Rapid-onset diabetic nephropathy in type II diabetes mellitus.

Abstract:

:We report a case of rapidly progressive diabetic nephropathy, from little diabetic change on renal biopsy to severe, nodular, diabetic nephrosclerosis over 32 months. The patient was taking an angiotensin converting enzyme inhibitor and had a mean arterial pressure of 95 mm Hg over this time period. Her dietary protein intake was low, at least upon presentation. She had three additional mechanisms or potential mechanisms of injury: monoclonal kappa light chains; IgA immune deposits on the first, but not the second biopsy; and longstanding hypertension. Her renal histology was typical for diabetic nephropathy but was not characteristic of kappa light chain disease. We suggest that diabetic nephropathy may develop more rapidly than previously assumed, especially when additional mechanisms of injury, or additional promoters of mesangial matrix accumulation are present.

journal_name

Ren Fail

journal_title

Renal failure

authors

Dillon JJ,Sedmak DD,Cosio FG

doi

10.3109/08860229709037223

subject

Has Abstract

pub_date

1997-11-01 00:00:00

pages

819-22

issue

6

eissn

0886-022X

issn

1525-6049

journal_volume

19

pub_type

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