Abstract:
BACKGROUND:Previous studies have demonstrated the role of inflammation in diabetic nephropathy (DN). Neutrophil to lymphocyte ratio (NLR) rather than other white cell parameters was found to be a useful inflammatory marker to predict adverse outcomes in medical and surgical conditions. Nevertheless, the value of NLR in predicting DN has not been elucidated. METHOD:An observational study included 338 diabetic patients, who were followed at our clinic between 2007 and 2009. We arranged our patients into tertiles according to their 2007 NLR. The primary outcome was continuous decrease of GFR >12 mL/min between 2007 and 2009 with the last GFR <60 mL/min. RESULT:The lowest NLR tertile had fewer patients (2.7%) with primary outcome (i.e., worsening renal function) compared with middle and highest NLR tertiles, which had more patients with primary outcomes (8.7% and 11.5%, respectively) with a significant p-value 0.0164. When other potential confounders were individually analyzed with NLR tertile, the NLR tertiles remained a significant predictor of poor GFR outcome in the presence of other variables (hemoglobin A1C, systolic blood pressure, diastolic blood pressure, age, and congestive heart failure with p-values 0.018, 0.019, 0.017, 0.033, and 0.022, respectively). CONCLUSION:NLR predicted the worsening of the renal function in diabetic patients. Further studies are needed to confirm this result.
journal_name
Ren Failjournal_title
Renal failureauthors
Azab B,Daoud J,Naeem FB,Nasr R,Ross J,Ghimire P,Siddiqui A,Azzi N,Rihana N,Abdallah M,Azzi N,Patel P,Kleiner M,El-Sayegh Sdoi
10.3109/0886022X.2012.668741subject
Has Abstractpub_date
2012-01-01 00:00:00pages
571-6issue
5eissn
0886-022Xissn
1525-6049journal_volume
34pub_type
杂志文章相关文献
RENAL FAILURE文献大全abstract::Background: Elevated serum levels of sIL-2R are commonly observed in patients undergoing maintenance hemodialysis (MHD). However, the clinical implications in these subjects are unclear. This study is aimed to assess the significance of elevated sIL-2R levels in MHD patients.Methods: A total of 382 MHD patients were f...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2020.1761388
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:An increased red blood cell (RBC) phosphatidylserine (PS) exposure in uremic patients was found that could promote macrophage recognition and decrease RBC survival time. Furthermore, a reduced red cell life span was found to contribute anemia in patients with renal failure. It is therefore possible to hypoth...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220600839647
更新日期:2006-01-01 00:00:00
abstract::The role of the kidney in the control of blood pressure has been convincingly demonstrated by several studies. Recent evidence has suggested that subtle acquired tubulointerstitial injury may cause a defect in sodium excretion function, thus leading to salt-sensitive hypertension. There are no reports, however, examin...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220600779058
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Previous studies have found significant stressors experienced by nurses working in hemodialysis units. The purpose of this study was to determine the burnout levels of hemodialysis nurses working in hemodialysis units and their relation with some sociodemographic variables. METHODS:The study was conducted b...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2014.917559
更新日期:2014-08-01 00:00:00
abstract::Renal biopsy data indicate that tubular epithelial cells serve as a reservoir for HIV-1 infection. We studied the effect of HIV-1 gp120 envelope gene expression on tubular cell apoptosis. HIV-1 gp120 was expressed in a lentiviral vector pHR-CMV-IRES2-EGFP-DeltaB. This plasmid construct was used to produce pseudotyped ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220902780101
更新日期:2009-01-01 00:00:00
abstract::Chronic kidney disease (CKD) is a world-wide public health problem. The purpose of this study was to identify the role of some controversial potential risk factors in development of CKD. "Community Complex Health Screening" is a large-scale, free, health program for individuals ≥40 years of age that has been available...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2013.866017
更新日期:2014-04-01 00:00:00
abstract::Prevention of secondary hyperparathyroidism (SHPTH) and treatment of the moderate cases by small p.os doses of Vitamin D has not been thoroughly investigated on the long term, while large doses of Vitamin D have been successful in the short term treatment of this entity. We administered calcitriol p.os 0.5-1.0 microgr...
