour Z,Hercule H,Oyekan AO,Newaz MA

    更新日期:2007-01-01 00:00:00

  • Low prevalence of hepatitis C virus infection in hemodialysis units: effect of isolation?

    abstract::Hepatitis C virus (HCV) infection has recently become the major cause of chronic liver disease among patients on chronic hemodialysis. The use of erythropoietin for treatment of anemia has reduced the number of blood transfusions, but the frequency of HCV infection has not declined in hemodialysis units. The exact mod...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-120013968

    authors: Harmankaya O,Cetin B,Obek A,Seber E

    更新日期:2002-09-01 00:00:00

  • Interleukin-22 attenuates renal tubular cells inflammation and fibrosis induced by TGF-β1 through Notch1 signaling pathway.

    abstract::Transforming growth factor-β1 (TGF-β1) is a crucial factor implicated in the development of renal inflammation and tubulointerstitial fibrosis (TIF). The cytokine interleukin 22 (IL-22) was previously reported to involve in the pathogenesis of chronic inflammatory diseases, however recent studies showed that IL-22 cou...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2020.1753538

    authors: Tang R,Xiao X,Lu Y,Li H,Zhou Q,Kwadwo Nuro-Gyina P,Li X

    更新日期:2020-11-01 00:00:00

  • Acute toxic kidney injury.

    abstract::Substances toxic to the kidney are legion in the modern world. The sheer number and variety, their mutual interactions and, metabolism within the body are a challenge to research. Moreover, the kidney is especially prone to injury owing to its physiology. Acute kidney injury (AKI) induced by poisonous or primarily nep...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:10.1080/0886022X.2019.1628780

    authors: Petejova N,Martinek A,Zadrazil J,Teplan V

    更新日期:2019-11-01 00:00:00

  • Urinary transforming growth factor-beta1 excretion in renal allograft recipients during the early post-transplantation period.

    abstract:BACKGROUND:Transforming growth factor-beta1 (TGF-beta1), the major fibrogenic growth factor, is implicated in the pathogenesis of renal scarring in experimental and clinical nephropathies as well as in chronic allograft nephropathy. In this study we examined the pattern of changes of TGF-beta1 excretion in the urine an...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-120022547

    authors: Goumenos DS,Tsakas S,Karavias D,Savidaki I,Karatzas T,Vlachojannis JG

    更新日期:2003-07-01 00:00:00

  • Epidemiologic trend changes in acute renal failure--a tertiary center experience from South India.

    abstract:BACKGROUND:There are little data on the incidence of acute renal failure (ARF) from India due to the absence of central registry. The etiology, course, and outcome of ARF differ in various parts of India. Significant trend changes were reported even within a same center over a period of time. AIM:To find out the epide...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220600689034

    authors: Jayakumar M,Prabahar MR,Fernando EM,Manorajan R,Venkatraman R,Balaraman V

    更新日期:2006-01-01 00:00:00

  • Outcomes of normotensive IgA nephropathy patients with mild proteinuria who have impaired renal function.

    abstract::Purpose: Typically, IgA nephropathy is a slowly progressive type of glomerulonephritis. High-grade proteinuria and hypertension are predictors of reduced kidney function. However, we found some normotensive patients with mild proteinuria could exhibit impaired renal function at the time of IgAN diagnosis. We therefore...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2019.1654512

    authors: Tan M,Fang J,Xu Q,Zhang C,Zou G,Wang M,Li W

    更新日期:2019-11-01 00:00:00

  • Salt sensitivity of blood pressure in non-dialysis patients with chronic kidney disease.

    abstract:BACKGROUND:Chronic kidney disease (CKD) is a world-wide public health problem. Hypertension is both a cause and a complication of CKD, and a risk factor for progression of kidney disease. The effect of salt intake on blood pressure (BP) and the salt sensitivity in non-dialysis patients with CKD were studied. METHODS:O...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2013.866008

    authors: Meng L,Fu B,Zhang T,Han Z,Yang M

    更新日期:2014-04-01 00:00:00

  • Normal mesenteric lymph ameliorates acute kidney injury following lipopolysaccharide challenge in mice.

    abstract:BACKGROUND:The kidney is one of the prior damaged organs subjected to severe infection and sepsis shock. Our previous studies have shown that the normal mesenteric lymph (NML) obtained from healthy dogs could alleviate multiple organ injuries following endotoxic shock. In the current study, we further investigated the ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2014.938585

    authors: Zhao ZG,Zhang LM,Song W,Du HB,Cui H,Niu CY

    更新日期:2014-09-01 00:00:00

  • Rhabdomyolysis and acute renal failure following cardioversion and cardiopulmonary resuscitation.

    abstract::A 39-year-old male suffered a myocardial infarction at work and cardiopulmonary resuscitation was initiated immediately. After 15 cardioversions, ventricular fibrillation converted to sinus rhythm. Rhabdomyolysis with a 100-fold increase of serum creatine kinase level and myoglobinuria with acute renal failure ensued,...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229509037645

    authors: Hojs R,Sinkovic A,Hojs-Fabjan T

    更新日期:1995-11-01 00:00:00

  • Leukocyte involvement in renal reperfusion-induced liver damage.

    abstract:BACKGROUNDS/AIMS:Renal ischemia-reperfusion (IR) induces organ damage in remote organs. The aim of this study was to assess the role of leukocytes in the induction of liver damage after renal IR injury. METHODS:Inbred mice were subjected to either sham operation or bilateral renal IR injury (60 min ischemia followed b...

