Efficacy comparison of atorvastatin versus rosuvastatin on blood lipid and microinflammatory state in maintenance hemodialysis patients.

Abstract:

INTRODUCTION:To investigate the effect of Atorvastatin (ATO) and Rosuvastatin (ROS) on blood lipid, high sensitivity CRP (hs-CRP), interleukin-6 (IL-6), albumin (ALB), prealbumin (PA), and transferring (TF) in maintenance hemodialysis (MHD) patients. METHODS:Eighty MHD patients were enrolled and divided into two groups: ROS and ATO. Patients in Group ROS (n = 38) received ROS (10 mg/day), and those in group ATO (n = 42) received ATO (20 mg/day) for 12 weeks, respectively. FINDINGS:Administration of ROS and ATO both significantly reduced the concentrations of TC, LDL-C, TG, hs-CRP, and IL-6, but increased high-density lipoproteincholesterol (HDL-C), ALB, PA, and TF levels. Furthermore, the level of LDL-C decreased more significantly with inhibited microinflammation and improved nutrition situation in ROS group compared with ATO group. ATO and ROS not only decreased blood lipid levels but also inhibited the microinflammatory state and improved nutrition situation in MHD patients. DISCUSSION:The results have shown that ROS is better than ATO in the treatment of MHD patients.

journal_name

Ren Fail

journal_title

Renal failure

authors

Tian J,Hou X,Hu L,Chen T,Wu K,Cai C,Bai X

doi

10.1080/0886022X.2016.1256309

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

153-158

issue

1

eissn

0886-022X

issn

1525-6049

journal_volume

39

pub_type

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