journal_title:Renal failure
pub_type: 临床试验,杂志文章
doi:10.3109/08860229909066984
更新日期:1999-03-01 00:00:00
abstract::To examine immune activation rate of interstitial and glomeruli infiltrating MNC in different conditions of human renal allograft function deterioration, 33 renal transplant biopsies were performed 1-30 months after transplantations. Forty-one patients observed were on immunosuppressives: Pr, Aza, CsA following renal ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229309054973
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Patients with chronic kidney disease (CKD) often have CD4+ regulatory T cells (Tregs) dysfunction and chronic inflammation. We aim to investigate the effect, function, and related mechanism of low-dose IL-2 on CD4+ regulatory T cells expansion in vitro from patients with CKD. METHODS:A total of 148 newly di...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2018.1456462
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVES:Chronic kidney disease (CKD) is a major risk factor for cardiovascular disease (CVD). We previously reported renal parenchymal damage in autopsy subjects with stroke or abdominal aortic aneurysm. The aim of this study is to evaluate the relationship between renal histology and clinical characteristics of pat...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2011.605531
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Asymmetric dimethylarginine (ADMA) as a uremia toxin is accumulated in end-stage renal disease (ESRD) patients. Elevated ADMA level has been shown to be predictive of cardiovascular diseases (CVDs) and all-cause mortality in ESRD. Therefore, we investigated the removal of ADMA by different dialysis treatment...
journal_title:Renal failure
pub_type: 杂志文章,随机对照试验
doi:10.3109/0886022X.2010.502281
更新日期:2010-01-01 00:00:00
abstract::Currently, obesity has reached an epidemic stage and represents a challenge for health authorities across the globe. Certainly, with emergence of obesity epidemic, we started to see an increase in the prevalence of chronic kidney disease (CKD) and nephrolithiasis. Interestingly, epidemiologic studies have shown that t...
journal_title:Renal failure
pub_type: 杂志文章,评审
doi:10.3109/0886022X.2012.723777
更新日期:2012-01-01 00:00:00
abstract::The prognosis of uremia patients on continuous ambulatory peritoneal dialysis (CAPD) is related to frequent peritonitis rate. Frequent peritonitis will lead to peritoneum failure, making CAPD unfeasible. We have performed proteomic profiling of peritoneal dialysis effluent samples from a cross-section of CAPD patients...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220802248969
更新日期:2008-01-01 00:00:00
abstract::Synthetic arteriovenous grafts for hemodialysis constitute the second choice in comparison with native arteriovenous fistulas. Lower patency rates and significantly more frequent infections are the main disadvantages of hemodialysis grafts over fistulas. Infectious complications could vary between a simple local eryth...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2014.883910
更新日期:2014-05-01 00:00:00
abstract::Continuous efforts have been made to find out precise and simple method for determination of glomerular filtration rate (GFR). Cystatin C (cysteine proteinase inhibitor = CyC) is a low molecular weight (LMW) protein which is produced constantly by all nucleated cells independently of different pathological conditions ...
journal_title:Renal failure
pub_type: 临床试验,杂志文章
doi:10.1081/jdi-120017475
更新日期:2003-01-01 00:00:00
abstract:INTRODUCTION:Dyslipidemia is one of the onset and risk factors of chronic kidney disease and renal function drop is seen in lipoprotein abnormal animal models. However, the detailed molecular mechanism of renal lipotoxicity has not been clarified. Therefore, the present study aimed to investigate the influence of chole...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2017.1419974
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Cardiac valve calcification (CVC) and left ventricular (LV) alterations are frequent complication in end-stage renal disease (ESRD). We determined the prevalence of CVC and LV hypertrophy (LVH) in ESRD patients before renal replacement therapy and 12 months after peritoneal dialysis (PD). METHODS:A prospect...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2015.1073495
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Glutathione S-transferases (GSTs) belong to a family of ubiquitous and multifunctional enzymes that work as one of the endogenous antioxidants in our body. This study was designed to look into the association of GST polymorphism with oxidative stress in both diabetic and nondiabetic chronic kid...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2010.517348
更新日期:2010-01-01 00:00:00
abstract::Secondary hyperparathyroidism (SHP) is a frequent complication of long-term dialysis patients, and surgical parathyroidectomy remains necessary in patients resistant to medical therapy. The present paper reports single center results in subtotal parathyroidectomy, presenting diagnostic procedure, indications for parat...