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    pub_type: 杂志文章

    doi:10.3109/0886022X.2010.541585

    authors: Khastar H,Kadkhodaee M,Sadeghipour HR,Seifi B,Hadjati J,Delavari F,Soleimani M

    更新日期:2011-01-01 00:00:00

  • Infectious complications of prosthetic arteriovenous grafts for hemodialysis: prevention is better than cure.

    abstract::Synthetic arteriovenous grafts for hemodialysis constitute the second choice in comparison with native arteriovenous fistulas. Lower patency rates and significantly more frequent infections are the main disadvantages of hemodialysis grafts over fistulas. Infectious complications could vary between a simple local eryth...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2014.883910

    authors: Galanopoulos G,Lambidis C

    更新日期:2014-05-01 00:00:00

  • Lipid abnormalities and oxidized LDL in chronic kidney disease patients on hemodialysis and peritoneal dialysis.

    abstract::Dyslipoproteinemia and oxidative modification of low-density lipoprotein (oxLDL) contribute to the development of oxidative stress and atherosclerosis in chronic kidney disease (CKD). On the contrary, high-density lipoprotein cholesterol (HDL-C), especially HDL3-C subtype, has protective effect against oxidative damag...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2011.641515

    authors: Samouilidou EC,Karpouza AP,Kostopoulos V,Bakirtzi T,Pantelias K,Petras D,Tzanatou-Exarchou H,J Grapsa E

    更新日期:2012-01-01 00:00:00

  • Bacterial colonization in hemodialysis temporary dual lumen catheters: a prospective study.

    abstract:AIMS:The use of hemodialysis temporary dual-lumen catheters is often complicated by infections, which may be a significant cause of death among patients with end stage renal disease (ESRD). The aim of this study was to assess the incidence of bacteremia and bacterial colonization related to non-tunneled, non-cuffed, du...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220701741940

    authors: de Freitas LW,Neto MM,Nascimento MM,Figueiredo JF

    更新日期:2008-01-01 00:00:00

  • Renin-angiotensin system blockade is not associated with hyperkalemia in chronic hemodialysis patients.

    abstract:BACKGROUND:Serious hyperkalemia was reported in 10% of chronic hemodialysis (HD) patients that could lead to arrhythmia and death. Angiotensin-converting enzyme inhibitors (ACE-I) and angiotensin II receptor blockers (ARB) are well accepted for cardio-protective benefits. The relationship between renin-angiotensin syst...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860220903216147

    authors: Lin HH,Yang YF,Chang JK,Ting IW,Kuo HL,Wang IK,Huang CC

    更新日期:2009-01-01 00:00:00

  • Therapeutic use of the natriuretic peptide ularitide in acute renal failure.

    abstract:BACKGROUND:Ularitide is a member of the natriuretic peptide family. This hormone exhibits an N-terminal extension by four amino acids compared with atrial natriuretic peptide. Ularitide was shown to exert strong diuretic and natriuretic effects when infused intravenously. Its main action sites are the glomerulum, induc...

    journal_title:Renal failure

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.3109/08860229909066972

    authors: Meyer M,Pfarr E,Schirmer G,Uberbacher HJ,Schöpe K,Böhm E,Flüge T,Mentz P,Scigalla P,Forssmann WG

    更新日期:1999-01-01 00:00:00

  • Safety and efficacy of mizoribine treatment in nephrotic syndrome complicated with hepatitis B virus infection: a clinical study.

    abstract::Objective The objective of this study is to explore the efficacy and safety of mizoribine (MZR) in treating nephrotic syndrome patients afflicted with hepatitis B virus (HBV). Methods The present study included 36 nephrotic syndrome patients accompanied with HBV infection. A draft of MZR (150-200 mg/d), methylpredniso...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2016.1158035

    authors: Liu J,Zhang K,Ji Y,Zhang W,Li W,Yong Q,Wang J,Sun J,Zhang H

    更新日期:2016-06-01 00:00:00

  • Adenylate cyclase responses and biochemical characterization of primary rabbit proximal tubular cell cultures and LLC-PK1 cells.

    abstract::Freshly isolated rabbit proximal tubules (PT), confluent primary rabbit proximal tubule cultures (PTC) and LLC-PK1 cells were characterised. Brushborder enzyme activities were lower in PTC than in LLC-PK1: ratios were 0.026 for alkaline phosphatase (AP), 0.458 for alanine aminopeptidase (AAP) and 0.514 for gamma-gluta...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229009065561

    authors: Toutain H,Courjault F,Vauclin-Jacques N,Morin JP

    更新日期:1990-01-01 00:00:00