Abstract:
:We report a case of rapidly progressive diabetic nephropathy, from little diabetic change on renal biopsy to severe, nodular, diabetic nephrosclerosis over 32 months. The patient was taking an angiotensin converting enzyme inhibitor and had a mean arterial pressure of 95 mm Hg over this time period. Her dietary protein intake was low, at least upon presentation. She had three additional mechanisms or potential mechanisms of injury: monoclonal kappa light chains; IgA immune deposits on the first, but not the second biopsy; and longstanding hypertension. Her renal histology was typical for diabetic nephropathy but was not characteristic of kappa light chain disease. We suggest that diabetic nephropathy may develop more rapidly than previously assumed, especially when additional mechanisms of injury, or additional promoters of mesangial matrix accumulation are present.
journal_name
Ren Failjournal_title
Renal failureauthors
Dillon JJ,Sedmak DD,Cosio FGdoi
10.3109/08860229709037223subject
Has Abstractpub_date
1997-11-01 00:00:00pages
819-22issue
6eissn
0886-022Xissn
1525-6049journal_volume
19pub_type
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