journal_title:Renal failure
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Human urotensin-II (hU-II) is one of the most potent vasoconstrictors in mammals. To our knowledge, there is no study about the role of U-II in childhood glomerulonephritis. We first determined the expression of h U-II in kidneys of children with chronic glomerular diseases. METHODS:Normal human kidneys wer...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220701392108
更新日期:2007-01-01 00:00:00
abstract::We previously described a method to measure GFR in conscious spontaneously voiding rats. This method circumvents the need for anesthesia and for bladder instrumentation. It's main principle is the correction of renal 125I-iothalamate clearance for incomplete urine collection by the ratio of plasma and renal clearance ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229809045109
更新日期:1998-03-01 00:00:00
abstract::Renal involvement is an unusual but significant Behcet´s disease (BD) complication and AA amyloidosis appears to be the most common etiology. IL-6 is a pro-inflammatory cytokine with an important role in AA amyloidosis development. Tocilizumab (TCZ) is a humanized anti-IL-6 receptor antibody that has emerged as an eff...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2013.773913
更新日期:2013-01-01 00:00:00
abstract::Compared to prior studies which frequently pinpoint the impairment of one parameter or function, this paper reports for the first time an extensive characterization of the toxic effects of gentamicin in a single model of primary cultured rabbit proximal tubule cells developed without insulin and glucose. Biochemical, ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229309054962
更新日期:1993-01-01 00:00:00
abstract::Depression is common in patients with end-stage renal disease (ESRD) and is associated with increased mortality and morbidity. Several investigators have estimated that depression occurs in about 20% to 30% of dialysis patients. The aim of this study was to investigate the relationship between depression, some laborat...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220500242728
更新日期:2005-01-01 00:00:00
abstract::Glomerular function shows a progression directly correlated to gestational age (GA) and postnatal age in preterm infants. In preterms, glomerular filtration rate (GFR) is significantly lower than in term infants, and it matures more slowly in the postnatal period. In infants with very low GA, due to decreased GFR, nor...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2011.585263
更新日期:2011-01-01 00:00:00
abstract::The use of colistin in the treatment of multidrug-resistant Gram-negative bacterial infections is restricted due to nephrotoxicity. We investigated the effects of aged black garlic extract (ABGE) on colistin-induced kidney injury in rats. Rats were assigned to four groups. Normal saline was intraperitoneally and intra...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2018.1561375
更新日期:2019-11-01 00:00:00
abstract::Objectives: To improve the mouse model of relief for unilateral ureteral obstruction (RUUO) and explore the pathological process of renal fibrosis after the obstruction was relieved. Methods: C57BL/6 mice in model group were randomly divided into RUUO group, improved RUUO group, and UUO group. After leaving Unilateral...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2019.1624263
更新日期:2019-11-01 00:00:00
abstract::Oxidative stress is one of the important mechanisms of cisplatin-induced nephrotoxicity. Therefore, this study was designed to explore the potential protective effects of morin and/or hesperidin on oxidative stress in cisplatin-induced nephrotoxicity. This study was performed on 42 Wistar rats. Rats were divided into ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2016.1209383
更新日期:2016-09-01 00:00:00
abstract::Podocyte injury is a vital factor, which induces massive proteinuria. Studies have shown that tacrolimus (TAC) protected podocyte via stabilizing cytoskeleton. Our latest study indicates that calcineurin binding protein 1 (Cabin1) undergoes nuclear translocation during podocytes injury. Whether TAC targets on Cabin1 d...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2016.1148936
更新日期:2016-01-01 00:00:00
abstract::We evaluated the feasibility of magnetic resonance imaging (MRI) for early detection of tubular injury by monitoring changes in the apparent diffusion coefficient (ADC) of renal water in a rat model of myohemoglobinuric glycerol-induced acute renal failure (ARF). Diffusion-weighted MRI was performed concurrently with ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229609052773
更新日期:1996-01-01 00:00:00